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21. 发明申请

WO2004050142A3 CATHETER LOOP MANAGER 审中-公开
公开(公告)号：WO2004050142A3
公开(公告)日：2007-05-03
申请号：PCT/US0338548
申请日：2003-12-04
申请人： DURECT CORP , POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
发明人： POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
IPC分类号： A61M5/32 , A61M20060101 , A61M5/142 , A61M25/00 , A61M25/01 , A61M39/12
CPC分类号： A61M5/14276 , A61M25/0097 , A61M25/0113 , A61M39/12
摘要： A catheter loop manager (10) which controls the slack portion of a catheter located adjacent to an implanted pump (12) and prevents fibrotic encapsulation of the slack catheter portion. The catheter loop manager comprises a retainer element (18) configured to associate with an implantable pump and to releasibly hold or retain a loop or section of catheter adjacent to the pump. A pull tool (20) is used to releasibly engage a catheter section and pull the catheter section into a loop within a retention channel in the retainer element.
摘要翻译：导管回路管理器（10），其控制位于植入泵（12）附近的导管的松弛部分并防止松弛导管部分的纤维化封装。导管回路管理器包括被配置为与可植入泵相关联并且可释放地保持或保持与泵相邻的导管的环或部分的保持器元件（18）。拉动工具（20）用于可释放地接合导管部分并将导管部分拉入保持器元件中的保持通道内的环中。

22. 发明申请

WO2004052336A3 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 审中-公开
标题翻译：高粘度液体控制输送系统和医疗或手术装置
公开(公告)号：WO2004052336A3
公开(公告)日：2006-06-15
申请号：PCT/US0339311
申请日：2003-12-10
申请人： DURECT CORP , GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
发明人： GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
IPC分类号： A61K8/60 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/70 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00 , A61K9/10 , A61F6/06 , A61F9/02 , A61K9/20 , A61L27/00 , A61L25/00
CPC分类号： A61K47/10 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0073 , A61K9/1647 , A61K9/4858 , A61K9/7015 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L24/0026 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/252 , A61L2300/402 , A61L2300/43 , A61L2300/602 , A61Q5/006
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.
摘要翻译：本发明涉及形成液体，高粘度材料的新型非聚合物和组合物，其适于以受控的方式递送生物活性物质，并用作医疗或手术装置。该材料可以任选地用溶剂稀释以形成较低粘度的材料，使得材料易于施用。该溶剂可以是水不溶性或水溶性的，其中水溶性溶剂在体内快速扩散或迁移离开材料，留下较高粘度的液体材料。

23. 发明申请

WO2004054542A3 ORAL DRUG DELIVERY SYSTEM COMPRISING HIGH VISCOSITY LIQUID CARRIER MATERIALS 审中-公开
标题翻译：包含高粘度液体载体材料的口服药物输送系统
公开(公告)号：WO2004054542A3
公开(公告)日：2004-08-26
申请号：PCT/US0340156
申请日：2003-12-15
申请人： DURECT CORP , YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
发明人： YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
摘要翻译：适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。

24. 发明申请

WO02067895A3 IMPLANT DOSAGE FORM AND USE THEREOF FOR THE DELIVERY OF A CHOLESTEROL LOWERING AGENT 审中-公开
标题翻译：植入剂形式及其用途，用于输送胆固醇降低剂
公开(公告)号：WO02067895A3
公开(公告)日：2003-04-17
申请号：PCT/US0146714
申请日：2001-11-08
申请人： DURECT CORP , STRUIJKER-BOUDIER HARRY A J
发明人： STRUIJKER-BOUDIER HARRY A J
IPC分类号： A61K9/00 , A61K31/22 , A61K31/366 , A61K31/404 , A61K31/405 , A61K31/4418 , A61K47/34
CPC分类号： A61K9/0024 , A61K31/22 , A61K31/366 , A61K31/404 , A61K31/405 , A61K31/4418 , A61K47/34
摘要： Implanted, sustained release dosage forms, devices and methods for the delivery of a cholesterol lowering agent.
摘要翻译：植入性缓释剂型，用于递送降胆固醇剂的装置和方法。

25. 发明申请

WO03009883A2 CATHETER FOR MODIFICATION OF AGENT FORMULATION 审中-公开
标题翻译：改性剂配方的导管
公开(公告)号：WO03009883A2
公开(公告)日：2003-02-06
申请号：PCT/US0222837
申请日：2002-07-16
申请人： DURECT CORP , CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
发明人： CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
IPC分类号： A61L29/16 , A61M25/00 , A61M25/16 , A61M
CPC分类号： A61L29/16 , A61M25/00 , A61M25/0068 , A61M25/0082 , A61M2025/0057 , A61M2025/0073 , A61M2025/0076 , A61M2025/105 , A61M2025/1086
摘要： The present invention provides a catheter (10) for use in delivering formulation that allows modification of the formulation prior to or concomitant with its transport or at a delivery site. The catheter (10) comprises an elongate body (20), which defines an inner lumen (26) extending between the proximal (21) and distal (23) ends, and a modifying element (40), which provides for modification of one or more components of a formulation prior to or concomitant with release at the delivery site.
摘要翻译：本发明提供了一种用于输送制剂的导管（10），该制剂允许在制剂在其运输之前或伴随其运输或在递送部位对制剂进行改性。导管10包括限定在近端21和远端23之间延伸的内腔26的细长主体20和修改元件40，在递送部位释放之前或伴随释放的制剂的更多组分。

26. 发明申请

WO0054745A3 DEVICES AND METHODS FOR PAIN MANAGEMENT 审中-公开
标题翻译：用于疼痛管理的装置和方法
公开(公告)号：WO0054745A3
公开(公告)日：2000-11-30
申请号：PCT/US0007068
申请日：2000-03-16
申请人： DURECT CORP , JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04 , A61F13/02 , A61K9/70 , A61M5/00
CPC分类号： A61M37/0069 , A61K9/0004 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a matrix within the controlled drug delivery device). The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures (i.e., no unacceptable degradation) for the entire pre-selected treatment period. The drug delivery devices store the drug formulation safely (e.g., without dose dumping), provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site, and the drug formulation is released from the drug delivery device to a delivery site. The delivery site may be the same as, near, or distant from the implantation site. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response (e.g., the brain or other pain sensory location).
摘要翻译：本发明的特征在于全身递送芬太尼或芬太尼同源物（例如舒芬太尼）以治疗疼痛的装置和方法。在本发明中，包含芬太尼或芬太尼同源物的药物制剂储存在药物递送装置（例如容纳在储库中或浸渍在受控药物递送装置内的基质内）内。药物制剂包含足以治疗的量的药物，并且在整个预选治疗期间在体温下稳定（即没有不可接受的降解）。药物输送装置安全地储存药物制剂（例如，无剂量倾倒），提供对身体过程的充分保护以防止制剂不可接受的降解，并且以受控的方式以治疗有效的速率释放药物制剂以治疗疼痛。在使用中，药物递送装置在植入部位植入受治疗者体内，药物制剂从药物递送装置释放到递送部位。输送部位可以与植入部位相同，接近或远离。一旦在递送部位释放，药物制剂进入全身循环并被运送到体内作用部位以调节疼痛反应（例如，大脑或其他疼痛感觉部位）。

27. 发明申请

WO2009051845A3 BIODEGRADABLE IMPLANTS WITH CONTROLLED BULK DENSITY 审中-公开
标题翻译：具有控制密度的生物可降解植入物
公开(公告)号：WO2009051845A3
公开(公告)日：2010-01-28
申请号：PCT/US2008011967
申请日：2008-10-20
申请人： DURECT CORP , YUM SU II , GOSKONDA SANJAY , SU HUEY-CHING
发明人： YUM SU II , GOSKONDA SANJAY , SU HUEY-CHING
IPC分类号： A61K9/00 , A61K38/09
CPC分类号： A61K9/0024 , A61K9/0004 , A61K38/09
摘要： Disclosed solid water permeable implants that include a water permeable polymer and an osmotically active drug formulation that comprises a drug; wherein the solid water permeable implant has a ratio R of bulk density of the solid water permeable implant to osmotic pressure of the drug formulation wherein R is greater than about 0.244 grams/milliliter-atm. Also disclosed are methods of making and using such solid water permeable implants.
摘要翻译：公开的固体水可渗透植入物，其包括水可渗透聚合物和包含药物的渗透活性药物制剂; 其中固体水可渗透植入物具有固体水可渗透植入物的体积密度与药物制剂的渗透压的比R，其中R大于约0.244克/毫升。还公开了制造和使用这种固体水可渗透植入物的方法。

28. 发明申请

WO2008143992A3 IMPROVED DEPOT FORMULATIONS 审中-公开
标题翻译：改进的DEPOT制剂
公开(公告)号：WO2008143992A3
公开(公告)日：2009-09-24
申请号：PCT/US2008006320
申请日：2008-05-16
申请人： DURECT CORP , WRIGHT JEREMY C , THEEUWES FELIX , GIBSON JOHN W , BRANHAM KEITH E , SJOBECK STEFANIA
发明人： WRIGHT JEREMY C , THEEUWES FELIX , GIBSON JOHN W , BRANHAM KEITH E , SJOBECK STEFANIA
IPC分类号： A61K9/08 , A61K9/10 , A61K31/519 , A61K47/06 , A61K47/34
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K47/22 , A61K47/26 , A61K47/34
摘要： Disclosed are formulations and related methods that comprise a non- polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37°C that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity. Preferably the formulations contain sucrose acetate isobutyrate (SAIB), poly(lactide-c glycolide) (PLGA) and a suitable solvent, being preferably NMP. Exemplified drugs ar risperidone and naltrexone.
摘要翻译：公开了包含非常优选的非水溶性高粘度液体载体材料的制剂和相关方法，其在37℃下的粘度至少为5,000cP，在环境或生理条件下不结晶; 包含丙交酯重复单元的指定线性聚合物; 和一种或多种具有溶剂能力的溶剂。优选地，制剂含有蔗糖乙酸异丁酸酯（SAIB），聚（丙交酯 - 乙交酯）（PLGA）和合适的溶剂，优选为NMP。示例药物为利培酮和纳曲酮。

29. 发明申请

WO2008066642A2 TRANSDERMAL DELIVERY SYSTEMS 审中-公开
标题翻译：变送器系统
公开(公告)号：WO2008066642A2
公开(公告)日：2008-06-05
申请号：PCT/US2007022927
申请日：2007-10-29
申请人： DURECT CORP , YUM SU II , KWON SUNG YUN , SONG XIAO PING , BROWN JAMES E
发明人： YUM SU II , KWON SUNG YUN , SONG XIAO PING , BROWN JAMES E
IPC分类号： A61L15/58 , A61K9/70 , A61L15/44
CPC分类号： A61K31/445 , A61K9/0014 , A61K9/7023 , A61K9/7053 , A61K9/7084 , A61K47/26 , A61L15/58
摘要： Disclosed are bupivacaine transdermal delivery systems, and related methods.
摘要翻译：公开了布比卡因透皮递送系统及相关方法。

30. 发明申请

WO2004047839A8 HIGH CONCENTRATION FORMULATIONS OF OPIOIDS AND OPIOID DERIVATIVES 审中-公开
标题翻译：阿片类药物和阿片类衍生物的高浓度配方
公开(公告)号：WO2004047839A8
公开(公告)日：2004-08-19
申请号：PCT/US0338174
申请日：2003-11-25
申请人： DURECT CORP , CHAN TAI WAH
发明人： CHAN TAI WAH
IPC分类号： A61K9/00 , A61K9/08 , A61K31/19 , A61K31/445 , A61K47/12 , A61K31/44
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/19 , A61K31/445 , A61K47/12
摘要： The present invention provides opioid formulations suitable for long-term delivery to a subject. The formulation of the invention comprises an opioid or opioid derivative (e.g., morphine, hydromorphone, fentanyl or a fentanyl congener), and an aqueous solvent comprising a low molecular weight carboxylic acid (e.g., C2-4, C2-7). The invention thus provides for formulations comprising morphine, hydromorphone, fentanyl or fentanyl congeners in concentrations significantly in excess of conventional aqueous formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations.
摘要翻译：本发明提供了适合于长期递送至受试者的阿片样物质制剂。本发明的制剂包含阿片样物质或阿片样物质衍生物（例如吗啡，氢吗啡酮，芬太尼或芬太尼同源物）和包含低分子量羧酸（例如C2-4，C2-7）的水性溶剂。因此，本发明提供了包含吗啡，氢吗啡酮，芬太尼或芬太尼同类物的制剂，其浓度显着超过常规水性制剂，例如比常规制剂高约2倍至约10,000倍，例如目前市售制剂。

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