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11. 发明申请

WO2014160903A2 BIOLOGICAL SAMPLE PROCESSING 审中-公开
标题翻译：生物样品处理
公开(公告)号：WO2014160903A2
公开(公告)日：2014-10-02
申请号：PCT/US2014032092
申请日：2014-03-27
申请人： THERANOS INC
发明人： HOLMES ELIZABETH A , LATH ADRIT
IPC分类号： G01N1/28
CPC分类号： G01N35/00732 , B01L3/545 , B01L2200/16 , B01L2300/021 , B01L2300/022 , G01N35/0099 , G01N35/021 , G01N35/1002 , G01N2035/00346 , G01N2035/00752 , G01N2035/00851 , G01N2035/0436 , G01N2035/0489 , Y10S901/01 , Y10S901/41
摘要： Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.
摘要翻译：提供了用于处理生物样品的系统和方法。在一个实施例中，该方法包括接收含有样品的样品器皿; 从与样本相关联的信息存储单元中检索信息; 使用所述信息从至少两个或更多个不同的盒中选择至少一个盒，每个盒被配置为与样品处理装置一起使用; 将至少一种或多种试剂加载到所述盒上，其中所述一种或多种待添加的试剂至少部分基于从所述信息导出的信息或指令来选择; 并将样品器皿放入盒中。

12. 发明申请

WO2014145269A1 THERMOSTABLE BLUNT-END LIGASE AND METHODS OF USE 审中-公开
标题翻译：可热膨胀的蓝色结晶器和使用方法
公开(公告)号：WO2014145269A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030003
申请日：2014-03-15
申请人： THERANOS, INC.
发明人： CHRISTIANS, Frederick
IPC分类号： C12N9/00 , C12Q1/68
CPC分类号： C12N9/93 , C07K14/4702 , C07K2319/21 , C07K2319/80 , C12P19/34 , C12Q1/6844 , C12Y605/01001
摘要： Thermostable blunt-end ligases suitable for use in nucleic acid ligation reactions at elevated temperatures are provided. The ligases comprise fusion proteins including a DNA ligase and a DNA binding protein, e.g., a T4 DNA ligase with an N-terminal p50 fusion. The fusion proteins may include peptide linkers, peptide mimetics, terminal additions, tag peptides, D-amino acids, sugars, non-amino acid organic moieties, and polymers. The ligases are suitable for use in ligation reactions, including uniform-temperature ligation reactions, performed at about 60 °C or higher, e.g., at about 75 °C. The ligases are suitable for use in nucleic acid amplification schemes with temperature cycling, e.g., temperature cycles to about 60 °C or higher, or temperature cycles from about 94 °C to about 60 °C. Such nucleic acid amplification schemes may include one, two, three, or more temperature cycles. Methods of using the ligases, and articles of manufacture comprising the ligases are provided.
摘要翻译：提供了适用于高温下核酸连接反应的热稳定性平端连接酶。连接酶包括融合蛋白，包括DNA连接酶和DNA结合蛋白，例如具有N端p50融合物的T4 DNA连接酶。融合蛋白可以包括肽接头，肽模拟物，末端添加物，标签肽，D-氨基酸，糖，非氨基酸有机部分和聚合物。连接酶适用于连接反应，包括在约60℃或更高（例如约75℃）下进行的均匀温度连接反应。连接酶适用于具有温度循环的核酸扩增方案，例如温度循环至约60℃或更高，或约94℃至约60℃的温度循环。这样的核酸扩增方案可以包括一个，两个，三个或更多个温度循环。提供了使用连接酶的方法和包含连接酶的制品。

13. 发明申请

WO2014138137A3 NETWORK CONNECTIVITY METHODS AND SYSTEMS 审中-公开
公开(公告)号：WO2014138137A3
公开(公告)日：2014-09-12
申请号：PCT/US2014/020440
申请日：2014-03-04
申请人： THERANOS, INC.
发明人： BALWANI, Sunny
IPC分类号： H04L12/905
摘要： Methods and systems are provided for connecting an electronic device to a network. In some situations, the electronic device connects to a first network provider and pings a first server having a static internet protocol address and a second server having a dedicated uniform resource locator. If the electronic device receives a response from the first and second server, the electronic device maintains its connection to the first network provider. Otherwise, the electronic device connects to a second network provider and pings the first and second servers.

14. 发明申请

WO2014127379A1 SYSTEMS AND METHODS FOR MULTI-ANALYSIS 审中-公开
标题翻译：多分析系统与方法
公开(公告)号：WO2014127379A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/016997
申请日：2014-02-18
申请人： THERANOS, INC.
发明人： Holmes, Elizabeth A. , Balwani, Sunny , Chen, Michael , Frankovich, John K. , Frenzel, Gary , Surekha, Gangakhedkar , Samartha, Anekal , Lath, Adrit , Loo, Alexander , Pangarkar, Chinmay , Patel, Paul , Roy, Joy , Smith, Timothy , Young, Daniel
IPC分类号： G01N1/10 , G01N35/10 , G01N21/00
CPC分类号： G01N35/1065 , B01L3/0275 , B01L3/5025 , B01L2300/0681 , B01L2300/0858 , B01L2300/1838 , B01L2400/0409 , G01N35/0092 , G01N35/0099 , G01N2015/1006 , G01N2035/00326 , G01N2035/00881 , G01N2035/1076
摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
摘要翻译：提供系统和方法用于样品处理。可以提供能够接收样品并执行样品制备，样品测定和检测步骤中的一种或多种的装置。该装置可能能够进行多个测定。该装置可以包括一个或多个可以执行样品制备，样品测定和检测步骤中的一个或多个的模块。该装置可以能够使用小体积的样品来执行步骤。

15. 发明申请

WO2013052318A1 SYSTEMS AND METHODS FOR MULTI-ANALYSIS 审中-公开
标题翻译：多分析系统与方法
公开(公告)号：WO2013052318A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/057155
申请日：2012-09-25
申请人： THERANOS, INC. , HOLMES, Elizabeth , BALWANI, Sunny , ROY, Joy , FRANKOVICH, John, Kent , FRENZEL, Gary
发明人： HOLMES, Elizabeth , BALWANI, Sunny , ROY, Joy , FRANKOVICH, John, Kent , FRENZEL, Gary
IPC分类号： C12M1/00 , G01N35/00 , A61B6/00
CPC分类号： G01N35/1065 , G01N35/00 , G01N2035/00326
摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
摘要翻译：提供系统和方法用于样品处理。可以提供能够接收样品并执行样品制备，样品测定和检测步骤中的一种或多种的装置。该装置可能能够进行多个测定。该装置可以包括一个或多个可以执行样品制备，样品测定和检测步骤中的一个或多个的模块。该装置可以能够使用小体积的样品来执行步骤。

16. 发明申请

WO2013049051A1 NETWORK CONNECTIVITY METHODS AND SYSTEMS 审中-公开
标题翻译：网络连接方法和系统
公开(公告)号：WO2013049051A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057093
申请日：2012-09-25
申请人： THERANOS, INC. , BALWANI, Sunny
发明人： BALWANI, Sunny
IPC分类号： G06F15/16
CPC分类号： H04L43/0811 , G06F13/00 , G16H10/20 , H04L29/08234 , H04L41/0654 , H04L43/10 , H04L45/22 , H04L45/28 , H04L47/728 , H04L47/746 , H04L67/1023 , H04W76/18
摘要： Methods and systems are provided for connecting an electronic device to a network. In some situations, the electronic device connects to a first network provider and pings a first server having a static internet protocol address and a second server having a dedicated uniform resource locator. If the electronic device receives a response from the first and second server, the electronic device maintains its connection to the first network provider. Otherwise, the electronic device connects to a second network provider and pings the first and second servers.
摘要翻译：提供了用于将电子设备连接到网络的方法和系统。在一些情况下，电子设备连接到第一网络提供商并ping通具有静态互联网协议地址的第一服务器和具有专用统一资源定位符的第二服务器。如果电子设备接收到来自第一和第二服务器的响应，则电子设备保持其与第一网络提供商的连接。否则，电子设备连接到第二网络提供商并ping第一和第二服务器。

17. 发明申请

WO2017044888A1 METHODS AND DEVICES FOR SAMPLE COLLECTION AND SAMPLE SEPARATION 审中-公开
标题翻译：样品采集和样品分离的方法和设备
公开(公告)号：WO2017044888A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051158
申请日：2016-09-09
申请人： THERANOS, INC.
发明人： SLOAN, Deborah , ROBERTSON, Channing
IPC分类号： G01N1/10 , G01N1/28 , A61J1/05
CPC分类号： A61B5/150755 , A61B5/150022 , A61B5/150099 , A61B5/150343 , A61B5/150351 , A61B5/150763 , A61J1/05 , B01L3/502 , B01L2200/026 , B01L2300/042 , B01L2300/0672 , B01L2300/12 , B01L2400/0406 , G01N1/4077 , G01N33/491 , G01N2001/4088
摘要： Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.
摘要翻译：提供了样品收集和样品分离的方法和装置。在一个实施例中，提供了用于与形成的部件液体样品一起使用的装置，该装置包括用于接收所述样品的至少一个样品入口; 至少第一出口，用于仅输出所形成的成分液体样品的液体部分; 至少第二出口，用于输出形成的组分液体样品至少混合在其中的第一材料。

18. 发明申请

WO2017035513A1 SYSTEMS, DEVICES, AND METHODS FOR SAMPLE INTEGRITY VERIFICATION 审中-公开
标题翻译：系统，设备和方法，用于样品完整性验证
公开(公告)号：WO2017035513A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/049133
申请日：2016-08-26
申请人： THERANOS, INC.
发明人： MORRISON, Zachary , YOUNG, Daniel , BALWANI, Sunny , CHEN, Michael
IPC分类号： G06K9/20 , G01N1/00
CPC分类号： G01N35/00 , G01N35/00732 , G01N2021/1765 , G01N2035/00495
摘要： The devices, systems, and methods disclosed herein provide sample verification capabilities in a single device or system. Devices are disclosed herein. Systems including these devices are also provided. These devices and systems may be configured for verifying sample integrity prior to a subject leaving a sample collection site so that any further samples or other corrective action can occur without having to make a separate visit.
摘要翻译：本文公开的设备，系统和方法在单个设备或系统中提供样本验证能力。本文公开了装置。还提供了包括这些设备的系统。这些设备和系统可以被配置用于在对象离开样本采集站点之前验证样本完整性，使得可以发生任何进一步的样本或其他校正动作而不必单独访问。

19. 发明申请

WO2017015517A1 SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION, TRANSPORT, AND HANDLING 审中-公开
标题翻译：系统，设备和方法用于体液样品采集，运输和处理
公开(公告)号：WO2017015517A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043435
申请日：2016-07-21
申请人： THERANOS, INC.
发明人： HOLMES, Elizabeth , LUI, Clarissa , CHEN, Michael , YOUNG, Daniel , ANEKAL, Samartha
IPC分类号： B01L3/14 , A61J1/05 , G01N1/28
CPC分类号： A61J1/05 , A61B5/150022 , A61B5/15003 , A61B5/150099 , A61B5/150251 , A61B5/150305 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150572 , A61B5/150732 , A61B5/150755 , A61B5/150793 , A61B5/150824 , A61B5/150954 , A61B5/150984 , A61B5/150992 , A61B5/15109 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/154 , B01L3/14 , B01L3/5021 , B01L9/06 , G01N1/28 , G01N33/491 , G01N2001/4083
摘要： Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step.
摘要翻译：提供了体液样品收集系统，装置和方法。将样品收集在第一位置并进行第一样品处理步骤。样品可以运送到第二位置，并进行不会将污染物引入到由第一处理步骤形成的样品的等离子体部分中的第二样品处理步骤。

20. 发明申请

WO2016138013A1 METHODS AND SYSTEMS FOR OBTAINING CLINICAL SAMPLES 审中-公开
标题翻译：用于获取临床样品的方法和系统
公开(公告)号：WO2016138013A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019160
申请日：2016-02-23
申请人： THERANOS, INC.
发明人： HOLMES, Elizabeth , BLICKMAN, Jeffrey , MENCHEL, Nicholas
IPC分类号： A61B5/15
CPC分类号： A61B5/15142 , A47B13/00 , A47B13/16 , A47B31/02 , A47B97/00 , A61B5/150022 , A61B5/150076
摘要： Methods for obtaining a sample from a subject include providing a sample collection room within a retail store or physician's office; and obtaining a sample. Methods for analyzing a sample include providing a sample collection room within a retail store or physician's office; obtaining a sample; and analyzing it. A waiting room; a bathroom; and a pass-through from bathroom to sample collection room may be provided. Sample collection rooms may include a warming table; a warming plate; a finger warmer; a fingertip warmer; an air-warmer; a reclining chair; a calming feature; and adjustable lighting. Samples may be analyzed at the collection location or sent to elsewhere for analysis. Sample collection rooms may house a sample analysis device or system. Samples may be small, e.g., a finger-stick, and may be analyzed in a short period of time, e.g., in less than five hours, or less than four hours.
摘要翻译：从受试者获取样本的方法包括在零售商店或医生办公室内提供样本收集室; 并获得样品。用于分析样品的方法包括在零售商店或医生办公室内提供样品收集室; 取样并进行分析。候车室一个卫生间; 并且可以提供从浴室到采样室的通行证。样品收集室可包括升温台; 一个暖板; 手指暖指尖温暖; 一个暖气的; 斜躺椅子一个平静的功能; 和可调节照明。样品可以在收集位置进行分析，或发送到其他地方进行分析。样品收集室可以容纳样品分析装置或系统。样品可以是小的，例如手指棒，并且可以在短时间内进行分析，例如在少于5小时或小于4小时内。

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