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11. 发明申请

WO1997038708A1 MODULATING EPITHELIAL-MESENCHYMAL INTERACTIONS 审中-公开
标题翻译：调制上传 - 中间交互
公开(公告)号：WO1997038708A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006309
申请日：1997-04-17
申请人： THE GENERAL HOSPITAL CORPORATION , GOETINCK, Paul, F. , SONG, HeeKyung , WANG, Yuying
发明人： THE GENERAL HOSPITAL CORPORATION
IPC分类号： A61K38/18
CPC分类号： A61K8/64 , A61K38/1825 , A61Q7/00
摘要： A method of modulating the development of a cutaneous appendage, consisting of modulating FGF-2 activity in one or both of the dermis and epidermis.
摘要翻译：一种调节皮肤附属物发育的方法，其包括在真皮和表皮中的一种或两种中调节FGF-2活性。

12. 发明申请

WO1997034618A1 ADMINISTRATION OF POLYPEPTIDE GROWTH FACTORS FOLLOWING CENTRAL NERVOUS SYSTEM ISCHEMIA OR TRAUMA 审中-公开
标题翻译：根据中央神经系统ISCHEMIA或TRAUMA的多肽生长因子的管理
公开(公告)号：WO1997034618A1
公开(公告)日：1997-09-25
申请号：PCT/US1997005071
申请日：1997-03-21
申请人： THE GENERAL HOSPITAL CORPORATION , FINKLESTEIN, Seth, P.
发明人： THE GENERAL HOSPITAL CORPORATION
IPC分类号： A61K38/00
CPC分类号： A61K38/1875
摘要： The present invention relates to the treatment of central nervous system injuries by intracisternal or intravenous administration of polypeptide growth factors, such as basic fibroblast growth factor. This method provides significant benefits because administration can occur a substantial amount of time following an injury.
摘要翻译：本发明涉及通过内部或静脉内施用多肽生长因子如碱性成纤维细胞生长因子治疗中枢神经系统损伤。该方法提供了显着的益处，因为在受伤后可能发生大量的时间。

13. 发明申请

WO1997033989A1 TRANSGENIC ANIMALS HAVING A DISRUPTED eNOS GENE AND USE THEREOF 审中-公开
标题翻译：具有破坏性eNOS基因的转基因动物及其用途
公开(公告)号：WO1997033989A1
公开(公告)日：1997-09-18
申请号：PCT/US1997004184
申请日：1997-03-14
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , HUANG, Paul, L. , FISHMAN, Mark, C. , MOSKOWITZ, Michael, A.
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , C12N9/0075 , C12N9/0077
摘要： This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.
摘要翻译：本发明涉及包含破坏的内皮一氧化氮合酶基因的转基因非人动物。这些动物表现出异常的伤口愈合特性和高血压。本发明还涉及使用转基因动物筛选具有血管内皮疾病（例如高血压，脑缺血或中风），动脉粥样硬化和伤口愈合活性的潜在治疗效用的化合物的方法。此外，本发明还涉及使用转基因动物鉴定的化合物治疗患有高血压和伤口愈合异常的患者的方法，以及制备转基因动物的方法。还提供了使用硝酸甘油治疗伤口的方法。

14. 发明申请

WO1997019684A1 RETINOIC ACID TREATMENT OF CARDIAC ARRHYTHMIA 审中-公开
标题翻译：心脏病ARRHYTHMIA的再次治疗
公开(公告)号：WO1997019684A1
公开(公告)日：1997-06-05
申请号：PCT/US1996019026
申请日：1996-11-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , LEAF, Alexander , KANG, Jing, X.
IPC分类号： A61K31/20
CPC分类号： A61K31/203
摘要： Disclosed is a method for terminating an existing potentially lethal cardiac arrhythmia, or preventing an imminent potentially lethal cardiac arrhythmia. The method involves administration of all-trans-retinoic acid or an antiarrhythmically active analog. Antiarrhythmic effects of all-trans-retinoic acid occur within minutes.
摘要翻译：公开了一种终止现有的潜在致死心律失常或预防即将发生的致命心律失常的方法。该方法包括给予全反式视黄酸或抗心律失常的类似物。全反式视黄酸的抗心律失常作用发生在几分钟内。

15. 发明申请

WO1997011598A1 METHOD FOR TREATING HEPATITIS VIRUS INFECTION 审中-公开
标题翻译：治疗乙型肝炎病毒感染的方法
公开(公告)号：WO1997011598A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015554
申请日：1996-09-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , TAKAHASHI, Hiroshi
IPC分类号： A01K67/027
CPC分类号： C12Q1/706 , A01K67/0271 , A61K38/215 , C12Q1/6804
摘要： The invention features methods for treating hepatitis B infection by administering an asialo-interferon. The invention also features an animal model of hepatitis and methods for measuring hepatitis B virus in a biological sample.
摘要翻译：本发明的特征在于通过施用脱唾液酸干扰素治疗乙型肝炎感染的方法。本发明还具有肝炎动物模型和生物样品中乙型肝炎病毒测定方法。

16. 发明申请

WO1997003715A1 METHOD AND APPARATUS OF ENHANCING THE DELIVERY OF A PHARMACEUTICAL FORMULATION 审中-公开
标题翻译：增加药物配方的方法和装置
公开(公告)号：WO1997003715A1
公开(公告)日：1997-02-06
申请号：PCT/US1996011927
申请日：1996-07-18
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , JAIN, Rakesh, K. , NETTI, Paolo
IPC分类号： A61M05/14
CPC分类号： A61M37/00 , A61B2017/00022 , A61B2090/064 , A61M5/14 , A61M5/1723
摘要： The invention provides a method of enhancing the amount of a pharmaceutical composition delivered to a target tissue site in a mammal, by creating a transient repetitive pressure or pulsatile pressure differential between the hydrostatic pressure of the target tissue site and a region near the target tissue site whereby the composition is transported toward the site. An apparatus for performing the method is also provided.
摘要翻译：本发明提供了一种通过在目标组织部位的静水压力和目标组织部位附近的区域之间产生瞬时重复压力或脉动压力差来增强递送至哺乳动物目标组织部位的药物组合物的量的方法从而将组合物运送到现场。还提供了一种用于执行该方法的装置。

17. 发明申请

WO1996037155A1 MICROMECHANICAL DEVICE AND METHOD FOR ENHANCING DELIVERY OF COMPOUNDS THROUGH THE SKIN 审中-公开
标题翻译：微生物装置和通过皮肤递送化合物的方法
公开(公告)号：WO1996037155A1
公开(公告)日：1996-11-28
申请号：PCT/US1996006697
申请日：1996-05-10
申请人： SILICON MICRODEVICES, INC. , THE GENERAL HOSPITAL CORPORATION
发明人： SILICON MICRODEVICES, INC. , THE GENERAL HOSPITAL CORPORATION , GODSHALL, Ned, Allen , ANDERSON, R., Rox
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/00761 , A61M35/00 , A61M2037/0007 , A61M2037/0046 , A61M2037/0053
摘要： This invention is an apparatus (60) for disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin in question. The apparatus (60) includes a cutter having a plurality of micro-protrusions (61) having a height less than or equal to the thickness of the layer of skin, and a stop for preventing the apparatus (60) from penetrating said layer of skin beyond a predetermined distance. In the preferred embodiment of the present invention the micro-protrusions (61) comprise first and second groups of micro-protrusions (61) extending from a substrate, and the stop comprises a region of the substrate separating the first and second groups and recessed below the tops of the first and second groups of micro-protrusions (61). In one embodiment of the present invention, a means for moving the apparatus (60) relative to the layer of skin, is provided.
摘要翻译：本发明是用于破坏具有已知厚度的皮肤层的装置（60），而基本上不破坏所讨论的皮肤层之下的潜在的真皮层。所述装置（60）包括具有多个微小突起（61）的切割器，所述多个微突起（61）的高度小于或等于所述皮肤层的厚度，以及用于防止所述装置（60）穿透所述皮肤层超出预定距离。在本发明的优选实施例中，微突起（61）包括从衬底延伸的第一和第二组微突起（61），并且止动件包括分离第一和第二组并且在下方凹陷的衬底的区域第一和第二组微突起（61）的顶部。在本发明的一个实施例中，提供了一种用于相对于皮肤层移动设备（60）的装置。

18. 发明申请

WO1996023447A1 HAIR REMOVAL USING OPTICAL PULSES 审中-公开
标题翻译：使用光学脉冲的头发去除
公开(公告)号：WO1996023447A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001235
申请日：1996-01-31
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, R., Rox , GROSSMAN, Melanie , FARINELLI, William
IPC分类号： A61B17/36
CPC分类号： A61B18/203 , A61B18/22 , A61B2017/00154 , A61B2017/00172 , A61B2017/22085 , A61B2017/306 , A61B2018/00023 , A61B2018/00452 , A61B2018/00476 , A61B2090/065
摘要： A method and apparatus for simultaneously effecting the removal of multiple hairs from a skin region by using light energy to destroy hair follicles in the region. Light energy is applied to the region through an applicator which converges the light energy to enhance destruction of desired portions of the follicles, is preferably pressed against the skin region to deform the upper layers of the skin reducing the distance from the skin surface to portions of hair follicles which are to be destroyed, including the bulge and papilla of the follicles, and which applicator is preferably cooled to minimize or eliminate thermal damage to the epidermis in the region being irradiated. Parameters for the irradiation, including pulse duration, are selected to effect complete damage of desired portions of the hair follicles in the region with minimal damage to surrounding tissue and to the patient's epidermis.
摘要翻译：一种用于通过使用光能同时实现从皮肤区域去除多个毛发以破坏该区域中的毛囊的方法和装置。光能通过会聚光能以增加卵泡所需部分的破坏的施加器施加到该区域，优选地压靠皮肤区域以使皮肤的上层变形，从而减少从皮肤表面到部分的皮肤表面的距离要被破坏的毛囊，包括卵泡的隆起和乳头，并且哪个施用器优选被冷却以最小化或消除被照射的区域中对表皮的热损伤。选择包括脉冲持续时间在内的照射参数，以对周围组织和患者表皮的损伤最小的区域完成对该区域毛囊期望部分的完全损伤。

19. 发明申请

WO1996021938A1 VIDEO-RATE CONFOCAL SCANNING LASER MICROSCOPE 审中-公开
标题翻译：视频速度扫描激光显微镜
公开(公告)号：WO1996021938A1
公开(公告)日：1996-07-18
申请号：PCT/US1996000448
申请日：1996-01-16
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , ANDERSON, R., Rox , WEBB, Robert , RAJADHYAKSHA, Milind
IPC分类号： H01J03/14
CPC分类号： G02B21/0084 , G02B21/0036 , G02B21/0048
摘要： A confocal microscope (10) for generating a video-rate, real-time image of a sample (22). The microscope (10) includes an optical delivery system, and horizontal (44) and vertical (56) scanning elements for generating a two-dimensional imaging field. The confocal microscope (10) additionally includes a focal-plane scanning element (16), positioned along the imaging fields' optical pathway, which includes an oscillating, motor-driven reflecting or transmitting optical component for spatially varying, in a time-dependent manner, the focal plane of the two-dimensional imaging field. Alternatively, in another aspect the microscope (10) features a pivoting articulated arm (20) for housing the vertical scanning element (56) and the imaging lens (72). The arm (20) includes at least one reflective elbow joint (68) configured to receive the two-dimensional imaging field from the vertical scanning element (56) and then deliver the field to the imaging lens (72).
摘要翻译：一种用于产生样品（22）的视频速率实时图像的共聚焦显微镜（10）。显微镜（10）包括光学传送系统以及用于产生二维成像场的水平（44）和垂直（56）扫描元件。共聚焦显微镜（10）还包括沿着成像场的光学路径定位的焦平面扫描元件（16），其包括以时间依赖的方式空间变化的振荡的，马达驱动的反射或透射光学部件，二维成像领域的焦平面。或者，在另一方面，显微镜（10）具有用于容纳垂直扫描元件（56）和成像透镜（72）的枢转铰接臂（20）。臂（20）包括至少一个反射肘关节（68），其被配置为从垂直扫描元件（56）接收二维成像场，然后将场传送到成像透镜（72）。

20. 发明申请

WO1996013211A1 APPARATUS AND METHOD FOR IMPROVED TISSUE IMAGING 审中-公开
标题翻译：用于改进组织成像的装置和方法
公开(公告)号：WO1996013211A1
公开(公告)日：1996-05-09
申请号：PCT/US1995013618
申请日：1995-10-23
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , MOORE, Richard , KOPANS, Daniel, B.
IPC分类号： A61B06/00
CPC分类号： A61B6/502 , A61B6/0414
摘要： An improved tissue imaging system is provided, in which tissue (26) can be sheared without direct manual manipulation, so that different perspective images of the tissue (26) can be determined, preferably in a single compression cycle. In one aspect of the invention, a traction system is provided, comprising at least a layer of radiolucent material (28) dimensioned and constructed such that the layer can pass between tissue (26) and a surface of a tissue imaging device. The radiolucent material (28) has sufficient tensile strength that the layer can slide without tearing against the surface of the tissue imaging device when tension is exerted on the layer, the sliding resulting in movement of the tissue (26) relative to the surface of the tissue imaging device. A method of moving tissue (26) relative to at least one surface of a tissue imaging device is also provided.
摘要翻译：提供了一种改进的组织成像系统，其中可以剪切组织（26）而不需要直接手动操作，使得可以优选地在单个压缩循环中确定组织（26）的不同透视图像。在本发明的一个方面，提供了一种牵引系统，其包括至少一层尺寸和构造的射线可透过材料（28），使得该层可以在组织（26）和组织成像装置的表面之间通过。射线可透过材料（28）具有足够的拉伸强度，当张力施加在该层上时，该层可以滑动而不会撕裂到组织成像装置的表面，该滑动导致组织（26）相对于该表面的运动组织成像装置。还提供了相对于组织成像装置的至少一个表面移动组织（26）的方法。

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