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    • 18. 发明申请
    • A PROCESS FOR THE PREPARATION OF PARA-FLUOROPHENOL
    • 一种制备对苯二酚的方法
    • WO99002473A1
    • 1999-01-21
    • PCT/IL1998/000248
    • 1998-05-28
    • C07B61/00C07C37/02C07C39/27
    • C07C37/02C07C39/27
    • A method for the preparation of p-fluorophenol by the alkaline hydrolysis of p-bromofluorobenzene in the presence of a copper-containing catalyst at an elevated temperature under pressure, the alkaline agent being a strong base, characterized in that said p-bromofluorobenzene, copper-containing catalyst and strong base are contacted with water where at least the base is gradually added to the reaction zone at an essentially uniform flow rate such that the addition of the base lasts at least the time required to complete the reaction in a batch operation, and less than 12 hours, and the molar ratio of the base is between 1.8 to 3 with respect to said p-bromofluorobenzene.
    • 一种在含铜催化剂存在下,在高压下在压力下碱性水解对氟苯酚的方法,碱性试剂是强碱,其特征在于所述对溴氟苯,铜 的催化剂和强碱与水接触,其中至少碱以基本均匀的流速逐渐加入到反应区中,使得碱的添加持续至少在间歇操作中完成反应所需的时间, 和小于12小时,相对于所述对溴氟苯,碱的摩尔比为1.8-3。