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11. 发明申请

WO1991012077A1 MULTI-CHANNEL PIPETTE 审中-公开
标题翻译：多渠道管道
公开(公告)号：WO1991012077A1
公开(公告)日：1991-08-22
申请号：PCT/DE1990001001
申请日：1990-12-27
申请人： SPINDLER, Jörg
IPC分类号： B01L03/02
CPC分类号： B01L3/0217 , G01N35/1065
摘要： The multi-channel pipette described has a very large number, in particular ninety-six, parallel pump cylinders with fitting plungers (20). The pump cylinders are designed as apertures (18) in a cylinder block (14). The plungers (20) are mounted in an array corresponding to the disposition of the apertures (18), in particular an 8x12 array, preferably with a degree of play about the vertical, on a plate (16) which can be raised and lowered along guide-bars parallel to the longitudinal axes of the cylinders.

12. 发明申请

WO1998023376A1 MICROMECHANICAL EJECTION PUMP FOR EXTRACTING SMALL FLUID VOLUMES FROM A FLOWING SAMPLE FLUID 审中-公开
标题翻译： MICRO机械排出泵切出最小的流体体积从流动的液体样本
公开(公告)号：WO1998023376A1
公开(公告)日：1998-06-04
申请号：PCT/EP1997006543
申请日：1997-11-22
申请人： EVOTEC BIOSYSTEMS GMBH , HENCO, Karsten , HOWITZ, Steffen , WEGENER, Thomas , GÜNTHER, Rolf
发明人： EVOTEC BIOSYSTEMS GMBH
IPC分类号： B01L03/02
CPC分类号： B01L3/0268 , B01L3/5027 , B01L3/50273 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0442 , G01N30/6095 , G01N2030/326 , G01N2030/383 , G01N2035/1041
摘要： The micromechanical ejection pump for extracting small fluid volumes from a flowing sample fluid is provided with a substrate (7), a canal (2) for a sample fluid, embodied in the substrate (7), and a canal (1') for pressurized working fluid. The micromechanical ejection pump also has a canal (1'') for ejecting a fluid volume from the sample fluid. The working fluid canal (1') runs into the extension of the sample fluid canal (2) discharging crosswise thereto. The ejection canal (1'') connected to the sample fluid canal (2) branches off from the working fluid canal (1') opposite to the sample fluid canal (2). The working fluid canal (1') and the ejection canal (1'') have in particular a substantially similar cross-section of 0.01-0.12 mm , wherein the ratio of the cross-section of the sample fluid canal (2) to the cross-section of the working fluid canal or the ejection canal (1', 1'') is preferably between 0.2 and 0.5, more particularly between 0.3 and 0.4 and most preferably 0.35.
摘要翻译：用于从流动的样品流体中分离出非常小的流体体积的微机械喷射泵被提供用于与基板（7），一个在所述衬底（7）的样品流体通道（2）用于对样品流体和工作流体管道（1“）形成加压工作流体。另外，微机械喷射以喷射从所述样品流体的流体体积泵驱逐通道（1“”）。工作流体管道（1“）横向打开以延伸到该样品流体管道（2）的延伸部。与样品流体通道中的一个（2）连接到所述排出通道（1“”）分支出来的工作流体管道（1“）从所述样品流体通道（2）相对。工作流体管道（1“）和喷射管（1”特别“）具有0.01毫米<2>之间至0.12mm基本相同的横截面<2>，其中所述样品流体通道的横截面的比率（2）到工件的横截面或喷射管道（1“ 1' ”）较好是在0.2和0.5之间0.35，特别是0.3至0.4，最优选之间。

13. 发明申请

WO1997048491A1 METHOD FOR ACHIEVING CHEMICAL, IN PARTICULAR BIOCHEMICAL REACTIONS AND PIPETTE TIP WITH REACTION VESSEL AND WITH OPTIONAL ADDITIONAL RECEIVING COMPONENT FOR SAID PIPETTE TIP 审中-公开
标题翻译：方法具体化学品，包括生化反应器和反应器，并且可以移液吸头与有额外的记录元件移液器尖
公开(公告)号：WO1997048491A1
公开(公告)日：1997-12-24
申请号：PCT/EP1997003258
申请日：1997-06-20
申请人： HAMILTON BONADUZ AG , HOFSTETTER, Meinrad , LEYSSENS, Herwig , ARPAGAUS, Renato , WESTEDT, Jens
发明人： HAMILTON BONADUZ AG
IPC分类号： B01L03/02
CPC分类号： B01L3/5082 , B01L3/0275 , G01N2035/103 , G01N2035/106
摘要： The invention proposes a method for achieving chemical, in particular biochemical reactions in a reaction liquid (168) using a pipette tip (114) of a pipetting device, by means of which the reaction liquid (168) is picked up by a suction opening (126) in the pipette tip (114) and transferred to a reaction chamber (149) in a reaction liquid receiving unit (112). At least one part or part of the component of the reaction liquid (168) is transferred to the reaction chamber (149) using the pipette tip (114). To seal the reaction chamber (149), an opening in the reaction chamber is sealed by means of the pipette tip (114), whereby the suction opening (126) of the pipette tip lies inside the reaction chamber (149). The reaction takes place inside the reaction chamber (149).
摘要翻译：它是用于使用移液管尖端进行化学，在反应液（168）特定的生化反应的方法（114），通过移液管尖端（114）的吸入口（126），该反应液体（168）的装置提出了一个移液装置，可以接收用于随后的递送成Reaktonsflüssigkeits接收单元（112），其中至少一个部分或反应液体（168）与所述移液管尖端（114）进入反应室（149）的部分构成被传送时，在该反应室的端部的反应室（149）（149）包括反应室 -Öffnung由移液管尖端（114）的装置中的移液装置被关闭，其中，所述移液管尖端的进气开口（126）的反应空间（149）内，并且在所述反应室（149）进行反应。

14. 发明申请

WO1997029846A1 PIPETTING DEVICES PRELOADED WITH STANDARDIZED CONTROL SAMPLE MATERIALS 审中-公开
标题翻译：用标准化控制样品材料进行管理的设备
公开(公告)号：WO1997029846A1
公开(公告)日：1997-08-21
申请号：PCT/US1997001712
申请日：1997-02-11
申请人： AALTO SCIENTIFIC, LTD.
发明人： AALTO SCIENTIFIC, LTD. , MAURO, Stephen, F. , REYNOLDS, Robert, A.
IPC分类号： B01L03/02
CPC分类号： B01L3/0275 , B01J2219/00292 , C40B60/14 , G01N2035/1055
摘要： Devices and apparatus are disclosed for rapid, consistent, precise and accurate formation of standard solutions for use as reference samples without error, excessive costs, waste and degradation problems. Test reactants, normally solutes, are preloaded in measured amounts into pipette tips or instrument tubing. The devices draw in a measured quantity of liquid, normally solvent, through the tip or tubing, which quickly dissolves or disperses the solute, forming a consistent and accurate solution for an individual test. Since only the amount of solute and solvent which is needed for each individual test is used, there is no preparation of excess solution. Since the invention involves the production of pipette tips preloaded with stable solute, it can be used in many different settings, including emergency rooms and vehicles. Also disclosed is a container for retaining a readily available supply of solvent adjacent to detached pipette tips containing preloaded solute samples, such that when the technician connects the pipette tip to the pipette, the required quantity of solvent can also be obtained and the desired solution sample produced in a single operation.
摘要翻译：公开了用于快速，一致，精确和准确地形成用于参考样品的标准溶液的设备和装置，无误差，成本过高，浪费和降解问题。将测试反应物（通常为溶质）以测量的量预先加载到移液管尖端或仪器管道中。这些装置通过尖端或管道吸取测量量的液体，通常是溶剂，其迅速溶解或分散溶质，形成用于单独测试的一致且准确的溶液。由于仅使用每个单独测试所需的溶质和溶剂量，所以不能制备过量的溶液。由于本发明涉及生产具有稳定溶质的移液管吸头，所以它可以用于许多不同的设置，包括急诊室和车辆。还公开了一种用于在容纳预先加载的溶质样品的分离的移液管尖端附近保持容易获得的溶剂供应的容器，使得当技术人员将移液管连接到移液管时，也可以获得所需量的溶剂，并且所需溶液样品在单一操作中产生。

15. 发明申请

WO1997016251A1 AUTOMATED PIPETTING OF SMALL VOLUMES 审中-公开
标题翻译：小容量的自动化管道
公开(公告)号：WO1997016251A1
公开(公告)日：1997-05-09
申请号：PCT/EP1996004691
申请日：1996-10-29
申请人： TECAN AG
发明人： TECAN AG , SICKINGER, Anselm , BALMER, Johannes, Konrad
IPC分类号： B01L03/02
CPC分类号： B01L3/0268 , G01N35/10 , G01N2035/1039 , Y10T436/25625 , Y10T436/2575
摘要： The device is useful for automated pipetting of small volumes of liquid. It comprises: A) a diluter (1) with a syringe (2) and a valve (3), said syringe (2) comprising a piston (11) and a piston drive (9); B) a pipetting needle (4); C) a tubing (5) connecting said diluter (1) with said needle (4); and D) an impulse generator (6) acting on the liquid in the device.
摘要翻译：该装置可用于小量液体的自动移液。它包括：A）具有注射器（2）和阀（3）的稀释器（1），所述注射器（2）包括活塞（11）和活塞驱动器（9）; B）移液针（4）; C）连接所述稀释器（1）与所述针（4）的管（5）; 和D）作用在装置中的液体上的脉冲发生器（6）。

16. 发明申请

WO1997003752A3 MANUAL PIPETTE WITH MAGNET ASSIST 审中-公开
公开(公告)号：WO1997003752A3
公开(公告)日：1997-02-06
申请号：PCT/US1996011617
申请日：1996-07-12
申请人： RAININ INSTRUMENT CO., INC.
发明人： RAININ INSTRUMENT CO., INC. , HOMBERG, William, D.
IPC分类号： B01L03/02

17. 发明申请

WO1996021508A1 POROUS, SOLID STRUCTURE FOR BIOASSAYS 审中-公开
标题翻译：多元，生物多样性的固体结构
公开(公告)号：WO1996021508A1
公开(公告)日：1996-07-18
申请号：PCT/US1996000491
申请日：1996-01-11
申请人： AT POINT BIO , BAUMAN, David, S. , SHECKLER, Chad, A.
发明人： AT POINT BIO
IPC分类号： B01L03/02
CPC分类号： B01L3/5085 , B01L3/5023 , B01L3/50825 , B01L2200/0684 , B01L2200/16 , B01L2300/028 , B01L2300/069 , B01L2300/0819 , B01L2300/12 , B01L2400/0406 , G01N33/54366
摘要： An assembly for use in biological assays containing an integral ceramic core (12) and, partially abutting the core, a sheath. The ceramic core (12) has a mean pore size of from about 1 to about 400 microns, an apparent porosity of from about 25 to about 60 percent, a hydrophilic surface, a length of from about 10 to about 200 millimeters, and a wicking rate of at least about 20 millimeters per minute; the sheath (14) has a wicking rate of less than 5 millimeters per minute.
摘要翻译：一种用于生物测定的组件，其包含整体式陶瓷芯（12）并且部分地邻接所述芯部。陶瓷芯（12）具有约1至约400微米的平均孔径，约25至约60％的表观孔隙率，亲水表面，约10至约200毫米的长度和芯吸速率至少约20毫米/分钟; 护套（14）具有小于5毫米/分钟的芯吸速率。

18. 发明申请

WO1995030483A1 FILTERED MICROPIPETTE TIP FOR HIGH/LOW VOLUME PIPETTORS 审中-公开
标题翻译：用于高/低体积输送管的过滤式麦克风提示
公开(公告)号：WO1995030483A1
公开(公告)日：1995-11-16
申请号：PCT/US1995005563
申请日：1995-05-04
申请人： SORENSON BIOSCIENCE
发明人： SORENSON BIOSCIENCE , GAZIT, Arnono , YANIV, Abraham
IPC分类号： B01L03/02
CPC分类号： B01L3/0275 , B01L2200/141 , B01L2300/0681 , G01N35/10 , G01N2035/1053 , G01N2035/1055
摘要： A micro volume, filter pipette tip device useful with either of two respective pipettors comprising: (i) manual or electronic, air displacement pipettor operable with the approximate range of 0 to 20 microliters; and (ii) a manual or electronic, air displacement pipettor operable within the approximate range of 20 to 200 microliters and having a relatively short insert tip. The filtered pipette tip device includes a pipette tip body having insert and fill chambers (34a, 34b) extending in continuous tapering configuration from the mounting end (31) to the fluid contacting end (33). A filter (35) is positioned within the axial bore in the intermediate section (32) providing a dividing barrier between the insert and fill chambers of the pipette tip device. The insert fill chamber (34a, 34b) includes a tapering internal wall structure configured to receive a continuously taper terminal insert portion of each of the two respective pipettors in a snug, sealed fit within the insert chamber without contacting the filter.
摘要翻译：一种用于两个相应移液器中的任一个的微量的过滤器吸头提示装置，包括：（i）手动或电子式移液移液器，其操作范围为0至20微升; 和（ii）可在20至200微升的大约范围内操作并且具有相对较短的插入尖端的手动或电子式排气移液器。过滤的移液管末端装置包括移液管末端体，其具有从安装端（31）延伸到流体接触端（33）的连续锥形构造的插入和填充腔（34a，34b）。过滤器（35）位于中间部分（32）中的轴向孔内，在移液管末端装置的插入和填充室之间提供分隔壁。插入填充室（34a，34b）包括锥形内壁结构，其被构造成以两个相应移液器中的每一个的连续锥形端子插入部分，以不会接触过滤器的方式在插入室内贴合地密封配合。

19. 发明申请

WO1995021696A1 PIPETTE TIP MOUNTING AND TRANSFER APPARATUS AND METHOD 审中-公开
标题翻译： PIPETTE TIP安装和传送装置和方法
公开(公告)号：WO1995021696A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001450
申请日：1995-02-03
申请人： POINT PLASTICS INCORPORATED
发明人： POINT PLASTICS INCORPORATED , STOLP, Philip, E.
IPC分类号： B01L03/02
CPC分类号： B01L9/543 , Y10T436/119163
摘要： A pipette tip assembly (10) is provided which includes one or more pipette tips (12), a tip support and a tip holder (32) which is movable between a tip-holding (38) and a tip-releasing position (40). Additionally, a pipette tip assembly (10) is provided which includes one or more pipette tips (12) and a tip holder (32) which has tapered apertures (36) therein. Methods of using such assemblies are further provided. The invention provides pipette tip assemblies that facilitate secure transport, minimal handling, and convenient and user-controlled operation.
摘要翻译：提供了一种移液器末端组件（10），其包括一个或多个移液管末端（12），尖端支撑件和尖端保持器（32），其可在尖端保持件（38）和尖端释放位置（40）之间移动，。另外，提供了移液管末端组件（10），其包括一个或多个移液管吸头（12）和在其中具有锥形孔（36）的尖端保持器（32）。还提供了使用这种组件的方法。本发明提供了移液器尖端组件，其便于安全的运输，最小的操作和方便的用户控制的操作。

20. 发明申请

WO1995013138A2 DISPENSING DEVICE SUCH AS A PIPETTE 审中-公开
标题翻译：分配设备如管脚
公开(公告)号：WO1995013138A2
公开(公告)日：1995-05-18
申请号：PCT/GB1994002463
申请日：1994-11-09
申请人： SEWELL, Miles, Atholl, Blackwood
IPC分类号： B01L03/02
CPC分类号： B01L3/0217
摘要： In order to provide a pipette device which is easier and more accurate to use than those using known pipette fillers, a piston (2), which is preferably flexible, is provided to fit into the pipette bore (6). The plastics piston rod (1) sits conveniently in a guide cap at the mouth of the pipette tube and the piston rod is operated by stroking its upper surface, which is serrated along its length, with a digit; thus dispensing by a positive displacement method.
摘要翻译：为了提供比使用已知移液管填充物的那些更容易和更准确使用的移液管装置，提供优选为柔性的活塞（2）以装配到移液管孔（6）中。塑料活塞杆（1）方便地位于移液管的口处的导向盖中，并且活塞杆通过沿着其长度方向以数字进行扫描而操作; 从而通过正位移法进行分配。

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