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    • 21. 发明申请
    • SALT FREE HYALURONATE OPHTHALMIC SOLUTION
    • 无盐透明质酸盐眼药水
    • WO2009006130A2
    • 2009-01-08
    • PCT/US2008/068090
    • 2008-06-25
    • BAUSCH & LOMB INCORPORATEDVENKATESH, SriniXIA, Erning
    • VENKATESH, SriniXIA, Erning
    • A61K9/08A61K31/535A61K31/195A61K31/155
    • A61K31/155A61K9/0048A61K31/195A61K31/535
    • The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially of an ophthalmologically active agent, an ion sensitive, hydrophilic polymer in an amount a of 0.004 to 1.5% by weight, at least one salt selected from the group of inorganic salts and buffers in a total amount of from 0.01 to 2.0% by weight, a wetting agent in an amount of 0 to 3.0% by weight, a preservative in an amount of 0 to 0.02% by weight, water, and optionally a pH regulating agent in an amount sufficient to give a pH of 4.0 to 8.0 to the composition, the ratio between salt and polymer components being such that the solution exhibits a viscosity of less than 1000 mPas. The composition contains a sufficient amount of polymer to provide for a controlled absorption of the drug into the eye, its viscosity having been reduced to provide for better handling characteristics.
    • 本发明涉及局部用水溶液形式的眼科用组合物,其基本上由眼科活性剂,离子敏感的亲水性聚合物组成,其量为0.004-1.5重量% ,选自无机盐和缓冲剂中的至少一种盐,其总量为0.01-2.0重量%,润湿剂为0-3.0重量%,防腐剂的量为0-0.02 重量%的水和任选的pH调节剂,其量足以使组合物的pH值为4.0-8.0,盐和聚合物组分之间的比率使得溶液显示小于1000mPas的粘度。 该组合物含有足够量的聚合物以提供药物对眼睛的可控吸收,其粘度已经降低以提供更好的处理特性。