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11. 发明申请

WO2009017767A3 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用奥昔地尔皮肤治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A3
公开(公告)日：2009-12-30
申请号：PCT/US2008009222
申请日：2008-07-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
发明人： ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
IPC分类号： A01N43/54 , A61K8/00 , A61K31/505
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含米诺地尔的胶粘剂固化制剂，其可用于治疗包括糖尿病性神经病在内的神经病。该制剂可以包含一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，所述挥发性溶剂能够促进米诺地尔在持续的一段时间内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，该配制剂可以具有适合施用于皮肤表面的粘度。当施用于皮肤时，在至少一部分挥发性溶剂体系蒸发后，制剂可形成固化层。

12. 发明申请

WO2008150995A3 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A3
公开(公告)日：2009-03-05
申请号：PCT/US2008065285
申请日：2008-05-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0C to 42 0C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

13. 发明申请

WO2013003827A3 MACROGOL 15 HYDROXYSTEARATE FORMULATIONS 审中-公开
标题翻译： MACROGOL 15羟基硬脂酸酯配方
公开(公告)号：WO2013003827A3
公开(公告)日：2013-05-02
申请号：PCT/US2012045145
申请日：2012-06-29
申请人： ALLERGAN INC , GORE ANURADHA V , WARNER KEVIN S , PUJARA CHETAN P , GRAHAM RICHARD S , PARASHAR AJAY P , LEE MU-LAN , JORDAN ROBERT S , LIKITLERSUANG SUKHON
发明人： GORE ANURADHA V , WARNER KEVIN S , PUJARA CHETAN P , GRAHAM RICHARD S , PARASHAR AJAY P , LEE MU-LAN , JORDAN ROBERT S , LIKITLERSUANG SUKHON
IPC分类号： A61K9/00 , A61K47/14
CPC分类号： A61K31/417 , A61K9/0048 , A61K9/06 , A61K9/1075 , A61K31/165 , A61K31/4025 , A61K31/4164 , A61K31/4174 , A61K31/5575 , A61K31/568 , A61K31/5685 , A61K38/13 , A61K47/14
摘要： Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.
摘要翻译：本文提供了包含活性药物成分和聚乙二醇15羟基硬脂酸酯的组合物，以及使用其来治疗疾病或病症的方法。

14. 发明申请

WO2011057269A3 COMPOSITIONS FOR ENHANCING HAIR GROWTH 审中-公开
标题翻译：用于增加头发生长的组合物
公开(公告)号：WO2011057269A3
公开(公告)日：2012-07-26
申请号：PCT/US2010056036
申请日：2010-11-09
申请人： ALLERGAN INC , GORE ANURADHA , WARNER KEVIN S
发明人： GORE ANURADHA , WARNER KEVIN S
IPC分类号： A61K8/42 , A61K8/06 , A61Q7/00
CPC分类号： A61Q7/00 , A61K8/062 , A61K8/42
摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein emulsions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal.
摘要翻译：公开了用于刺激毛发生长的方法和组合物，其中乳液包括式I表示的环戊烷庚酸，2-环烷基或芳基烷基化合物，其中虚线键代表可以是顺式或反式构型的单键或双键， A，B，Z，X，R 1和R 2如说明书中所定义。这样的组合物用于治疗人或非人动物的皮肤或头皮。

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