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11. 发明申请

WO2004017813A3 APPARATUS AND METHODS FOR FORMING SHOE INSERTS 审中-公开
标题翻译：用于形成鞋垫的装置和方法
公开(公告)号：WO2004017813A3
公开(公告)日：2007-12-13
申请号：PCT/US0326066
申请日：2003-08-20
申请人： FOOTCONTROLLE LLC , PHILLIPS EDWARD H
发明人： PHILLIPS EDWARD H
IPC分类号： B28B1/00 , A61B20060101 , B29C33/38
CPC分类号： A43B7/28 , A43B17/00 , A43B19/00 , A43D1/022 , A43D1/025
摘要： Foot impression generating apparatus (10) comprising impression platforms (12L, 12R) including buns of open-cell sponge material bonded to and supporting non-porous skins formed of non-blown sponge material is utilized for making foot impressions (18) by a consumer. The sponge material comprises a blended mixture of elastomeric thermosetting material and low melting temperature thermoplastic material chosen such that the buns and skins are respectively flexible and then become rigid when heated and then cooled above and below the plastic temperature range of the thermoplastic material. The consumer steps into heated impression platforms to form the foot impressions and then they are cooled and "frozen" in place. Next, scanning means are used to create a digital contour map of the foot impressions. Then a digitally controlled milling machine is utilized for forming shoe inserts in conformance with the digital contour map.
摘要翻译：包括印模平台（12L，12R）的印模生成装置（10）被用于由消费者制造足印（18），所述压印平台（12L，12R）包括结合到非支撑海绵材料形成的非多孔皮肤上并且支撑由非吹塑海绵材料形成的无孔皮肤的开孔细胞海绵材料的小圆面包。海绵材料包括弹性体热固性材料和低熔点热塑性材料的混合混合物，其选择为使得小圆面包和表皮分别是柔性的，然后在加热时变得刚性，然后在热塑性材料的塑料温度范围之上和之下冷却。消费者进入热烈的印象平台，形成脚印，然后冷却并“冻结”到位。接下来，扫描装置用于创建脚印迹的数字等值线图。然后使用数控铣床来形成符合数字轮廓图的鞋垫。

12. 发明申请

WO2004028342A3 ENDOGENOUS GRANZYME B IN HUMAN NON-HEMATOPOIETIC CELLS 审中-公开
标题翻译：人非球形细胞中的内源性GRANZYME B
公开(公告)号：WO2004028342A3
公开(公告)日：2007-12-06
申请号：PCT/US0329967
申请日：2003-09-24
申请人： UNIV TEXAS , XU HONG-JI , JU SHI-XUE , MILLS GORDON B
发明人： XU HONG-JI , JU SHI-XUE , MILLS GORDON B
IPC分类号： A01N43/04 , A61B20060101 , A61K31/70 , C07H21/04 , C12N5/00 , C12N5/02 , C12N9/64 , C12N15/00
CPC分类号： C12N9/6467
摘要： The instant invention relates to the determination that constitutively nearly silent GrB locus in human breast carcinoma and osteosarcoma cells activated upon retinoblastoma protein (pRB)-induced growth arrest owing to the usage of an alternative promoter/transcription start site. Cloned novel cDNA from the locus adds 34 amino acid residues to the N-terminus of GrB zymogen. The alternate product has been designated as GrB-NIC. Tumor cells with accumulated endogenous GrB-NIC, whose mature form was identical to lymphocyte GrB but with a distinctive glycosylation pattern, undergoes post-growth-arrest apoptosis that occurs concurrently with pRB cleavage, and are capable of inducing rapid apoptosis of bystander pRB - tumor cells. Expression of GrB-NIC is also observed in malignant cells of other types as well as in normal non-immune cells upon cell differentiation, especially in differentiating and differentiated neural cells. GrB-NIC plays a physiological role in embryonic, and particularly in early neuronal development. The disclosure further provides compositions and methods utilizing this new GrB-NIC technology.
摘要翻译：本发明涉及由于使用替代性启动子/转录起始位点，人乳腺癌和骨肉瘤细胞中组成型几乎无声的GrB基因座在视网膜母细胞瘤蛋白（pRB）上激活的生长停滞的测定。来自该基因座的克隆新的cDNA向GrB酶原的N末端添加34个氨基酸残基。备用产品已被指定为GrB-NIC。具有积累的内源性GrB-NIC的肿瘤细胞，其成熟形式与淋巴细胞GrB相同但具有独特的糖基化模式，经历与pRB切割同时发生的后生长停滞的凋亡，并且能够诱导旁观者pRB ^{- 肿瘤细胞。在细胞分化，特别是分化和分化的神经细胞中，其他类型的恶性细胞以及正常的非免疫细胞也观察到GrB-NIC的表达。 GrB-NIC在胚胎中起着生理作用，特别是在早期神经元发育中。本公开进一步提供了使用该新型GrB-NIC技术的组合物和方法。}

13. 发明申请

WO2004075725A3 BCRM-1 GENES AND USES THEREOF 审中-公开
标题翻译： BCRM-1基因及其用途
公开(公告)号：WO2004075725A3
公开(公告)日：2007-10-25
申请号：PCT/US2004005338
申请日：2004-02-24
申请人： DANA FARBER CANCER INST INC , CHEN LAN BO , AUCLAIR DANIEL , GONG YUHONG , DAI MEIRU
发明人： CHEN LAN BO , AUCLAIR DANIEL , GONG YUHONG , DAI MEIRU
IPC分类号： C07H21/04 , A61B20060101 , C07K14/47
CPC分类号： C07K14/4748 , C07K14/705 , C12Q1/6883 , C12Q2600/158
摘要： A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, transformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines are also within the scope of this invention.
摘要翻译：公开了能够赋予细胞多药耐药性的多肽。还公开了编码多肽，表达载体，表达多肽的转化体宿主细胞系和与多肽结合的抗体的核酸。使用上述多肽，核酸，抗体和宿主细胞系的筛选，诊断和治疗方法也在本发明的范围内。

14. 发明申请

WO2005034721A3 LANCING DEVICE END CAP WITH BLOOD-DIRECTING CONTACT FACE 审中-公开
标题翻译：带有指向接触面的起吊装置端盖
公开(公告)号：WO2005034721A3
公开(公告)日：2007-08-30
申请号：PCT/US2004024466
申请日：2004-07-28
申请人： FACET TECHNOLOGIES LLC , FLYNN STEPHEN , LEVAUGHN RICHARD W , RUF CHRISTOPHER J , KENNEDY GWENN E , LIPOMA MICHAEL V , SALLERAS JUAN D , HOLZAEPFEL JAC , RAMOS SYLVIA
发明人： FLYNN STEPHEN , LEVAUGHN RICHARD W , RUF CHRISTOPHER J , KENNEDY GWENN E , LIPOMA MICHAEL V , SALLERAS JUAN D , HOLZAEPFEL JAC , RAMOS SYLVIA
IPC分类号： A61B17/14 , A61B20060101 , A61B5/15
CPC分类号： A61B5/150259 , A61B5/150022 , A61B5/150061 , A61B5/150748 , A61B5/15105 , A61B5/15142
摘要： An endcap for a lancing device. The endcap has a substantially planar contact face surrounding an opening for passing a lancet tip. The contact face has a length substantially greater than its width, and at least one side edge along its length. The user tips the lancing device to bring a side edge into contact with the skin several inches from the intended sampling site, draws the contact face along the skin toward the sampling site, and lances the skin to obtain a fluid sample. The contact face can be repeatedly drawn along the skin toward the sampling site to stimulate blood-flow until the desired sample size is obtained.
摘要翻译：用于穿刺装置的端盖。端盖具有围绕用于通过刺血针尖端的开口的基本上平面的接触面。接触面的长度显着大于其宽度，以及沿其长度的至少一个侧边缘。用户提示穿刺装置使侧边缘与预期取样部位几英寸的皮肤接触，将接触面沿着皮肤拉向采样部位，并使皮肤伸出以获得流体样品。可以将接触面沿着皮肤反复抽吸到采样部位，以刺激血流，直到获得所需的样品大小。

15. 发明申请

WO2004069036A3 COMPUTER-ASSISTED KNEE REPLACEMENT APPARATUS AND METHOD 审中-公开
标题翻译：计算机辅助KNEE替换装置和方法
公开(公告)号：WO2004069036A3
公开(公告)日：2007-08-16
申请号：PCT/US2004002994
申请日：2004-02-04
申请人： Z KAT INC
IPC分类号： G06K9/00 , A61B20060101 , A61B1/00 , A61B5/05 , A61B17/58 , A61B19/00
CPC分类号： A61B34/20 , A61B34/10 , A61B34/25 , A61B2034/102 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2034/2072 , A61B2034/252 , A61B2034/254 , A61B2034/256
摘要： A computer-assisted knee replacement apparatus and method comprises a knee replacement application for assisting, guiding, and planning a unicondylar knee replacement procedure. The apparatus and method cooperates with a tracking system to determine implant sizing and location. The apparatus and method also cooperates with the tracking system to determine required tibial and femoral preparation corresponding to the implant size and location and provides real-time monitoring of the tibial and femoral surface preparation procedures.
摘要翻译：计算机辅助膝关节置换装置和方法包括膝关节置换应用程序，用于帮助，指导和规划单髁膝关节置换手术。该装置和方法与跟踪系统协调以确定植入物尺寸和位置。该装置和方法还与跟踪系统配合以确定对应于植入物尺寸和位置的所需胫骨和股骨准备，并提供胫骨和股骨表面准备程序的实时监测。

16. 发明申请

WO2004047618A3 SYSTEMS AND METHODS FOR RESPIRATION MEASUREMENT 审中-公开
标题翻译：用于呼吸测量的系统和方法
公开(公告)号：WO2004047618A3
公开(公告)日：2007-08-02
申请号：PCT/US0337680
申请日：2003-11-25
申请人： JEFFRIES BRADLEY , JOY JAMES A , PYLE WILTON J III
发明人： JEFFRIES BRADLEY , JOY JAMES A , PYLE WILTON J III
IPC分类号： A61B5/08 , A61B20060101
CPC分类号： A61B5/0816 , A61B5/4818 , A61B5/7232
摘要： In one embodiment, a portable data acquisition unit (104) includes a pressure sensor (200) that is configured to measure pressure signals at a high-frequency rate, the signals pertaining to patient breathing, a microcontroller (206) that receives pressure signals measured by the pressure sensor and determines clocks times associated with the pressure signals and an interface (212) that is configured to output sleep session data from the data acquisition unit to another device.
摘要翻译：在一个实施例中，便携式数据获取单元（104）包括压力传感器（200），其被配置成测量高频率的压力信号，与患者呼吸有关的信号，微控制器（206），其接收测量的压力信号通过压力传感器确定与压力信号相关联的时钟时间和被配置为将睡眠会话数据从数据获取单元输出到另一设备的接口（212）。

17. 发明申请

WO2005039393A3 TECHNIQUES TO TREAT NEUROLOGICAL DISORDERS BY ATTENUATING THE PRODUCTION OF PRO-INFLAMMATORY MEDIATORS 审中-公开
标题翻译：通过抑制炎症介质的产生来治疗神经病变的技术
公开(公告)号：WO2005039393A3
公开(公告)日：2007-03-08
申请号：PCT/US2004035194
申请日：2004-10-22
申请人： MEDTRONIC INC , SHAFER LISA L
发明人： SHAFER LISA L
IPC分类号： G01N33/68 , A61B20060101 , A61K9/22 , A61K39/395 , A61M5/142 , A61M5/172 , A61M39/02 , C07K16/18 , C07K16/24 , G01N33/53
CPC分类号： A61K38/02 , A61K38/1709 , A61K38/206 , A61K38/2066 , A61K2039/505 , A61M5/14276 , A61M5/1723 , A61M25/00 , A61M39/0208 , A61M2205/04 , A61M2210/0693 , C07K16/241 , G01N33/6863 , G01N33/6896 , G01N33/743 , G01N33/948 , G01N2333/54 , G01N2500/00
摘要： Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.
摘要翻译：描述了减轻CNS中肿瘤坏死因子（TNF）和其他促炎症介质以治疗神经系统，神经变性，神经精神障碍，疼痛和脑损伤的方法和装置。更具体地，描述靶向细胞内信号的TNF阻断剂和与TNF的产生和分泌相关的下游作用。所描述的装置包括治疗递送装置，其包括能够容纳TNF阻断剂的储存器和可操作地耦合到该装置并适于将TNF阻断剂输送到受试者内的靶位点的导管。

18. 发明申请

WO2005039394B1 AN APPARATUS FOR AUTOMATICALLY POINTING A DEVICE AT A TARGET 审中-公开
标题翻译：一种用于自动指定目标设备的设备
公开(公告)号：WO2005039394B1
公开(公告)日：2007-03-01
申请号：PCT/US2004035275
申请日：2004-10-22
申请人： TSX IND INC , VOGEL DAVID , MCCULLEY RICH , JOHNSON ERIK
发明人： VOGEL DAVID , MCCULLEY RICH , JOHNSON ERIK
IPC分类号： F21V33/00 , A61B20060101 , B64C1/00 , F41A27/28
CPC分类号： F41A27/28 , F41G5/14
摘要： A system (10) for pointing a device at a given target has a sensor (20) for sensing a number of positional Information points of the targe (14) with the sensor relaying the positional information points to a controller (18). The controller is for computing directional control information based on the relayed positional information points. The system also has an adjustment device for moving relationship to the target in response to the computed sensor senses the positional information of the target (14) and controller with the controller computing the directional control information to control the adjustment device. The adjustment device points the device at the target.
摘要翻译：用于将设备指向给定目标的系统（10）具有传感器（20），用于感测多个位置信息点（14），传感器将位置信息点中继到控制器（18）。控制器用于基于中继的位置信息点来计算定向控制信息。该系统还具有用于响应于计算出的传感器感测目标（14）和控制器的位置信息来移动与目标的关系的调节装置，控制器计算方向控制信息以控制调节装置。调整装置将设备指向目标。

19. 发明申请

WO2005046450A3 METHOD FOR DIAGNOSIS AND TREATMENT OF PULMONARY DISORDERS 审中-公开
标题翻译：诊断和治疗肺动脉疾病的方法
公开(公告)号：WO2005046450A3
公开(公告)日：2007-01-04
申请号：PCT/US2004037623
申请日：2004-11-12
申请人： CHILDRENS HOSP MEDICAL CENTER
发明人： WHITSETT JEFFREY A , MUCENSKI MICHAEL
IPC分类号： A61K48/00 , A01K67/027 , A61B20060101 , C07K14/475 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0375 , A61K48/00 , C07K14/475 , C12N15/85 , C12N2830/003 , C12Q1/6897
摘要： This invention relates to the discovery that midkine modulates pulmonary vasculature development and smooth muscle cell development. Modulation of midkine activity thus alters pulmonary vasculature development and smooth muscle cell development. The invention provides methods of modulating pulmonary disorders, smooth muscle cell related disorders, and pulmonary smooth muscle cell disorders. Disorders of particular interest include, but are not limited to, asthma and pulmonary hyperplasia. Further the invention relates to the discovery that TTF1 and HIF1-a exhibit midkine modulating activity. The invention pertains to the discovery that midkine modulates myorcardin activity.
摘要翻译：本发明涉及中期因子调节肺血管发育和平滑肌细胞发育的发现。因此调节中期因子活性改变肺血管发育和平滑肌细胞发育。本发明提供调节肺病，平滑肌细胞相关病症和肺平滑肌细胞病症的方法。特别感兴趣的疾病包括但不限于哮喘和肺部增生。此外，本发明涉及TTF1和HIF1-a显示中期因子调节活性的发现。本发明涉及中期因子调节myorcardin活性的发现。

20. 发明申请

WO2004107964A3 BLOOD HARVESTING DEVICE WITH ELECTRONIC CONTROL 审中-公开
标题翻译：血液收集装置与电子控制
公开(公告)号：WO2004107964A3
公开(公告)日：2006-12-14
申请号：PCT/US2004018132
申请日：2004-06-07
申请人： PELIKAN TECHNOLOGIES INC , BRIGGS BARRY DEAN , MARSOT TRAVIS , HEGENER JASON , FREEMAN DOMINIQUE M , BOECKER DIRK , ALDEN DON , SCHUMANN MATT , BEADMAN MIKE
发明人： BRIGGS BARRY DEAN , MARSOT TRAVIS , HEGENER JASON , FREEMAN DOMINIQUE M , BOECKER DIRK , ALDEN DON , SCHUMANN MATT , BEADMAN MIKE
IPC分类号： A61B5/00 , A61B20060101 , A61B5/103 , A61B5/15 , A61B10/00 , A61B17/32 , A61B19/00 , A61M5/32 , A61M37/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150412 , A61B5/150755 , A61B5/15113 , A61B5/15123 , A61B5/15151 , A61B5/15161
摘要： A method of controlling a penetrating member is provided. The method comprises providing a lancing device comprising a penetrating member driver having a position sensor and a processor that can determine the relative position and velocity of the penetrating member based on measuring relative position of the penetrating member with respect to time; providing a predetermined velocity control trajectory based on a model of the driver and a model of tissue to be contacted. In some embodiments, a feedforward control to maintain penetrating member velocity along said trajectory.
摘要翻译：提供了一种控制穿透构件的方法。该方法包括提供一种穿刺装置，其包括具有位置传感器和处理器的穿透构件驱动器，所述穿透构件驱动器可以基于测量穿透构件相对于时间的相对位置来确定穿透构件的相对位置和速度; 基于驾驶员的模型和待接触的组织的模型提供预定的速度控制轨迹。在一些实施例中，前馈控制器沿着所述轨迹保持穿透构件速度。

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