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21. 发明申请

WO2008077022A2 HIMF AND BTK IN PULMONARY, CARDIAC, AND INFLAMMATION DISORDERS 审中-公开
标题翻译： HIMF和BTK在肺，心脏和炎症疾病中的作用
公开(公告)号：WO2008077022A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087899
申请日：2007-12-18
申请人： THE JOHNS HOPKINS UNIVERSITY , JOHNS, Roger, A. , SU, Qingning , CHAMPION, Hunter, Clay
发明人： JOHNS, Roger, A. , SU, Qingning , CHAMPION, Hunter, Clay
IPC分类号： A61K39/395
CPC分类号： G01N33/6884 , A61K2039/505 , C07K14/4702 , C07K16/18 , C07K16/22 , C07K16/40 , C12N9/1205 , C12Y207/10002 , G01N33/54306 , G01N33/74 , G01N2333/47 , G01N2333/4703 , G01N2333/912 , G01N2500/02 , G01N2800/12 , G01N2800/122 , G01N2800/7038
摘要： Hypoxia induced mitogenic factor (HIMF) is a member of the "found in inflammatory zone" (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. We identified Bruton's tyrosine kinase (BTK) as a functional HIMF binding partner through GST-HIMF pull-downs and mass spectrometry. Using primary cultured HIMF-stimulated murine bone marrow cells, we demonstrated that BTK was recruited to the leading edge of the cells. We also demonstrated that BTK and the closely related tyrosine kinase Fyn, colocalized at the growth cone process in these cells. HIMF stimulation induced BTK autophosphorylation, which peaked at 2.5 minutes. A transwell migration assay showed that treatment with recombinant murine HIMF induced migration of primary cultured bone marrow cells, which was completely blocked by the BTK inhibitor, LFM-A13. In vivo studies, using the rat hindlimb ischemia model, revealed that HIMF can stimulate angiogenesis in the hypoxic tissue probably through inducing the migration of endothelial progenitor cells (EPCs) to areas of active angiogenesis. Our results indicate that HIMF may acts as a chemotactic molecule in stimulating the migration of leukocytes/EPCs from bone marrow to targeted tissues through activation of the BTK pathway.
摘要翻译：缺氧诱导的促有丝分裂因子（HIMF）是“在炎症区中发现的”的成员。（FIZZ）/抵抗素家族的蛋白质，并在肺血管系统中具有有效的促有丝分裂，血管生成和血管收缩作用。这个蛋白质家族的受体/结合伴侣在很大程度上是未知的。我们通过GST-HIMF pull-downs和质谱法将Bruton酪氨酸激酶（BTK）鉴定为功能性HIMF结合配偶体。使用原代培养的HIMF刺激的小鼠骨髓细胞，我们证明BTK被募集到细胞的前沿。我们还证明了BTK和密切相关的酪氨酸激酶Fyn在这些细胞的生长锥过程中共定位。 HIMF刺激诱导BTK自磷酸化，其在2.5分钟达到峰值。 transwell迁移试验表明，用重组鼠HIMF处理诱导了原代培养的骨髓细胞的迁移，其被BTK抑制剂LFM-A13完全阻断。在体内研究中，使用大鼠后肢缺血模型显示HIMF可能通过诱导内皮祖细胞（EPCs）迁移到活性血管生成区域来刺激缺氧组织中的血管生成。我们的研究结果表明HIMF可能作为一种趋化分子，通过激活BTK途径刺激白血球/ EPCs从骨髓迁移至靶向组织。

22. 发明申请

WO2008010975A2 EARLY DETECTION AND PROGNOSIS OF COLON CANCERS 审中-公开
标题翻译：结肠癌的早期发现和预后
公开(公告)号：WO2008010975A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016104
申请日：2007-07-16
申请人： THE JOHNS HOPKINS UNIVERSITY , ONCOMETHYLOME SCIENCES, S .A. , BAYLIN, Stephen, B. , CRIEKINGE, Wim, Van , SCHUEBEL, Kornel, E. , COPE, Leslie , SUZUKI, Hiromi , HERMAN, Jim
发明人： BAYLIN, Stephen, B. , CRIEKINGE, Wim, Van , SCHUEBEL, Kornel, E. , COPE, Leslie , SUZUKI, Hiromi , HERMAN, Jim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2523/125
摘要： A genome wide microarray gene expression approach for human colorectal cancer cells was used to identify hundreds of hypermethylated genes for colon cancer. We compared isogenic cells altered pharmacologically versus genetically to induce genomic demethylation, to pinpoint genes activated by DNA demethylation, but not by inhibition of class I and II histone deacetylases (HDACs). We achieve an 82% success rate in predicting genes with densely hypermethylated CpG islands and complete gene silencing. The genes are similarly hypermethylated in primary tumors and have previously undetected tumor suppressor functions. The genes can be used diagnostically to detect cancer, pre-cancer, and likelihood of developing cancer.
摘要翻译：使用人类结肠直肠癌细胞的全基因组微阵列基因表达方法来鉴定数百个用于结肠癌的高甲基化基因。我们比较了药理学和遗传学改变的等基因细胞诱导基因组去甲基化，以查明由DNA去甲基化激活的基因，但不是通过抑制I类和II类组蛋白脱乙酰酶（HDACs）。我们在预测具有密集超甲基化CpG岛和完全基因沉默的基因方面实现了82％的成功率。这些基因在原发性肿瘤中类似地高甲基化，并且以前未检测到肿瘤抑制剂功能。这些基因可以用于诊断癌症，癌症前期和发展癌症的可能性。

23. 发明申请

WO2007149432A2 SINGLE-MOLECULE PCR ON MICROPARTICLES IN WATER-IN-OIL EMULSIONS 审中-公开
标题翻译：单分子PCR在水中乳化液中的微量元素
公开(公告)号：WO2007149432A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014273
申请日：2007-06-19
申请人： THE JOHNS HOPKINS UNIVERSITY , DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
发明人： DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6876 , C12Q2600/16 , C12Q2527/125 , C12Q2527/153 , C12Q2565/537
摘要： Modulation of the viscosity of the oil phase of a microemulsion used for amplification of DNA on a bead increases the homogeneity of product beads and the amount of amplified DNA per bead. Moreover the number of separate microemulsion populations that can be formed in parallel is increased using multi-well plates and mixer mill disruptor machines designed to lyse biological samples.
摘要翻译：用于在珠上扩增DNA的微乳液的油相的粘度的调节增加了产物珠的均匀性和每个珠的扩增DNA的量。此外，可以使用设计用于裂解生物样品的多孔板和混合机研磨破碎机来增加可以平行形成的单独的微乳液种群的数量。

24. 发明申请

WO2007146046A2 GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS 审中-公开
标题翻译：脊柱侧凸性脊柱炎及其他脊髓损伤的基因治疗
公开(公告)号：WO2007146046A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013391
申请日：2007-06-07
申请人： GENZYME CORPORATION , DODGE, James , SHIHABUDDIN, Lamya , O'RIORDAN, Catherine, R.
发明人： DODGE, James , SHIHABUDDIN, Lamya , O'RIORDAN, Catherine, R.
IPC分类号： A61K48/00
CPC分类号： A61K38/30 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N2750/14143 , C12N2799/025
摘要： This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
摘要翻译：本公开提供了用于治疗影响受试者的运动功能和控制的疾病或损伤的方法和组合物。一方面，本发明通过将包含转基因的重组神经营养病毒载体给予脑，将转基因产物递送至受试者的脊髓。病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑，将转基因产物递送至受试者的脊髓的组合物。

25. 发明申请

WO2007095056A3 SLOW INTRAVENTRICULAR DELIVERY 审中-公开
公开(公告)号：WO2007095056A3
公开(公告)日：2007-08-23
申请号：PCT/US2007/003382
申请日：2007-02-08
申请人： GENZYME CORPORATION , DODGE, James , PASSINI, Marco , SHIHABUDDIN, Lamya , CHENG, Seng
发明人： DODGE, James , PASSINI, Marco , SHIHABUDDIN, Lamya , CHENG, Seng
IPC分类号： A61B5/00 , A61M37/00 , A61N1/30
摘要： Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain.

26. 发明申请

WO2007086932A2 PROSTATE STEM CELL ANTIGEN VACCINES AND USES THEREOF 审中-公开
标题翻译：前列腺干细胞抗原疫苗及其用途
公开(公告)号：WO2007086932A2
公开(公告)日：2007-08-02
申请号：PCT/US2006/028279
申请日：2006-07-19
申请人： THE JOHNS HOPKINS UNIVERSITY , JAFFEE, Elizabeth, M.
发明人： JAFFEE, Elizabeth, M.
IPC分类号： A61K38/17 , A61K39/395 , A61K39/00 , A61K38/08 , C07K7/06 , C07K14/47 , A61P35/00
CPC分类号： A61K39/0011 , C07K14/4748 , Y02A50/484
摘要： This invention relates to the identification of prostate stem cell antigen (PSCA) as a target of clinically relevant antitumor immune responses. The invention provides vaccines comprising PSCA, or fragments thereof, which are useful in inducing antitumor immune responses, including PSCA specific CD8+ T cell responses. Methods of using the compositions to treat cancer are also provided. The invention further provides methods of identifying compounds useful in antitumor vaccines and methods of assessing the responses of patients to cancer immunotherapy.
摘要翻译：本发明涉及鉴定前列腺干细胞抗原（PSCA）作为临床相关的抗肿瘤免疫应答的靶标。本发明提供了包含PSCA或其片段的疫苗，其可用于诱导抗肿瘤免疫应答，包括PSCA特异性CD8 + T细胞应答。还提供了使用该组合物治疗癌症的方法。本发明进一步提供了鉴定可用于抗肿瘤疫苗的化合物的方法和评估患者对癌症免疫疗法的应答的方法。

27. 发明申请

WO2007050713A2 BLOCKADE OF CALCIUM CHANNELS 审中-公开
标题翻译：钙通道碎片
公开(公告)号：WO2007050713A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041696
申请日：2006-10-26
申请人： THE JOHNS HOPKINS UNIVERSITY , MARBAN, Eduardo
发明人： MARBAN, Eduardo
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Knock-down of L-type calcium channel beta subunit (LTCCβ) attenuates the hypertrophic response both in vitro and in vivo without compromising systolic performance. Knock-down can be accomplished by administration of a vector encoding a short hairpin RNA which specifically modulates expression of LTCCβ. Suppression of the LTCCβ expression represents a therapeutic modality for cardiac hypertrophy.
摘要翻译： L型钙通道β亚基（LTCCβ）的敲低在体外和体内减弱肥大反应，而不损害收缩性能。可以通过施用编码特异性调节LTCCβ表达的短发夹RNA的载体来完成敲除。抑制LTCCβ表达代表心脏肥大的治疗方式。

28. 发明申请

WO2006113667A1 THERAPEUTIC PEPTIDES FOR THE TREATMENT OF METASTATIC CANCER 审中-公开
标题翻译：治疗癌症的治疗药物
公开(公告)号：WO2006113667A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/014485
申请日：2006-04-17
申请人： UNIVERSITY OF ARIZONA , SCHROEDER, Joyce, A.
发明人： SCHROEDER, Joyce, A.
IPC分类号： A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , C07K14/4727 , C07K2319/00 , C12N2740/16322
摘要： Interaction between MUCl and β-catenin can be interrupted using polypeptides or antibodies that specifically bind to the binding site on MUCl. Interruption provides the beneficial effect of inhibiting, reducing, and/or retarding invasiveness and metastasis. Fusion polypeptides and antibodies are provided to achieve a therapeutic effect.
摘要翻译：可以使用特异性结合MUC1上的结合位点的多肽或抗体中断MUC1和β-连环蛋白之间的相互作用。中断提供抑制，减少和/或延缓侵袭和转移的有益效果。提供融合多肽和抗体以实现治疗效果。

29. 发明申请

WO2006065383A2 A METHOD OF EVALUATING DRUG EFFICACY FOR TREATING ATHEROSCLEROSIS 审中-公开
标题翻译：评估药物治疗甲状腺功能亢进症的方法
公开(公告)号：WO2006065383A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/039855
申请日：2005-11-02
申请人： FOX HOLLOW TECHNOLOGIES, INC. , SIMPSON, John, B.
发明人： SIMPSON, John, B.
IPC分类号： A61B5/00
CPC分类号： A61B10/02 , A61B10/0233 , A61B17/320758 , A61B17/320783 , A61B2017/00685 , A61B2017/2927 , A61B2017/320032 , A61B2017/320791

30. 发明申请

WO2006004634A2 CITRUS SUDDEN DEATH 审中-公开
标题翻译： CITRUS SUDDEN死亡
公开(公告)号：WO2006004634A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022679
申请日：2005-06-28
申请人： CARGILL, INCORPORATED , GUSEK, Todd, W. , LEE, Richard, F. , KEREMANE, Manjunath, L. , AHARON, Eyal
发明人： GUSEK, Todd, W. , LEE, Richard, F. , KEREMANE, Manjunath, L. , AHARON, Eyal
IPC分类号： C12N15/82
CPC分类号： C12R1/38 , A01H5/08 , A01H6/78 , C12R1/01
摘要： A pathogenic bacterium has been identified which is associated with Sudden Death disease. The bacterium can be used to generate antibodies for immunological tests. Antibacterial agents can be used to treat infected trees or to keep uninfected trees from becoming infected. The environment of an infected tree, including soil and air, can also be treated to prevent or cure infections and/or spread of infections. Antibodies can be raised agains the pathogenic bacterium and can be used for identifying the pathogenic bacterium in soil and tree samples.
摘要翻译：已经鉴定出与突发性死亡病有关的病原菌。该细菌可用于产生用于免疫学测试的抗体。抗菌剂可用于治疗感染的树木或保持未感染的树木免受感染。受感染的树木，包括土壤和空气的环境也可以进行治疗，以预防或治愈感染和/或感染传播。抗体可以再次引起致病菌，可用于鉴定土壤和树样品中的致病菌。

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