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11. 发明申请

WO2012125698A1 SELF-ADJUSTING GASTRIC BAND HAVING VARIOUS COMPLIANT COMPONENTS AND/OR SATIETY BOOSTER 审中-公开
标题翻译：自调整带有各种合身部件和/或安心推杆
公开(公告)号：WO2012125698A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029036
申请日：2012-03-14
申请人： ALLERGAN, INC. , SNOW, Sean , BORRELL, Marcos , TEZEL, Ahmet , O'BRIEN, Paul
发明人： SNOW, Sean , BORRELL, Marcos , TEZEL, Ahmet , O'BRIEN, Paul
IPC分类号： A61F5/00 , A61B5/00
CPC分类号： A61F5/0056
摘要： In some embodiments, the present invention generally provides self-adjusting gastric banding systems (1100) for the treatment of obesity and obesity related conditions, as well as systems for allowing the automatic self - adjustment of gastric bands when a patient swallows a large bolus. In some embodiments, the present invention generally provides for gastric banding systems having a satiety booster (1117), for example, to increase satiety levels when a patient desires to curb appetite at a particular time. In some embodiments, the present invention may provide for gastric banding systems that allow for both the automatic self - adjustment of gastric bands when a patient swallows a large bolus and an incorporated satiety booster for increasing satiety levels when a patient desires to curb appetite at a particular time.
摘要翻译：在一些实施方案中，本发明通常提供用于治疗肥胖和肥胖相关病症的自调节胃束带系统（1100），以及当患者吞咽大量推注时允许胃束带自动自我调节的系统。在一些实施方案中，本发明通常提供具有饱腹感增强剂（1117）的胃束带系统，例如当患者希望在特定时间遏制食欲时增加饱腹感水平。在一些实施方案中，本发明可以提供胃束带系统，当患者吞咽大量推注时，允许胃束带的自动自我调节，并且当患者希望在一个患者期望遏制食欲时，增加饱和感觉增强剂特定的时间。

12. 发明申请

WO2011119468A1 POLYSACCHARIDE AND PROTEIN-POLYSACCHARIDE CROSS-LINKED HYDROGELS FOR SOFT TISSUE AUGMENTATION 审中-公开
标题翻译：用于软组织补充剂的多糖和蛋白多糖交联氢化物
公开(公告)号：WO2011119468A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029150
申请日：2011-03-21
申请人： ALLERGAN, INC. , GUILLEN, Karina, Heredia , TEZEL, Ahmet
发明人： GUILLEN, Karina, Heredia , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/50 , A61L27/52
CPC分类号： A61L27/26 , A61K47/36 , A61K47/42 , A61L27/20 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/426 , A61L2300/43 , A61L2300/434 , A61L2300/442 , C08L5/08 , C08L89/06
摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
摘要翻译：本文公开了基于透明质酸和任选地包括蛋白质的粘性软组织填充剂，例如真皮和皮下填充剂。一方面，本文所述的基于透明质酸的组合物包括零长度交联部分和任选的至少一种活性剂。与已知的基于透明质酸的组合物相比，本发明的透明质酸组合物具有增强的流动特性，硬度和持久性。还提供了制备这种基于透明质酸的组合物的方法和方法。

13. 发明申请

WO2011100450A1 REMOTELY ADJUSTABLE GASTRIC BANDING SYSTEM 审中-公开
标题翻译：远程可调节的带式系统
公开(公告)号：WO2011100450A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024375
申请日：2011-02-10
申请人： ALLERGAN, INC. , BIRK, Janel , LESLIE, Dustin , SNOW, Sean , TEZEL, Ahmet
发明人： BIRK, Janel , LESLIE, Dustin , SNOW, Sean , TEZEL, Ahmet
IPC分类号： A61F5/00
CPC分类号： A61F5/0056 , A61F5/003 , A61F5/0059
摘要： An implantable device comprises a reservoir for holding a fluid and a sensor positioned between the gastric band and the reservoir. The sensor monitors a parameter of the fluid when filling and draining the inflatable portion of the gastric band. A first flow control device controls a flow of the fluid when filling and draining the inflatable portion of the gastric band. A pumping device moves the fluid into and out of the inflatable portion of the gastric band, and the pumping device is capable of being activated and deactivated using a telemetric signal received from a remote device.
摘要翻译：可植入装置包括用于保持流体的储存器和位于胃带和储存器之间的传感器。当填充和排空胃带的可充气部分时，传感器监测流体的参数。第一流量控制装置在填充和排出胃束带的可充气部分时控制流体的流动。泵送装置将流体移入和移出胃束带的可膨胀部分，并且泵送装置能够使用从远程装置接收到的遥测信号被激活和去激活。

14. 发明申请

WO2011022235A3 REINFORCED PROSTHETIC IMPLANT WITH FLEXIBLE SHELL 审中-公开
公开(公告)号：WO2011022235A3
公开(公告)日：2011-02-24
申请号：PCT/US2010/044896
申请日：2010-08-09
申请人： ALLERGAN, INC. , SCHUESSLER, David, J. , TEZEL, Ahmet
发明人： SCHUESSLER, David, J. , TEZEL, Ahmet
IPC分类号： A61L27/18 , A61F2/12 , A61L27/50
摘要： A fluid-filled soft prosthetic implant having a shell with a reinforced shell wall. The soft prosthetic implant may be for breast reconstruction or augmentation, or to restore the normal appearance of soft tissue in the buttocks, chin, calf, etc. The implants may be reinforced using several methods: reinforcement of the shell wall, non-homogeneous gel-filling, or both. At least a portion of the perimeter region desirably has a shell wall thickness greater than the average shell wall thickness of either the anterior face or the posterior face. The added material at the perimeter region strengthens that area in which a large percentage of implant ruptures occur. The reinforced perimeter also helps prevent the implant from collapsing or folding, which can cause undesirable rippling or wrinkling visible through the patient's skin. The remainder of the shell will desirably have a nominal wall thickness to retain the overall softness and supple feel of the implant. The implant shell may be filled with gels of different gel cohesiveness to counterbalance any reinforced area or to provide added reinforcement.

15. 发明申请

WO2008147817A2 COATED HYALURONIC ACID PARTICLES 审中-公开
标题翻译：涂覆的羟丙酸颗粒
公开(公告)号：WO2008147817A2
公开(公告)日：2008-12-04
申请号：PCT/US2008/064378
申请日：2008-05-21
申请人： ALLERGAN, INC. , CHAMPION, Julie, A. , MITRAGOTRI, Samir , TEZEL, Ahmet
发明人： CHAMPION, Julie, A. , MITRAGOTRI, Samir , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/58 , A61K9/16 , A61K31/728
CPC分类号： A61L27/20 , A61K9/0019 , A61K9/5031 , A61K9/5036 , A61K9/5052 , A61K31/728 , A61L27/58 , A61L2430/34
摘要： The present invention generally relates to particles comprising hyaluronic acid, wherein the particles are coated or encapsulated with a coating. The coating preferably comprises a polymer, protein, polysaccharide, or combination thereof that decreases the rate of degradation of the hyaluronic acid once the particles are placed in an aqueous environment, such as inside mammalian skin. The compositions of the present invention comprising such coated hyaluronic acid are useful for soft tissue augmentation, and are particularly useful as dermal fillers.
摘要翻译：本发明一般涉及包含透明质酸的颗粒，其中颗粒被涂层包被或包封。涂层优选包含聚合物，蛋白质，多糖或其组合，其一旦将颗粒置于水性环境（例如哺乳动物皮肤内）中，则降低透明质酸的降解速率。包含这种涂覆的透明质酸的本发明的组合物可用于软组织增加，并且特别可用作皮肤填充剂。

16. 发明申请

WO2013074364A1 MODULAR INJECTION SYSTEM AND METHOD FOR DILUTING AN INJECTABLE FLUID 审中-公开
标题翻译：模块化注射系统和用于稀释注射液的方法
公开(公告)号：WO2013074364A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/064106
申请日：2012-11-08
申请人： ALLERGAN, INC.
发明人： MUDD, Christopher S. , DOMINGUEZ, Zachary P. , JOSENHANS, Corey L. , TEZEL, Ahmet , BABKES, Mitchell H. , PRICHARD, Michael J. , LLEWELLYN, Martha E. , QIU, Shaohui , POWERS, Lee F. , JOHNSON, Brett R.
IPC分类号： A61M5/14 , A61M5/142 , A61M5/145 , A61M5/19 , A61C5/06 , A61M5/24
CPC分类号： A61M5/1408 , A61M5/14244 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/172 , A61M5/19 , A61M2209/088
摘要： A modular injection system enables a user to control the dilution ratio of mixed injectable fluid. In one embodiment, modular injection system includes a handheld injection device operatively connected to a separate control device. In one embodiment, the control device includes a drive unit configured to apply extrusion forces to fluids. In another embodiment, the handheld injection device includes the drive unit. In one embodiment, the modular injection system produces the mixed injectable fluid based on a selected dilution ratio. In one embodiment, the modular injection system produces the mixed injectable fluid based on selected injection rates.
摘要翻译：模块化注射系统使得用户能够控制混合可注射流体的稀释比。在一个实施例中，模块化注射系统包括可操作地连接到单独的控制装置的手持式注射装置。在一个实施例中，控制装置包括构造成将挤压力施加到流体的驱动单元。在另一个实施例中，手持式注射装置包括驱动单元。在一个实施例中，模块化注射系统基于所选择的稀释比产生混合的可注射流体。在一个实施例中，模块化注射系统基于所选择的注射速率产生混合的可注射流体。

17. 发明申请

WO2014055895A1 INJECTABLE DEVICE AND METHOD FOR SCULPTING, AUGMENTING OR CORRECTING FACIAL FEATURES SUCH AS THE CHIN 审中-公开
标题翻译：用于雕刻，补充或修正诸如CHIN的特征的注射装置和方法
公开(公告)号：WO2014055895A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063507
申请日：2013-10-04
申请人： ALLERGAN, INC.
发明人： STROUMPOULIS, Dimitrios , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/50
CPC分类号： A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61L2430/34 , C08L5/08
摘要： An injectable device useful for facial sculpting and correction of facial features, for example, for augmenting the chin in a human being is provided, the device being made of a composition comprising a hyaluronic acid crosslinked with a multifunctional polyethylene glycol (PEG)-based crosslinking agent.
摘要翻译：提供了一种可用于面部雕刻和矫正面部特征的可注射装置，例如用于增加人体中的下巴，所述装置由包含透明质酸的组合物制成，所述透明质酸与多官能聚乙二醇（PEG）基交联剂。

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