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11. 发明申请

WO2009085864A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085864A3
公开(公告)日：2009-08-27
申请号：PCT/US2008087258
申请日：2008-12-17
申请人： HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY , NOVOZYMES AS
发明人： HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY
IPC分类号： C07K14/39 , C12N9/42
CPC分类号： C12N9/2434 , C07K14/37 , C12P19/14
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

12. 发明申请

WO2009085935A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085935A3
公开(公告)日：2009-10-15
申请号：PCT/US2008087402
申请日：2008-12-18
申请人： NOVOZYMES AS , HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY
发明人： HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY
IPC分类号： C12N9/24 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/42 , C12N15/56 , C12P19/14 , C12S3/02
CPC分类号： C12N9/2437 , C12N9/2434 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

13. 发明申请

WO2012044915A3 BETA-GLUCOSIDASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译： β-葡萄糖苷酶变体和编码它们的多核苷酸
公开(公告)号：WO2012044915A3
公开(公告)日：2012-06-14
申请号：PCT/US2011054185
申请日：2011-09-30
申请人： NOVOZYMES INC , WOGULIS MARK , HARRIS PAUL , OSBORN DAVID
发明人： WOGULIS MARK , HARRIS PAUL , OSBORN DAVID
IPC分类号： C12N9/42
CPC分类号： C12N9/2445 , C12P19/14 , C12Y302/01021 , Y02E50/16
摘要： The present invention relates to variants of a parent beta-glucosidase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及亲本β-葡糖苷酶的变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

14. 发明申请

WO2011035027A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维增强活性的多肽和编码其的多核苷酸
公开(公告)号：WO2011035027A3
公开(公告)日：2011-05-12
申请号：PCT/US2010049124
申请日：2010-09-16
申请人： NOVOZYMES INC , MAIYURAN SUCHINDRA , KRAMER RANDALL , HARRIS PAUL
发明人： MAIYURAN SUCHINDRA , KRAMER RANDALL , HARRIS PAUL
IPC分类号： C12N9/42 , C11D3/386
CPC分类号： C12N9/2437 , C11D3/386 , C11D3/38645 , C11D3/3869 , C12P19/02 , C12P19/14 , C12Y302/01 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

15. 发明申请

WO2010088463A3 POLYPEPTIDES HAVING EXPANSIN ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有扩展活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2010088463A3
公开(公告)日：2010-09-16
申请号：PCT/US2010022505
申请日：2010-01-29
申请人： NOVOZYMES INC , LOPES DE LEON ALFREDO , REY MICHAEL , HARRIS PAUL
发明人： LOPES DE LEON ALFREDO , REY MICHAEL , HARRIS PAUL
IPC分类号： C07K14/415 , C12N9/42 , C12P19/00
CPC分类号： C12P7/10 , C12N9/2437 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having expansin activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有扩展蛋白活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

16. 发明申请

WO2010059413A3 POLYPEPTIDES HAVING AMYLOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有AMYLOLYTIC增强活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2010059413A3
公开(公告)日：2010-08-19
申请号：PCT/US2009062955
申请日：2009-11-02
申请人： NOVOZYMES INC , HARRIS PAUL , WOGULIS MARK
发明人： HARRIS PAUL , WOGULIS MARK
IPC分类号： C12N15/31 , C12N9/24 , C12N15/56 , C12N15/63 , C12N15/67
CPC分类号： C12N9/2414 , C07K2319/50 , C12Y302/01001
摘要： The present invention relates to isolated polypeptides having amylolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有解淀粉增强活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

17. 发明申请

WO2008112278A3 METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM 审中-公开
标题翻译：用于调节胰岛素分泌和葡萄糖代谢的方法和组合物
公开(公告)号：WO2008112278A3
公开(公告)日：2008-11-20
申请号：PCT/US2008003338
申请日：2008-03-12
申请人： UNIV COLUMBIA , HARRIS PAUL , XIE YULI , LANDRY DONALD , DENG SHI-XIAN , MAFFEI ANTONELLA
发明人： HARRIS PAUL , XIE YULI , LANDRY DONALD , DENG SHI-XIAN , MAFFEI ANTONELLA
IPC分类号： A01N43/62 , A61K31/70
CPC分类号： A61K31/473 , A61K31/00 , A61K31/05 , A61K31/4741 , A61K31/4745 , A61K31/475
摘要： The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet ß-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及用于治疗或改善糖尿病的作用的方法和组合物。此外，本发明还涉及用于治疗或预防高血糖的方法和组合物，以及调节患者体内单胺水平，胰岛β细胞胰岛素分泌，胰岛素和/或胰高血糖素水平。在某些优选的实施方案中，这些方法包括向患者施用有效量的2型（VMAT2）囊泡单胺转运蛋白拮抗剂，如丁苯那嗪（TBZ），二氢丁苯那嗪（DTBZ），四氢小檗碱（THB），利血平，，或对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物，代谢物或药学上可接受的盐。

18. 发明申请

WO2006039122A3 FUNCTIONAL ADDITION POLYMERS AND A METHOD FOR THEIR PREPARATION 审中-公开
标题翻译：功能性加成聚合物及其制备方法
公开(公告)号：WO2006039122A3
公开(公告)日：2006-07-20
申请号：PCT/US2005033201
申请日：2005-09-16
申请人： BASF CORP , OHRBOM WALTER , CAMPBELL DONALD , ST AUBIN DONALD , RAMESH SWAMINATHAN , ROECKRATH ULRIKE , HARRIS PAUL
发明人： OHRBOM WALTER , CAMPBELL DONALD , ST AUBIN DONALD , RAMESH SWAMINATHAN , ROECKRATH ULRIKE , HARRIS PAUL
IPC分类号： C08G18/00 , C08F8/14 , C08F8/30 , C08F222/20 , C08F222/22 , C09D201/02
CPC分类号： C08F222/20 , C08F8/14 , C08F220/06 , C08F220/08 , C08F222/22 , C08G18/00 , C09D201/025 , Y10T428/31511 , C08F265/06
摘要： Disclosed is a method for making nongelled functional addition polymers from linear unsaturated anhydrides. The method subjects a linear unsaturated anhydride compound, an active hydrogen compound, and an epoxide compound to reaction conditions such that each of the following three reactions occur: (i) polymerization of polymerizable C=C bonds, (ii) ring opening of an anhydride functional group of the linear unsaturated anhydride compound by the active hydrogen compound to create an acid functional group, and (iii) reaction of the acid functional group resulting from the anhydride ring opening with the epoxide compound. At the time of reaction (iii), the acid functional group resulting from the anhydride ring opening may be selected from an ethylenically unsaturated monomer, a polymer, or both. In one embodiment, the method does not include the physical removal of any acid functional monomers or polymerization products. Also disclosed are a curable coating composition and a coated substrate.
摘要翻译：公开了由线性不饱和酸酐制备非胶凝功能加成聚合物的方法。该方法使直链不饱和酸酐化合物，活性氢化合物和环氧化合物发生反应条件，使得发生以下三种反应中的每一种：（i）可聚合的C = C键的聚合，（ii）酸酐的开环通过活性氢化合物形成直链不饱和酸酐化合物的官能团以产生酸官能团，和（iii）由酸酐开环得到的酸官能团与环氧化合物反应。在反应（iii）时，由酸酐开环得到的酸官能团可以选自烯属不饱和单体，聚合物或两者。在一个实施方案中，该方法不包括任何酸官能单体或聚合产物的物理去除。还公开了一种可固化涂料组合物和涂覆的基材。

19. 发明申请

WO2007005283A3 USE OF DTBZ FOR IMAGING ENDOCRINE PANCREAS AND BETA CELL MASS IN TYPE 1 DIABETES 审中-公开
标题翻译： DTBZ用于1型糖尿病内分泌腺和胰岛β细胞的成像
公开(公告)号：WO2007005283A3
公开(公告)日：2007-03-22
申请号：PCT/US2006024049
申请日：2006-06-21
申请人： UNIV COLUMBIA , HARRIS PAUL , MAFFEI ANTONELLA
发明人： HARRIS PAUL , MAFFEI ANTONELLA
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K51/0455
摘要： The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes. The present invention also provides kits for use in determining the beta cell mass in the pancreas of a subject, as well as diagnosing metabolic or neuroendocrine disorders in a subject.
摘要翻译：本发明提供了通过向受试者施用有效量的泡状单胺转运蛋白2型（VMAT2）特异性放射性配体来确定受试者胰腺中β细胞量的非侵入性方法; 获得对象的至少一部分胰腺的至少一个计算机化图像; 并定量分析计算机化图像以确定受试者胰腺中的β细胞量。本发明另外提供了用于诊断受试者中的代谢性神经内分泌紊乱的方法，所述紊乱包括胰岛瘤，糖尿病和临床前糖尿病，以及用于确定治疗代谢紊乱的功效的方法。本发明进一步提供了评估处于发展糖尿病风险中的受试者的预后的方法，以及用于管理糖尿病的治疗或预防的方法。本发明还提供用于测定受试者胰腺中的β细胞量以及诊断受试者中的代谢或神经内分泌紊乱的试剂盒。

20. 发明申请

WO02051948A3 PIGMENT DISPERSION AND METHOD OF PREPARING THE SAME 审中-公开
标题翻译：颜料分散体及其制备方法
公开(公告)号：WO02051948A3
公开(公告)日：2003-08-21
申请号：PCT/US0142956
申请日：2001-11-19
申请人： BASF CORP , RAMESH SWAMINATHAN , LANZA JOANN , HARRIS PAUL
发明人： RAMESH SWAMINATHAN , LANZA JOANN , HARRIS PAUL
IPC分类号： B01F17/00 , C08F8/40 , C09D7/45 , C09D17/00 , C08F8/00 , C09D5/02
CPC分类号： B01F17/0028 , B01F17/0057 , B01F17/0064 , C01P2004/61 , C01P2006/22 , C08F8/40 , C09D7/45 , C09D17/004
摘要： The present invention is directed to a water-based acrylic emulsion dispersant to be used as a grind resin to incorporate inorganic pigment into a pigment dispersion for a coating composition. The acrylic emulsion dispersant is the reaction product of butyl methacrylate, butyl acrylate, styrene, methyl ether polyethylene glycol methacrylate, polyethylene glycol methacrylate, and polyphosphoric acid. The present invention is also directed to a method of preparing the acrylic emulsion dispersant.
摘要翻译：本发明涉及一种水性丙烯酸乳液分散剂，用作研磨树脂，以将无机颜料掺入用于涂料组合物的颜料分散体中。丙烯酸乳液分散剂是甲基丙烯酸丁酯，丙烯酸丁酯，苯乙烯，甲基醚聚乙二醇甲基丙烯酸酯，聚乙二醇甲基丙烯酸酯和多聚磷酸的反应产物。本发明还涉及一种制备丙烯酸乳液分散剂的方法。

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