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11. 发明申请

WO2018129621A1 PROCESS FOR MANUFACTURING CARBON ANODES FOR ALUMINIUM PRODUCTION CELLS AND CARBON ANODES OBTAINED FROM THE SAME 审中-公开
公开(公告)号：WO2018129621A1
公开(公告)日：2018-07-19
申请号：PCT/CA2018/050026
申请日：2018-01-12
申请人： UNIVERSITÉ LAVAL , ALCOA USA CORP.
发明人： ALAMDARI, Houshang , ISHAK, Ramzi , LAROCHE, Gaétan , FAFARD, Mario , PICARD, Donald , ZIEGLER, Donald
IPC分类号： C25C3/12
CPC分类号： C25C3/125 , C04B35/532 , C04B35/62805 , C04B35/62886 , C04B2235/3409 , C04B2235/422 , C04B2235/5427 , C04B2235/5436 , C04B2235/5472 , C04B2235/6562 , C04B2235/6567 , C04B2235/6587 , C04B2235/72 , C04B2235/726 , C04B2235/77
摘要： There is provided a process for manufacturing a carbonaceous anode for an electrolysis cell for the production of aluminium. The process comprises contacting coke particles with a boron-containing solution to obtain boron-impregnated coke particles, mixing the boron- impregnated coke particles with coal tar pitch to form an anode paste, and forming a green anode with the anode paste. A carbonaceous anode for an electrolysis cell for the production of aluminium is also provided, which comprises at least a first fraction of coke particle, a second fraction of coke particles and coal tar pitch, wherein at least the first faction of coke particles comprises boron-impregnated coke particles, the boron- impregnated coke particles being distributed throughout the carbonaceous anode. The carbonaceous anode presents good resistivity towards air and CO 2 oxidation, which translates into less dusting of the anode, thus improving its integrity throughout its lifetime.

12. 发明申请

WO2018014108A1 SYSTEM AND METHOD FOR ESTIMATING SYNTHETIC QUANTITATIVE HEALTH VALUES FROM MEDICAL IMAGES 审中-公开
标题翻译：用于从医学图像估计合成定量健康值的系统和方法
公开(公告)号：WO2018014108A1
公开(公告)日：2018-01-25
申请号：PCT/CA2016/050871
申请日：2016-07-22
申请人： UNIVERSITÉ LAVAL , MCGILL UNIVERSITY
发明人： DUCHESNE, Simon , GRAVEL, Pierre , COLLINS, Louis
IPC分类号： G06T7/00 , A61B5/00 , G06T7/60
摘要： A computer-implemented method, an apparatus, and a system for estimating synthetic values of quantitative metrics are provided. They involve calculating new, more accurate boundaries using a classifier based on local intensity and spatial estimators, for the segmentation mask provided by a non- local means patch-based segmentation in a test image, and estimating for the pixels of interest at least one synthetic value of a quantitative metric using a given value of the quantitative metric assigned to the reference images and the boundaries. The method, apparatus, and system provide the advantage of generating synthetic values directly comparable against known values for given subjects or against predetermined scales for diagnostic or prognostic purposes. In the specific case of Alzheimer's disease, the invention stretches the predictive range up to two full decades, which constitutes a significant advance in the field of medical diagnostics.
摘要翻译：提供了用于估计定量度量的合成值的计算机实现的方法，装置和系统。它们涉及使用基于局部强度和空间估计量的分类器计算新的更准确的边界，用于由测试图像中的非局部平均基于块基的分割提供的分割掩模，并且针对感兴趣的像素估计至少一个合成使用分配给参考图像和边界的定量度量的给定值的定量度量的值。所述方法，装置和系统提供了产生合成值的优点，所述合成值与针对给定受试者的已知值或针对诊断或预后目的的预定比例直接可比较。在阿尔茨海默病的具体病例中，本发明将预测范围延长至两个十年，这构成了医学诊断领域的重大进步。

13. 发明申请

WO2015103709A1 METHOD AND APPARATUS FOR CREATION AND ELECTRICAL TUNING OF SPATIALLY NON-UNIFORM REFLECTION OF LIGHT 审中-公开
标题翻译：空间非均匀反射光的创建和电气调谐方法与装置
公开(公告)号：WO2015103709A1
公开(公告)日：2015-07-16
申请号：PCT/CA2015/050016
申请日：2015-01-12
申请人： UNIVERSITÉ LAVAL
发明人： GALSTIAN, Tigran
IPC分类号： G02F1/01 , G02C7/04 , G02F1/13 , G02F1/19 , H02S40/22
CPC分类号： G02F1/19 , A61F2/1627 , G02C7/04 , G02C7/083 , G02C7/12 , G02C7/14 , G02F1/061 , G02F1/13306 , G02F1/1334 , G02F1/133553 , G02F1/13363 , G02F1/1337 , G02F1/134309 , G02F1/134327 , G02F1/13471 , G02F1/137 , G02F1/29 , G02F2001/13775 , G02F2001/294 , G02F2203/18 , H01L31/0547 , H01S3/0071 , H01S3/08059 , H01S3/105 , H04N5/23287 , H04N5/23296 , Y02E10/52
摘要： A variable optical device for controlling properties of reflected light is described. The device includes a light reflecting surface, a layer of dynamically controllable material and an excitation source for generating an excitation field acting on the layer of dynamically controllable material. An electrical drive signal applied to the excitation source causes a change of optical properties in the layer of dynamically controllable material to provide a spatially varying change in light reflection having at least one of a desired phase curvature and a desired amplitude modulation profile.
摘要翻译：描述了用于控制反射光特性的可变光学装置。该装置包括光反射表面，动态可控材料层和用于产生作用在动态可控材料层上的激发场的激发源。施加到激发源的电驱动信号导致动态可控材料层中的光学特性的变化，以提供具有期望的相位曲率和期望的幅度调制曲线中的至少一个的光反射的空间上变化的变化。

14. 发明申请

WO2015051465A1 NANOPARTICULAR ANTIBODIES AND USES THEREOF AS CONTRAST AGENTS 审中-公开
标题翻译：作为对照药物的纳米抗体及其用途
公开(公告)号：WO2015051465A1
公开(公告)日：2015-04-16
申请号：PCT/CA2014/050983
申请日：2014-10-10
申请人： HÉMA-QUÉBEC , UNIVERSITÉ LAVAL
发明人： BROUARD, Danny , RATELLE, Olivier , BOUDREAU, Denis
IPC分类号： G01N33/566 , B22F1/02 , G01N33/52
CPC分类号： B22F1/02 , B22F1/0014 , B22F1/0018 , B22F1/0062 , G01N33/5432 , G01N2333/70589 , G01N2333/70596
摘要： Metal/silica core-shell nanoparticles, such as silver/silica core-shell nanoparticles, having low polydispersity, and a process for their preparation, are described. The nanoparticles may comprise one or more fluorophores embedded with the silica shell, as well as one or more targeting moieties, such as an antibody, attached to the silica shell. Use of such nanoparticles for various applications, including the detection of the presence of a biomolecule on the surface of a cell, is also described.
摘要翻译：描述了具有低多分散性的金属/二氧化硅核 - 壳纳米颗粒，如银/二氧化硅核 - 壳纳米颗粒及其制备方法。纳米颗粒可以包含一个或多个嵌入二氧化硅壳的荧光团，以及连接到二氧化硅壳上的一个或多个靶向部分，例如抗体。还描述了将这些纳米颗粒用于各种应用，包括在细胞表面上检测生物分子的存在。

15. 发明申请

WO2014176696A1 NOVEL BIOMARKERS FOR ACUTE MYELOID LEUKEMIA 审中-公开
标题翻译：新生儿生物标记为急性髓性白血病
公开(公告)号：WO2014176696A1
公开(公告)日：2014-11-06
申请号：PCT/CA2014/050410
申请日：2014-04-30
申请人： UNIVERSITÉ DE MONTRÉAL , UNIVERSITÉ LAVAL
发明人： WILHELM, Brian Thomas , BARABÉ, Frédéric
IPC分类号： G01N33/574 , A61K39/395 , A61P35/02 , C12Q1/68 , C40B30/04 , G01N33/48
CPC分类号： C12Q1/6886 , C07K16/18 , C07K16/2827 , C07K16/40 , C12Q2600/158 , C12Q2600/16 , G01N33/57426
摘要： Methods for the diagnosis of leukemias, and more specifically AML, such as MLL-AF9 AML, in a subject, based on the assessment of the expression or activity of one or more of the genes listed in Tables 1 and 2 are disclosed. The use of antibodies or antigen-binding fragments thereof that bind to one or more of proteins showing preferential expression at the cell surface of AML leukemic cells for treating AML is also disclosed.
摘要翻译：公开了基于对表1和表2中所列的一种或多种基因的表达或活性的评估来诊断受试者中白血病，更具体地AML的方法，例如MLL-AF9 AML。还公开了与在AML白血病细胞的细胞表面显示优先表达的一种或多种蛋白质结合的抗体或其抗原结合片段的用途，用于治疗AML。

16. 发明申请

WO2014138987A1 USE OF ELECTRORETINOGRAPHY (ERG) FOR THE ASSESSMENT OF PSYCHIATRIC DISORDERS 审中-公开
标题翻译：电子评估（ERG）用于评估心理障碍
公开(公告)号：WO2014138987A1
公开(公告)日：2014-09-18
申请号：PCT/CA2014/050233
申请日：2014-03-13
申请人： UNIVERSITÉ LAVAL
发明人： HÉBERT, Marc , MAZIADE, Michel , MÉRETTE, Chantal
IPC分类号： A61B5/0496 , A61B3/10 , A61B5/16 , A61K31/496
CPC分类号： A61B5/0496 , A61B3/10 , A61B5/16 , A61B5/165 , A61B5/167 , A61B5/4848 , A61B5/72 , A61B5/7246 , A61B5/7275 , G06F19/00 , G16H50/20
摘要： Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.
摘要翻译：描述了基于视网膜电图（ERG）参数的精神疾病患者诊断，预后，患者分层和预测药物反应的方法。

17. 发明申请

WO2014087380A1 OPTICAL INTERROGATION DEVICE 审中-公开
标题翻译：光学互连设备
公开(公告)号：WO2014087380A1
公开(公告)日：2014-06-12
申请号：PCT/IB2013/060686
申请日：2013-12-05
申请人： GENEPOC INC. , UNIVERSITÉ LAVAL
发明人： LEMIEUX, Hugo , CHAPDELAINE, Sébastien , BÉLIVEAU-VIEL, David , GRAVEL, Jean-François
IPC分类号： G01J3/443 , C12M1/34 , G01J3/10 , G01J3/12 , G01N21/07 , C12M1/38
CPC分类号： G01N21/6486 , G01J3/021 , G01J3/0213 , G01J3/0216 , G01J3/0218 , G01J3/443 , G01J2003/102 , G01N21/6408 , G01N21/6445 , G01N21/645 , G01N21/763 , G01N2021/6419 , G01N2021/6471 , G01N2021/6484 , G01N2201/061
摘要： An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.
摘要翻译：一种用于检测由各自具有各个光谱内容的多个激发光束激发的样品中的被分析物产生的发光光的询问装置，包括多个光源，每个光源产生激发光束; 用于检测由样品产生的发光的至少一个检测器; 以及光学组件，其为从光源到样品上的共同激发位置的每个激发光束定义不同且固定的激发光路径，并且限定用于从样品上的激发位点到该位置的发光的共享发光光路至少一个检测器，激发光路径和发光光路位于样品的同一侧，光学组件包括样品侧光学器件，将激发光投射到样品并收集来自样品的发光。

18. 发明申请

WO2013177695A1 METHOD AND APPARATUS FOR DETERMINING AN ICING CONDITION STATUS OF AN ENVIRONMENT 审中-公开
标题翻译：用于确定环境条件状态的方法和装置
公开(公告)号：WO2013177695A1
公开(公告)日：2013-12-05
申请号：PCT/CA2013/050380
申请日：2013-05-17
申请人： UNIVERSITÉ LAVAL
发明人： BEGIN-DROLET, André , RUEL, Jean , LEMAY, Jean
IPC分类号： G01N25/00
CPC分类号： G01W1/02 , F03D80/40 , G01N25/04 , G01W1/06 , G08B19/02 , Y02E10/72
摘要： The method includes receiving a value of a quantity of heat applied to at least a portion of a structure, said structure having a sensor surface exposed to the environment, receiving a temperature measurement of the sensor surface, receiving a wind speed measurement of the environment, receiving an ambient temperature measurement of the environment, determining a heat transfer projection of the sensor area using at least the wind speed measurement, the ambient temperature measurement, and one of the value of a quantity of heat and a target temperature of the sensor surface; comparing the heat transfer projection to an associated heat transfer value, and generating a signal indicating the icing condition status based on the comparison.
摘要翻译：该方法包括接收施加到结构的至少一部分的热量的值，所述结构具有暴露于环境的传感器表面，接收传感器表面的温度测量，接收环境的风速测量，接收环境的环境温度测量，使用至少风速测量，环境温度测量以及传感器表面的热量和目标温度的值之一来确定传感器区域的传热投影; 将热传递投影与相关联的传热值进行比较，并且基于比较产生指示结冰状态的信号。

19. 发明申请

WO2013071440A1 METHODS AND PRODUCTS FOR INCREASING FRATAXIN LEVELS AND USES THEREOF 审中-公开
标题翻译：增加FRATAXIN水平的方法和产品及其用途
公开(公告)号：WO2013071440A1
公开(公告)日：2013-05-23
申请号：PCT/CA2012/050817
申请日：2012-11-16
申请人： UNIVERSITÉ LAVAL
发明人： TREMBLAY, Jacques P. , ROUSSEAU, Joël , CHAPDELAINE, Pierre , COULOMBE, Zoé
IPC分类号： C07K19/00 , A61K38/17 , A61P25/28 , C07K14/195 , C07K14/47 , C07K17/02 , C12N15/62 , C12N15/85 , C12N5/07
CPC分类号： C07K19/00 , A61K38/00 , A61K38/16 , C07K14/195 , C07K14/47 , C07K2319/09 , C07K2319/10 , C07K2319/21 , C07K2319/71 , C07K2319/80
摘要： Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
摘要翻译：描述了用于增加细胞中frataxin表达/水平的方法和产物（例如重组蛋白），以及这些方法和产品的用途，例如用于治疗受试者的Friedreich共济失调。

20. 发明申请

WO2013000081A1 QUALITY CONTROL AND ASSURANCE OF IMAGES 审中-公开
标题翻译：质量控制和图像保证
公开(公告)号：WO2013000081A1
公开(公告)日：2013-01-03
申请号：PCT/CA2012/050427
申请日：2012-06-26
申请人： UNIVERSITÉ LAVAL , DUCHESNE, Simon , VALDIVIA, Fernando , CREPAULT, Burt
发明人： DUCHESNE, Simon , VALDIVIA, Fernando , CREPAULT, Burt
IPC分类号： G06T5/00 , A61B5/055 , G01R33/56
CPC分类号： G06K9/6262 , G06T7/0002 , G06T7/0014 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/30016 , G06T2207/30168
摘要： Applicants have discovered a multi-layer quality control / quality assurance system that provides higher quality data, without human intervention, by rejecting images that do not achieve a pre-determined quality threshold. In some embodiments of the present invention, there is provided a new method of processing an image from a data set through a pipeline wherein quality control/assurance allows to determine a quality of the image processing, the method comprising; receiving a test image; pre- processing the test image; registering the test image to a reference image; calculating a test image quality using a correlation of image intensity values between corresponding locations of the test image and the reference image; providing a plurality of training images and calculating training image quality distribution statistics for the training images with respect to the reference image; and relating the test image quality to the training image quality distribution.
摘要翻译：申请人已经发现了一个多层质量控制/质量保证体系，通过拒绝没有达到预定质量阈值的图像，无需人为干预就能提供更高质量的数据。在本发明的一些实施例中，提供了一种通过管线处理来自数据集的图像的新方法，其中质量控制/确认允许确定图像处理的质量，该方法包括：接收测试图像; 预处理测试图像; 将测试图像注册到参考图像; 使用测试图像的对应位置与参考图像之间的图像强度值的相关性来计算测试图像质量; 提供多个训练图像并计算训练图像相对于参考图像的训练图像质量分布统计; 并将测试图像质量与训练图像质量分布相关联。

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