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11. 发明申请

WO2006121845A2 MINIMIZING HEMODYNAMIC COMPROMISE DURING POST-MI PACING 审中-公开
标题翻译：在心肌梗死后最小化血液动力学反应
公开(公告)号：WO2006121845A2
公开(公告)日：2006-11-16
申请号：PCT/US2006017388
申请日：2006-05-05
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , HARTLEY JESSE W , KRAMER ANDREW P , STAHMANN JEFFREY E
发明人： PASTORE JOSEPH M , SALO RODNEY W , HARTLEY JESSE W , KRAMER ANDREW P , STAHMANN JEFFREY E
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an assessment of cardiac function in order to balance the beneficial effects of stress reduction with hemodynamic compromise.
摘要翻译：描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。根据心脏功能的评估调节预激励起搏，以平衡应力减少与血液动力学妥协的有益效果。

12. 发明申请

WO2008045434A2 IMPLANTABLE NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 审中-公开
标题翻译：可植入神经调节器用于调节心血管功能
公开(公告)号：WO2008045434A2
公开(公告)日：2008-04-17
申请号：PCT/US2007021570
申请日：2007-10-09
申请人： CARDIAC PACEMAKERS INC , CAPARSO ANTHONY V , LIBBUS IMAD , KRAMER ANDREW P
发明人： CAPARSO ANTHONY V , LIBBUS IMAD , KRAMER ANDREW P
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , Y10T29/49204
摘要： An implantable medical device includes an implantable capsule housing a circuit that delivers neurostimulation to modulate one or more cardiovascular functions. To limit displacement after implantation, a fixation device is coupled to the implantable capsule to fix the miniature implantable medical device to a position in the body of a patient, hi various embodiments, the fixation device include one or more of a suture loop, a cuff to wrap around a cylindrical structure such as a nerve of a vessel, and a transmural fixation device anchoring on the interior surface of a wall defining a cavity in the body.
摘要翻译：可植入医疗装置包括可植入胶囊，其容纳递送神经刺激以调节一种或多种心血管功能的电路。为了限制植入后的移位，将固定装置连接至可植入胶囊以将微型可植入医疗装置固定至患者体内的位置。在各种实施例中，固定装置包括缝合线环，箍的一个或多个环绕诸如血管神经的圆柱形结构，以及锚定在限定身体中的空腔的壁的内表面上的透壁固定装置。

13. 发明申请

WO2007130774A3 MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION 审中-公开
公开(公告)号：WO2007130774A3
公开(公告)日：2008-01-31
申请号：PCT/US2007066383
申请日：2007-04-11
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , BAYNHAM TAMARA COLETTE , KRAMER ANDREW P , SPINELLI JULIO C , ROSS JEFFREY , SALO RODNEY W
发明人： PASTORE JOSEPH M , BAYNHAM TAMARA COLETTE , KRAMER ANDREW P , SPINELLI JULIO C , ROSS JEFFREY , SALO RODNEY W
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

14. 发明申请

WO2006124729A3 CARDIAC PROTECTION PACING SYSTEM USING CORONARY STENT 审中-公开
标题翻译： CARDIAC保护起搏系统使用冠状动脉支架
公开(公告)号：WO2006124729A3
公开(公告)日：2006-12-28
申请号：PCT/US2006018642
申请日：2006-05-11
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , KRAMER ANDREW P , SPINELLI JULIO C , SALO RODNEY W , BAYNHAM TAMARA COLETTE , ROSS JEFFREY , PRINZEN FRITS , VANAGT WARD , CORNELUSSEN RICHARD
发明人： PASTORE JOSEPH M , KRAMER ANDREW P , SPINELLI JULIO C , SALO RODNEY W , BAYNHAM TAMARA COLETTE , ROSS JEFFREY , PRINZEN FRITS , VANAGT WARD , CORNELUSSEN RICHARD
IPC分类号： A61N1/365
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
摘要翻译：植入式心脏保护起搏系统提供起搏脉冲以保护心脏免受与缺血和心肌梗塞相关的损伤。该系统包括递送起搏脉冲的可植入脉冲发生器（PG）和电连接到可植入PG的冠状动脉支架，以起到传递起搏脉冲的起搏电极的作用。在一个实施例中，血管内导线提供冠状动脉支架和可植入PG之间的电连接，以允许植入式PG植入股骨区域。在另一个实施例中，冠状动脉支架和可植入PG被整合到血管内脉冲发生器支架中。

15. 发明申请

WO0218010A9 SITE REVERSION IN CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译： CARDIAC RHYTHM管理中的站点恢复
公开(公告)号：WO0218010A9
公开(公告)日：2003-03-20
申请号：PCT/US0127004
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , STAHMANN JEFFREY E , KRAMER ANDREW P
发明人： STAHMANN JEFFREY E , KRAMER ANDREW P
IPC分类号： A61N1/08 , A61N1/362 , A61N1/37
CPC分类号： A61N1/3706 , A61N1/3627 , A61N2001/083
摘要： Methods for failure recovery in a cardiac rhythm management system and apparatus capable of carrying out the methods. The methods include applying a first pacing therapy using one or more leads. The methods further include detecting a failure condition on one or more of the leads, wherein the failure condition prohibits or frustrates application of the first pacing therapy. The methods still further include applying a second pacing therapy using one or more of the leads subsequent to detecting the failure condition. The second pacing therapy is preferably chosen such that the detected failure does not interfere with the second pacing therapy. The second pacing therapy may be applied for only one cardiac cycle. The second pacing therapy may further be applied continuously until the failure condition is resolved, or it may be latched such that physician intervention is required to resume the first pacing therapy.
摘要翻译：心律管理系统的故障恢复方法和能够执行该方法的装置。所述方法包括使用一个或多个引线应用第一起搏治疗。所述方法还包括检测一个或多个引线上的故障状况，其中所述故障条件禁止或阻止所述第一起搏治疗的应用。所述方法还包括在检测到故障状况之后使用一个或多个引线应用第二起搏治疗。优选选择第二起搏治疗，使得检测到的失败不会干扰第二起搏治疗。第二起搏治疗可以仅应用于一个心动周期。可以进一步连续应用第二起搏治疗直到失败状况得到解决，或者可以锁定第二起搏治疗，以便需要医师介入以恢复第一起搏治疗。

16. 发明申请

WO0218010A2 SITE REVERSION IN CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译： CARDIAC RHYTHM管理中的站点恢复
公开(公告)号：WO0218010A2
公开(公告)日：2002-03-07
申请号：PCT/US0127004
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , STAHMANN JEFFREY E , KRAMER ANDREW P
发明人： STAHMANN JEFFREY E , KRAMER ANDREW P
IPC分类号： A61N1/08 , A61N1/362 , A61N1/37
CPC分类号： A61N1/3706 , A61N1/3627 , A61N2001/083
摘要： Methods for failure recovery in a cardiac rhythm management system and apparatus capable of carrying out the methods. The methods include applying a first pacing therapy using one or more leads. The methods further include detecting a failure condition on one or more of the leads, wherein the failure condition prohibits or frustrates application of the first pacing therapy. The methods still further include applying a second pacing therapy using one or more of the leads subsequent to detecting the failure condition. The second pacing therapy is preferably chosen such that the detected failure does not interfere with the second pacing therapy. The second pacing therapy may be applied for only one cardiac cycle. The second pacing therapy may further be applied continuously until the failure condition is resolved, or it may be latched such that physician intervention is required to resume the first pacing therapy.
摘要翻译：心律管理系统的故障恢复方法和能够执行该方法的装置。所述方法包括使用一个或多个引线应用第一起搏治疗。所述方法还包括检测一个或多个引线上的故障状况，其中所述故障条件禁止或阻止所述第一起搏治疗的应用。所述方法还包括在检测到故障状况之后使用一个或多个引线应用第二起搏治疗。优选选择第二起搏治疗，使得检测到的失败不会干扰第二起搏治疗。第二起搏治疗可以仅应用于一个心动周期。可以进一步连续应用第二起搏治疗直到失败状况得到解决，或者可以锁定第二起搏治疗，以便需要医师介入以恢复第一起搏治疗。

17. 发明申请

WO02051496A2 APPARATUS AND METHOD FOR PACING MODE SWITCHING DURING ATRIAL TACHYARRHYTHMIAS 审中-公开
标题翻译：装置和方法用于在三叉神经痛期间切换模式切换
公开(公告)号：WO02051496A2
公开(公告)日：2002-07-04
申请号：PCT/US0150034
申请日：2001-12-21
申请人： CARDIAC PACEMAKERS INC
发明人： STAHMANN JEFFREY E , KRAMER ANDREW P
IPC分类号： A61N1/362 , A61N1/368 , A61N
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A method for operating a cardiac pacemaker in which the mode of operation of the pacemaker is altered in response to detecting an episode of atrial tachycardia. In accordance with the invention, the pacemaker's pacing mode is altered in a manner that attempts to maintain hemodynamic stability during the atrial tachycardia. Such a mode switch is particularly applicable to pacemaker patients suffering from some degree of congestive heart failure.
摘要翻译：一种用于操作心脏起搏器的方法，其中起搏器的操作模式响应于检测心房心动过速的发作而改变。根据本发明，起搏器的起搏模式以在心房心动过速期间维持血液动力学稳定性的方式改变。这种模式切换特别适用于患有某种程度充血性心力衰竭的起搏器患者。

18. 发明申请

WO03053511A2 CARDIAC RHYTHM MANAGEMENT SYSTEM 审中-公开
标题翻译： CARDIAC RHYTHM管理系统
公开(公告)号：WO03053511A2
公开(公告)日：2003-07-03
申请号：PCT/US0240909
申请日：2002-12-20
申请人： CARDIAC PACEMAKERS INC
发明人： SPINELLI JULIO C , ZHU QINGSHENG , STAHMANN JEFFREY E , KRAMER ANDREW P
IPC分类号： A61N1/362 , A61N1/368 , A61N
CPC分类号： A61N1/3622 , A61N1/3684
摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.
摘要翻译：系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。一种或多种抗心律失常疗法被映射到每种心律失常分类。当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。

19. 发明申请

WO02064208A3 APPARATUS AND METHOD FOR VENTRICULAR RATE REGULARIZATION 审中-公开
标题翻译：心室率正常化的装置和方法
公开(公告)号：WO02064208A3
公开(公告)日：2002-12-05
申请号：PCT/US0149660
申请日：2001-12-26
申请人： CARDIAC PACEMAKERS INC
发明人： KRAMER ANDREW P , STAHMANN JEFFREY E
IPC分类号： A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3627
摘要： A cardiac rhythm management device which employs pacing therapy to regularize the ventricular rhythm. Such ventricular rate regularization may be employed with in bradycardia pacemakers, ventricular resynchronization devices, or implantable cardioverter/defibrillators.
摘要翻译：采用起搏治疗调节心室节律的心律管理装置。这种心室率调节可用于心动过缓起搏器，心室再同步装置或植入式心脏复律器/除颤器。

20. 发明申请

WO03065889A3 DYNAMICALLY OPTIMIZED MULTISITE CARDIAC RESYNCHRONIZATION DEVICE 审中-公开
标题翻译：动态优化多功能心脏再生装置
公开(公告)号：WO03065889A3
公开(公告)日：2003-10-02
申请号：PCT/US0303659
申请日：2003-02-06
申请人： CARDIAC PACEMAKERS INC
发明人： AURICCHIO ANGELO , SPINELLI JULIO C , KRAMER ANDREW P
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/3684
摘要： A cardiac rhythm management device comprises a plurality of sensing channels (23a, 23b, 33a, 33b, 43a, 43b, 53a, 53b) incorporating electrodes for disposition near different myocardial regions and a controller programmed to measure amplitudes of electrograms from one or more cardiac sites in order to ascertain the extent of hypertrophy. The device may then pace the heart by delivering pacing therapy in a manner that unloads the hypertrophied myocardium to effect reversal of undesirable remodeling.
摘要翻译：心律管理装置包括多个感测通道（23a，23b，33a，33b，43a，43b，53a，53b），其包括用于配置在不同心肌区域附近的电极和被编程以测量来自一个或多个心脏的电描记图以确定肥厚程度。然后，该装置可以通过以卸载肥厚心肌来实现不期望的重塑逆转的方式通过输送起搏治疗来对心脏进行步调。

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