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11. 发明申请

WO2010021823A2 OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT 审中-公开
标题翻译：含有着色剂的成骨组合物
公开(公告)号：WO2010021823A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/052360
申请日：2009-07-31
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61L27/50 , A61F2/00 , A61L27/22 , A61L27/24 , A61L27/26
CPC分类号： A61K38/1875 , A61L27/24 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/442 , A61L2300/45 , A61L2300/604 , A61L2430/02
摘要： An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair.
摘要翻译：提供成骨组合物用于植入皮肤下目标组织部位处或附近，该成骨组合物包含生长因子和着色剂，其中着色剂赋予生长因子颜色以允许用户看到目标组织部位处或附近的生长因子。在一些实施方案中，提供了用于加速骨修复的方法，所述方法包括混合骨形态发生蛋白-2和着色剂以形成混合物; 将混合物施加到多孔胶原基质的表面，其中着色剂允许使用者看到多孔胶原基质上或其中的骨形态发生蛋白-2分布; 以及将多孔胶原基质植入需要骨修复的靶组织部位处或附近。

12. 发明申请

WO2009129460A3 CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
公开(公告)号：WO2009129460A3
公开(公告)日：2009-10-22
申请号：PCT/US2009/040953
申请日：2009-04-17
申请人： WARSAW ORTHOPEDIC, INC. , MEDTRONIC, INC. , ZANELLA, John, Myers , KING, Vanja, Margareta , HOBOT, Christopher, M. , BIGGS, Danielle , SHAW, Katara , MCDONALD, Phillip, Edward , MCKAY, William, F. , REMSEN, Kathy, L.
发明人： ZANELLA, John, Myers , KING, Vanja, Margareta , HOBOT, Christopher, M. , BIGGS, Danielle , SHAW, Katara , MCDONALD, Phillip, Edward , MCKAY, William, F. , REMSEN, Kathy, L.
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4162 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

13. 发明申请

WO2009129433A4 ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE 审中-公开
公开(公告)号：WO2009129433A4
公开(公告)日：2009-10-22
申请号：PCT/US2009/040898
申请日：2009-04-17
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61K9/20 , A61P29/00 , A61K31/415 , A61K47/34 , A61P19/00
摘要： Effective treatments of pain and/or inflammation from degenerative disc disease and/or facet joint are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a degenerative disc and/or facet joint, one can reduce, prevent or treat pain and/or inflammation caused by the degenerative disc disease and/or facet joint.

14. 发明申请

WO2008079672A4 FLOWABLE CARRIER COMPOSITIONS FOR ORTHOPEDIC IMPLANTS AND METHODS OF USE 审中-公开
公开(公告)号：WO2008079672A4
公开(公告)日：2008-07-03
申请号：PCT/US2007/087117
申请日：2007-12-12
申请人： WARSAW ORTHOPEDIC, INC , MCKAY, William, F. , PECKHAM, Steven, M.
发明人： MCKAY, William, F. , PECKHAM, Steven, M.
IPC分类号： A61B19/02 , A61B17/00 , A61L27/46 , A61L27/58 , A61K38/18
摘要： A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

15. 发明申请

WO2008021921A2 MEDICAL IMPLANT SHEETS USEFUL FOR TISSUE REGENERATION 审中-公开
标题翻译：医用植入片用于组织再生
公开(公告)号：WO2008021921A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/075538
申请日：2007-08-09
申请人： WARSAW ORTHOPEDIC, INC , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61L27/10 , A61L27/12 , A61L27/24 , A61L27/42 , A61L27/58
CPC分类号： A61B17/58 , A61B17/06066 , A61B17/06166 , A61B17/80 , A61C8/0006 , A61F2/2846 , A61F2/30907 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/367 , A61F2/4081 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/2896 , A61F2002/30064 , A61F2002/30153 , A61F2002/30289 , A61F2002/30327 , A61F2002/30428 , A61F2002/30785 , A61F2002/30957 , A61F2220/0025 , A61F2230/0019 , A61F2230/0091 , A61F2250/0039 , A61F2310/00796 , A61F2310/0097 , A61F2310/00976 , A61F2310/00982 , A61L27/446 , A61L27/58
摘要： Described is a medical device in the form of a thin sheet having granules of a calcium-containing, osteoconductive material interconnected by a thin web of polymeric material. The device includes a first face and a second face, wherein at least the first face is populated with proturbances presenting exposed regions of the calcium-containing, osteoconductive material provided by underlying granules. Methods of making and using such devices are also described, as are methods and devices involving the use of very thin polymeric sheets conformed to bone-ingrowth surfaces of load-bearing orthopedic implants.
摘要翻译：描述了一种薄片形式的医疗装置，其具有由聚合物材料的薄网相互连接的含钙骨传导性材料的颗粒。该装置包括第一面和第二面，其中至少第一面填充有呈现由下面的颗粒提供的含钙骨传导性材料的暴露区域的前突。还描述了制造和使用这种装置的方法，以及涉及使用与承重整形外科植入物的骨向内生长表面相适应的非常薄的聚合物片的方法和装置。

16. 发明申请

WO2007127610A1 FACET FUSION IMPLANTS AND METHODS OF USE 审中-公开
标题翻译： FACET熔融植入物及其使用方法
公开(公告)号：WO2007127610A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/066328
申请日：2007-04-10
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61B17/70
CPC分类号： A61B17/7064
摘要： ABSTRACT An implant is insertable onto a vertebral facet joint includes a body with an inner surface that mates with one or both articular processes of the facet joint. The inner surface may define an interior cavity that accepts at least a portion of an inferior articular process and a superior articular process forming the facet joint. The body may be constructed of a bone growth material that fuses with the articular processes. The implant may help retain bone growth promoting substance that is inserted between or on articulating surfaces of the facet joint. A receiving portion of an exterior surface of one or both articular process may be prepared to stimulate bone growth. The implant may be placed onto the receiving portion to cover an exterior junction between or on the articulating surfaces of the facet joint. The implant may be secured to one or both of the articular processes.
摘要翻译：摘要植入物可插入到椎骨小关节中，包括具有与小关节的一个或两个关节过程相配合的内表面的主体。内表面可以限定内腔，其接受下关节进程的至少一部分和形成小关节的上关节进程。身体可以由与关节进程融合的骨生长材料构成。植入物可以帮助保留插入在小关节的关节表面之间或之上的骨生长促进物质。可以制备一个或两个关节过程的外表面的接收部分以刺激骨生长。植入物可以放置在接收部分上以覆盖小面关节的关节表面之间或之上的外部连接。植入物可以固定在一个或两个关节突的过程中。

17. 发明申请

WO2007002339A2 OSTEOGRAFT TREATMENT TO PROMOTE OSTEOINDUCTION AND OSTEOGRAFT INCORPORATION 审中-公开
标题翻译： OSTEOGRAFT治疗促进骨质疏松和骨质疏松综合征
公开(公告)号：WO2007002339A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024389
申请日：2006-06-21
申请人： WARSAW ORTHOPEDIC, INC. , GROSS, Jeffrey, M. , MCKAY, William, F. , ZANELLA, John, M.
发明人： GROSS, Jeffrey, M. , MCKAY, William, F. , ZANELLA, John, M.
CPC分类号： A61F2/28 , A61F2/4601 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/3021 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30677 , A61F2002/3068 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0068 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/02
摘要： The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that the dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.
摘要翻译：本发明提供了骨移植物或骨移植物，其具有改善的生物活性剂在骨移植物表面内的保留性。在骨移植物表面内形成的凹坑或凹坑具有置于其内的多孔塞子以保持包含生物活性剂的流体。还可以形成凹坑，使得凹坑的尺寸通过液体分子在凹坑内的静水吸引而促进流体在凹坑内的保留。

18. 发明申请

WO2006119126A3 SHAPED OSTEOCHONDRAL GRAFTS AND METHODS OF USING SAME 审中-公开
公开(公告)号：WO2006119126A3
公开(公告)日：2006-11-09
申请号：PCT/US2006/016491
申请日：2006-05-01
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61F2/30
摘要： Described are plug grafts and in particular embodiments osteochondral plug grafts and grafting methods which utilize unique plug geometries and cooperative graft/host tissue interfaces to improve stability of grafted plugs within host tissue. Embodiments of the invention include harvested osteochondral or synthetic plug grafts having bore geometries other than circular cylinders and which are implantable in correspondingly prepared host sites to resist rotation and improve stability.

19. 发明申请

WO2006113249A3 METHODS AND DEVICES FOR PRESERVING MOTION IN AN ARTICULATING PROSTHETIC DISC 审中-公开
公开(公告)号：WO2006113249A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/013571
申请日：2006-04-11
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William, F.
发明人： MCKAY, William, F.
IPC分类号： A61L27/50 , A61L27/54 , A61L27/34 , A61L31/14 , A61L31/16 , A61L31/10 , A61L24/00
摘要： The present invention overcomes the problem of undesirable bone growth and/or unwanted scar tissue formation on the articulating surfaces and in the articulating spaces of prosthetic intervertebral discs. The invention comprises a method for preserving motion in a prosthetic disc having at least one articulating surface comprising applying an anti-infiltration agent on and around an articulating surface of the prosthetic disc. Suitable anti-infiltration agents include but are not limited to, hemostatic compounds, anti-adhesion compounds, bone-formation inhibiting compounds, or any combination thereof.

20. 发明申请

WO2010009111A2 A DRUG DEPOT IMPLANTABLE WITHIN A SYNOVIAL JOINT 审中-公开
标题翻译：在SYNOVIAL JOINT中的药物容器可植入
公开(公告)号：WO2010009111A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050520
申请日：2009-07-14
申请人： WARSAW ORTHOPEDIC, INC. , MEDTRONIC, INC. , KIMBLE, Toya, D. , DRAPEAU, Susan, J. , MCKAY, William, F. , ZANELLA, John, Myers , TENBROEK, Erica, M.
发明人： KIMBLE, Toya, D. , DRAPEAU, Susan, J. , MCKAY, William, F. , ZANELLA, John, Myers , TENBROEK, Erica, M.
IPC分类号： A61K9/00 , A61P19/02 , A61P29/00 , A61F2/38
CPC分类号： A61K9/0024
摘要： Methods and compositions for treating a tissue within a synovial joint in a patient in need of such treatment are provided. The methods and compositions involve inserting a drug depot through the synovial joint and attaching the drug depot to the inside of the synovial joint capsule so that the drug depot does not substantially interfere with movement of the joint, wherein said depot comprises a polymer and at least one pharmaceutical agent.
摘要翻译：提供了用于治疗需要这种治疗的患者的滑膜关节内组织的方法和组合物。所述方法和组合物涉及将药物贮库插入滑液关节并将药物贮库连接至滑液关节囊的内部，使得药物贮存库基本上不干扰关节的运动，其中所述贮库包含聚合物，并且至少一种药剂。

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