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21. 发明申请

WO2012155123A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2012155123A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/037676
申请日：2012-05-12
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/74 , G01N2333/495 , G01N2333/545 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Transforming growth factor beta-1, Transforming growth factor beta-2, Transforming growth factor beta-3, and Interleukin-1 receptor-like 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标志物：转化生长因子β-1，转化生长因子β-2，转化生长因子β-3和白细胞介素-1 1受体样1作为肾损伤的诊断和预后生物标志物。

22. 发明申请

WO2012048082A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2012048082A3
公开(公告)日：2012-06-21
申请号：PCT/US2011055055
申请日：2011-10-06
申请人： ASTUTE MEDICAL INC , ANDERBERG JOSEPH , GRAY JEFF , MCPHERSON PAUL , NAKAMURA KEVIN , KAMPF JAMES PATRICK
发明人： ANDERBERG JOSEPH , GRAY JEFF , MCPHERSON PAUL , NAKAMURA KEVIN , KAMPF JAMES PATRICK
IPC分类号： G01N33/573
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Beta-nerve growth factor, Interleukin-17A, Follitropin subunit beta, Collagenase 3, Follistatin, Vitamin D Binding Protein, Islet amyloid polypeptide, Insulin C-peptide, Complement Factor H, Gastric inhibitory polypeptide, Glucagon-like peptide 1, Glucagon, Involucrin, Type II cytoskeletal Keratin- 1/Keratin- 10, Type II cytoskeletal Keratin- 6 A/6B/6C, Osteocalcin, Lipopolysaccharide, Pancreatic prohormone, Peptide YY, Agouti-related protein, Ciliary neurotrophic factor, Appetite-regulating hormone, Transthyretin, Insulin receptor substrate 1, and NF-kappa-B inhibitor alpha as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种生物标志物的测定法，所述生物标志物选自β-神经生长因子，白细胞介素-177，富立替丁亚基β，胶原酶3，胶质蛋白，维生素D结合蛋白，胰岛淀粉样蛋白多肽，胰岛素 C肽，补体因子H，胃抑制性多肽，胰高血糖素样肽1，胰高血糖素，Involucrin，II型细胞骨架角蛋白-1 /角蛋白-10，II型细胞骨架角蛋白-6A / 6B / 6C，骨钙素，脂多糖，胰腺激素，肽YY，Agouti相关蛋白，睫状神经营养因子，食欲调节激素，Transthyretin，胰岛素受体底物1和NF-κB抑制剂α作为肾损伤中的诊断和预后生物标志物测定。

23. 发明申请

WO2012048082A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：肾损伤和肾功能衰竭的诊断和预后的方法和组合物
公开(公告)号：WO2012048082A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/055055
申请日：2011-10-06
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Beta-nerve growth factor, Interleukin-17A, Follitropin subunit beta, Collagenase 3, Follistatin, Vitamin D Binding Protein, Islet amyloid polypeptide, Insulin C-peptide, Complement Factor H, Gastric inhibitory polypeptide, Glucagon-like peptide 1, Glucagon, Involucrin, Type II cytoskeletal Keratin- 1/Keratin- 10, Type II cytoskeletal Keratin- 6 A/6B/6C, Osteocalcin, Lipopolysaccharide, Pancreatic prohormone, Peptide YY, Agouti-related protein, Ciliary neurotrophic factor, Appetite-regulating hormone, Transthyretin, Insulin receptor substrate 1, and NF-kappa-B inhibitor alpha as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。特别地，本发明涉及使用检测选自以下的一种或多种生物标记的测定法：β-神经生长因子，白细胞介素-17A，促卵泡素亚基β，胶原酶3，卵泡抑素，维生素D结合蛋白，胰岛淀粉样多肽，胰岛素 C-肽，补体因子H，胃抑制性多肽，胰高血糖素样肽1，胰高血糖素，Involucrin，II型细胞骨架角蛋白-1 /角蛋白-10，II型细胞骨架角蛋白-6A / 6B / 6C，骨钙蛋白，脂多糖，胰腺激素原，肽YY，刺鼠相关蛋白，睫状神经营养因子，食欲调节激素，转甲状腺素蛋白，胰岛素受体底物1和NF-κB抑制剂α作为肾损伤诊断和预后生物标志物测定。

24. 发明申请

WO2012040592A1 METHODS AND COMPOSITIONS FOR THE EVALUATION OF RENAL INJURY USING HYALURONIC ACID 审中-公开
标题翻译：使用羟丙酸评估肾损伤的方法和组合
公开(公告)号：WO2012040592A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/053015
申请日：2011-09-23
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： C08B37/08 , G01N33/50
CPC分类号： G01N33/5308 , G01N33/50 , G01N2400/40 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测透明质酸（HA）中的一种或多种作为肾损伤中的诊断和预后生物标志物测定的测定法。

25. 发明申请

WO2011162821A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011162821A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/001128
申请日：2011-06-23
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/48 , G01N33/53
CPC分类号： G01N33/6893 , G01N2333/475 , G01N2333/49 , G01N2333/52 , G01N2333/521 , G01N2333/54 , G01N2333/5418 , G01N2333/71 , G01N2333/7155 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C-C motif chemokine 1, C-C motif chemokine 17, C-C motif chemokine 21, C-C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and MMP9:TIMP2 complex as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自胸腺基质淋巴细胞生成素，血管内皮生长因子受体1，CC基序趋化因子1，CC基序趋化因子17，CC基序趋化因子 21，CC基序趋化因子27，FLT-3配体，免疫球蛋白G亚类3，白细胞介素-1受体I型，白细胞介素-20，白细胞介素-29，白介素-7，血小板衍生生长因子A / B二聚体，血小板衍生生长因子A / A二聚体和MMP9：TIMP2复合物作为肾损伤的诊断和预后生物标志物。

26. 发明申请

WO2011109446A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE IN A NON-SURGICAL ICU POPULATION 审中-公开
标题翻译：用于诊断和预防非手术ICU人群的肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011109446A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026759
申请日：2011-03-01
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , G01N33/5091 , G01N33/74 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects admitted to a hospital critical care setting for other than a post-surgical or trauma indication. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Insulin-like growth factor IA, soluble Epidermal growth factor receptor, and Leukocyte elastase as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于监测，诊断，预后和确定住院医院关键护理设置的受试者的治疗方案和组合物，而不是术后或外伤指征。特别地，本发明涉及使用检测选自胰岛素样生长因子IA，可溶性表皮生长因子受体和白细胞弹性蛋白酶的一种或多种标志物作为肾损伤中的诊断和预后生物标志物的测定法。

27. 发明申请

WO2011017654A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011017654A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/044772
申请日：2010-08-06
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/775 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Beta-2-glycoprotein 1 as a diagnostic and prognostic biomarker in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测β-2-糖蛋白1作为肾损伤中的诊断和预后生物标志物的测定法。

28. 发明申请

WO2010091236A9 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND FAILURE 审中-公开
公开(公告)号：WO2010091236A9
公开(公告)日：2010-08-12
申请号：PCT/US2010/023297
申请日：2010-02-05
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
IPC分类号： G01N33/48
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced glycosylation end product- specific receptor, Bactericidal permeability-increasing protein, Interleukin 12, Fibroblast growth factor 23, and Intestinal fatty acid-binding protein as diagnostic and prognostic biomarkers in renal injuries.

29. 发明申请

WO2010091233A1 DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：诊断和预防肾损伤和肾功能衰竭
公开(公告)号：WO2010091233A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023294
申请日：2010-02-05
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin
IPC分类号： C12Q1/02
CPC分类号： G01N33/6893 , G01N2333/50 , G01N2800/347 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced glycosylation end product- specific receptor, Bactericidal permeability-increasing protein, Interleukin 12, Fibroblast growth factor 23, Vitamin K-dependent protein C, and Intestinal fatty acid-binding protein as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种选自由可溶性高级糖基化终产物特异性受体，杀菌通透性增加蛋白，白细胞介素12，成纤维细胞生长因子23，维生素K依赖性蛋白C 和肠脂肪酸结合蛋白作为肾损伤的诊断和预后生物标志物。

30. 发明申请

WO2008094198A2 DEVICES AND METHODS FOR PERFORMING RECEPTOR BINDING ASSAYS USING MAGNETIC PARTICLES 审中-公开
标题翻译：使用磁性颗粒进行受体结合测定的装置和方法
公开(公告)号：WO2008094198A2
公开(公告)日：2008-08-07
申请号：PCT/US2007/016909
申请日：2007-07-27
申请人： BIOSITE INCORPORATED , GREGORY, David, M. , ANDERBERG, Joseph, Michael
发明人： GREGORY, David, M. , ANDERBERG, Joseph, Michael
CPC分类号： G01N33/54326 , B03C1/01 , B03C1/288 , B03C2201/18 , G01N27/745
摘要： The present invention provides methods, devices, and systems for performing receptor binding assays. In particular, magnetically responsive particles configured to form a complex with a labeled conjugate corresponding to one or more analytes of interest can be moved within an assay device to one or more discrete detection regions through the application of one or more magnetic fields. By positioning the detection region such that the direction of this movement is, for at least a portion of the movement, counter to the direction of fluid flow within the device, detection of assay signals can be performed without the need for separate wash steps. Moreover, contamination of the signals resulting from labeled conjugate being carried in the direction of fluid flow is substantially reduced.
摘要翻译：本发明提供用于进行受体结合测定的方法，装置和系统。特别地，配置成与对应于感兴趣的一种或多种分析物的标记共轭物形成复合物的磁响应颗粒可以通过施加一个或多个磁场在测定装置内移动到一个或多个离散检测区域。通过定位检测区域使得该移动的方向对于运动的至少一部分与装置内的流体流动的方向相反，可以执行检测信号的检测，而不需要单独的洗涤步骤。此外，标记的共轭物在流体流动方向上携带的信号的污染显着降低。

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