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11. 发明申请

WO2018219983A1 PROPORTIONAL PINCH VALVE 审中-公开
公开(公告)号：WO2018219983A1
公开(公告)日：2018-12-06
申请号：PCT/EP2018/064137
申请日：2018-05-30
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： BARGH, Neil
IPC分类号： F16K7/04 , F16K41/12
摘要： A proportional pinch valve (10) for controlling the pressure of a fluid in a continuous flow system comprises an anvil (22) for pinching a length of a tubing (12) in the continuous flow system, and a drive mechanism including a displacement element for moving the anvil towards the tubing (12). The anvil (22) is indirectly coupled to the displacement element via an elastic spring element (36). The elastic spring element (36) provides a defined play (i.e. elasticity) for the anvil (22) at least as long as the tubing (12) is not fully pinched so that displacement of the anvil (22) is force-controlled by the elastic spring element (36). A method of controlling the pressure of a fluid in a continuous flow system makes use of such a proportional pinch valve (10).

12. 发明申请

WO2018138160A1 AUTOMATED MODULAR FILTRATION SYSTEM 审中-公开
公开(公告)号：WO2018138160A1
公开(公告)日：2018-08-02
申请号：PCT/EP2018/051743
申请日：2018-01-24
申请人： SARTORIUS STEDIM BIOTECH GMBH , THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： BARGH, Neil , PILGRIM, James , WALES, Richard , LEUTHOLD, Martin
IPC分类号： B01D61/22 , B01D65/00 , B01D65/02
摘要： An automated modular filtration system, in particular for low volume tangential flow filtration processes, comprises a plurality of filtration modules (10)formed as separate assemblies. Each filtration module (10) contains at least one individual filtration unit (12) being designed for executing a filtration process independent of the other filtration units (12) of the filtration system. Each filtration module (10) includes first input ports for receiving a first type of fluids. The fluids of the first type are process fluids which are specific to the respective filtration processes executed in the individual filtration units (12). Each filtration module (10) includes second input ports for receiving a second type of fluids. The fluids of the second type are system fluids which are not specific to the respective filtration processes executed in the individual filtration units (12). Each filtration module (10) includes exit ports for outputting unused system fluids. The second input and exit ports are designed for establishing inter-module connections so that the system fluids can be forwarded from one filtration module (10) to an adjacent filtration module (10) of the filtration system. The modular filtration system further comprises at least one control unit (14) designed for jointly controlling the filtration processes executed in the individual filtration units (12).

13. 发明申请

WO2004096327A1 DISPENSER 审中-公开
标题翻译：饮水机
公开(公告)号：WO2004096327A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/003964
申请日：2004-04-15
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED , BARGH, Adrian, Neil
发明人： BARGH, Adrian, Neil
IPC分类号： A61M5/36
CPC分类号： A61M5/36 , A61M5/14216 , A61M5/1452
摘要： A dispensing array is disclosed which comprises a number of dispensers (10). Each of the dispensers consists of a syringe (11) and two two-port rotary valves (15, 16). The inlet two-port rotary valve (15) allows fluid to be drawn into the syringe from a reservoir and the outlet two-port rotary valve (16) allows fluid to be dispensed from a dispensing tip.
摘要翻译：公开了一种分配阵列，其包括多个分配器（10）。每个分配器由注射器（11）和两个两端口旋转阀（15,16）组成。入口双口旋转阀（15）允许流体从储存器被吸入注射器，并且出口双口旋转阀（16）允许流体从分配尖端分配。

14. 发明申请

WO2023285672A1 CONSUMABLE FOR A BIOREACTOR SYSTEM 审中-公开
公开(公告)号：WO2023285672A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/069897
申请日：2022-07-15
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： VARLEY, Mark , SULLIVAN, Sean , BARGH, Adrian Neil
IPC分类号： C12M1/12 , C12M3/00 , C12M1/06 , C12M1/00 , B01F33/00 , B01F31/42 , B01F31/445 , B01F33/81 , B01F35/33
摘要： A consumable (1) for a bioreactor system is provided. The consumable comprises a plurality of bioreaction vessels (2), each suitable for holding the contents of a bioreaction. The plurality of bioreaction vessels are provided as a single-piece construction, and each bioreaction vessel includes an agitator (4) configured to agitate the contents of the respective bioreaction vessel. Each agitator has a stirring end which extends into the bioreaction vessel and a drive end.

15. 发明申请

WO2019154700A1 SCALING TOOL 审中-公开
公开(公告)号：WO2019154700A1
公开(公告)日：2019-08-15
申请号：PCT/EP2019/052312
申请日：2019-01-31
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： STACEY, Adrian , SCHOLZ, Jochen
IPC分类号： G05B23/02 , G05B19/418
摘要： The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment. Particularly, there is provided a computer- implemented method of scaling a production process to produce a chemical, pharmaceutical and/or biotechnological product, the scaling being from a source scale to a target scale, wherein the production process is defined by a plurality of steps specified by one or more process parameters controlling an execution of the production process, the method comprising: (a) retrieving: parameter evolution information that describes the time evolution of the process parameter(s); a plurality of recipe templates, wherein a recipe comprises the plurality of steps defining the production process, and wherein a recipe template is a recipe in which at least one of the process parameters specifying the plurality of steps is a parameter being variable and having no predetermined value at the outset; (b) receiving: a source setup specification of a source setup to be used for executing the production process at the source scale, the source setup specification comprising the source scale value; a target setup specification of a target setup to be used for executing the production process at the target scale, the target setup specification comprising the target scale value; a source recipe defining the production process at the source scale; at least one acceptability function defining conditions for the values of the process parameter(s) at the source scale and/or at the target scale; (c) simulating the execution of the production process at the source scale using the source setup specification, the source recipe and the parameter evolution information; (d) determining, from the simulation, one or more source trajectories for the process parameters), wherein a trajectory corresponds to a time-based profile of values recordable during the simulated execution of the production process; (e) performing a target determination step comprising: selecting a recipe template pertinent to the production process out of the plurality of recipe templates; providing an input value for the at least one variable parameter in the selected recipe template; simulating the execution of the production process at the target scale using the target setup specification, the selected recipe template, the input value for the at least one variable parameter and the parameter evolution information; determining, from the simulation, one or more target trajectories for the process parameters; comparing the source trajectory(ies) and the target trajectory(ies); computing, based on the comparison and on the at least one acceptability function, an acceptability score for the selected recipe template; computing an optimal value for the at least one variable parameter in the selected recipe template by optimising the acceptability score and/or computing an acceptable range for the at least one variable parameter, wherein values within the acceptable range yield an acceptability score above a specific threshold; (f) if there is at least another pertinent recipe template, repeating the target determination step for at least another pertinent recipe template; (g) selecting at least one of the plurality of recipe templates and corresponding computed value(s) for variable parameters) as target recipe based on the acceptability scores computed for one or more recipe templates.

16. 发明申请

WO2018015405A1 LIQUID FILTRATION SYSTEM WITH INTEGRATED BLEED FUNCTION 审中-公开
标题翻译：集成冲洗功能的液体过滤系统
公开(公告)号：WO2018015405A1
公开(公告)日：2018-01-25
申请号：PCT/EP2017/068165
申请日：2017-07-18
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： GRANT, Paul
IPC分类号： C12M1/00 , C12M1/26 , C12M1/34
CPC分类号： C12M47/10 , C12M29/18 , C12M33/00 , C12M41/36 , C12M41/40 , C12M41/44 , C12M41/46
摘要： A liquid filtration system according to the present invention comprises a bioreactor; a filter configured to filter liquid passing therethrough; a perfusion pump configured to move liquid between the bioreactor and the filter; a liquid line providing fluidic communication between the bioreactor, perfusion pump and filter; and a bleed outlet provided on the liquid line, the bleed outlet configured to provide means to remove liquid selectively from the system under the action of the perfusion pump. With the liquid filtration system according to the present invention, both the filtering and bleed functions may be performed under the action of a single pump, thereby significantly reducing the complexity and cost of the components required.
摘要翻译：根据本发明的液体过滤系统包括生物反应器; 配置成过滤通过其中的液体的过滤器; 灌注泵，其被配置为在生物反应器和过滤器之间移动液体; 在生物反应器，灌注泵和过滤器之间提供流体连通的液体管线; 以及设置在液体管线上的排出口，排出口构造成提供在灌注泵的作用下从系统选择性地去除液体的装置。利用根据本发明的液体过滤系统，可以在单个泵的作用下执行过滤和排出功能，从而显着降低所需组件的复杂性和成本。

17. 发明申请

WO2018015406A1 LIQUID FILTRATION AND PUMP SYSTEM 审中-公开
标题翻译：液体过滤和泵系统
公开(公告)号：WO2018015406A1
公开(公告)日：2018-01-25
申请号：PCT/EP2017/068166
申请日：2017-07-18
申请人： THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
发明人： GRANT, Paul
IPC分类号： C12M1/26 , C12M1/12 , C12M1/00 , C12M1/34 , B01D63/02 , C12M1/36
CPC分类号： C12M29/10 , B01D29/01 , B01D29/52 , B01D29/90 , C12M29/00 , C12M29/04 , C12M29/12 , C12M33/04 , C12M37/02 , C12M37/04 , C12M41/48 , C12M47/10
摘要： A liquid filtration system according to the present invention comprises a syringe pump comprising a gas chamber and a movable plunger, wherein the gas chamber has an aperture at a first end and the plunger forms a seal within the internal walls of the chamber; a liquid chamber having two openings, the openings positioned at opposite ends of the chamber and the first opening connected to the aperture of the gas chamber; a bioreactor in fluidic communication with the second opening of the liquid chamber; a filter arranged to filter liquid passing between the bioreactor and the liquid chamber, the filter comprising a permeate outlet for removing filtered liquid; wherein, in use, the plunger may be moved in a reciprocating motion causing a corresponding movement of gas which drives liquid alternately between the liquid chamber and the bioreactor such that liquid passes through the filter and filtered liquid may be removed via the permeate outlet.
摘要翻译：根据本发明的液体过滤系统包括注射泵，该注射泵包括气体腔室和可移动柱塞，其中气体腔室在第一端具有孔，并且柱塞在内部形成密封房间的墙壁; 具有两个开口的液体腔室，所述开口位于所述腔室的相对端部处，并且所述第一开口连接至所述气体腔室的所述开口; 与液体腔室的第二开口流体连通的生物反应器; 布置成过滤在生物反应器和液体室之间通过的液体的过滤器，所述过滤器包括用于除去过滤液体的渗透物出口; 其中在使用中，柱塞可以以往复运动的方式运动，引起气体的相应运动，所述气体在液体室和生物反应器之间交替地驱动液体，使得液体通过过滤器，并且过滤后的液体可以通过渗透物出口移除。 / p>

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