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11. 发明申请

WO2004052415A1 ABSORBENT HYDROGEL COMPOSITIONS 审中-公开
标题翻译：吸收水凝胶组合物
公开(公告)号：WO2004052415A1
公开(公告)日：2004-06-24
申请号：PCT/GB2003/005432
申请日：2003-12-12
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , HOSKINS, Richard , SAINZ GARCIA, Susana , BURGESS, Helen , BARNES, Justin
发明人： MUNRO, Hugh, Semple , HOSKINS, Richard , SAINZ GARCIA, Susana , BURGESS, Helen , BARNES, Justin
IPC分类号： A61L15/58
CPC分类号： A61L15/60 , A61B5/04087 , A61L15/425 , A61L15/58 , A61N1/0428 , A61N1/0456 , A61N1/046 , A61N1/0468 , A61N1/0496 , C08L33/08
摘要： The invention provides an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive. The porous hydrogel has wide applicability, e.g. in wound or burn dressings, biomedical electrodes, etc., as an absorbent and/or adhesive component.
摘要翻译：本发明提供一种吸收剂（多孔）水凝胶组合物，其包含泡沫部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，以及包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的连续部分。水凝胶组合物的连续部分包括通过连续部分的外表面和泡沫部分之间的连续部分提供流体流动连通的孔，由此泡沫部分可以通过孔的部分将外部水或其它流体吸收到多孔结构中连续部分。水凝胶组合物的连续部分可能对皮肤发粘，允许其用作生物粘合剂。多孔水凝胶具有广泛的适用性，例如作为吸收剂和/或粘合剂组分的伤口或烧伤敷料，生物医学电极等。

12. 发明申请

WO2004052414A1 ABSORBENT MULTILAYER HYDROGEL WOUND DRESSINGS 审中-公开
标题翻译：吸收式多层液压龙头连衣裙
公开(公告)号：WO2004052414A1
公开(公告)日：2004-06-24
申请号：PCT/GB2003/005460
申请日：2003-12-12
申请人： JOHNSON & JOHNSON MEDICAL LIMITED , MUNRO, Hugh, Semple , SILCOCK, Derek , BAYLIFF, Simon, William , HOSKINS, Richard , GARCIA, Susana, Sainz , BURGESS, Helen , BARNES, Justin
发明人： MUNRO, Hugh, Semple , SILCOCK, Derek , BAYLIFF, Simon, William , HOSKINS, Richard , GARCIA, Susana, Sainz , BURGESS, Helen , BARNES, Justin
IPC分类号： A61L15/42
CPC分类号： A61L15/60 , A61L15/425 , A61L15/58
摘要： The invention provides wound dressings comprising an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticised hydrophilic polymer matrix having relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive.
摘要翻译：本发明提供了包含吸收剂（多孔）水凝胶组合物的伤口敷料，其包含泡沫部分，该泡沫部分包括具有内部细胞结构的柔性增塑的亲水性聚合物基质，以及包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的连续部分。水凝胶组合物的连续部分包括通过连续部分的外表面和泡沫部分之间的连续部分提供流体流动连通的孔，由此泡沫部分可以通过孔的部分将外部水或其它流体吸收到多孔结构中连续部分。水凝胶组合物的连续部分可能对皮肤发粘，允许其用作生物粘合剂。

13. 发明申请

WO2007113453A1 ABSORBENT HYDROGEL COMPOSITES 审中-公开
标题翻译：吸收水凝胶复合材料
公开(公告)号：WO2007113453A1
公开(公告)日：2007-10-11
申请号：PCT/GB2006/001218
申请日：2006-04-03
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
发明人： MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
IPC分类号： A61L15/60 , A61L15/26 , A61L15/42
CPC分类号： A61L15/26 , A61L15/42 , A61L15/60
摘要： The invention provides an absorbent material or article comprising an absorbent hydrogel composite sheet. The sheet includes an absorbent layer part having two major faces which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a second part which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The second part may be associated with the layer part such that the second part infiltrates some but not all of the cellular voids of the absorbent layer part over a major face of the absorbent layer part. Alternatively, the second part may be associated with the layer part such that the second part overlies a major face of the absorbent layer part. By this arrangement, some but not all of the absorbent layer part is effectively exposed for absorption of external water or other fluid through the side of the sheet corresponding to that said major face of the absorbent layer.
摘要翻译：本发明提供了一种包含吸收性水凝胶复合片材的吸收材料或制品。片材包括具有两个主表面的吸收层部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，和包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的第二部分。第二部分可以与层部分相关联，使得第二部分在吸收层部分的主表面上渗透吸收层部分的一些但不是全部的细胞空隙。或者，第二部分可以与层部分相关联，使得第二部分覆盖在吸收层部分的主表面上。通过这种布置，一些但不是全部的吸收层部分被有效地暴露以吸收外部水或其它流体通过与吸收层的所述主面对应的片材的侧面。

14. 发明申请

WO2003051408A1 HYDROGEL COMPOSITIONS COMPRISING AN ACRYLOYL MORPHOLINE POLYMER 审中-公开
标题翻译：包含丙烯酸多羟基聚合物的水凝胶组合物
公开(公告)号：WO2003051408A1
公开(公告)日：2003-06-26
申请号：PCT/GB2002/005681
申请日：2002-12-13
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , CERDAN, Carine , HOSKINS, Richard
发明人： MUNRO, Hugh, Semple , CERDAN, Carine , HOSKINS, Richard
IPC分类号： A61L15/24
CPC分类号： C08F20/58 , A61L15/425 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L26/008 , A61L26/0085 , C08L39/04
摘要： The invention provides a hydrogel composition comprising a plasticised cross-linked hydrophilic polymer of acryloyl morpholine and optionally one or more comonomers.
摘要翻译：本发明提供一种水凝胶组合物，其包含丙烯酰吗啉的可塑化的交联亲水性聚合物和任选的一种或多种共聚单体。

15. 发明申请

WO2010007436A3 COMPOSITIONS FOR USE AS OR IN WOUND DRESSINGS 审中-公开
公开(公告)号：WO2010007436A3
公开(公告)日：2010-01-21
申请号：PCT/GB2009/050870
申请日：2009-07-16
申请人： FIRST WATER LIMITED , MUNRO, Hugh Semple , ANDREWS, Philip
发明人： MUNRO, Hugh Semple , ANDREWS, Philip
IPC分类号： A61L15/22 , A61L15/28 , A61L15/42 , A61L15/60
摘要： The present invention provides a composition for the treatment of a wound, the composition comprising: a first layer, which comprises a porous, optionally hydrophilic material capable of absorbing fluid from the wound at least in part by capilliary action, a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer, wherein, in the treatment, the first layer is disposed closer to the wound than the second layer and the composition modulates the concentration of dissolved ions in the fluid in the wound. The present invention further provides uses of the composition and methods of making the composition.

16. 发明申请

WO2010007436A2 COMPOSITIONS FOR USE AS OR IN WOUND DRESSINGS 审中-公开
标题翻译：组合物用作或在连衣裙中使用
公开(公告)号：WO2010007436A2
公开(公告)日：2010-01-21
申请号：PCT/GB2009050870
申请日：2009-07-16
申请人： FIRST WATER LTD , MUNRO HUGH SEMPLE , ANDREWS PHILIP
发明人： MUNRO HUGH SEMPLE , ANDREWS PHILIP
IPC分类号： A61L15/22 , A61L15/28 , A61L15/42 , A61L15/60
CPC分类号： A61L15/60 , A61L15/425
摘要： The present invention provides a composition for the treatment of a wound, the composition comprising: a first layer, which comprises a porous, optionally hydrophilic material capable of absorbing fluid from the wound at least in part by capilliary action, a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer, wherein, in the treatment, the first layer is disposed closer to the wound than the second layer and the composition modulates the concentration of dissolved ions in the fluid in the wound. The present invention further provides uses of the composition and methods of making the composition.
摘要翻译：本发明提供了一种用于治疗伤口的组合物，该组合物包括：第一层，其包含多孔的，任选亲水的材料，其能够至少部分地通过毛细作用从伤口吸收流体;第二层，包含吸收剂水凝胶，所述第一层与所述第二层相关联，其中在所述处理中，所述第一层被设置为比所述第二层更靠近所述伤口，并且所述组合物调节所述伤口中流体中的溶解离子的浓度。本发明还提供组合物的用途和制备该组合物的方法。

17. 发明申请

WO2009098518A2 HYDROGEL COMPOSITES AND WOUND DRESSINGS 审中-公开
标题翻译： HYDROGEL复合材料和连衣裙
公开(公告)号：WO2009098518A2
公开(公告)日：2009-08-13
申请号：PCT/GB2009/050121
申请日：2009-02-06
申请人： FIRST WATER LIMITED , MUNRO, Hugh Semple , ANDREWS, Philip , JEFFREY, Charles
发明人： MUNRO, Hugh Semple , ANDREWS, Philip , JEFFREY, Charles
IPC分类号： A61L15/22 , A61L15/60 , A61F13/00
CPC分类号： A61L15/22 , A61L15/60
摘要： The present invention provides an absorbent hydrogel composite for use in the manufacture of an article for application to a fluid-emitting surface, e.g. a wound, the composite having a laminar structure comprising first and second layers, the first layer being a surface contacting layer comprising a porous net structure having a surface contacting face and an outwardly directed face, the second layer comprising a low-crosslinked absorbent hydrogel disposed over the outwardly directed face of the first layer and arranged so that in use it is in fluid flow communication with the surface through apertures of the net structure.
摘要翻译：本发明提供一种用于制造用于流体发射表面的制品的吸收性水凝胶复合材料，所述复合材料具有包括第一和第二层的层状结构，所述第一层是包括具有表面接触面和向外指向表面的多孔网结构的表面接触层，所述第二层包含低交联吸收性水凝胶在第一层的向外指向的表面上并且布置成使得在使用中它通过网状结构的孔与表面流体连通。

18. 发明申请

WO2009090403A1 HYDROGEL CO-POLYMER COMPOSITION AND ITS USES, FOR EXAMPLE AS A WOUND DRESSING 审中-公开
标题翻译： HYDROGEL共聚合物组合物及其用途，例如作为一个创造性的连接
公开(公告)号：WO2009090403A1
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000128
申请日：2009-01-16
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , BOOTE, Nicholas
发明人： MUNRO, Hugh, Semple , BOOTE, Nicholas
IPC分类号： A61L15/58 , A61L24/06 , C08F220/58
CPC分类号： A61K31/795 , A61L15/60 , A61L26/0014 , A61L26/008 , C08F220/58
摘要： The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanohwater partition coefficient LogP value of less than 0, and, the LogP value of the first monomer is greater (more positive) than the second monomer. Preferably the difference between the LogP value for the two monomers is at least 0.1, preferably at least 0.2. The difference between the LogP value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same.
摘要翻译：本发明提供一种水凝胶组合物，优选用于治疗伤口，其包含携带多个侧阴离子基团的亲水性共聚物，其中该聚合物衍生自第一单体和第二单体，其中两种单体具有八氢水分配系数LogP 值小于0，第一单体的LogP值比第二单体大（更正）。优选地，两种单体的LogP值之间的差异为至少0.1，优选至少为0.2。两个单体的LogP值之间的差值优选小于2.水凝胶组合物中第一单体/第二单体的重量比（w / w）优选等于或大于约1.侧阴离子基团可以是磺酰基，例如磺酸基或其盐。第一和第二单体中的阴离子基团可以是盐形式，两个单体的抗衡离子优选相同。

19. 发明申请

WO2007007115A2 TREATMENT OF CHRONIC ULCEROUS SKIN LESIONS 审中-公开
标题翻译：治疗慢性溃疡性皮肤病
公开(公告)号：WO2007007115A2
公开(公告)日：2007-01-18
申请号：PCT/GB2006002632
申请日：2006-07-14
申请人： FIRST WATER LTD , MUNRO HUGH SEMPLE
发明人： MUNRO HUGH SEMPLE
CPC分类号： A61L26/008 , A61L26/0009 , A61L26/0014 , C08L101/02
摘要： The invention provides a method of treating a wound (for example, a chronic ulcerous skin lesion) in a human or non-human mammal (particularly a human). The wound is contacted with a topical hydrogel composition comprising a hydrophilic polymer carrying multiple pendant sulphonyl groups, optionally with multiple pendant carboxylic groups, on each polymer molecule.
摘要翻译：本发明提供了治疗人或非人哺乳动物（特别是人）的伤口（例如，慢性溃疡性皮肤损伤）的方法。在每个聚合物分子上使伤口与包含携带多个侧磺酰基的亲水性聚合物（任选地具有多个侧羧基）的局部水凝胶组合物接触。

20. 发明申请

WO2004028255A1 ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：WO2004028255A1
公开(公告)日：2004-04-08
申请号：PCT/GB2003/004098
申请日：2003-09-25
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , BURGESS, Helen
发明人： MUNRO, Hugh, Semple , BURGESS, Helen
IPC分类号： A01N59/00
CPC分类号： A01N59/16 , A01N2300/00
摘要： The invention relates to the use, in an antimicrobial composition comprising (a) an antimicrobially effective amount of a dissolved antimicrobial metal ion and (b) a dissolved halide ion present in a molar excess relative to the metal ion, of a sufficient excess of the halide ion to stabilise the antimicrobial activity of the metal ion against loss on exposure to light and gamma radiation.
摘要翻译：本发明涉及在抗微生物组合物中使用，其包含（a）抗微生物有效量的溶解的抗微生物金属离子和（b）相对于金属离子以摩尔过量存在的溶解的卤离子，其足够过量的卤化物离子以稳定金属离子的抗微生物活性，防止在暴露于光和γ辐射下的损失。

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