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21. 发明申请

WO2020068751A1 VENTILATION ADAPTOR AND METHOD OF USE THEREOF 审中-公开
公开(公告)号：WO2020068751A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/052602
申请日：2019-09-24
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： LI, Jie , ROBERTS, Keith, M. , WEISS, Tyler, T.
IPC分类号： A61M16/04 , A61M16/00 , A61M16/06 , A61M16/08 , A61M16/20
摘要： The present disclosure relates generally to an adaptor for use with an endotracheal ventilation system and to a method of using such a device. In one embodiment, the adaptor provides for a method of replacing a ventilation filter without interrupting ventilation of the patient.

22. 发明申请

WO2018226928A1 VAPORIZATION SYSTEM FOR DELIVERY IN A CONTROLLED CONCENTRATION 审中-公开
公开(公告)号：WO2018226928A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036412
申请日：2018-06-07
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： STAMLER, Jonathan, S.
IPC分类号： A61M16/00 , A61M16/01 , A61M16/10 , A61M16/12 , A61M16/20 , A61M11/04 , C01B21/20 , A61M16/06
摘要： Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.

23. 发明申请

WO2018057578A1 FORMATIVE STRUCTURAL CAKE SYSTEM 审中-公开
标题翻译：形成结构蛋糕系统
公开(公告)号：WO2018057578A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/052428
申请日：2017-09-20
申请人： CAKE EFFECTS LLC
发明人： TOWNSEND, Robert, E. , TOWNSEND, Elizabeth
IPC分类号： A23G3/54 , A23G3/18 , A23G3/22 , A23G1/18 , A23G1/21 , A23G1/50
CPC分类号： A21B3/132 , A21B3/136 , A21B3/138 , A21B3/139 , A47J37/01
摘要： Methods and mold systems for an edible composition that minimize both compression forces (weight of inner portion and/or covering acting upon itself) and lateral forces (relative to moving / handling an edible composition) are provided.
摘要翻译：提供了用于使压缩力（内部部分的重量和/或覆盖作用于其本身）和横向力（相对于移动/处理可食用组合物）最小化的可食用组合物的方法和模具系统。

24. 发明申请

WO2018026407A1 ALGORITHM, DATA PIPELINE, AND METHOD TO DETECT INACCURACIES IN COMORBIDITY DOCUMENTATION 审中-公开
标题翻译：算法，数据管道和检测并行文档中不准确性的方法
公开(公告)号：WO2018026407A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/032229
申请日：2017-05-11
申请人： RUSH UNIVERSITY MEDICAL CENTER
发明人： LATEEF, Omar , HOTA, Bala
IPC分类号： G06F17/30 , G06F19/00
CPC分类号： G16H10/60 , G06F16/2282 , G06F16/23 , G06F16/2365 , G16H50/20 , G16H50/70 , G16H70/60
摘要： Systems and methods for detecting inaccuracies in comorbidity documentation are provided. An example method can include retrieving patient data from a hospital records database, generating a first data structure representing a list of patient identifiers, retrieving patient symptom data for each patient identifier listed in the first data structure, generating, a second data structure by assigning the retrieved patient symptom data to the eligible patients represented in the first data structure, retrieving, a plurality of lookup tables, generating a third data structure by applying the lookup tables to the second data structure to assign a CC or a MCC value to at least one unique patient identifier of the second data structure, and storing the third data structure to the memory. In some implementations, the method can include updating the hospital records database with the CC or the MCC value assigned to the at least one unique patient.
摘要翻译：
提供了用于检测共病性文档中的不准确性的系统和方法。示例方法可包括从医院记录数据库中检索患者数据，生成表示患者标识符列表的第一数据结构，检索第一数据结构中列出的每个患者标识符的患者症状数据，通过将第二数据结构分配将检索到的患者症状数据提供给第一数据结构中表示的符合条件的患者，检索多个查找表，通过将查找表应用于第二数据结构以将CC或MCC值分配给至少一个第二数据结构的唯一患者标识符以及将第三数据结构存储到存储器。在一些实现中，该方法可以包括利用分配给至少一个独特患者的CC或MCC值来更新医院记录数据库。

25. 发明申请

WO2015191857A1 ERK1 AND ERK2 MUTATIONS THAT CONFER RESISTANCE TO MAPK PATHWAY INHIBITORS 审中-公开
标题翻译： ERK1和ERK2突变体，其能够抵抗MAPK途径抑制剂
公开(公告)号：WO2015191857A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035337
申请日：2015-06-11
申请人： DANA-FARBER CANCER INSTITUTE, INC. , GOETZ, Eva, M. , GARRAWAY, Levi, A.
发明人： GOETZ, Eva, M. , GARRAWAY, Levi, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12N9/12 , C12Q2600/106 , C12Q2600/156 , C12Y207/11024 , G01N33/5011
摘要： Isolated mutant ERK polypeptides and nucleic acids encoding the mutant ERK polypeptides are provided. Methods of screening cancer-containing samples for an ERK polypeptide mutation that confers resistance to treatment with a first MAPK pathway inhibitor are provided. Methods of optimizing treatment of a subject having cancer and methods of identifying compounds useful in treating cancer are also provided.
摘要翻译：提供了分离的突变型ERK多肽和编码突变型ERK多肽的核酸。提供了筛选含有第一MAPK通路抑制剂治疗抗性的ERK多肽突变的含癌样品的方法。还提供了优化具有癌症的受试者的治疗方法和鉴定可用于治疗癌症的化合物的方法。

26. 发明申请

WO2014165105A3 DELIVERY DEVICE AND STORAGE SYSTEM FOR OROPHARYNGEAL ADMINISTRATION OF MOTHER'S COLOSTRUM AND MILK 审中-公开
公开(公告)号：WO2014165105A3
公开(公告)日：2014-10-09
申请号：PCT/US2014/024404
申请日：2014-03-12
申请人： RUSH UNIVERSIYT MEDICAL CENTER , NORTHSHORE UNIVERSITY HEALTH SYSTEM
发明人： RODRIGUEZ, Nancy, A.
IPC分类号： A61J7/00 , A61M5/19 , A61J9/00
摘要： A delivery system and method for storing and delivering colostrum or milk to an infant are provided. In one aspect, the system includes a syringe for delivering a dose of colostrum or milk, a swab container, and a swab. The swab is contained in the swab container and the swab container connected to the syringe. In another aspect, the delivery system includes a plurality of syringes for delivering a dose of colostrum or milk and a storage container for storing the plurality of syringes having the colostrum or milk therein. The method includes loading a first syringe with a dose of colostrum or milk and placing the loaded first syringe in a first slot in a storage container. The method further includes loading a second syringe with a dose of colostrum or milk and placing the loaded second syringe in a second slot in the storage container.

27. 发明申请

WO2013163076A1 ANTI-ASPIRATION VALVE 审中-公开
标题翻译：防吸阀
公开(公告)号：WO2013163076A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/037578
申请日：2013-04-22
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： LIDDY, Alison , NEILAN, John , RYAN, Michael , TREACY, Gerard
IPC分类号： A61F2/04 , A61F2/24
CPC分类号： A61F2/04 , A61F2/06 , A61F2/07 , A61F2/2412 , A61F2/2415 , A61F2002/044 , A61F2230/0069 , A61F2250/0069
摘要： A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.
摘要翻译：提供了一种用于制造用于控制通过体腔流动的假体的假体和方法。假体包括具有近端部分，远侧部分和延伸穿过其中的内腔的主体，并且还包括可操作地连接到身体的瓣膜。阀具有远端，其包括阀腔表面的第一部分和表面的彼此接触并形成封闭构造的密封件的第二部分。阀的远端形成为使得阀腔的表面的第一部分和第二部分彼此接触，并且远端构造成响应于大于大气压的压力而打开。

28. 发明申请

WO2009100106A1 ADAPTOR FOR ENDOSCOPIC ORIENTATION OF AN ELONGATE MEDICAL DEVICE 审中-公开
标题翻译：适用于直肠长方形医疗器械的内镜方向
公开(公告)号：WO2009100106A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033033
申请日：2009-02-04
申请人： WILSON-COOK MEDICAL, INC. , COOK IRELAND LTD. , MCGRATH, Darach
发明人： MCGRATH, Darach
IPC分类号： A61B1/018 , A61B1/00 , A61B8/08 , A61B8/12
CPC分类号： A61B1/00128 , A61B1/018 , A61B8/12
摘要： An adaptor, a system and a method to orient an elongate medical device in relation to an endoscope are provided. The adaptor includes a first portion and a second portion. The first portion includes a connecting portion to rotationally securable to a distal end of the first portion to the endoscope, a first lumen extending longitudinally through the first portion and operably connectable to a working channel of the endoscope, and one of an orienting key or a keyway extending longitudinally at least partially along the first portion. The second portion is releasably connectable to the first portion and includes the other of the key or the keyway extending longitudinally along at least a portion of the second portion and a second lumen operably connectable to the first lumen and configured to receive an elongate medical device rotationally secured in relation to the second portion therethrough.
摘要翻译：提供了一种用于相对于内窥镜定向细长医疗装置的适配器，系统和方法。适配器包括第一部分和第二部分。第一部分包括可旋转地固定到第一部分的远端到内窥镜的连接部分，纵向延伸穿过第一部分并且可操作地连接到内窥镜的工作通道的第一腔，以及定向键或键槽沿着第一部分至少部分地纵向延伸。第二部分可释放地连接到第一部分，并且包括沿着第二部分的至少一部分纵向延伸的键或键槽中的另一个，以及可操作地连接到第一内腔的第二腔，并且被配置成旋转地容纳细长的医疗装置相对于第二部分固定。

29. 发明申请

WO2009021030A1 DISTAL TIP FOR AN ENDOSCOPE 审中-公开
标题翻译：内窥镜的距离
公开(公告)号：WO2009021030A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/072323
申请日：2008-08-06
申请人： WILSON-COOK MEDICAL INC. , SURTI, Vihar, C.
发明人： SURTI, Vihar, C.
IPC分类号： A61B1/00 , A61B1/273
CPC分类号： A61B1/018 , A61B1/0008 , A61B1/2736 , A61B2017/00473
摘要： A system configured for endoscopic treatment of tissue is provided. The system includes an elongate shaft having a proximal portion, a distal portion and a working channel extending at least partially through the shaft. The elongate shaft further includes a longitudinally extending central axis. A distal end of the distal portion of the elongate shaft includes a distal tip having a curvilinear portion. The curvilinear portion is configured to dilate a stricture in a gastrointestinal tract for passing a portion of the system through the stricture to the tissue. The distal tip includes a working channel port connected to the working channel.
摘要翻译：提供了一种配置用于组织内镜治疗的系统。该系统包括细长轴，其具有近端部分，远侧部分和至少部分延伸穿过轴的工作通道。细长轴还包括纵向延伸的中心轴线。细长轴的远端部分的远端包括具有曲线部分的远端。曲线部分构造成在胃肠道中扩张狭窄，以使系统的一部分通过狭窄到组织。远端包括连接到工作通道的工作通道端口。

30. 发明申请

WO2008103572A1 PROSTHESIS HAVING A SLEEVE VALVE 审中-公开
标题翻译：具有一个套筒阀
公开(公告)号：WO2008103572A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/053633
申请日：2008-02-12
申请人： WILSON-COOK MEDICAL INC. , SKERVEN, Gregory, J.
发明人： SKERVEN, Gregory, J.
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2/06 , A61F2/24 , A61F2002/044
摘要： Disclosed is a pressure sensitive prosthesis that includes a tubular member having a passageway extending therethrough and a sleeve attached about one end of the tubular member. The sleeve functions as a one-way valve to permit fluid flowing through the sleeve lumen in a first, distal direction and under a first pressure, while collapsing in response to fluid flowing in a second direction when the pressure thereof exceeds that of the first direction or pressure. One aspect of the invention includes a first opening and a second opening configured for allowing fluid flow from the passage to the lumen in the first direction.
摘要翻译：公开了一种压敏假体，其包括具有延伸穿过其中的通道的管状构件和围绕管状构件的一端附接的套筒。套筒用作单向阀，以允许流体在第一远端方向和第一压力下流过套筒内腔，同时响应于当第二方向上的流体超过第一方向时流体流动而折叠或压力。本发明的一个方面包括第一开口和第二开口，第一开口和第二开口被构造成允许流体沿着第一方向从通道流到内腔。

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