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21. 发明申请

WO2013173376A1 hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS 审中-公开
标题翻译：肺和肺动脉疾病和疾病的预防性调理剂的hUTC调节
公开(公告)号：WO2013173376A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/041002
申请日：2013-05-14
申请人： DEPUY SYNTHES PRODUCTS, LLC.
发明人： KIHM, Anthony J.
IPC分类号： A61K35/48 , A61P11/00
CPC分类号： A61K35/51
摘要： This invention encompasses methods, pharmaceutical compositions, and kits, which utilize umbilical cord tissue-derived cells, for modulating (e.g. reducing) the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. The invention also encompasses methods, pharmaceutical compositions, and kits, which utilize umbilical cord tissue-derived cells, for inhibiting the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury utilizing umbilical cord tissue-derived cells. In one embodiment, the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, lack the production of CD117 or CD45, and do not express hTERT or telomerase.
摘要翻译：本发明包括使用脐带组织来源的细胞的方法，药物组合物和试剂盒，用于调节（例如减少）参与肺疾病，病症和/或损伤的病理学的促炎介导体的产生患有肺部疾病，病症和/或损伤的患者。本发明还包括利用脐带组织来源的细胞的方法，药物组合物和试剂盒，用于抑制参与患有肺疾病，病症和/或损伤的病人的炎性介质的产生，所述患者具有利用脐带组织来源细胞的肺部疾病，疾病和/或损伤。在一个实施方案中，脐带组织来源的细胞从基本上没有血液的人脐带组织中分离，能够在培养中自我更新和扩增，缺少CD117或CD45的产生，并且不表达hTERT或端粒酶。

22. 发明申请

WO2013173138A1 A MEASURING DEVICE FOR A DRILL 审中-公开
标题翻译：用于钻头的测量装置
公开(公告)号：WO2013173138A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/040086
申请日：2013-05-08
申请人： DEPUY SYNTHES PRODUCTS, LLC , SYNTHES GMBH
发明人： BAUMGARTNER, Adrian
IPC分类号： A61B17/16 , G01D5/14
CPC分类号： G01D11/245 , A61B17/1622 , A61B17/1626 , A61B17/1628 , A61B17/1633 , A61B17/17 , A61B90/06 , A61B2017/00991 , A61B2090/062 , B23B49/00 , B23B2251/52 , G01D5/145
摘要： A measuring device 1 configured to receive a drill bit 3, and determine the relative displacement of the drill bit 3, is disclosed. The measuring device 1 is configured to be deployed proximate to the material to be drilled, reset, and subsequently determine the relative displacement of the drill bit 3. The measuring device 1 can be used in orthopaedic surgery procedures for determining the depth of a bore hole in bone.
摘要翻译：公开了一种被配置为接收钻头3并确定钻头3的相对位移的测量装置1。测量装置1构造成靠近待钻探材料，重新设置并随后确定钻头3的相对位移。测量装置1可用于整形外科手术中以确定钻孔深度在骨头。

23. 发明申请

WO2012129205A8 FUSION CAGE WITH IN-LINE SINGLE PIECE FIXATION 审中-公开
标题翻译：具有直插单面固定的熔接笼
公开(公告)号：WO2012129205A8
公开(公告)日：2013-10-31
申请号：PCT/US2012029760
申请日：2012-03-20
申请人： DEPUY SYNTHES PRODUCTS LLC , GAMACHE THOMAS , CHILDS JOSEPH , PARSONS MATTHEW , FLAHERTY KEVIN
发明人： GAMACHE THOMAS , CHILDS JOSEPH , PARSONS MATTHEW , FLAHERTY KEVIN
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61B17/0642 , A61B17/0682 , A61B2017/0641 , A61F2/4611 , A61F2002/2835 , A61F2002/30092 , A61F2002/30161 , A61F2002/30196 , A61F2002/30484 , A61F2002/30509 , A61F2002/30518 , A61F2002/30576 , A61F2002/30579 , A61F2002/30604 , A61F2002/30607 , A61F2002/30616 , A61F2002/30774 , A61F2002/30787 , A61F2002/30841 , A61F2002/30843 , A61F2002/30904 , A61F2002/4475 , A61F2002/4623 , A61F2002/4625 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161
摘要： Methods for securing a intervertebral cage to one or more levels of the spine with fixation. The fixation, which is typically a staple, is intended to be driven perpendicular to the proximal face of the cage and in-line with the inserter. After the cage is placed and positioned according to surgeon preference, a single piece fixation clip is then deployed and fixed in a manner that produces a zero-profile device.
摘要翻译：用固定将椎间盘固定到脊柱的一个或多个水平的方法。通常是钉子的固定件旨在垂直于保持架的近侧面并与插入件成一直线地驱动。在根据外科医生优选放置和定位保持架之后，然后以产生零轮廓装置的方式部署和固定单件固定夹。

24. 发明申请

WO2013148678A1 METHODS AND DEVICES FOR TISSUE RETRACTION 审中-公开
标题翻译：用于组织回缩的方法和装置
公开(公告)号：WO2013148678A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/033873
申请日：2013-03-26
申请人： DEPUY SYNTHES PRODUCTS, LLC , HAWKINS, John, Riley , RAMSAY, Christopher
发明人： HAWKINS, John, Riley , RAMSAY, Christopher
IPC分类号： A61B1/32
CPC分类号： A61B17/0206 , A61B17/025 , A61B17/0293 , A61B90/92 , A61B90/94 , A61B2017/00477 , A61B2017/0256
摘要： Methods and devices are provided for retracting tissue. In one exemplary embodiment, a retractor is provided that includes a base and a plurality of blades configured to removably and replaceably mate to the base. One or more of the plurality of blades can be configured to mate to the base in one of a plurality of available positions. In use, one or more adjustment mechanisms can be actuated to move one or more of the blades, thereby forming a pathway through tissue. The retractor can be formed from one or more radiolucent materials.
摘要翻译：提供用于回缩组织的方法和装置。在一个示例性实施例中，提供了牵开器，其包括基部和被配置成可移除地和可更换地配合到基部的多个叶片。多个叶片中的一个或多个可被配置为在多个可用位置之一中与基座配合。在使用中，可以致动一个或多个调节机构以移动一个或多个叶片，从而形成穿过组织的通路。牵开器可以由一个或多个射线可透过材料形成。

25. 发明申请

WO2013134210A1 NUBBED PLATE 审中-公开
标题翻译： NUBBED板
公开(公告)号：WO2013134210A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029026
申请日：2013-03-05
申请人： DEPUY SYNTHES PRODUCTS, LLC
发明人： PAVENTO, Nicholas , HAWKINS, John Riley , FRANK, Sheryl , RAYMOND, Douglas
IPC分类号： A61B17/70
CPC分类号： A61F2/447 , A61B17/7059 , A61F2/30744 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2002/2817 , A61F2002/2835 , A61F2002/30378 , A61F2002/30428 , A61F2002/30482 , A61F2002/305 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30607 , A61F2002/30616 , A61F2002/30622 , A61F2002/30774 , A61F2002/30784 , A61F2002/30785 , A61F2002/30787 , A61F2002/30836 , A61F2002/30843 , A61F2002/4475 , A61F2002/448 , A61F2220/0008 , A61F2310/00011 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00047 , A61F2310/00053 , A61F2310/00101 , A61F2310/00161 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00359 , A61F2310/00407
摘要： A separate nub component between the plate and an intervertebral fusion cage, wherein the nub is attached to the plate. The nub lessens the undesired pivotal movement of the plate. It is believed that when the nub fits snugly between the end plates of the adjacent vertebral bodies, it acts as a stop against the undesired pivotal movement of the plate.
摘要翻译：在板和椎间融合器之间的单独的母体部件，其中所述突出部附接到所述板。凸块减少了板的不期望的枢转运动。可以相信，当纽扣紧密地配合在相邻椎体的端板之间时，其作用是阻止板的不期望的枢转运动。

26. 发明申请

WO2013123136A1 DRUG ELUTING INSERT FOR IMPLANTABLE BODY 审中-公开
标题翻译：用于可植入体的药物涂抹刀
公开(公告)号：WO2013123136A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/026059
申请日：2013-02-14
申请人： DEPUY SYNTHES PRODUCTS, LLC , SYNTHES GMBH
发明人： ARMBRUSTER, David , ADLON, Katlin , CHOMYN, Jeffrey , YU, Aaron
IPC分类号： A61L31/16 , A61B17/70 , A61B17/72 , A61B17/80 , A61M37/00
CPC分类号： A61L31/16 , A61B17/72 , A61B17/80 , A61B17/84 , A61B2017/00004 , A61B2017/561 , A61F2002/30677 , A61L2300/406 , A61L2430/02 , Y10T29/49826
摘要： The present application discloses embodiments related to an implant and a method of forming an implant configured to treat a fractured bone. The implant (10) can include a body (20) having a proximal end, a distal end, and an outer surface (28) extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; and a high tensile strand (60) positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent.
摘要翻译：本申请公开了与植入物相关的实施例以及形成用于治疗骨折骨的植入物的方法。植入物（10）可以包括具有近端，远端和从近端延伸到远端延伸的外表面（28）的主体（20），其中主体限定从近端延伸的中心轴线到远端以及位于所述主体附近的高拉伸股线（60），使得所述股线的至少一部分沿着与所述中心轴线基本平行的方向至少部分地沿着所述主体的外表面延伸，并且其中所述股线被加载有活性剂。

27. 发明申请

WO2015069675A1 CLAVICLE REAMER 审中-公开
公开(公告)号：WO2015069675A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/063981
申请日：2014-11-05
申请人： DEPUY SYNTHES PRODUCTS, LLC
发明人： MCMANUS, Joshua
IPC分类号： A61B17/16 , B23D77/00
CPC分类号： A61B17/1631 , A61B17/164 , A61B17/1684
摘要： A device (100) for reaming a bone includes an elongated shaft (102) extending along a first longitudinal axis (101) from a first end to a second end (104), the shaft being sufficiently longitudinally flexible to enable it to be passed through a path having a curvature of a target bone and a reaming head (106) extending along a second longitudinal axis (111) from the second end to a third free end (108), wherein the first longitudinal axis is parallel to and laterally offset from the second longitudinal axis so that, upon rotation of the shaft, the reaming head rotates eccentrically with respect to the first longitudinal axis. The device can be a clavicle reamer. The offset movement of the reamer head and the flexibility of the shaft guides the clavicle reamer along the curvature of the medullary canal and permits it to skive off a cortical wall of the clavicle.
摘要翻译：用于铰接骨的装置（100）包括沿着第一纵向轴线（101）从第一端延伸到第二端（104）的细长轴（102），所述轴具有足够的纵向柔性以使其能够通过具有目标骨的曲率的路径和沿着第二纵向轴线（111）从第二端延伸到第三自由端（108）的扩孔头（106），其中第一纵向轴线平行于并且横向偏离所述第二纵向轴线使得当所述轴旋转时，所述扩孔头相对于所述第一纵向轴线偏心地旋转。该装置可以是锁骨铰刀。铰刀头的偏移运动和轴的柔性引导锁骨铰刀沿着髓质管的曲率，并允许其摆脱锁骨的皮质壁。

28. 发明申请

WO2015047626A1 AN INSTRUMENT FOR POSITIONING A CUP COMPONENT OF AN ORTHOPAEDIC JOINT PROSTHESIS 审中-公开
标题翻译：用于定位正交联合检测的杯子组件的仪器
公开(公告)号：WO2015047626A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/052681
申请日：2014-08-26
申请人： DEPUY SYNTHES PRODUCTS, LLC
发明人： RHOADES, Joel C. , SCHMIT, Matthew D.
IPC分类号： A61F2/46
CPC分类号： A61F2/4609 , A61F2002/4624 , A61F2002/4627 , A61F2002/4681 , A61F2002/4685
摘要： An instrument (10) for positioning a hollow cup component (24) of an orthopaedic joint prosthesis. The instrument includes a longitudinal member (12) having a first end (14) and a second end (16) opposite the first end. The instrument further includes a resilient cup engaging member (18) coupled to the first end. The resilient cup engaging member has a convex outer surface (20) adapted to engage an interior of the hollow cup component. The entire outer convex surface is manufactured of a resilient material. An actuator (17, 26, 44) in fluid communication with the resilient cup engaging member is also included. When the actuator is actuated, the suction force between the resilient cup engaging member and the hollow cup increases.
摘要翻译：一种用于定位整形外科关节假体的中空杯部件（24）的仪器（10）。仪器包括具有第一端（14）和与第一端相对的第二端（16）的纵向构件（12）。仪器还包括耦合到第一端的弹性杯接合构件（18）。弹性杯接合构件具有适于接合中空杯部件内部的凸形外表面（20）。整个外凸表面由弹性材料制成。还包括与弹性杯接合构件流体连通的致动器（17,26,44）。当致动器被致动时，弹性杯接合构件和中空杯之间的吸力增加。

29. 发明申请

WO2015038489A1 COATING PROCESS FOR NON-CONDUCTIVE SUBSTRATES AND DEVICES MADE FROM THE COATING PROCESS 审中-公开
标题翻译：非导电基板的涂层工艺和涂层工艺的器件
公开(公告)号：WO2015038489A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/054650
申请日：2014-09-09
申请人： DEPUY SYNTHES PRODUCTS, LLC
发明人： BARKER, Paul , PATSCHEIDER, JöRG , THORWARTH, GöTZ
IPC分类号： A61L27/18 , A61L27/30 , A61L31/06 , A61L31/08
CPC分类号： C23C14/35 , A61B17/80 , A61B17/84 , A61F2/44 , A61F2310/00407 , A61F2310/00544 , A61L27/18 , A61L27/306 , A61L31/06 , A61L31/088 , A61L2420/02 , A61L2430/02 , A61L2430/24 , A61L2430/38 , C23C14/3485 , C23C28/00 , C08L71/00
摘要： A method for manufacturing a surgical implant. A metal layer is deposited onto a polyaryletherketone (PAEK) substrate by generating a series of pulses using a high power impulse magnetron sputtering process. Each pulse is applied in a series of micro pulse steps comprising (i) micro pulse on steps ranging from 10 µs to 100 µs and (ii) micro pulse off steps ranging from 5 µs to 400 µs; at a repetition frequency ranging from 50-2000 Hz with 2 micropulses to 20 micropulses per repetition, a total pulse on time ranging from 25 µs to 800 µs for 5 minutes to 300 minutes at averaged power ranging from 200 W to 3000 W. The series of pulses are performed in a unipolar mode or a bipolar mode.
摘要翻译：一种用于制造手术植入物的方法。通过使用高功率脉冲磁控溅射工艺产生一系列脉冲，将金属层沉积在聚芳醚酮（PAEK）衬底上。每个脉冲以一系列微脉冲步骤施加，包括（i）10μs至100μs范围内的微脉冲，和（ii）5μs至400μs的微脉冲关闭步骤; 重复频率范围为50-2000 Hz，每次重复2个脉冲，20个微脉冲，时间范围从25μs到800μs的总脉冲时间为5分钟至300分钟，平均功率范围为200 W至3000 W。的脉冲在单极模式或双极模式下执行。

30. 发明申请

WO2015038370A1 MINIMALLY INVASIVE BIOMATERIAL INJECTION SYSTEM 审中-公开
标题翻译：微生物入侵生物注射系统
公开(公告)号：WO2015038370A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/053691
申请日：2014-09-02
申请人： DEPUY SYNTHES PRODUCTS, LLC
发明人： CHEGINI, Salman , RICHTER, Joern , THOMMEN, Daniel
IPC分类号： A61B17/88
CPC分类号： A61F2/441 , A61B17/7097 , A61B17/7098 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8819 , A61B17/8827 , A61F2/4601 , A61F2/4611
摘要： This invention relates generally to an instrumentation and implant system providing minimally invasive vertebral augmentation. The apparatus including an expandable membrane sized and configured to be located within a cavity in a patient's bone and having an interior volume for receiving bone filler material; a delivery cannula in communication with the membrane for providing bone filler material to the membrane; and an evacuation cannula in fluid communication with the membrane for receiving a portion of the provided bone filler material from the membrane.
摘要翻译：本发明一般涉及提供微创脊椎增大的仪器和植入系统。所述装置包括可膨胀膜，其尺寸设计成位于患者骨骼中的空腔内并且具有用于接收骨填充材料的内部容积; 与所述膜连通的输送插管，用于向所述膜提供骨填充材料; 以及与所述膜流体连通的排泄插管，用于从所述膜接收所提供的骨填充材料的一部分。

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