专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2010128859A8 GLUCOOLIGOSACCHARIDES COMPRISING (ALPHA 1?4) AND (ALPHA 1?6) GLYCOSIDIC BONDS, USE THEREOF, AND METHODS FOR PRODUCING THEM 审中-公开
标题翻译：包含（ALPHA 1→4）和（ALPHA 1→6）GLYCOSIDIC BONDS的GLUCOOLIGOSACCHARIDES及其用途及其生产方法
公开(公告)号：WO2010128859A8
公开(公告)日：2011-12-15
申请号：PCT/NL2010050269
申请日：2010-05-10
申请人： UNIV GRONINGEN , DIJKHUIZEN LUBBERT , VAN DER MAAREL MARC JOS ELISE CORNELIS , KAMERLING JOHANNIS PAULUS , LEEMHUIS REINDER JOHANNES , KRALJ SLAVKO , DOBRUCHOWSKA JUSTYNA MALGORZATA
发明人： DIJKHUIZEN LUBBERT , VAN DER MAAREL MARC JOS ELISE CORNELIS , KAMERLING JOHANNIS PAULUS , LEEMHUIS REINDER JOHANNES , KRALJ SLAVKO , DOBRUCHOWSKA JUSTYNA MALGORZATA
IPC分类号： C12P19/00 , C12P19/04
CPC分类号： C12P19/00 , C12N9/1051 , C12P19/04 , C12Y204/01005
摘要： The invention relates to the field of poly- and oligosaccharides and their nutritional effects. In particular, it relates to the application of a-glucanotransferases in methods for preparing dietary fibers, including prebiotic oligosaccharides, and to novel oligosaccharides obtainable thereby. Provided is a method for producing a mixture of gluco-oligosaccharides having one or more consecutive (a1?6) glucosidic linkages and one or more consecutive (a1?4) glucosidic linkages, comprising contacting a poly- and/or oligosaccharide substrate comprising at least two (a1?4) linked D-glucose units with an a-glucanotransferase capable of cleaving (a1?4) glucosidic linkages and making new (a1?4) and (a1?6) glucosidic linkages. Also provided are (isolated) gluco-oligosaccharides obtainable thereby, and their application in nutritional and cosmetic compositions.
摘要翻译：本发明涉及多糖和寡糖的领域及其营养效果。特别涉及α-葡聚糖转移酶在制备膳食纤维，包括益生元寡糖的方法中的应用，以及由此得到的新型寡糖。提供了一种制备具有一个或多个连续（a1→6）糖苷键和一个或多个连续（a1→4）糖苷键的葡萄糖寡糖的混合物的方法，包括使包含至少包含两个（a1→4）连接的D-葡萄糖单元与能够切割（a1→4）糖苷键的α-葡聚糖转移酶并产生新的（a1→4）和（a1→6）糖苷键。还提供了可由此获得的（分离的）葡糖寡糖，以及它们在营养和美容组合物中的应用。

12. 发明申请

WO2010100056A3 ANTIBODIES AGAINST A PROLIFERATING INDUCING LIGAND (APRIL) 审中-公开
标题翻译：抗增殖诱导配体的抗体（4月）
公开(公告)号：WO2010100056A3
公开(公告)日：2010-11-18
申请号：PCT/EP2010052254
申请日：2010-02-23
申请人： STICHTING TOP INST PHARMA , ORGANON NV , VRIJE UNIVERSITEIT MEDISCH CT , AMC AMSTERDAM , UNIV GRONINGEN , GRONINGEN ACAD ZIEKENHUIS , PEPSCAN HOLDING N V , MEDEMA JAN PAUL , EENENNAAM VAN HANS , GUADAGNOLI MARCO , KIMBERLEY FIONA CLARE , PHAN UYEN TRUONG
发明人： MEDEMA JAN PAUL , EENENNAAM VAN HANS , GUADAGNOLI MARCO , KIMBERLEY FIONA CLARE , PHAN UYEN TRUONG
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译：本发明涉及结合人APRIL的结合化合物。更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这些抗体调节APRIL的生物学活性，特别是在炎性疾病，细胞增殖和癌症的抑制中的方法。

13. 发明申请

WO2010033027A3 POLYMERIC AMINES AND BIOMEDICAL USES THEREOF 审中-公开
标题翻译：聚合物及其生物医学用途
公开(公告)号：WO2010033027A3
公开(公告)日：2010-06-10
申请号：PCT/NL2009050562
申请日：2009-09-18
申请人： UNIV GRONINGEN , BROEKHUIS ANTONIUS AUGUSTINUS , ZHANG YOUCHUN , PICCHIONI FRANCESCO , ROKS ANTONIUS JACOBUS MARINUS
发明人： BROEKHUIS ANTONIUS AUGUSTINUS , ZHANG YOUCHUN , PICCHIONI FRANCESCO , ROKS ANTONIUS JACOBUS MARINUS
IPC分类号： C08G73/00 , A61L31/00 , C08G67/00 , C08G67/02 , C08G69/00
CPC分类号： C08L79/04 , A61L27/18 , C08G73/0611 , C08L79/02
摘要： The invention relates to the field of polymers and biomedical applications thereof. In particular, it relates to the use of polymeric amines derived from alternating polyketones.Provided is the use of a polymeric amine for modulating or supporting cellular behavior, said polymeric amine being an alternating aliphatic polyketone comprising N-substituted 2,5-pyrrolediyl groups incorporated in the polymer backbone and bearing an amino functional group pendant from the polymer backbone.
摘要翻译：本发明涉及聚合物及其生物医学应用领域。特别地，本发明涉及使用衍生自交替聚酮的聚合胺。提供了使用聚合胺调节或支持细胞行为，所述聚合胺是包含N-取代的2,5-吡咯烷基的交替脂族聚酮，在聚合物主链中并且具有来自聚合物主链的氨基官能团。

14. 发明申请

WO2008115061A3 DUAL TARGETING SYSTEM 审中-公开
标题翻译：双向系统
公开(公告)号：WO2008115061A3
公开(公告)日：2008-11-06
申请号：PCT/NL2008050161
申请日：2008-03-20
申请人： UNIV GRONINGEN , BOS NICOLAAS ADRIANUS
发明人： BOS NICOLAAS ADRIANUS
IPC分类号： A61K47/48 , A61P43/00 , C07K14/51 , C07K14/705 , C07K16/30 , C12N15/62
CPC分类号： C07K14/52 , A61K47/6811 , A61K47/6813 , A61K47/6863 , A61K47/6889 , A61K47/6901 , C07K16/3046 , C07K2317/52 , C07K2317/622 , C07K2319/30
摘要： The invention relates to the field of drug delivery. In particular, it relates to use of probiotic bacteria, generally Gram-positive bacteria such as Lactococcus sp., in providing biologically active polypeptides in the body, especially in the gastrointestinal (GI) tract. Provided is a non-invasive microbial host cell expressing a chimeric protein comprising a therapeutic proteinaceous substance fused to a microbial membrane anchoring domain, said therapeutic proteinaceous substance comprising at least one targeting moiety capable of binding to a target cell surface molecule, and at least one bioactive polypeptide, wherein said bioactive polypeptide is flanked on both sides by at least one cleavage site for an endopeptidase activity associated with said target cell. Also provided are pharmaceutical and nutritional compositions comprising a host cell according to the invention.
摘要翻译：本发明涉及药物递送领域。特别地，它涉及益生菌（通常是革兰氏阳性细菌如乳球菌属）在体内，特别是在胃肠道（GI）中提供生物活性多肽的用途。提供了表达嵌合蛋白质的非侵入性微生物宿主细胞，其包含融合到微生物膜锚定结构域的治疗性蛋白质物质，所述治疗性蛋白质物质包含至少一种能够结合靶细胞表面分子的靶向部分，以及至少一种生物活性多肽，其中所述生物活性多肽在两侧由至少一个用于与所述靶细胞相关的内肽酶活性的切割位点侧接。还提供了包含根据本发明的宿主细胞的药物和营养组合物。

15. 发明申请

WO2005013863A3 PROSTHESIS MADE OF A FIBRE-REINFORCED HYDROGEL, METHOD OF MANUFACTURING AND USE THEREOF 审中-公开
标题翻译：纤维增强水凝胶的制备方法，制造方法及其应用
公开(公告)号：WO2005013863A3
公开(公告)日：2005-04-07
申请号：PCT/NL2004000495
申请日：2004-07-08
申请人： UNIV EINDHOVEN TECH , UNIV GRONINGEN , HUYGHE JACQUES MARIE RENE JAN , VAN DONKELAAR CORRINUS CORNELI , WIJLAARS MARCELLUS WILHELMUS , VERKERKE GIJSBERTUS JACOB , EIJKELKAMP MARCUS FRANCISCUS , VELDHUIZEN ALBERT GERRIT
发明人： RIJKSUNIVERSITEIT GRONINGEN , HUYGHE JACQUES MARIE RENE JAN , VAN DONKELAAR CORRINUS CORNELI , WLILAARS MARCELLUS WILHELMUS , VERKERKE GIJSBERTUS JACOB , EIJKELKAMP MARCUS FRANCISCUS , VELDHUIZEN ALBERT GERRIT
IPC分类号： A61F2/00 , A61F2/30 , A61F2/44
CPC分类号： A61F2/442 , A61F2/3094 , A61F2/30965 , A61F2002/30009 , A61F2002/30014 , A61F2002/30075 , A61F2002/4495 , A61F2210/0061 , A61F2250/0018 , A61F2250/0028
摘要： The present application relates to a prosthesis comprising a flexible portion (1) and at least one less flexible portion (2), which flexible portion comprises a fibre-reinforced hydrogel. In addition to that, the application relates to a prosthesis consisting of a fibre-reinforced hydrogel, which prosthesis is intended to replace cartilaginous materials. The application further relates to the use of the prosthesis and to a method for manufacturing the prosthesis. The application furthermore relates to a method of preparing the flexible portion for a prosthesis. Finally, the application relates to a fibre material apparently intended for use in the prosthesis.
摘要翻译：本申请涉及一种包括柔性部分（1）和至少一个较少柔性部分（2）的假体，该柔性部分包括纤维增强的水凝胶。除此之外，本申请涉及由纤维增强的水凝胶组成的假体，假体旨在代替软骨材料。本申请还涉及假体的使用和制造假体的方法。本申请还涉及制备用于假体的柔性部分的方法。最后，本申请涉及明显用于假体的纤维材料。

16. 发明申请

WO02057779A8 CLONING AND EXPRESSION OF A NEW MCP RECEPTOR IN GLIAL CELLS 审中-公开
标题翻译：在GL细胞中克隆和表达新的MCP受体
公开(公告)号：WO02057779A8
公开(公告)日：2003-11-13
申请号：PCT/NL0200039
申请日：2002-01-18
申请人： UNIV GRONINGEN , BODDEKE ERIK HENDRIKUS WILHELM , BIBER KNUT PETER HEINRICH
发明人： BODDEKE ERIK HENDRIKUS WILHELM , BIBER KNUT PETER HEINRICH
IPC分类号： A61K38/00 , C07K14/715 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5088 , A01K2267/0356 , A61K38/00 , C07K14/7158 , G01N33/5008 , G01N33/502 , G01N33/5029 , G01N33/6863 , G01N33/6896
摘要： The invention relates to the fields of inflammation and immunology, and more specifically to the field of chemokines and receptors therefor, and their role in neurodegenerative or neuroinflammatory disease. The invention provides a method for identifying a candidate drug compound for the treatment of inflammatory or degenerative brain disease comprising testing said compound for its capacity to modulate or mimic MCP-1 binding with a chemokine receptor capable of being expressed on brain glial cells, said receptor known in the mouse as L-CCR or in humans as CRAM-B.
摘要翻译：本发明涉及炎症和免疫学领域，更具体地涉及趋化因子及其受体领域，以及它们在神经变性或神经炎症性疾病中的作用。本发明提供了一种用于鉴定用于治疗炎性或退行性脑疾病的候选药物化合物的方法，包括测试所述化合物的调节或模拟与能够在脑胶质细胞上表达的趋化因子受体的MCP-1结合的能力，所述受体在小鼠中称为L-CCR或人类作为CRAM-B。

17. 发明申请

WO0133605A9 ATMOSPHERIC PRESSURE PHOTOIONIZATION (APPI): A NEW IONIZATION METHOD FOR LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY 审中-公开
标题翻译：大气压力光化学（APPI）：用于液相色谱 - 质谱法的新型离子化方法
公开(公告)号：WO0133605A9
公开(公告)日：2002-08-29
申请号：PCT/CA0001270
申请日：2000-10-26
申请人： UNIV GRONINGEN , ROBB DAMON B , BRUINS ANDRIES PIETER
发明人： ROBB DAMON B , BRUINS ANDRIES PIETER
IPC分类号： G01N27/62 , G01N27/64 , G01N30/72 , H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/162 , H01J49/045 , H01J49/049
摘要： There is provided a method of, and apparatus for, analyzing a sample of an analyte provided as a sample solution comprising a solvent and an analyte. A dopant is provided, either separately or as the solvent of the sample solution. The sample solution is formed into a spray, for example in a nebulizer, and the solvent evaporated. The sample stream is irradiated in a region at atmospheric pressure, either in the liquid state prior to formation of a spray, or in the liquid state after formation of a droplet spray, or in the vapour state after evaporation of the sprayed droplets, to ionize the dopant. Then, subsequent collisions between the ionized dopant and the analyte, either directly or indirectly, result in ionization of the analyte. Analyte ions are passed from the atmospheric pressure ionization region into a mass analyzer for mass analysis. This technique has been found to give much enchanced inonization for some substances, as compared to atmospheric pressure chemical ionization.
摘要翻译：提供了一种用于分析作为包含溶剂和分析物的样品溶液提供的分析物的样品的方法和装置。分别提供掺杂剂或作为样品溶液的溶剂。将样品溶液形成为喷雾剂，例如在喷雾器中，并蒸发溶剂。样品流在大气压下，在形成喷雾前处于液态，或者在形成液滴喷射后处于液态，或在蒸发喷雾后的蒸汽状态下照射到离子化掺杂剂。然后，直接或间接地离子化的掺杂剂和分析物之间的随后的碰撞导致分析物的离子化。分析离子从大气压电离区域通入质量分析仪进行质量分析。与大气压化学电离相比，已经发现这种技术对某些物质进行了大量的加强。

18. 发明申请

WO0171015A3 NON-SQUAMOUS EPITHELIUM-SPECIFIC TRANSCRIPTION 审中-公开
标题翻译：非平面上皮特异性转录
公开(公告)号：WO0171015A3
公开(公告)日：2002-01-31
申请号：PCT/NL0100166
申请日：2001-02-28
申请人： UNIV GRONINGEN , LEIJ LOU FRANCISCUS MARIA HUBE , RUITERS MARCEL HERMAN JOSEF , MCLAUGHLIN PAMELA MARIJKE JANE , HARMSEN MARTIN CONRAD , MOLEN HENK V D , TERPSTRA PETER , DOKTER WILLEM HENDRIK ABRAHAM
发明人： DE LEIJ LOU FRANCISCUS MARIA H , RUITERS MARCEL HERMAN JOSEF , MCLAUGHLIN PAMELA MARIJKE JANE , HARMSEN MARTIN CONRAD , VAN DER MOLEN HENK , TERPSTRA PETER , DOKTER WILLEM HENDRIK ABRAHAM
IPC分类号： A61K48/00 , A61P35/00 , C12N15/85 , A01K67/027 , C12N15/63
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C12N2830/008 , C12N2830/85
摘要： The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific promoter or functional fragment thereof allowing for expression of a nucleic acid of interest operably linked to said promoter or functional fragment thereof in a cancer cell wherein said expression in said cancer cell is essentially carcinoma selective.
摘要翻译：本发明涉及癌症治疗和诊断领域，尤其涉及癌症领域。本发明提供了分离的和/或重组的核酸，其包含组织特异性启动子或其功能片段，其允许在癌细胞中与所述启动子或其功能片段可操作地连接的目的核酸可操作地连接，其中所述癌细胞中的所述表达是基本上是癌选择性的。

19. 发明申请

WO2014195520A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195520A3
公开(公告)日：2015-02-26
申请号：PCT/EP2014063068
申请日：2014-06-20
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： KLAASSEN PAUL , DE WAAL PAULUS PETRUS , DE JONG RENÉ MARCEL , DRIESSEN ARNOLD JACOB MATTIEU , NIJLAND JEROEN GERBEN , SHIN HYUN YONG
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Y of SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及一种对F85T / A / C / H / M / N，T89H / D / C / A / N，V187T / C / D / E / F / G / H / K / M / Q / R / S / W / Y，A191N / G / P / C / D / F / H / I / K / Q / V / W / Y，Y214V / Q / G / L / M / N / P / R / S，Q215L / M / I / A / C / D / F / S，I218K / N / A / C / D / E / H / L，T219G / F / D / N，I222D / C / H / E / G / P / S / V / Y，Y226D / M / R / C / G / H / I / L / P / Q / T / W，Q338C / E / F / D / G / / P / R / S / T / V / W / Y，M339N / V / D / E / H / K / P / Q / R / Y，Q341T / M / N / S / Y，Q342Y / S / C / A / D / F / G / H / I / K / L / N / P / R / T / V / W，L343K / R / P / C / D / E / G / H / I / M / N / Q / S / T / Y，N346W / Y / F / G / H / K / L / M / R / T，N347A / I / E / H / L，Y350R / L / T / D / K / M / N / V，G373L / E / N / F / K / M / R / V / W / Y，N376I / T / M / A / C / E / F / H / K / L / P / Q / R / V / W / Y，T380M / F / H / N / P / Q / R / S / V，S383Q / T / C / D / E / F / I / K / L / M / R / V / W / Y，F444Y / D / E / H / K / N / P / Q / R / W，F446Q / L / H / D / E / I / M / N，T448M / H / D / E / F / K / R / W / Y，T449F / M / N / S / D / E / G / H / I / K / L / P / Q / R / V / W / Y，T451I / E / C / D / F / H / K / L / M / N / Q / R / S / T / V / W / Y，W455T / N / A / C / E / L / P / Q / T，N478P / F / V / G / I / K / R / W，或SEQ ID NO：59的W479T / S / Q / D / E / F / G / H / I / M / N / P / R / V / Y，主要辅导员超家庭成员（MFS）的成员。

20. 发明申请

WO2014184726A2 COMPOUNDS AND THEIR USE IN THERAPY 审中-公开
标题翻译：化合物及其在治疗中的使用
公开(公告)号：WO2014184726A2
公开(公告)日：2014-11-20
申请号：PCT/IB2014061379
申请日：2014-05-12
申请人： STICHTING HET NL KANKER INST ANTONI VAN LEEUWENHOEK ZIEKENHUIS , UNIV ERASMUS MEDICAL CT , UNIV GRONINGEN
发明人： VAN HELL ALBERT , VERHEIJ MARCEL , MARRINK SIEWERT JAN , KONING GERBEN
IPC分类号： A61K47/24
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/1271 , A61K31/538 , A61K31/704 , A61K47/24
摘要： The present invention pertains generally to the field of therapy and medical treatment, and more specifically to certain compounds of the following formula (for convenience, collectively referred to herein as "short-chain phosphatidylcholine lipids" and "SCPC lipids"), which, inter alia, are useful in methods of improving drug delivery, bioavailability, and efficacy. The present invention also pertains to pharmaceutical formulations, and more specifically to co-formulations of known drugs (e.g., amphiphilic drugs) (e.g., anthracyclines) (e.g., doxorubicin) with these SCPC lipids, and their use, for example, in therapy.
摘要翻译：本发明一般涉及治疗和治疗领域，更具体地涉及下列配方的某些化合物（为方便起见，本文统称为“短链磷脂酰胆碱脂”和“SCPC脂质”），其中，尤其可用于改善药物递送，生物利用度和功效的方法。本发明还涉及药物制剂，更具体地涉及与这些SCPC脂质的已知药物（例如，两亲性药物）（例如，蒽环类抗生素）（例如，多柔比星）的共同制剂，以及它们在治疗中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式