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21. 发明申请

WO2023283385A1 WEARABLE, NON-INTRUSIVE MICRONEEDLE SENSOR 审中-公开
公开(公告)号：WO2023283385A1
公开(公告)日：2023-01-12
申请号：PCT/US2022/036424
申请日：2022-07-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： TEHRANI, Farshad , TEYMOURIAN, Hazhir , WANG, Joseph
IPC分类号： A61B5/00 , A61B5/1486 , G01N33/50
摘要： Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

22. 发明申请

WO2022104230A1 SYSTEMS AND METHODS FOR SYNTHETIC APERTURE ULTRASOUND IMAGING OF AN OBJECT 审中-公开
公开(公告)号：WO2022104230A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/059424
申请日：2021-11-15
申请人： DECISION SCIENCES MEDICAL COMPANY, LLC
发明人： KRUSE, Dustin E.
IPC分类号： A61B8/14 , G01N29/06 , G01S15/89 , G10K11/26 , G10K11/34
摘要： Techniques, systems, and devices are disclosed for synthetic aperture ultrasound imaging using a beamformer that incorporates a model of the object. In some aspects, a system includes an array of transducers to transmit and/or receive acoustic signals at an object that forms a synthetic aperture of the system with the object, an object beamformer unit to (i) beamform the object coherently as a function of position, orientation, and/or geometry of the transducers with respect to a model of the object, and (ii) produce a beamformed output signal including spatial information about the object derived from beamforming the acoustic echoes; a data processing unit to process data and produce an image of the object based on a rendition of the position, the orientation, the geometry, and/or the surface properties of the object, relative to the coordinate system of the array, as determined by the data processing unit.

23. 发明申请

WO2020181213A1 METHODS FOR MANUFACTURING AND DISTRIBUTING SEMI-RIGID ACOUSTIC COUPLING ARTICLES AND PACKAGING FOR ULTRASOUND IMAGING 审中-公开
公开(公告)号：WO2020181213A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/021456
申请日：2020-03-06
申请人： DECISION SCIENCES MEDICAL COMPANY, LLC
发明人： STAEBLER, Zachary , WEGNER, Allan
IPC分类号： B32B29/00 , B32B37/10 , B32B37/15
摘要： Disclosed are methods for scalable, cost-effective, and rapid production manufacturing and packaging a semi-rigid acoustic coupling medium that can be used for ultrasound diagnostic and treatment systems and techniques. In some aspects, a method includes forming a staged solution by adding together a stock solution comprising a monomer and a block copolymer in deoxygenated water and a primed solution comprising a covalent crosslinking agent and a catalyst; forming a gel-sol by mixing the staged solution with a first network activator solution comprising a monomer activator and a second network activator solution comprising a block copolymer activator; dispensing the gel-sol into a mold; and curing the gel-sol in the mold to produce a semi-rigid acoustic coupling material, where the method is carried under an inert atmosphere.

24. 发明申请

WO2019161406A1 SYSTEMS, DEVICES AND METHODS FOR THREE-DIMENSIONAL IMAGING OF MOVING PARTICLES 审中-公开
公开(公告)号：WO2019161406A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018631
申请日：2019-02-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , HAN, Yuanyuan
IPC分类号： G01N15/14 , G01N15/00 , G01N15/10 , G01N21/00 , G06T17/00
摘要： Disclosed are methods, devices, systems and applications for camera-less, high-throughput three-dimensional imaging of particles in motion. In some aspects, a system includes a particle motion device to allow particles to move along a travel path; an optical illumination system to produce an asymmetric illumination area of light in a region of the travel path of a particle that scans over a plurality of sections of the particle at multiple time points while the particle is moving; an optical detection system optically interfaced with the particle motion device to obtain optical signal data associated with different parts of the particle corresponding to the particle's volume during motion in the travel path; and a data processing unit to process the optical signal data obtained by the optical detection system and produce data including information indicative of 3D features of the particle.

25. 发明申请

WO2019143741A1 SYSTEMS, DEVICES AND METHODS FOR ESTIMATING BLOOD GLUCOSE CONCENTRATIONS FROM SIGNALS OF SENSORS DEPLOYED IN TISSUE 审中-公开
公开(公告)号：WO2019143741A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/013876
申请日：2019-01-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GOUGH, David A. , ABBASI, Shaghayegh , HEINZ, Stefanie
发明人： GOUGH, David A. , ABBASI, Shaghayegh , HEINZ, Stefanie
IPC分类号： A61B5/00 , A61B5/1455 , A61M5/172
摘要： Disclosed are systems, devices and methods for estimating blood glucose parameters, including blood glucose concentration glucose sensor signals. In some aspects, a method for estimating blood glucose concentration from signals of glucose sensors includes obtaining a set of time-series values that includes tissue glucose sensor values from a glucose sensor and reference blood glucose concentration values associated with a subject; generating a set of matched blood glucose reference values by determining a temporal matching of the tissue glucose sensor values and the reference blood glucose concentration values; isolating error associated with the matched blood glucose reference values to determine a residual error time series, wherein the isolated error includes a composite error comprising a measurement error, a process error, and random error; and producing estimated blood glucose values for true blood glucose of the subject by adding the reference blood glucose concentration values to the residual error time series.

26. 发明申请

WO2019055572A1 DEVICES AND METHODS FOR BINAURAL SPATIAL PROCESSING AND PROJECTION OF AUDIO SIGNALS 审中-公开
公开(公告)号：WO2019055572A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050756
申请日：2018-09-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： YADEGARI, Shahrokh
IPC分类号： G10L19/008 , H04R5/04 , H04S1/00 , H04S3/00 , H04S7/00
CPC分类号： H04S3/008 , H04R5/033 , H04R2420/07 , H04S7/304 , H04S7/305 , H04S7/308 , H04S2420/01
摘要： Disclosed are devices, systems and methods for binaural spatial audio processing based on a pair of head-related transfer functions (HRTFs) for each of a listener's two ears to synthesize a binaural sound that seems to come from a particular point in space. Applications of the disclosed devices, systems and methods include digital audio reproduction, recording, and multimedia applications including virtual reality and augmented reality experiences.

27. 发明申请

WO2018129390A1 MICROMOTORS AND NANOMOTORS FOR GASTROINTESTINAL DIAGNOSIS AND TREATMENT APPLICATIONS 审中-公开
公开(公告)号：WO2018129390A1
公开(公告)日：2018-07-12
申请号：PCT/US2018/012678
申请日：2018-01-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： WANG, Joseph , ZHANG, Liangfang
IPC分类号： A61K9/50 , A61K9/54 , A61K47/02 , A61K47/32
摘要： Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.

28. 发明申请

WO2014194139A1 ENERGY STORAGE AND CONVERSION WITH HOT CARBON DEPOSITION 审中-公开
标题翻译：能量储存和转化与热碳沉积
公开(公告)号：WO2014194139A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/040090
申请日：2014-05-29
申请人： MCALISTER TECHNOLOGIES, LLC
发明人： MCALISTER, Roy, Edward
IPC分类号： F02M21/02 , F02B43/10
CPC分类号： H01M8/0618 , B01J19/088 , B01J2219/0803 , B01J2219/0871 , B01J2219/0875 , C01B3/06 , C01B3/24 , C01B32/15 , C01B2203/02 , C01B2203/06 , C01B2203/84 , Y02E60/36
摘要： In one aspect, a method to convert a fuel into energy and specialized fuel includes, in a reactor, dissociating a fuel to produce hot carbon and hydrogen, the hot carbon having a temperature state in a range of 700 to 1500 °C, in which the dissociating includes providing heat and/or electric energy to produce the hot carbon and the hydrogen; and removing the hot carbon and the hydrogen from the reactor, the removing including depositing the hot carbon to a chamber, in which the hot carbon includes an increased chemical potential energy and is capable of storing energy from an external source. In some implementations, the method can further include supplying an oxygen- and hydrogen-containing reactant to contact the hot carbon to produce carbon monoxide (CO) and hydrogen (H 2 ); and obtaining the produced CO and H 2 , which, after the supplying, remaining deposited carbon forms a durable carbon-based good or product.
摘要翻译：一方面，将燃料转化为能量和专用燃料的方法包括在反应器中解离燃料以产生热碳和氢，所述热碳的温度状态在700至1500℃的范围内，其中解离包括提供热和/或电能以产生热碳和氢; 并且从反应器中除去热碳和氢，所述去除包括将热碳沉积到室中，其中热碳包括增加的化学势能并且能够存储来自外部源的能量。在一些实施方案中，该方法还可以包括提供含氧和氢的反应物以接触热碳以产生一氧化碳（CO）和氢气（H 2）; 并获得所生产的CO和H 2，其在供应后剩余的沉积碳形成耐用的碳基物料或产品。

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