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11. 发明申请

WO2013120531A1 PARAMETRIC ENCODER FOR ENCODING A MULTI-CHANNEL AUDIO SIGNAL 审中-公开
标题翻译：编码多通道音频信号的参数编码器
公开(公告)号：WO2013120531A1
公开(公告)日：2013-08-22
申请号：PCT/EP2012/052734
申请日：2012-02-17
申请人： HUAWEI TECHNOLOGIES CO., LTD. , LANG, Yue , VIRETTE, David , XU, Jianfeng
发明人： LANG, Yue , VIRETTE, David , XU, Jianfeng
IPC分类号： H04S3/00 , G10L19/00
CPC分类号： G10L19/008 , H04S3/008 , H04S2400/03 , H04S2420/03
摘要： The invention relates to a parametric audio encoder (100) for generating an encoding parameter (ICC) for an audio channel signal (X 1 [b]) of a plurality of audio channel signals (X 1 [b], X 2 [b]) of a multi-channel audio signal, each audio channel signal (X 1 [b], X 2 [b]) having audio channel signal values (X 1 [k], X 2 [k]), the parametric audio encoder (100) comprising a parameter generator (105), the parameter generator (105) being configured - to determine for the audio channel signal (X 1 [b]) of the plurality of audio channel signals a first set of encoding parameters (IPD[b]) from the audio channel signal values (X 1 [k]) of the audio channel signal (X 1 [b]) and reference audio signal values (X 2 [k]) of a reference audio signal (X 2 [b]), wherein the reference audio signal is another audio channel signal (X 2 [b]) of the plurality of audio channel signals or a downmix audio signal derived from at least two audio channel signals of the plurality of multi-channel audio signals, - to determine for the audio channel signal (X1[b]) a first encoding parameter average (IPD mean [i]) based on the first set of encoding parameters (IPD[b]) of the audio channel signal (X 1 [b]), - to determine for the audio channel signal (X 1 [b]) a second encoding parameter average (IPD mean_long_term )based on the first encoding parameter average (IPD mean [i]) of the audio channel sigmean_long_termnal (X 1 [b]) and at least one other first encoding parameter average (IPD mean [i-1]) of the audio channel signal (X 1 [b]), and - to determine the encoding parameter (ICC) based on the first encoding parameter average (IPD mean [i]) of the audio channel signal (X1[b]) and the second encoding parameter average (IPD mean_long_term ) of the audio channel signal (X 1 [b]).
摘要翻译：本发明涉及一种用于为多个音频信道信号（X1 [b]，X2 [b]）的音频信道信号（X1 [b]）生成编码参数（ICC）的参数音频编码器（100）具有音频信道信号值（X1 [k]，X2 [k]）的每个音频信道信号（X1 [b]，X2 [b]），参数音频编码器（100） 105），所述参数发生器（105）被配置为从所述音频信道信号值确定所述多个音频信道信号中的音频信道信号（X1 [b]）第一组编码参数（IPD [b]）（X1 [b]）的音频信号（X1 [k]）和参考音频信号（X2 [b]）的参考音频信号值（X2 [k]），其中参考音频信号是另一声道信号（X2 [b]）或由多个多声道音频信号中的至少两个音频信道信号导出的下混合音频信号，以确定音频通道信号（X1 [b]）基于音频通道信号（X1 [b]）的第一组编码参数（IPD [b]））的第一编码参数平均值（IPDmean [i]），以确定基于音频信道sigmean_long_termnal（X1 [b]）的第一编码参数平均值（IPDmean [i]）和至少一个其他第一编码参数的音频信道信号（X1 [b]）第二编码参数平均值（IPDmean_long_term）（X1 [b]）的平均值（IPDmean [i-1]），以及 - 基于音频信道信号的第一编码参数平均值（IPDmean [i]）来确定编码参数（ICC） X1 [b]）和音频通道信号（X1 [b]）的第二编码参数平均值（IPDmean_long_term）。

12. 发明申请

WO2012045203A1 METHOD AND APPARATUS FOR ENCODING/DECODING MULTICHANNEL AUDIO SIGNAL 审中-公开
标题翻译：编码/解码多通道音频信号的方法和装置
公开(公告)号：WO2012045203A1
公开(公告)日：2012-04-12
申请号：PCT/CN2010/077571
申请日：2010-10-05
申请人： HUAWEI TECHNOLOGIES CO., LTD. , VIRETTE, David , LANG, Yue , XU, Jianfeng
发明人： VIRETTE, David , LANG, Yue , XU, Jianfeng
IPC分类号： G10L19/00 , H04S3/02
CPC分类号： G10L19/008 , G10L25/06
摘要： A method and apparatus for decoding a multichannel audio signal is provided, wherein the method comprises the steps of receiving a downmix audio signal (SD) and an interchannel cross correlation parameter (ICCi); deriving (S42) an interchannel phase difference parameter (IPDi) from the received interchannel cross correlation parameter (ICCi); and calculating (S43) a decoded multichannel audio signal for the received downmix audio signal (SD) depending on the derived interchannel phase difference parameter (IPDi).
摘要翻译：提供一种用于对多声道音频信号进行解码的方法和装置，其中该方法包括以下步骤：接收下混合音频信号（SD）和通道间相互关联参数（ICCi）; 从所接收的信道间相互关联参数（ICCi）中导出（S42）信道间相位差参数（IPDi）; 以及根据导出的信道间相位差参数（IPDi），计算（S43）所接收的下混音频信号（SD）的解码多声道音频信号。

13. 发明申请

WO2013149673A1 METHOD FOR INTER-CHANNEL DIFFERENCE ESTIMATION AND SPATIAL AUDIO CODING DEVICE 审中-公开
标题翻译：用于信道间差分估计和空间音频编码装置的方法
公开(公告)号：WO2013149673A1
公开(公告)日：2013-10-10
申请号：PCT/EP2012/056342
申请日：2012-04-05
申请人： HUAWEI TECHNOLOGIES CO., LTD. , LANG, Yue , VIRETTE, David , XU, Jianfeng
发明人： LANG, Yue , VIRETTE, David , XU, Jianfeng
IPC分类号： G10L19/008 , H04S3/00
CPC分类号： G10L19/008 , H04S3/008 , H04S2400/01 , H04S2420/01 , H04S2420/03
摘要： Methods and devices for a low complex inter-channel difference estimation are provided. A method for the estimation of inter-channel differences, ICD, comprises applying a transformation from a time domain to a frequency domain to a plurality of audio channel signals, calculating a plurality of ICD values for the ICDs between at least one of the plurality of audio channel signals and a reference audio channel signal over a predetermined frequency range, each ICD value being calculated over a portion of the predetermined frequency range, calculating, for each of the plurality of ICD values, a weighted ICD value by multiplying each of the plurality of ICD values with a corresponding frequency-dependent weighting factor, and calculating an ICD range value for the predetermined frequency range by adding the plurality of weighted ICD values.
摘要翻译：提供了用于低复杂信道间差分估计的方法和装置。用于估计信道间差异ICD的方法包括将从时域到频域的变换应用于多个音频信道信号，在多个信道中的至少一个之间计算ICD的多个ICD值音频通道信号和参考音频通道信号，每个ICD值在预定频率范围的一部分上被计算，对于多个ICD值中的每一个，通过将多个ICD值中的每一个乘以加权ICD值具有对应的频率相关加权因子的ICD值，并且通过添加多个加权ICD值来计算预定频率范围的ICD范围值。

14. 发明申请

WO2012009851A1 AUDIO SIGNAL SYNTHESIZER 审中-公开
标题翻译：音频信号合成器
公开(公告)号：WO2012009851A1
公开(公告)日：2012-01-26
申请号：PCT/CN2010/075308
申请日：2010-07-20
申请人： HUAWEI TECHNOLOGIES CO., LTD. , CHRISTOF, Faller , DAVID, Virette , LANG, Yue , XU, Jianfeng
发明人： CHRISTOF, Faller , DAVID, Virette , LANG, Yue , XU, Jianfeng
IPC分类号： G10L19/00 , H04S3/00 , H04S5/00
CPC分类号： G10L19/008
摘要： An audio signal synthesizer for synthesizing a multi-channel audio signal from a down-mix audio signal is provided. The audio signal synthesizer comprises: a transformer (101) for transforming the down-mix audio signal into frequency domain to obtain a transformed audio signal which represents a spectrum of the down-mix audio signal; a signal generator (103,201) for generating a first auxiliary signal, a second auxiliary signal and a third auxiliary signal upon the basis of the transformed audio signal; a de-correlator (105) for generating a first de-correlated signal and a second de-correlated signal from the third auxiliary signal, wherein the first de-correlated signal and the second de-correlated signal are at least partly de-correlated; and a combiner (107) for combining the first auxiliary signal with the first de-correlated signal to obtain a first audio signal, and for combining the second auxiliary signal with the second de-correlated signal to obtain a second audio signal, wherein the first audio signal and the second audio signal form the multi-channel audio signal.
摘要翻译：提供一种用于从缩混音频信号合成多声道音频信号的音频信号合成器。音频信号合成器包括：变换器（101），用于将混音音频信号变换成频域以获得表示缩混音频信号的频谱的变换音频信号; 用于基于经变换的音频信号产生第一辅助信号，第二辅助信号和第三辅助信号的信号发生器（103,201）; 用于从所述第三辅助信号产生第一去相关信号和第二去相关信号的去相关器（105），其中所述第一去相关信号和所述第二去相关信号至少部分地不相关; 以及组合器（107），用于将第一辅助信号与第一去相关信号组合以获得第一音频信号，并且用于将第二辅助信号与第二去相关信号组合以获得第二音频信号，其中第一音频信号和第二音频信号形成多声道音频信号。

15. 发明申请

WO2022226229A1 CELLULAR HETEROGENEITY–ADJUSTED CLONAL METHYLATION (CHALM): A METHYLATION QUANTIFICATION METHOD 审中-公开
公开(公告)号：WO2022226229A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025824
申请日：2022-04-21
申请人： HELIO HEALTH INC. , LI, Wei , XU, Jianfeng , TAGGART, David J.
发明人： LI, Wei , XU, Jianfeng , TAGGART, David J.
IPC分类号： C12Q1/68 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , G16B30/00 , G16B40/00
摘要： In certain aspects, provided herein are methods and systems for methylation quantification based on a Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) quantification methodology described herein. Disclosed herein, in some aspects, are methods for identifying the methylation status of a biomarker in a single cell. In certain aspects, provided herein are methods for generating a methylation profile of a biomarker associated with a tumor species.

16. 发明申请

WO2012031207A2 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK 审中-公开
标题翻译：前列腺癌风险相关遗传标记的方法和组合物
公开(公告)号：WO2012031207A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050337
申请日：2011-09-02
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES , XU, Jianfeng , ZHENG, Siqun Lilly , SUN, Jielin , KADER, Andrew Karim
发明人： XU, Jianfeng , ZHENG, Siqun Lilly , SUN, Jielin , KADER, Andrew Karim
IPC分类号： C12Q1/68 , G06F19/22 , C12N15/11
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of assessing an individual subjects risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and/or chemoprevention.
摘要翻译：本发明提供了评估发展中前列腺癌的个体受试者风险的方法，包括：a）分析从受试者获得的核酸样品，并确定受试者的基因型为多个双等位性多态性其中所述多个中的每一个具有相关联的等位基因和非关联等位基因，其中所述基因型选自对于所述未关联的等位基因为纯合的，杂合的和纯合的; 和b）基于步骤（a）中确定的基因型计算受试者的累积相对风险（CRR）。大于1.00的CRR确定受试者具有增加的患前列腺癌的风险，并且还可以鉴定是早期PSA筛选，前列腺活检和/或化学预防的候选者。

17. 发明申请

WO2011002509A1 SEMICONDUCTOR NANOCRYSTALS USED WITH LED SOURCES 审中-公开
标题翻译：半导体纳米晶体与LED光源
公开(公告)号：WO2011002509A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/001871
申请日：2010-06-30
申请人： QIAO, Tiecheng Alex , BATTAGLIA, David , SUNDERRAJAN, Suresh , ZHANG, Qiang , ZHU, Haoguo , XU, Jianfeng
发明人： QIAO, Tiecheng Alex , BATTAGLIA, David , SUNDERRAJAN, Suresh , ZHANG, Qiang , ZHU, Haoguo , XU, Jianfeng
IPC分类号： H01J1/62
CPC分类号： C09K11/883 , H01L33/502 , Y02B20/181
摘要： The present invention relates to the use of light-converting, colloidal, doped semiconductor nanocrystals to provide a new generation of high performance, low cost monochromatic and white light sources based on LEDs.
摘要翻译：本发明涉及使用光转换胶体掺杂的半导体纳米晶体来提供基于LED的新一代高性能，低成本的单色和白光源。

18. 发明申请

WO2005069845A3 METHODS OF PRODUCING PEPTIDES/PROTEINS IN PLANTS AND PEPTIDES/PROTEINS PRODUCED THEREBY 审中-公开
公开(公告)号：WO2005069845A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/001160
申请日：2005-01-14
申请人： OHIO UNIVERSITY , KIELISZEWSKI, Marcia, J. , XU, Jianfeng , KOPCHICK, John , OKADA, Shigeru
发明人： KIELISZEWSKI, Marcia, J. , XU, Jianfeng , KOPCHICK, John , OKADA, Shigeru
IPC分类号： C07K19/00 , C07H21/04 , C07H21/02 , C07H21/00 , C12N15/82
摘要： Methods of increasing the yield in plant expression of recombinant proteins comprising: engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.

19. 发明申请

WO2022226231A1 LIVER CANCER METHYLATION AND PROTEIN MARKERS AND THEIR USES 审中-公开
公开(公告)号：WO2022226231A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025826
申请日：2022-04-21
申请人： HELIO HEALTH INC. , CHAHINE, Kenneth , XU, Jianfeng , GALLANT, Maxime A. , TAGGART, David J. , ROY, Dhruvajyoti
发明人： CHAHINE, Kenneth , XU, Jianfeng , GALLANT, Maxime A. , TAGGART, David J. , ROY, Dhruvajyoti
IPC分类号： C12Q1/6886 , G01N33/50
摘要： Disclosed herein, in some aspects, are methods for identifying a subject having liver cancer, in particular, hepatocellular carcinoma. Also provided herein, in certain aspects, are methods for generating a methylation profile of a biomarker and/or protein marker associated with liver cancer, and system, kits, and components thereof (such as probes) useful for the methodology described herein.

20. 发明申请

WO2007008708A2 METHODS OF PREDICTING HYP-GLYCOSYLATION SITES FOR PROTEINS EXPRESSED AND SECRETED IN PLANT CELLS, AND RELATED METHODS AND PRODUCTS 审中-公开
标题翻译：预测植物细胞中表达和分泌的蛋白质的HYP-糖蛋白化位点的方法及相关方法和产品
公开(公告)号：WO2007008708A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026594
申请日：2006-07-10
申请人： OHIO UNIVERSITY , KIELISZEWSKI, Marcia, J. , XU, Jianfeng
发明人： KIELISZEWSKI, Marcia, J. , XU, Jianfeng
IPC分类号： G06F19/00
CPC分类号： C12N15/8257 , G06F19/22
摘要： Proteins with Hyp-glycosylation are more likely to be secreted in plant cells at high levels than those without. Methods are disclosed for the prediction of Pro-hydroxylation and Hyp-glycosylationsites in proteins. Such methods can be used to identify (1) proteins which, without modfication, are predisposed to develop Hyp-glycosylation, if expressed in plant cells, and (2) modifications (especially substitution mutations) which increase the propensity of a protein to develop Hyp-glycosylation, with a view to high level or increased secretion. It is also possible to determine empirically whether a particular protein will undergo Hyp-glycosylation suitable for the desired level of secretion in plant cells. Both modified proteins, and methods for the expression and secretion of predisposed and modified proteins, are claimed.
摘要翻译：具有低糖基化功能的蛋白质在植物细胞中比没有高蛋白质的蛋白质更可能被分泌。公开了用于预测蛋白质中的Pro-羟基化和Hyp-糖基化的方法。这样的方法可以用于鉴定（1）如果在植物细胞中表达，而不改变，发生Hyp糖基化的蛋白质，（2）增加蛋白质发展Hyp的倾向的修饰（特别是取代突变）糖基化，以达到高水平或增加分泌。也可以根据经验确定特定蛋白质是否将进行适合植物细胞中所需水平分泌的Hyp糖基化。要求修饰的蛋白质，以及倾向和修饰的蛋白质的表达和分泌的方法。

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