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11. 发明申请

WO2020198582A1 FAST DIFFUSION TENSOR MRI USING DEEP LEARNING 审中-公开
公开(公告)号：WO2020198582A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025205
申请日：2020-03-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TIAN, Qiyuan , HUANG, Susie, Yi , BILGIC, Berkin
IPC分类号： A61B5/055 , G01R33/54 , G01R33/56 , G06N3/02
摘要： Higher quality diffusion metrics and/or diffusion-weighted images are generated from lower quality input diffusion-weighted images using a suitably trained neural network (or other machine learning algorithm). High-fidelity scalar and orientational diffusion metrics can be extracted using a theoretical minimum of a single non-diffusion-weighted image and six diffusion-weighted images, achieved with data-driven supervised deep learning. As an example, a deep convolutional neural network ("CNN") is used to map the input non-diffusion-weighted image and diffusion-weighted images sampled along six optimized diffusion-encoding directions to the residuals between the input and output high-quality non-diffusion-weighted image and diffusion-weighted images, which enables residual learning to boost the performance of CNN and full tensor fitting to generate any scalar and orientational diffusion metrics.

12. 发明申请

WO2020150726A1 METHODS AND SYSTEMS FOR PRODUCING MAGNETIC RESONANCE IMAGES WITH SUB-MILLISECOND TEMPORAL RESOLUTION 审中-公开
公开(公告)号：WO2020150726A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/014345
申请日：2020-01-21
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHOU, Xiaohong Joe , ZHONG, Zheng , KARAMAN, Meryem Muge
发明人： ZHOU, Xiaohong Joe , ZHONG, Zheng , KARAMAN, Meryem Muge
IPC分类号： G01R33/48 , G01R33/483 , G01R33/50 , G01R33/54 , G01R33/56 , G01R33/561
摘要： A system and method for producing a series of time-resolved magnetic resonance (MR) images is set forth. The system can perform method steps of encoding spatial information into an MRI signal by manipulating a phase of the MRI signal within an MRI system, generating and outputting a phase-encoded MRI signal over time by digitizing a plurality of time points in the MRI signal, repeating the generating and outputting step for a plurality of phase-encoded signals, each phase-encoded signal in synchrony with a trigger, producing a plurality of digitized time points, and reconstructing a series of time resolved MR images, each image of the series of MR images at one specific time point selected from the plurality of digitized time points for each phase-encoded step. Each image in the series of time-resolved MR images corresponding to a specific time point in a cyclic event.

13. 发明申请

WO2020104455A1 DETERMINATION OF A FURTHER PROCESSING LOCATION IN MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2020104455A1
公开(公告)日：2020-05-28
申请号：PCT/EP2019/081797
申请日：2019-11-19
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SOMMER, Karsten , HELLE, Michael, Günter
IPC分类号： G06K9/62 , G01R33/56 , G06N3/08 , G06N3/04 , G01R33/563 , G01R33/54
摘要： The invention provides for a method of training a neural network (322) configured for providing a further processing location (326). The method comprises providing (200) a labeled medical image (100), wherein the labeled medical image comprises multiple labels each indicating a truth processing location (102, 104, 106). The method further comprises inputting (202) the labeled medical image into the neural network to obtain one trial processing location. The one trial processing location comprises a most likely trial processing location (108). The method further comprises determine (204) the closest truth processing location (106) for the most likely trial processing location. The method further comprises calculating (206) an error vector (110) using the closest truth processing location and the most likely trial processing location. The method further comprises training (208) the neural network using the error vector.

14. 发明申请

WO2019232437A1 SOLID-STATE MRI AS A NONINVASIVE ALTERNATIVE TO COMPUTED TOMOGRAPHY (CT) 审中-公开
公开(公告)号：WO2019232437A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/034997
申请日：2019-05-31
申请人： THE TRUSTEES OF THE UNIIVERSITY OF PENNSYLVANIA
发明人： WEHRLI, Felix W. , BARTLETT, Scott P. , LEE, Hyunyeol , SONG, Hee, Kwon , ZHAO, Xia
IPC分类号： A61B5/05 , A61B5/055 , G01R33/48 , G01R33/54
摘要： The present disclosure provides systems, apparatuses, and methods for generating images of the human body by solid-state magnetic resonance imaging. An example method can comprise receiving first imaging data at two or more echo times taken with a first radiofrequency configuration, receiving second imaging data at two or more echo times taken with a second radiofrequency configuration. An example method can comprise generating, based on at least the first imaging data and the second imaging data, two or more k-space datasets. An example method can comprise generating, based on at least the two or more k- space datasets, one or more images. The one or more images can comprise different image contrast.

15. 发明申请

WO2019232279A1 WHITE MATTER FIBROGRAPHY BY SYNTHETIC MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2019232279A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/034756
申请日：2019-05-30
申请人： BOSTON MEDICAL CENTER CORPORATION
发明人： JARA, Hernan
IPC分类号： A61B5/05 , A61B5/055 , G01R33/20 , G01R33/54
摘要： Methods of making a white matter fibrogram representing the connectome of the brain of a subject, comprising: (a) performing a multi spectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) rendering a white matter fibrogram of the brain of the subject from the plurality of magnetic resonance images.

16. 发明申请

WO2019032423A1 APPARATUS AND METHODS FOR DETERMINING PROPERTIES OF HYDROGEN-CONTAINING SAMPLES USING NUCLEAR MAGNETIC RESONANCE 审中-公开
公开(公告)号：WO2019032423A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045313
申请日：2018-08-06
申请人： SCHLUMBERGER TECHNOLOGY CORPORATION , SCHLUMBERGER CANADA LIMITED , SERVICES PETROLIERS SCHLUMBERGER , SCHLUMBERGER TECHNOLOGY B.V.
发明人： KADAYAM VISWANATHAN, Ravinath Kausik , SONG, Yi-Qiao
IPC分类号： G01R33/54 , G01N24/08 , G01V3/32
摘要： Nuclear magnetic resonance (NMR) methods and apparatus are provided for investigating a sample utilizing NMR pulse sequences. In various embodiments, the NMR pulse sequences have a solid state portion and a line-narrowing portion. In other embodiments, the NMR pulse sequences have a first line-narrowing portion and a second line-narrowing portion where the sequences of the different portions are different. In yet other embodiments, the NMR pulse sequences have a T 1 portion and a line-narrowing portion. Processing of detected signals permits determination of characteristics of the sample including, in some cases, a differentiation of multiple components of the sample.

17. 发明申请

WO2018217658A1 SELECTIVE SAMPLING FOR ASSESSING STRUCTURAL SPATIAL FREQUENCIES WITH SPECIFIC CONTRAST MECHANISMS 审中-公开
公开(公告)号：WO2018217658A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033727
申请日：2018-05-21
申请人： BIOPROTONICS, LLC
发明人： JAMES, Kristin , JAMES, Timothy
IPC分类号： A61B5/055 , G01R33/48 , G01R33/385 , G01R33/54
摘要： The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k- values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

18. 发明申请

WO2018178343A1 SUB VOXEL RESOLUTION MAGNETIC RESONANCE FINGERPRINTING IMAGING 审中-公开
公开(公告)号：WO2018178343A1
公开(公告)日：2018-10-04
申请号：PCT/EP2018/058308
申请日：2018-03-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas, Erik , DONEVA, Mariya, Ivanova , SOMMER, Karsten , KOKEN, Peter
IPC分类号： G01R33/56 , G01R33/561 , G01R33/483 , G01R33/54 , G01R33/24 , G01R33/44 , A61B5/055 , G01R33/485 , G01R33/565
摘要： The invention provides for a magnetic resonance imaging (MRI) system (100) that comprises a memory (134) for storing machine executable instructions (140) and MRF pulse sequence commands (142). The MRF pulse sequence commands cause the MRI system to acquire MRF magnetic resonance data (144) according to a magnetic resonance (MR) fingerprinting protocol. The pulse sequence commands are configured for acquiring the MRF magnetic resonance data in two dimensional slices (410, 412, 414, 416, 418, 420), wherein the two dimensional slices have a slice selection direction, wherein the pulse sequence commands comprises a train of pulse sequence repetitions. The train of pulse sequence repetitions comprises a sampling event where the MRF magnetic resonance data is repeatedly sampled. The MRI system further comprises a processor for controlling the magnetic resonance imaging system. Execution of the machine executable instructions causes the processor to: acquire (200) the MRF magnetic resonance data by controlling the magnetic resonance imaging system with the MRF pulse sequence commands; and construct (202) a series (148) of at least one magnetic resonance parameter value for each voxel of the two dimensional slices using the MRF magnetic resonance data, wherein each of the series corresponds to the sampling event of each pulse sequence repetition; and calculate (204) a composition (502, 504, 506, 508) of each of a set of predetermined substances within two or more sub voxels (306, 308) for each voxel of the two dimensional slices using a sub-voxel magnetic resonance fingerprinting dictionary (150) for each of the two or more sub voxels and the series of the at least one magnetic resonance parameter value, wherein sub voxels divide each voxel in the slice selection direction.

19. 发明申请

WO2018138065A1 SELF-LEARNING SYSTEM FOR SCAN PLANNING 审中-公开
公开(公告)号：WO2018138065A1
公开(公告)日：2018-08-02
申请号：PCT/EP2018/051504
申请日：2018-01-23
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WENZEL, Fabian , WAECHTER-STEHLE, Irina , STEHLE, Thomas Heiko , SAALBACH, Axel , HOOGENRAAD, Frank Gerardus Cornelis , BOERNERT, Peter
IPC分类号： G01R33/54
CPC分类号： G01R33/543
摘要： The present disclosure relates to a method for planning a scan geometry for imaging a predefined anatomy (308) using a scanning imaging system (100, 300). The method comprises: building a database using data mining during a learning phase comprising determining clinical context information, anatomy information and scan geometries of previously performed scans; planning the scan geometry during a planning phase comprising performing a survey scan of the anatomy (308) using the scanning imaging system (100, 300), thereby generating scan information indicative of the scan and anatomy; matching the generated scan information with the content of the database; based on the matching result, providing one or more scan geometries.

20. 发明申请

WO2018136705A1 ESTIMATING ABSOLUTE PHASE OF RADIO FREQUENCY FIELDS OF TRANSMIT AND RECEIVE COILS IN A MAGNETIC RESONANCE 审中-公开
公开(公告)号：WO2018136705A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014365
申请日：2018-01-19
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： WANG, Jinghua , DING, Yu
IPC分类号： A61B5/055 , G01R33/48 , G01R33/54
摘要： Methods and apparatuses for determining spatial distribution of an absolute phase of RF transmit field B 1 + and/or RF receive field B 1 - in an MRI system are described herein. An example method can include selecting a transmit coil for which to measure the absolute phase of the RF transmit field B 1 + , exciting nuclear spins in MR nuclei using at least two transmit configurations of the transmit coil, and detecting first and MR signals arising from exciting nuclear spins in MR nuclei using first and second transmit configurations, respectively. The method can also include acquiring first and second sets of complex k-space data from the first and second MR signals, respectively, and estimating an absolute phase B 1 + map of the transmit coil using the first set of complex k-space data and the second set of complex k-space data.

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