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11. 发明申请

WO2013070073A1 DEVICE FOR CULTURING CELLS 审中-公开
标题翻译：培养细胞的装置
公开(公告)号：WO2013070073A1
公开(公告)日：2013-05-16
申请号：PCT/NL2012/050783
申请日：2012-11-07
申请人： TULIP LIFE SCIENCE PRODUCTS B.V.
发明人： NELISSEN, Franciscus Petrus Nicolaas , VAN BEEK, Antoon
IPC分类号： C12M1/24
CPC分类号： C12M29/10 , C12M23/08 , C12M25/06
摘要： The invention relates to a device for culturing cells, which device comprises a bottom wall, at least one side wall as well as an upper wall for forming an interior volume that can be shut off from the outside world, a liquid culture comprising cells being present on the bottom wall in use, between the at least one side wall, to which volume fluid can be supplied via at least one supply channel disposed in the upper wall and from which fluid can be discharged via at least one discharge channel disposed in the upper wall.
摘要翻译：本发明涉及一种用于培养细胞的装置，该装置包括底壁，至少一个侧壁和用于形成可与外界隔绝的内部容积的上壁，包含存在细胞的液体培养物在使用的底壁上，在至少一个侧壁之间，可通过设置在上壁中的至少一个供应通道供应体积流体，并且可以经由设置在上部的至少一个排出通道将流体排出流体壁。

12. 发明申请

WO2012009425A2 IN VITRO PHARMACOKINETICS/PHARMACODYNAMICS BELLOWS PERFUSION SYSTEM FOR ENHANCING EFFECTIVENESS OF CANCER CHEMOTHERAPY 审中-公开
标题翻译：体外药代动力学/药物流体灌注系统增强癌症化疗的有效性
公开(公告)号：WO2012009425A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/043837
申请日：2011-07-13
申请人： ORDWAY RESEARCH INSTITUTE, INC. , LIN, Hung-Yun , DRUSANO, George , LOUIE, Arnold , DAVIS, Paul, J.
发明人： LIN, Hung-Yun , DRUSANO, George , LOUIE, Arnold , DAVIS, Paul, J.
IPC分类号： C12M3/02 , C12M1/24 , C12N5/09 , C12Q1/04 , G01N33/50 , G01N33/15
CPC分类号： C12M25/10 , C12M23/08 , C12M23/26 , C12M25/16 , C12N5/0693 , C12N2513/00 , C12N2531/00 , G01N33/5011 , G01N2800/52
摘要： Provided herein is a continuous cell perfusion model system that provides useful pharmacokinetic and pharmacodynamic information on the application of new drugs or combinations of various agents in vitro to human cancer cell lines. Also provided are methods of using this system to individualize cancer treatment.
摘要翻译：本文提供了连续细胞灌注模型系统，其提供了关于新药或体外各种药物与人癌细胞系的组合的应用的有用药代动力学和药效学信息。还提供了使用此系统个性化癌症治疗的方法。

13. 发明申请

WO2011104612A3 DEVICE FOR CELL CULTURE AND ANALYSIS 审中-公开
标题翻译：用于细胞培养和分析的装置
公开(公告)号：WO2011104612A3
公开(公告)日：2011-11-17
申请号：PCT/IB2011000365
申请日：2011-02-23
申请人： UNI DEGLI STUDI DI VERONA , CHILOSI MARCO , KRAMPERO MAURO , RICCIARDI MARIO
发明人： CHILOSI MARCO , KRAMPERO MAURO , RICCIARDI MARIO
IPC分类号： C12M1/24 , B01L3/08 , G01N1/36
CPC分类号： C12Q1/04 , C12M23/08 , C12M23/22 , C12M25/02 , G01N1/06 , G01N1/36
摘要： The present invention relates to a device (1) for cell culture and analysis, comprising a first containing element (2), a second containing element (3) sealingly couplable to one another to define a culture chamber (4) and a flexible film (11) housable in said culture chamber (4) and available alternatively on one of said first element (2) or second element (3). The flexible film (11) can be made of a transparent material selected from the group consisting of polycarbonate, polystyrene and polyethylene. A method for cell analysis is also provided.
摘要翻译：本发明涉及一种用于细胞培养和分析的装置（1），该装置包括第一容纳元件（2），第二容纳元件（3），该第二容纳元件（3）彼此密封耦合以限定培养室（4） 11）可放置在所述培养室（4）中并且可替换地位于所述第一元件（2）或第二元件（3）中的一个上。柔性膜（11）可以由选自聚碳酸酯，聚苯乙烯和聚乙烯的透明材料制成。还提供了细胞分析的方法。

14. 发明申请

WO2011124730A1 REACTOR PARA EL ESTUDIO Y CULTIVO DE BIOCAPAS 审中-公开
标题翻译：用于研究和培养生物膜的反应器
公开(公告)号：WO2011124730A1
公开(公告)日：2011-10-13
申请号：PCT/ES2011/000067
申请日：2011-03-09
申请人： CENTRO DE ESTUDIOS E INVESTIGACIONES TÉCNICAS DE GUIPÚZCOA (CEITG) , PAREDES PUENTE, Jacobo , ARANA ALONSO, Sergio , GEIJO ARENAL, David
发明人： PAREDES PUENTE, Jacobo , ARANA ALONSO, Sergio , GEIJO ARENAL, David
IPC分类号： B01J19/26 , B01J19/32 , C12M1/42
CPC分类号： C12M23/08 , C12M23/38 , C12M41/36
摘要： Reactor para el estudio y cultivo de biocapas, que comprende un vaso que se cierra por su parte superior con una tapa provista de unas entradas para fluidos y unos orificios por los que se insertan unos vástagos (9) que disponen de, al menos, un sensor (10) removible, sobre el que se forma la biocapa, estando relacionado dicho sensor (10) con una placa (11) de conexiones, para la medición, desde el exterior del reactor, de parámetros físicos de biocrecimiento de la biocapa que se forma sobre el sensor (10).
摘要翻译：本发明涉及用于研究和培养生物膜的反应器，其包括在其上端处封闭的容器，其具有用于插入具有至少一个可移除传感器（10）的杆（9）的用于流体和孔的入口的盖，在其上形成生物膜，所述传感器（10）与连接板（11）相关联，允许从反应器外部测量在传感器（10）上形成的生物膜的物理生物生长参数。

15. 发明申请

WO2010118709A3 METHOD OF PRODUCTION OF SYNCHRONIZED ADHERENTLY GROWING CELL LINES AND DEVICE FOR CARRYING OUT SAID METHOD 审中-公开
标题翻译：生产同步生长细胞系的方法和实施所述方法的装置
公开(公告)号：WO2010118709A3
公开(公告)日：2010-12-23
申请号：PCT/CZ2010000043
申请日：2010-04-12
申请人： UNIV PALACKEHO , MISTRIK MARTIN , BARTEK JIRI
发明人： MISTRIK MARTIN , BARTEK JIRI
IPC分类号： C12M3/04
CPC分类号： C12M23/08 , C12M23/46 , C12M27/16 , C12M33/08
摘要： The present invention relates to a method for production of a synchronized adherently growing cell line, wherein a culture bottle with culture medium containing adherent cell line is subjected to a vibration under standard cultivation conditions in an incubator, and after finishing the vibrational treatment, the washed- out cell fraction suspension is removed and transferred to a new culture bottle or taken for analysis. The vibration causes the washout of the poorly adhering mitotic cells to the culture medium and initiates inhibition of their proliferation. The invention further relates to a device for carrying out said method, containing a movable platform (1), flexibly mounted on a stationary support structure (3), said movable platform (1) having attachment means (10) and being connected to a vibrator (5), said vibrator being connected by a cable (6) to a vibration regulator (7) embedded in a box (8), said box (8) holding an energy supply (9).
摘要翻译：本发明涉及一种同步贴壁生长细胞系的制造方法，其中将含有贴壁细胞系的培养基的培养瓶在标准培养条件下在恒温箱中进行振动，振动处理结束后， - 除去细胞部分悬浮液并转移到新的培养瓶中或用于分析。振动导致粘附不良的有丝分裂细胞冲洗到培养基中并引发其增殖的抑制。本发明还涉及一种用于执行所述方法的设备，该设备包括柔性地安装在固定支撑结构（3）上的可移动平台（1），所述可移动平台（1）具有连接装置（10）并连接到振动器（5），所述振动器通过电缆（6）连接到嵌入盒子（8）中的振动调节器（7），所述盒子（8）保持能量供应（9）。

16. 发明申请

WO2009074806A8 ANAEROBIC PROCESS 审中-公开
标题翻译： ANAEROBIC过程
公开(公告)号：WO2009074806A8
公开(公告)日：2010-08-05
申请号：PCT/GB2008004103
申请日：2008-12-11
申请人： CPI INNOVATION SERVICES LTD , COOPER JEREMY , DOWLE CHRISTOPHER JONATHAN , DONEGAN STEPHEN , THEODOROU MICHAEL K , VAN HOUTEN BERND
发明人： COOPER JEREMY , DOWLE CHRISTOPHER JONATHAN , DONEGAN STEPHEN , THEODOROU MICHAEL K , VAN HOUTEN BERND
IPC分类号： C12M1/02
CPC分类号： C12M27/20 , B01J19/006 , B01J19/185 , C12M21/04 , C12M23/08 , C12M41/12 , C12M41/28 , Y02P20/582
摘要： An anaerobic process uses a continuous oscillatory flow reactor (1) having a reaction tube with baffles (7) along its length. Fluid material is introduced into the tube through a circulating loop (41) and control valve (28) configuration. The fluid comprises the following components: a finely divided substrate material, e.g. of ground straw, and facultative and/or obligate anaerobic organisms such as rumen organisms. The fluid material passes through the tube at a speed that allows anaerobic fermentation to take place, and is caused to oscillate with respect to the baffles. The microbial biomass, extra-cellular enzymes and liquid and gaseous fermentation end-products can be collected at outlets (5, 9). The oscillating-f low system can be used to grow obligately anaerobic microorganisms and is ideal for fermentation processes because of its thorough mixing at low shear force and controllable conditions. In it rumen processes in particular can be run, resulting in a much faster digestion than in conventional anaerobic digesters.
摘要翻译：厌氧方法使用具有沿其长度的挡板（7）的反应管的连续振荡流动反应器（1）。流体材料通过循环回路（41）和控制阀（28）构型被引入到管中。流体包括以下组分：细碎的基底材料，例如，的地面秸秆，兼性和/或专性的厌氧生物体如瘤胃生物。流体材料以允许厌氧发酵发生的速度穿过管并相对于挡板振荡。微生物生物量，细胞外酶和液态和气态发酵终产物可以在出口收集（5,9）。振荡低系统可用于生长专业厌氧微生物，是发酵过程的理想选择，因为它在低剪切力和可控条件下充分混合。在其中，特别是可以运行瘤胃过程，导致比常规厌氧消化器快得多的消化。

17. 发明申请

WO2010036023A3 SYRINGE-SHAPED CULTURE TUBE AND CELL CULTURE APPARATUS USING SAME 审中-公开
标题翻译： SYRINGE形文化管和使用相同的细胞培养装置
公开(公告)号：WO2010036023A3
公开(公告)日：2010-07-15
申请号：PCT/KR2009005427
申请日：2009-09-23
申请人： CORESTEM CO LTD , HONG SEOK KEE , YANG SI EUN , KIM KYUNG SUK , YOON HYUN SOO , LEE TAE YONG , LEE JIN HWA
发明人： HONG SEOK KEE , YANG SI EUN , KIM KYUNG SUK , YOON HYUN SOO , LEE TAE YONG , LEE JIN HWA
IPC分类号： C12M1/24
CPC分类号： C12M27/10 , C12M23/08
摘要： The present invention relates to a syringe-shaped culture tube which has a wide surface area and is changeable by a user to a desirable size, and a cell culture apparatus in which plural culture tubes are mounted. The cell culture apparatus allows the culture medium to constantly and smoothly contact the entire inner circumference of the culture tube and rotate by a rotation unit at a preset speed when the culture tube is filled with the culture medium. Thus, the cell culture apparatus can promote stirring and gas supply and increase the gas exchange rate. Also, the cell culture apparatus can reduce consumption of the culture medium. The cell culture apparatus according to the present invention comprises: the culture tube with culture space therein, wherein a vent hole in which the culture medium flows in and out of the culture tube is formed at one or both ends thereof and the inner diameter gradually tapers toward the outside at the other end; a rotation support member with plural culture tubes horizontally mounted in a longitudinal direction that rotates around a rotation shaft formed at the center; and a rotation unit for rotating the rotation support member around the rotation shaft.
摘要翻译：本发明涉及一种注射器形的培养管，其具有宽的表面积并可由使用者改变到理想的尺寸，并且其中安装有多个培养管的细胞培养装置。细胞培养装置在培养管充满培养基时，使培养基始终平稳地接触培养管的整个内周并通过旋转单元以预设速度旋转。因此，细胞培养装置可以促进搅拌和气体供应并提高气体交换率。而且，细胞培养装置可以减少培养基的消耗。根据本发明的细胞培养装置包括：其中具有培养空间的培养管，其中培养基流入和流出培养管的通气孔形成在其一端或两端，并且内径逐渐变细向另一端的外面; 具有多个培养管的旋转支撑构件，所述培养管沿纵向方向水平地安装，所述纵向方向围绕形成在中心处的旋转轴旋转; 以及用于围绕旋转轴旋转旋转支撑构件的旋转单元。

18. 发明申请

WO2010006055A3 IMPROVED GAS PERMEABLE CELL CULTURE DEVICE AND METHOD OF USE 审中-公开
标题翻译：改进的气体渗透型细胞培养装置和使用方法
公开(公告)号：WO2010006055A3
公开(公告)日：2010-03-04
申请号：PCT/US2009049944
申请日：2009-07-08
申请人： WOLF WILSON MFG CORP , WILSON JOHN R
发明人： WILSON JOHN R
IPC分类号： C12M3/00 , C12M1/24
CPC分类号： C12M23/24 , C12M23/08 , C12M23/34 , C12M23/40
摘要： Gas permeable devices and methods are disclosed that provide more efficient cell culture.
摘要翻译：公开了提供更有效细胞培养的气体可渗透装置和方法。

19. 发明申请

WO2009128892A2 FLEXIBLE MEMBRANE VALVE FOR CELL CULTURE VESSEL 审中-公开
标题翻译：用于细胞培养血管的柔性膜片
公开(公告)号：WO2009128892A2
公开(公告)日：2009-10-22
申请号：PCT/US2009002302
申请日：2009-04-14
申请人： CORNING INC , CATTADORIS HENRY J , MARTIN GREGORY R , TANNER ALLISON J
发明人： CATTADORIS HENRY J , MARTIN GREGORY R , TANNER ALLISON J
IPC分类号： C12M1/24
CPC分类号： C12M37/04 , C12M23/08 , C12M23/10 , C12M23/24 , C12M23/26 , C12M23/38 , C12M37/02
摘要： An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a contiguous side wall, an end wall, and a microbial filter. The end wall has an opening and extends across one end of the side wall to form a major cavity within the side wall and the end wall. The flexible membrane has a slit spanning the membrane and is disposable within the major cavity such that the membrane sealingly divides the major cavity into (i) a chamber formed between the end wall and the membrane and (ii) a minor cavity formed by the membrane and a portion of the side wall. The minor cavity is in fluid communication with the reservoir. The slit is biased in a closed position to prevent fluid from passing from the minor cavity into the chamber and is configured to open to allow gas to pass from the minor cavity into the chamber when the pressure differential across the membrane is above a threshold. The filter is disposed between the membrane and the opening such that air flowing through the opening in the end wall into the chamber passes through the filter.
摘要翻译：用于培养细胞的组件包括限定用于容纳细胞培养基的储存器和与储存器流体连通的开口的壳体。细胞培养组件还包括被配置为密封地接合开口的过滤阀组件。过滤阀组件包括柔性膜，邻接侧壁，端壁和微生物过滤器。端壁具有开口并且延伸穿过侧壁的一端以在侧壁和端壁内形成主腔。柔性膜具有横跨膜的狭缝，并且在主空腔内是一次性的，使得膜将主腔密封地划分为（i）形成在端壁和膜之间的腔室和（ii）由膜形成的小腔和侧壁的一部分。小空腔与储存器流体连通。狭缝被偏压在关闭位置，以防止流体从小空腔进入腔室，并被构造成打开，以允许气体在薄膜上的压差高于阈值时从小腔进入腔室。过滤器设置在膜和开口之间，使得流过端壁中的开口进入室的空气通过过滤器。

20. 发明申请

WO2009069960A2 A CELL CULTURE FLASK AND THE CELL CULTURE DEVICE HAVING IT 审中-公开
标题翻译：细胞培养皿和具有它的细胞培养装置
公开(公告)号：WO2009069960A2
公开(公告)日：2009-06-04
申请号：PCT/KR2008/007035
申请日：2008-11-28
申请人： CORESTEM CO., LTD. , KIM, Kyung Suk , CHOUNG, Jai Jun
发明人： KIM, Kyung Suk , CHOUNG, Jai Jun
IPC分类号： C12M1/00
CPC分类号： C12M23/08 , C12M23/22 , C12M23/38 , C12M23/44 , C12M29/00 , C12M29/26
摘要： The present invention relates to a cell culture flask for culturing a cell using a culture solution, particularly to a cell culture flask enabling to culture a cell without any contamination, to automatically introduce and discharge the culture solution or gases and to be stacked in turn, and a cell culture device having the same. The present invention provides a cell culture flask comprising a culture space with a predetermined area for culturing the cell; one or more culture solution inlet ports for introducing the culture solution or the cell into the culture space; one or more culture solution outlet ports for discharging the culture solution or the cell supplied to the culture space; and one or more gas inlet ports for introducing the various gases into the culture space, wherein the cell culture flask is made airtight and formed of a transparent material so that a user can see an internal portion of the cell culture flask, and a cell culture device having the same.
摘要翻译：本发明涉及使用培养液培养细胞的细胞培养用烧瓶，特别涉及能够无污染地培养细胞的细胞培养用烧瓶，以自动导入培养液或排出培养液，或者气体并依次堆积，以及具有该气体的细胞培养装置。本发明提供了一种细胞培养瓶，其包含具有用于培养细胞的预定区域的培养空间; 一个或多个用于将培养溶液或细胞引入培养空间的培养溶液入口; 一个或多个培养溶液出口端口，用于排出供给培养空间的培养液或细胞; 以及用于将各种气体引入培养空间的一个或多个气体入口端口，其中细胞培养瓶被气密地制成并由透明材料形成，使得使用者可以看到细胞培养瓶的内部部分，并且细胞培养物设备具有相同的功能。

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