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11. 发明申请

WO1997030156A2 NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IgE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS 审中-公开
标题翻译：与伊朗IgE重链连锁区相关的核苷酸和相关方法
公开(公告)号：WO1997030156A2
公开(公告)日：1997-08-21
申请号：PCT/US1997002322
申请日：1997-02-14
申请人： IDEXX LABORATORIES, INC.
发明人： IDEXX LABORATORIES, INC. , MERMER, Brion , HARRIS, Rachel, A. , SIEFRING, Ann, E.
IPC分类号： C12N15/13
CPC分类号： C07K16/00 , A61K38/00 , C07K2319/02
摘要： Recombinant DNA molecules encoding complete canine IgE heavy chain constant region and the DNA sequence for all six exons of canine IgE are disclosed. The canine IgE heavy chain constant region DNA sequence was isolated using a nested walking procedure that is also disclosed. Also disclosed are peptides encoded by said sequences, including recombinant canine IgE heavy chain peptides produced by prokaryotic or eukaryotic cells. Such peptides are used in methods to treat the manifestation of allergy in dogs. Disclosed are antibodies that bind to peptides disclosed herein, as well as such antibodies for use to treat the manifestations of allergy in dogs.
摘要翻译：公开了编码完整犬IgE重链恒定区的重组DNA分子和犬IgE的所有六个外显子的DNA序列。使用也公开的嵌套步行程序分离犬IgE重链恒定区DNA序列。还公开了由所述序列编码的肽，包括由原核或真核细胞产生的重组犬IgE重链肽。这些肽用于治疗狗过敏表现的方法。公开了结合本文公开的肽的抗体，以及用于治疗狗中过敏表现的抗体。

12. 发明申请

WO1997018455A1 METHOD FOR QUANTIFICATION OF BIOLOGICAL MATERIAL IN A SAMPLE 审中-公开
标题翻译：一种样品中生物材料定量的方法
公开(公告)号：WO1997018455A1
公开(公告)日：1997-05-22
申请号：PCT/US1996018119
申请日：1996-11-12
申请人： IDEXX LABORATORIES, INC.
发明人： IDEXX LABORATORIES, INC. , CROTEAU, Andrew, J. , PIERSON, Mark, W. , TOWNSEND, David, E. , NAQUI, Ali
IPC分类号： G01N01/00
CPC分类号： B01L3/5088 , B01L3/5085 , C12M23/10 , C12M23/12 , C12M23/20 , C12M23/38 , C12M41/36
摘要： Method for detection of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquefied sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.
摘要翻译：检测样品中生物材料的方法。该方法包括如下步骤：将样品液化（如有必要）并将液化样品倒入培养板中。培养板具有大致平坦的水平表面，并且表面被分成多个至少20个凹入的孔。每个孔适于保持液体的等分试样，并且其尺寸和形状由合适的材料形成，以通过表面张力将等分试样保持在孔内。来自液化样品的任何多余液体从板的表面倒出。然后该方法包括孵育该培养板直到确定生物材料的存在或不存在。

13. 发明申请

WO1996015435A2 MEDIUM FOR DETECTING ENTEROCOCCI IN A SAMPLE 审中-公开
标题翻译：用于在样品中检测食品的中间体
公开(公告)号：WO1996015435A2
公开(公告)日：1996-05-23
申请号：PCT/US1995013579
申请日：1995-10-23
申请人： IDEXX LABORATORIES, INC.
发明人： IDEXX LABORATORIES, INC. , CHEN, Chun-Ming , GU, Haoyi
IPC分类号： G01N00/00
CPC分类号： C12Q1/10 , Y10S435/885
摘要： Medium for growing Enterococci so that detection may be obtained within 24 hours.
摘要翻译：培养肠球菌，以便24小时内可以获得检测。

14. 发明申请

WO1993003176A1 REVERSIBLE FLOW CHROMATOGRAPHIC BINDING ASSAY 审中-公开
标题翻译：可逆流量色谱结合测定
公开(公告)号：WO1993003176A1
公开(公告)日：1993-02-18
申请号：PCT/US1992006348
申请日：1992-07-31
申请人： IDEXX LABORATORIES, INC.
发明人： IDEXX LABORATORIES, INC. , CLARK, Scott, M.
IPC分类号： C12Q01/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0663 , B01L2300/0672 , B01L2400/0677 , B01L2400/0683 , G01N30/02 , G01N30/40 , G01N30/90 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10S436/81 , B01D15/3804
摘要： Disclosed are devices and methods for performing an assay which determines the presence or quantity of an analyte in a fluid sample by detecting binding of the analyte to at least one immobilized analyte capture reagent and washing unbound material from the immobilized analyte capture reagent. The devices and methods involve an elongated solid phase flow matrix, including capillary channels capable of driving capillary fluid movement, and further including (i) a first region adapted for receipt of the fluid sample, (ii) a second region at which the analyte capture reagent is immobilized, (iii) a third region for application of a wash reagent capable of removing unbound substances from the second region; and (iv) an absorbent reservoir of high volume capacity. The second region is positioned intermediate to the first region and the third region and intermediate to the absorbent reservoir and the third region. The device also includes means to detect analyte bound at the second region. The flow matrix and the regions thereof are sized and positioned to cause the fluid sample to flow initially along the elongated flow matrix in one direction toward and through the second region, and subsequently, the liquid reagent to flow along the elongated flow matrix in a second direction opposite the first direction, through the second region, and into the absorbent reservoir, drawing unbound substances with it.
摘要翻译：公开了用于进行测定的装置和方法，其通过检测分析物与至少一种固定的分析物捕获试剂的结合并从固定的分析物捕获试剂洗涤未结合的材料来确定流体样品中分析物的存在或数量。所述装置和方法包括细长的固相流矩阵，包括能够驱动毛细管流体运动的毛细通道，并且还包括（i）适于接收流体样品的第一区域，（ii）分析物捕获的第二区域试剂被固定，（iii）用于施加能够从第二区域除去未结合物质的洗涤试剂的第三区域; 和（iv）高容量的吸收剂储存器。第二区域位于第一区域和第三区域的中间并且位于吸收容器和第三区域的中间。该装置还包括检测在第二区域处结合的分析物的装置。流动基质及其区域的尺寸和位置被设计成使得流体样品沿着细长流动基质首先沿着一个方向流动并穿过第二区域，随后液体试剂沿着细长流动基质在第二区域中流动方向与第一方向相反，通过第二区域，并进入吸收剂储存器，用它吸引未结合的物质。

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