专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2010094663A1 INACTIVATED DENGUE VIRUS VACCINE WITH ALUMINIUM-FREE ADJUVANT 审中-公开
标题翻译：灭活的登革热疫苗与无铝辅料
公开(公告)号：WO2010094663A1
公开(公告)日：2010-08-26
申请号：PCT/EP2010/051882
申请日：2010-02-16
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BARAS, Benoit , GHEYSEN, Dirk , KNOTT, Isabelle, Solange, Lucie , PRIEELS, Jean-Paul , TOUSSAINT, Jean-Francois
发明人： BARAS, Benoit , GHEYSEN, Dirk , KNOTT, Isabelle, Solange, Lucie , PRIEELS, Jean-Paul , TOUSSAINT, Jean-Francois
IPC分类号： C07K14/18 , A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/55583 , C12N2770/24134 , Y02A50/386
摘要： The present disclosure provides immunogenic compositions for the prevention and/or treatment of disease caused by dengue virus.
摘要翻译：本公开提供用于预防和/或治疗由登革热病毒引起的疾病的免疫原性组合物。

12. 发明申请

WO0074716A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO0074716A2
公开(公告)日：2000-12-14
申请号：PCT/EP0005164
申请日：2000-06-06
申请人： SMITHKLINE BEECHAM BIOLOG , PRIEELS JEAN PAUL
发明人： PRIEELS JEAN-PAUL
IPC分类号： A61K39/00 , A61P37/08 , A61K39/385
CPC分类号： A61K39/0008 , A61K2039/5555 , A61K2039/55577 , A61K2039/6068
摘要： The present invention provides a composition for the prophylaxis or treatment of allergy. The composition comprises a plurality of allergy peptides linked together by an inert carrier; characterised in that said allergy peptides are derived from IgE or IgE receptor, and that the inert carrier does not contain a peptidic T-cell helper epitope which is capable of binding to an MHC molecule and is capable of stimulating T-cell proliferation, and in a preferred embodiment the carrier does not provide bystander T-cell cytokine help in the induction of the anti-peptide immune response. Also provided are methods of their manufacture and their use in medicine. There is also provided a method of treatment of allergy comprising priming the immune system with an IgE peptide/protein conjugate, followed by boosting the immune response with a composition of the present invention.
摘要翻译：本发明提供了用于预防或治疗过敏的组合物。该组合物包含多个通过惰性载体连接在一起的过敏肽; 其特征在于，所述过敏肽衍生自IgE或IgE受体，并且惰性载体不含有能够结合MHC分子并能够刺激T细胞增殖的肽T细胞辅助表位，并且在载体不提供旁观者T细胞细胞因子有助于诱导抗肽免疫应答的优选实施方案。还提供了它们的制造方法及其在医学中的应用。还提供了一种治疗过敏的方法，包括用IgE肽/蛋白质缀合物引发免疫系统，随后用本发明的组合物增强免疫应答。

13. 发明申请

WO1998018819A1 PURIFICATION OF RESPIRATORY SYNCYTIAL VIRUS ANTIGENS 审中-公开
标题翻译：呼吸道同源性病毒抗原的纯化
公开(公告)号：WO1998018819A1
公开(公告)日：1998-05-07
申请号：PCT/EP1997006016
申请日：1997-10-27
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , BOLLEN, Alex , GHEYSEN, Dirk , HOUARD, Sophie , PRIEELS, Jean-Paul , SLAOUI, Moncef, Mohamed , VAN OPSTAL, Omar , ANDRE, Christophe, Jacques, Robert
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： C07K14/135
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/18522
摘要： The present invention relates to purification of respiratory syncytial virus (RSV) proteins and for use in vaccines.
摘要翻译：本发明涉及呼吸道合胞病毒（RSV）蛋白的纯化并用于疫苗。

14. 发明申请

WO1994000153A1 VACCINE COMPOSITION CONTAINING ADJUVANTS 审中-公开
标题翻译：含有ADJUVANTS的疫苗组合物
公开(公告)号：WO1994000153A1
公开(公告)日：1994-01-06
申请号：PCT/EP1993001524
申请日：1993-06-15
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , PRIEELS, Jean-Paul , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude , SLAOUI, Moncef , PALA, Pietro
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K39/39
CPC分类号： A61K39/292 , A61K39/015 , A61K39/12 , A61K39/245 , A61K39/29 , A61K39/39 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2730/10134 , Y02A50/412 , Y02A50/464
摘要： The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and (gamma) IFN responses.
摘要翻译：本发明提供包含3个De-O-酰化单磷酰脂质A和QS21的疫苗组合物。疫苗组合物是CTL和（γ）IFN应答的有效诱导剂。

15. 发明申请

WO1992016231A1 HERPES SIMPLEX VACCINE COMPRISING HSV GLYCOPROTEIN gD AND 3 dEACYLATED MONOPHOSPHORYL LIPID A 审中-公开
标题翻译：含有HSV GLYCOPROTEIN GD和3种乙酰单磷酸脂酸酯的简单真菌
公开(公告)号：WO1992016231A1
公开(公告)日：1992-10-01
申请号：PCT/EP1992000592
申请日：1992-03-17
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , FRANCOTTE, Myriam , PRIEELS, Jean-Paul , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2710/16634
摘要： Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.
摘要翻译：提供新型单纯疱疹（HSV）疫苗制剂。这些包括HSV糖蛋白gD或与3个去酰基化单磷酰脂质A结合的免疫学片段。

16. 发明申请

WO1992011291A1 VACCINES BASED ON HEPATITIS B SURFACE ANTIGEN 审中-公开
标题翻译：基于乙型肝炎表面抗原的疫苗
公开(公告)号：WO1992011291A1
公开(公告)日：1992-07-09
申请号：PCT/EP1991002422
申请日：1991-12-16
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , VAN WIJNENDALE, Frans , BAIJOT, Michelle , PRIEELS, Jean-Paul
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C07K15/04
CPC分类号： C07K14/005 , C07K19/00 , C12N2730/10122
摘要： Novel antigen are presented which are useful in vaccine formulations for the prophylactic treatment of a range of infectious diseases. The antigens comprise a hybrid polypeptide, one part being the S antigen of the hepatitis B virus, the other being a heterologous antigen, such as gD from HSV. The two antigens are linked by chemical spacers through a native sulphydryl group present on the surface of the S antigen.
摘要翻译：提供了可用于预防性治疗一系列感染性疾病的疫苗制剂中的新型抗原。抗原包括杂合多肽，其中一部分是乙型肝炎病毒的S抗原，另一部分是异源抗原，例如来自HSV的gD。两种抗原通过化学间隔物通过存在于S抗原表面上的天然巯基连接。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式