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11. 发明申请

WO1995030004A1 MONOCLONAL ANTIBODIES WHICH PROMOTE CENTRAL NERVOUS SYSTEM REMYELINATION 审中-公开
标题翻译：促进中央神经系统复苏的单克隆抗体
公开(公告)号：WO1995030004A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005262
申请日：1995-04-27
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , RODRIGUEZ, Moses , MILLER, David, J.
发明人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
IPC分类号： C12N15/13
CPC分类号： C07K16/18 , A61K38/00 , Y10S530/809 , Y10S530/839 , Y10S530/863
摘要： Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determinants on glial cells.
摘要翻译：公开了当给予患有脱髓鞘疾病的哺乳动物时促进中枢神经系统髓鞘再生的单克隆IgM抗体。这些抗体显示多器官自身反应性，并识别胶质细胞上的表面和细胞质决定因素。

12. 发明申请

WO1984000948A1 APPARATUS AND METHOD FOR UNLOADING BULK MATERIALS 审中-公开
标题翻译：卸载大容量材料的装置和方法
公开(公告)号：WO1984000948A1
公开(公告)日：1984-03-15
申请号：PCT/US1983001349
申请日：1983-09-01
申请人： MILLER, David, J. , MILLER, Allen, R. , MILLER, Charles, P.
IPC分类号： B65G63/04
CPC分类号： B65G67/606 , B65G53/48 , B65G65/22
摘要： An unloader (8) for bulk materials (3) to transfer material such as cement from a barge (2) or other bulk container. It includes a moveable and rotatable support (12) such as a crane or cantilevered arm that is adjacent the bulk container. A first conveyor (14) or auger is connected to the support for pivotal movement and extends generally horizontally. A second conveyor (16) or auger is connected to the distal end of the first conveyor for pivotal movement and is generally vertically oriented. A feeder (18) is connected to the distal end of the second conveyor for universal and rotational movement. The feeder includes an uplift portion (72) communicating with the second conveyor, the uplift portion advancing the bulk material at a rate slower than the second conveyor, and a collector portion (74) communicating with the uplift portion. The collector portion includes converging augers (80, 82) to advance the bulk material towards the uplift portion and to assist in transferring it into the uplift portion. The apparatus may further include a selectively operable energy responsive aeration system (150, 152, 154) to inject air into the bulk material while it is being handled by the unloader, a scraper (110, 112) attached to the feeder to assist in removing the last of the bulk material from its container, and a take-away mechanism (130) to transport the bulk material away from the unloader.

13. 发明申请

WO2011119195A3 MODERN HYDRIDE VAPOR-PHASE EPITAXY SYSTEM & METHODS 审中-公开
标题翻译：现代氢气蒸气相外延系统与方法
公开(公告)号：WO2011119195A3
公开(公告)日：2012-01-12
申请号：PCT/US2010062610
申请日：2010-12-30
申请人： CBL TECHNOLOGIES INC , SOLOMON GLENN S , MILLER DAVID J
发明人： SOLOMON GLENN S , MILLER DAVID J
IPC分类号： H01L21/205
CPC分类号： C30B29/406 , C30B25/08 , C30B25/10
摘要： Hydride vapor-phase deposition (HVPE) systems are disclosed. An HVPE hydride vapor-phase deposition system may include a reactant source chamber and a growth chamber containing a susceptor coupled to the reactant source chamber. The reactant source chamber may be configured to create a reactant gas through a chemical reaction between a solid or liquid precursor and a different precursor gas. The reactant source chamber can be configured to operate at a temperature T(M) significantly above room temperature. The reactant gas can be chemically unstable at or near room temperature. The susceptor is configured to receive a substrate and maintain the substrate at a substrate temperature T(S). The growth chamber includes walls can be configured to operate at a temperature T(C) such that T(M), T(S) are greater than T(C).
摘要翻译：公开了氢化物气相沉积（HVPE）系统。 HVPE氢化物气相沉积系统可以包括反应物源室和包含耦合到反应物源室的基座的生长室。反应物源室可经配置以通过固体或液体前体与不同前体气体之间的化学反应产生反应气体。反应物源室可以被配置为在明显高于室温的温度T（M）下操作。反应物气体在室温或室温下可能化学不稳定。基座构造成接收基板并将基板保持在基板温度T（S）。生长室包括壁可被配置成在温度T（℃）下操作使得T（M），T（S）大于T（℃）。

14. 发明申请

WO2010057141A3 ALPHAVIRUS INHIBITORS AND USES THEREOF 审中-公开
标题翻译： ALPHAVIRUS抑制剂及其用途
公开(公告)号：WO2010057141A3
公开(公告)日：2010-09-16
申请号：PCT/US2009064672
申请日：2009-11-17
申请人： UNIV MICHIGAN , MILLER DAVID J , PELTIER DANIEL C , PENG WEIPING
发明人： MILLER DAVID J , PELTIER DANIEL C , PENG WEIPING
IPC分类号： C07D495/04 , A61K31/4535 , A61P31/12 , C07D409/14
CPC分类号： C07D495/04 , A61K31/4535
摘要： The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of alphaviruses.
摘要翻译：本发明涉及化学化合物，其发现方法及其治疗用途。特别地，本发明提供作为甲病毒抑制剂的化合物。

15. 发明申请

WO2004077012A3 METHODS AND SYSTEMS FOR CONTROLLING AND/OR INCREASING IONTOPHORETIC FLUX 审中-公开
标题翻译：用于控制和/或增加IOPOPHORETIC FLUX的方法和系统
公开(公告)号：WO2004077012A3
公开(公告)日：2006-09-08
申请号：PCT/US2004004126
申请日：2004-02-13
申请人： ACIONT INC , HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
发明人： HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/30 , A61N1/327
摘要： An iontophoretic method is provided to selectively transport a compound of interest through a localized region of an individual's body tissue that exhibits a low electrical resistance and/or a high permeability. The method involves placing a permselective material, typically having a resistance comparable or higher than the resistance of the localized region, in ion-conducting relation to the localized region. An electrical current is then applied through the permselective material to the localized region, thereby transporting the compound of interest iontophoretically through the localized region. When the permselective material is capable of hindering iontophoretic transport of a competing ion, the transference efficiency of the compound of interest is increased during iontophoresis. As a result, the compound of interest is delivered into or extracted from the localized region at an enhanced rate. As transport efficiencies approach unity, absolute predictivity of transport also becomes possible. Also provided are electrode assemblies and iontophoretic systems capable of carrying out the iontophoretic method.
摘要翻译：提供离子电渗疗法以选择性地将感兴趣的化合物输送通过显示低电阻和/或高渗透性的个体身体组织的局部区域。该方法包括将通常具有与局部区域的电阻相当或更高的电阻的选择性选择材料置于与局部区域的离子传导关系中。然后通过选择选择材料将电流施加到局部区域，从而通过局部区域输送离子电渗透的化合物。当选择选择性材料能够阻碍竞争离子的离子电渗转运时，在离子电渗中增加感兴趣的化合物的转移效率。结果，感兴趣的化合物以增强的速率被递送到局部区域或从局部区域提取。随着运输效率达到统一，运输的绝对预测也成为可能。还提供了能够进行离子电渗法的电极组件和离子电渗系统。

16. 发明申请

WO2004077012A2 METHODS AND SYSTEMS FOR CONTROLLING AND/OR INCREASING IONTOPHORETIC FLUX 审中-公开
标题翻译：用于控制和/或增加IOPOPHORETIC FLUX的方法和系统
公开(公告)号：WO2004077012A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/004126
申请日：2004-02-13
申请人： ACIONT, INC. , HIGUCHI, William, I. , MILLER, David, J. , LI, Kevin, S.
发明人： HIGUCHI, William, I. , MILLER, David, J. , LI, Kevin, S.
IPC分类号： G01N
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/30 , A61N1/327
摘要： An iontophoretic method is provided to selectively transport a compound of interest through a localized region of an individual's body tissue that exhibits a low electrical resistance and/or a high permeability. The method involves placing a permselective material, typically having a resistance comparable or higher than the resistance of the localized region, in ion-conducting relation to the localized region. An electrical current is then applied through the permselective material to the localized region, thereby transporting the compound of interest iontophoretically through the localized region. When the permselective material is capable of hindering iontophoretic transport of a competing ion, the transference efficiency of the compound of interest is increased during iontophoresis. As a result, the compound of interest is delivered into or extracted from the localized region at an enhanced rate. As transport efficiencies approach unity, absolute predictivity of transport also becomes possible. Also provided are electrode assemblies and iontophoretic systems capable of carrying out the iontophoretic method.
摘要翻译：提供离子电渗疗法以选择性地将感兴趣的化合物输送通过显示低电阻和/或高渗透性的个体身体组织的局部区域。该方法包括将通常具有与局部区域的电阻相当或更高的电阻的选择性选择材料置于与局部区域的离子传导关系中。然后通过选择选择材料将电流施加到局部区域，从而通过局部区域输送离子电渗透的化合物。当选择选择性材料能够阻碍竞争离子的离子电渗转运时，在离子电渗中增加感兴趣的化合物的转移效率。结果，感兴趣的化合物以增强的速率被递送到局部区域或从局部区域提取。随着运输效率达到统一，运输的绝对预测也成为可能。还提供了能够进行离子电渗法的电极组件和离子电渗系统。

17. 发明申请

WO2012154657A2 ROBUST ANOMALY DETECTION AND REGULARIZED DOMAIN ADAPTATION OF CLASSIFIERS WITH APPLICATION TO INTERNET PACKET-FLOWS 审中-公开
标题翻译：具有适用于互联网分组流的分类器的稳健异常检测和定期的域名适配
公开(公告)号：WO2012154657A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/036752
申请日：2012-05-07
申请人： THE PENN STATE RESEARCH FOUNDATION , MILLER, David, J , KESIDIS, George , RAGHURAM, Jayaram
发明人： MILLER, David, J , KESIDIS, George , RAGHURAM, Jayaram
IPC分类号： G06F11/08
CPC分类号： G06F21/554 , H04L63/0227 , H04L63/1425
摘要： Sound, robust methods identify the most suitable, parsimonious set of tests to use with respect to prioritized, sequential anomaly detection in a collected batch of sample data. While the focus is on detecting anomalies in network traffic flows and classifying network traffic flows into application types, the methods are also applicable to other anomaly detection and classification application settings, including detecting email spam, (e.g. credit card) fraud detection, detecting imposters, unusual event detection (for example, in images and video), host-based computer intrusion detection, detection of equipment or complex system failures, as well as of anomalous measurements in scientific experiments.
摘要翻译：声音，强健的方法确定了在收集的批次样本数据中对优先顺序的异常检测使用的最合适，简约的测试集。虽然重点是检测网络流量流中的异常，并将网络流量流分类为应用类型，但该方法也适用于其他异常检测和分类应用设置，包括检测电子邮件垃圾邮件（例如信用卡）欺诈检测，检测骗子，异常事件检测（例如图像和视频），基于主机的计算机入侵检测，设备检测或复杂的系统故障，以及科学实验中的异常测量。

18. 发明申请

WO2011119195A2 MODERN HYDRIDE VAPOR-PHASE EPITAXY SYSTEM & METHODS 审中-公开
标题翻译：现代氢气蒸气相外延系统与方法
公开(公告)号：WO2011119195A2
公开(公告)日：2011-09-29
申请号：PCT/US2010/062610
申请日：2010-12-30
申请人： CBL TECHNOLOGIES, INC. , SOLOMON, Glenn S. , MILLER, David J.
发明人： SOLOMON, Glenn S. , MILLER, David J.
CPC分类号： C30B29/406 , C30B25/08 , C30B25/10
摘要： Hydride vapor-phase deposition (HVPE) systems are disclosed. An HVPE hydride vapor-phase deposition system may include a reactant source chamber and a growth chamber containing a susceptor coupled to the reactant source chamber. The reactant source chamber may be configured to create a reactant gas through a chemical reaction between a solid or liquid precursor and a different precursor gas. The reactant source chamber can be configured to operate at a temperature T(M) significantly above room temperature. The reactant gas can be chemically unstable at or near room temperature. The susceptor is configured to receive a substrate and maintain the substrate at a substrate temperature T(S). The growth chamber includes walls can be configured to operate at a temperature T(C) such that T(M), T(S) are greater than T(C).
摘要翻译：公开了氢化物气相沉积（HVPE）系统。 HVPE氢化物气相沉积系统可以包括反应物源室和包含耦合到反应物源室的基座的生长室。反应物源室可经配置以通过固体或液体前体与不同前体气体之间的化学反应产生反应气体。反应物源室可以被配置为在明显高于室温的温度T（M）下操作。反应物气体在室温或室温下可能化学不稳定。基座构造成接收基板并将基板保持在基板温度T（S）。生长室包括壁可被配置成在温度T（℃）下操作使得T（M），T（S）大于T（℃）。

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