专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2003051343A1 PULSATILE RELEASE HISTAMINE H2 ANTAGONIST DOSAGE FORMS 审中-公开
标题翻译： PULSATILE RELEASE HISTAMINE H2 ANTAGONIST剂型
公开(公告)号：WO2003051343A1
公开(公告)日：2003-06-26
申请号：PCT/US2002/039238
申请日：2002-12-09
申请人： EURAND PHARMACEUTICALS LTD. , PERCEL, Philip, J. , VENKATESH, Gopi, M. , VISHNUPAD, Krishna, S. , VYAS, Nehal, H.
发明人： PERCEL, Philip, J. , VENKATESH, Gopi, M. , VISHNUPAD, Krishna, S. , VYAS, Nehal, H.
IPC分类号： A61K9/50
CPC分类号： A61K9/5084 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5078 , Y10S514/965
摘要： A unit dosage form, such as a capsule or the like, for delivering drugs into the body in a circadian release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release drug delivery system is designed to provide a plasma concentration - time profile, which varies according to physiological need at different times during the dosing period, i.e., mimicking the circadian rhythm and severity/manifestation of gastric acid secretion (and/or midnight gerd), predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
摘要翻译：公开了一种用于以包含一种或多种含药颗粒（珠粒，丸粒，颗粒等）群体的昼夜释放方式将药物输送到体内的单位剂型，例如胶囊等。每个珠粒表现出具有或不具有3至5小时的预定滞后时间的预设计的快速或持续释放曲线。这种昼夜节律释放药物递送系统被设计成提供血浆浓度 - 时间分布，其在给药期间的不同时间根据生理需要而变化，即模拟昼夜节律和胃酸分泌的严重性/表现（和/ 或午夜g d），基于药物动力学和药物动力学考虑以及体外/体内相关性预测。

12. 发明申请

WO2003028708A1 TIMED, SUSTAINED RELEASE MULTI-PARTICULATE DOSAGE FORMS OF PROPRANOLOL 审中-公开
标题翻译：定时，持续释放Propranolol的多剂量剂型
公开(公告)号：WO2003028708A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031535
申请日：2002-10-02
申请人： EURAND PHARMACEUTICALS LTD. , PERCEL, Phillip, J. , VENKATESH, Gopi, M. , VISHNUPAD, Krishna, S.
发明人： PERCEL, Phillip, J. , VENKATESH, Gopi, M. , VISHNUPAD, Krishna, S.
IPC分类号： A61K9/62
CPC分类号： A61K31/138 , A61K9/5078 , A61K9/5084
摘要： A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more population of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a predesigned rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration - time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity manifestation of a cardiovascular disease, prodicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
摘要翻译：用于以昼夜节律释放方式将药物输送到体内的单位剂型，例如胶囊等，包含一种或多种含普萘洛尔颗粒（珠粒，丸粒，颗粒等）的群体。每个珠粒显示具有或不具有3至5小时的预定滞后时间的预先设计的快速或持续释放曲线。这种昼夜节律释放心血管药物递送系统旨在提供血浆浓度 - 时间分布，其根据白天的生理需要而变化，即模仿基于药物动力学的心血管疾病的昼夜节律和严重程度的表现和药物动力学考虑和体外/体内相关性。

13. 发明申请

WO2012075455A2 RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS 审中-公开
标题翻译：快速分散颗粒，ORALLY DISPATTING DISPATTING AND METHODS
公开(公告)号：WO2012075455A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/063172
申请日：2011-12-02
申请人： APTALIS PHARMATECH, INC. , VENKATESH, Gopi M. , SWAMINATHAN, Vijaya , LAI, Jin-Wang , CLEVENGER, James M.
发明人： VENKATESH, Gopi M. , SWAMINATHAN, Vijaya , LAI, Jin-Wang , CLEVENGER, James M.
IPC分类号： A61K9/16
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/167 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2095 , A61K31/137 , A61K31/167 , A61K31/351 , A61K31/4453 , A61K31/485 , A61K31/53 , A61K31/5513
摘要： This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
摘要翻译：本发明涉及快速分散包含至少一种糖醇或糖，至少一种超级崩解剂和具有多官能度的药学上可接受的添加剂（例如，作为粘合剂的淀粉，崩解剂，稀释剂/填充剂，助流剂等）的微粒体，在低水平，其可以通过不仅消除湿磨步骤而且可以避免广泛的干磨步骤形成。此外，这种快速分散的微粒还可以包含药物活性剂，从而提供药物组合物，或由此制备的快速分散的微粒适合于与任选地掩蔽和/或控释的微粒的药物活性剂混合，还提供药物组合物，并且本发明还涉及以高可用产率制造这种快速分散的微粒的方法，以及包含这种快速分散的微粒的口腔崩解片剂。快速分散的微粒也是自由流动的。

14. 发明申请

WO2011140106A1 MICROPELLET COMPOSITIONS COMPRISING PANCREATIN CONTAINING DIGESTIVE ENZYME MIXTURES 审中-公开
标题翻译：含有包含消化酶混合物的胰蛋白酶的麦克风组合物
公开(公告)号：WO2011140106A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035023
申请日：2011-05-03
申请人： EURAND PHARMACEUTICALS LIMITED , VENKATESH, Gopi M. , KRAMER, Craig , FABIANI, Flavio , MAPELLI, Luigi , ORTENZI, Giovanni , LATINO, Massimo
发明人： VENKATESH, Gopi M. , KRAMER, Craig , FABIANI, Flavio , MAPELLI, Luigi , ORTENZI, Giovanni , LATINO, Massimo
IPC分类号： A61K9/26
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/1641 , A61K9/1652 , A61K9/5042 , A61K9/5047 , A61K9/5089 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： The present invention relates to a small particle size composition comprising pancreatin containing digestive enzymes for use in patients in need, including pediatric, geriatric, and adult patients, particularly those patients with dysphagia or wherein enteral administration using such composition would be suitable. In addition, the invention is directed to the composition as particles, such as micropellets or microgranules having a high potency, high useable yield and at least 10% - 90% of 400-800 µm. Furthermore, the composition optionally has an improved enteric coating and concomitant improved stability and enzyme activity compared to conventional prepared enterically coated pancreatic enzyme particles.
摘要翻译：本发明涉及一种小粒径组合物，其包含用于需要的患者的含有胰酶的消化酶，包括儿科，老年和成年患者，特别是那些吞咽困难的患者或其中使用这种组合物的肠内施用是合适的。此外，本发明涉及作为颗粒的组合物，例如具有高效力，高可用收率和400-800μm的至少10％至90％的微丸或微粒。此外，与常规制备的肠溶包衣胰酶颗粒相比，组合物任选地具有改善的肠溶衣并伴随改善的稳定性和酶活性。

15. 发明申请

WO2007090082A3 DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC SELECTIVE SEROTONIN 5-HT3 BLOCKING AGENT AND ORGANIC ACIDS 审中-公开
标题翻译：包含弱碱性选择性丝氨酸5-HT3阻断剂和有机酸的药物递送系统
公开(公告)号：WO2007090082A3
公开(公告)日：2007-12-21
申请号：PCT/US2007061217
申请日：2007-01-29
申请人： EURAND INC , VENKATESH GOPI M , LAI JIN-WANG , VYAS NEHAL H
发明人： VENKATESH GOPI M , LAI JIN-WANG , VYAS NEHAL H
IPC分类号： A61K9/22
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/5073 , A61K9/5084 , A61K31/4178
摘要： A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a weakly basic, nitrogen (N)-containing selective serotonin 5- HT 3 blocking agent having a pKa in the range of from about 5 to 14 and a solubility of not more than about 200 µg/mL at pH 6.8 into the body in a sustained-released fashion, suitable for a once-daily dosing regimen, comprises at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT 3 blocking agent prior to releasing it into the hostile intestinal environment wherein the blocking agent is practically insoluble. The unit dosage form may be composed of a multitude of multicoated particulates (i.e., immediate-release beads, sustained-release beads and/or one or more timed, pulsatile- release bead populations) and is designed in such a way that the weakly basic blocking agent and the organic acid do not come into close contact during processing and/or storage thereby avoiding in-situ formation of acid addition compounds while ensuring that the acid is not depleted prior to completion of the drug release.
摘要翻译：一种药物剂型，例如胶囊，常规或口腔崩解片，其能够递送具有pKa范围的弱碱性，含氮（N）的选择性5-羟色胺5-羟色胺阻断剂约5至14，并且以pH 6.8的不超过约200μg/ mL的溶解度以持续释放的方式适应于每日一次的给药方案，包含至少一种有机酸，其溶解所述弱化碱性选择性5-羟色胺5-HT 3封闭剂，然后将其释放到敌对的肠道环境中，其中封闭剂几乎不溶。单位剂量形式可以由多种多重微粒（即即释丸，缓释珠和/或一个或多个定时，脉冲释放珠群）组成，并且以这样的方式设计：弱碱性封闭剂和有机酸在加工和/或储存期间不会紧密接触，从而避免了原位形成酸加成化合物，同时确保在药物释放完成之前酸不被耗尽。

16. 发明申请

WO2005105049A3 Orally disintegrating tablets and methods of manufacture 审中-公开
标题翻译：口腔崩解片和制造方法
公开(公告)号：WO2005105049A3
公开(公告)日：2006-06-29
申请号：PCT/US2005010901
申请日：2005-03-31
申请人： EURAND PHARMACEUTICALS LTD , VENKATESH GOPI M , QIAN KEN KANGYI , VANGALA SHYAM , CLEVENGER JAMES M , GUENTHER DONALD
发明人： VENKATESH GOPI M , QIAN KEN KANGYI , VANGALA SHYAM , CLEVENGER JAMES M , GUENTHER DONALD
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/46 , A61K9/50 , A61K31/34
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2095 , A61K9/5042 , A61K31/34 , A61K31/341 , A61K31/4045
摘要： A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.
摘要翻译：一种在口腔内快速崩解的片剂，其包含通过将平均粒度小于约30微米的糖醇或糖或其混合物制成的快速分散的微粒的压缩共混物和崩解剂，以及掩味微胶囊含有至少一种药物，所述微胶囊通过将包含至少一种治疗有效量的药物的药学上可接受的制剂和至少一种改善微粒回弹性的聚合物粘合剂制粒，湿法研磨造粒物质，并将研磨的颗粒微胶囊化以提供微胶囊。

17. 发明申请

WO2011085181A1 TASTE MASKED TOPIRAMATE COMPOSITION AND AN ORALLY DISINTEGRATING TABLET COMPRISING THE SAME 审中-公开
标题翻译：将所述掩蔽的TOPIRAMATE组合物和包含该组合物的口服灭菌片
公开(公告)号：WO2011085181A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020493
申请日：2011-01-07
申请人： EURAND, INC. , VENKATESH, Gopi, M. , HARMON, Troy, M.
发明人： VENKATESH, Gopi, M. , HARMON, Troy, M.
IPC分类号： A01N43/04 , A61K31/70 , A61K31/445
CPC分类号： A61K31/35 , A61K9/0056 , A61K9/2081 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/4178
摘要： In various embodiments, the present invention is directed to a taste masked pharmaceutical composition comprising a therapeutically effective amount of taste masked sulfamate-substituted monosaccharide particles comprising a sulfamate-substituted monosaccharide or a pharmaceutically acceptable salt or derivative thereof that are coated with one or more taste-masking layers, and optionally one or more of taste-masked neltrexone, 5-HT 3 receptor antagonist, phentermine, and vitamin B-12. The present invention relates to methods of making the taste masked and ODT compositions, and methods of using the compositions for treating a patient subject to an epileptic condition, migraines, dysphagia, achieving / maintaining weight loss, or alcoholism or drug addiction.
摘要翻译：在各种实施方案中，本发明涉及一种掩味药物组合物，其包含治疗有效量的掩味氨基磺酸酯取代的单糖颗粒，其包含氨基磺酸盐取代的单糖或其药学上可接受的盐或衍生物，其被涂覆有一种或多种味道掩蔽层，以及任选的一种或多种掩味的奈非曲塞，5-HT 3受体拮抗剂，phentermine和维生素B-12。本发明涉及制作掩味的方法和ODT组合物，以及使用该组合物治疗患有癫痫病症，偏头痛，吞咽困难，达到/维持体重减轻或酒精中毒或药物成瘾的患者的方法。

18. 发明申请

WO2011066289A1 ONDANSETRON ORALLY DISINTEGRATING TABLET COMPOSITIONS FOR PREVENTION OF NAUSEA AND VOMITING 审中-公开
标题翻译： ONDANSETRON ORALLYRON OR DISETEGATING TABLET COMPOSITIONS FOR EVEREN NAUSEA AND VOMITING
公开(公告)号：WO2011066289A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057813
申请日：2010-11-23
申请人： EURAND, INC. , VENKATESH, Gopi M.
发明人： VENKATESH, Gopi M.
IPC分类号： A01N43/50
CPC分类号： A61K31/4178 , A61K9/0056 , A61K9/2077 , A61K9/2081 , A61K9/5026 , A61K9/5031 , A61K9/5047 , A61K9/5078
摘要： This invention is related to a pharmaceutical composition in the patient-friendly orally disintegrating tablet form comprising a weakly basic, selective serotonin 5-HT3 blocking agent for the prevention of nausea and/or vomiting for up to 24 hrs postdosing in cancer patients prior to undergoing moderately emetogenic chemotherapy or partial or whole body radiotherapy or in subjects at moderate to high risk of postoperative or postdischarge nausea and/or vomiting prior to inpatient or outpatient ambulatory surgery. The unit dosage form comprising a multitude of immediate-release drug particles providing dissolution profiles similar to that of reference drug product, and one or more timed, pulsatile-release bead populations, comprising at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT3 blocking agent prior to releasing it into the hostile intestinal environment.
摘要翻译：本发明涉及一种患者友好的口腔崩解片形式的药物组合物，其包含弱碱性选择性5-羟色胺5-HT 3阻断剂，用于预防恶心和/或呕吐在癌症患者之前多达24小时后进行中度排卵化疗或部分或全身放射治疗或中度至高风险的患者术后或出院后恶心和/或呕吐在住院或门诊门诊手术之前。所述单位剂量形式包含大量立即释放的药物颗粒，其提供类似于参考药物产品的溶出曲线，以及一个或多个定时的脉冲释放珠粒群，其包含至少一种有机酸，其溶解所述弱碱性选择性5-羟色胺 5-HT3阻断剂在将其释放到敌对肠道环境中之前。

19. 发明申请

WO2011066287A1 COMPRESSIBLE-COATED PHARMACEUTICAL COMPOSITIONS AND TABLETS AND METHODS OF MANUFACTURE 审中-公开
标题翻译：可压缩的药物组合物和片剂及其制备方法
公开(公告)号：WO2011066287A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057811
申请日：2010-11-23
申请人： EURAND, INC. , VENKATESH, Gopi, M. , LAI, Jin-Wang , CLEVENGER, James, M. , KRAMER, Craig
发明人： VENKATESH, Gopi, M. , LAI, Jin-Wang , CLEVENGER, James, M. , KRAMER, Craig
IPC分类号： A61K9/16
CPC分类号： A61K9/0056 , A61K9/2081 , A61K9/5015 , A61K9/5073 , A61K9/5078 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/221 , A61K31/341 , A61K31/455 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： There is provided a method for preparing a pharmaceutical composition comprising compressible coated, taste-masked and/or controlled-release coated drug-containing particles, rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol, a saccharide, or a mixture thereof, and other optional, pharmaceutically acceptable excipients wherein the orally disintegrating tablet (ODT) or rapidly dispersing tablet (RDT) composition having acceptable tableting, organoleptic, and pharmacokinetic properties.
摘要翻译：提供了一种制备药物组合物的方法，所述药物组合物包含可压缩涂覆，掩味和/或控释包衣的含药颗粒，包含崩解剂和糖醇，糖或其混合物的快速分散微粒，以及其它任选的药学上可接受的赋形剂，其中具有可接受的压片，感官和药代动力学性质的口腔崩解片（ODT）或快速分散片剂（RDT）组合物。

20. 发明申请

WO2010127346A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS COMPRISING COMBINATIONS OF NON-OPIOID AND OPIOID ANALGESICS 审中-公开
标题翻译：包含不含鸦片和阿片类药物组合的片剂组合物
公开(公告)号：WO2010127346A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/033392
申请日：2010-05-03
申请人： EURAND, INC. , VENKATESH, Gopi, M. , CLEVENGER, James , GOSSELLIN, Michael , LAI, Jin-Wang
发明人： VENKATESH, Gopi, M. , CLEVENGER, James , GOSSELLIN, Michael , LAI, Jin-Wang
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K9/5047 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4415 , A61K31/4468 , A61K31/485 , A61K31/5415 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked non-opioid analgesic/opioid analgesic drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of non-opioid and opioid analgesics which provide for more convenient and palatable administration of drug combinations, for example for treating pain.
摘要翻译：本发明涉及包含多种掩味的非阿片类镇痛/阿片类止痛药物的微粒的药物组合物，包含这种药物组合物的剂型（例如口腔崩解片），以及制备该药物组合物的方法和本发明的剂型。包含本发明药物组合物的剂型是非阿片类和阿片样镇痛药的改进的均匀混合物，其提供药物组合的更方便和可口的给药，例如用于治疗疼痛。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式