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11. 发明申请

WO2007084670A3 SPECIFIC THERAPY USING INTEGRIN LIGANDS FOR TREATING CANCER 审中-公开
标题翻译：使用整合配体治疗癌症的特殊治疗
公开(公告)号：WO2007084670A3
公开(公告)日：2007-11-22
申请号：PCT/US2007001446
申请日：2007-01-18
申请人： MERCK PATENT GMBH , GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
发明人： GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
IPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K41/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K38/12 , A61K41/00 , A61K2300/00
摘要： The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.
摘要翻译：本发明涉及用于治疗肿瘤和肿瘤转移的组合疗法，其包括施用整联蛋白配体，优选整联蛋白拮抗剂，以及当与所述配体连续施用时具有协同效力的辅助治疗剂或疗法形式，例如化疗剂和或放射疗法。该疗法导致每种单独治疗剂对肿瘤细胞增殖的抑制作用的协同潜在增加，产生比通过同时或不在本发明的剂量方案中单独施用单独组分而发现的更有效的治疗。

12. 发明申请

WO0049871A9 AN ANTI-ANGIOGENIC KRINGLE PROTEIN AND ITS MUTANTS 审中-公开
标题翻译：抗神经生长因子蛋白及其突变体
公开(公告)号：WO0049871A9
公开(公告)日：2002-06-20
申请号：PCT/US0004798
申请日：2000-02-24
申请人： FORD HENRY HEALTH SYSTEM , DOU DEXIAN , CHOPP MICHAEL , WANG LEI , MIKKELSEN TOM
发明人： DOU DEXIAN , CHOPP MICHAEL , WANG LEI , MIKKELSEN TOM
IPC分类号： A61K38/00 , C07K14/78 , C12N9/68 , C12N9/72 , A01N37/18 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C12N9/6435 , A61K38/00 , C07K14/78 , C07K2319/00 , C12N9/6459 , C12Y304/21007 , C12Y304/21069
摘要： There is provided a pharmaceutical composition including at least one kringle protein and a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating a disease by administering an effective amount of a compound from the group consisting of kringle proteins, KED and a kringle derived from the tPA protein.
摘要翻译：提供了包含至少一种三环蛋白和药学上可接受的载体的药物组合物。本发明还提供了一种治疗疾病的方法，该方法是通过施用有效量的由来自tPA蛋白的三环蛋白，KED和三环的组合组成的组。

13. 发明申请

WO2010075230A2 BODY SUPPORT WITH FLUID SYSTEM AND METHOD OF OPERATING SAME 审中-公开
标题翻译：具有流体系统的身体支持及其操作方法
公开(公告)号：WO2010075230A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/068814
申请日：2009-12-18
申请人： TEMPUR-PEDIC MANAGEMENT, INC. , MIKKELSEN, Tom, D. , CHANDLER, Kelly, W.
发明人： MIKKELSEN, Tom, D. , CHANDLER, Kelly, W.
IPC分类号： A47C27/08
CPC分类号： A47C21/044 , A47C27/144 , A47C27/15
摘要： A body support assembly comprising a first layer (e.g., a visco-elastic foam) having a lower surface, and a second layer supporting the first layer and having an upper surface. One of the upper and lower surfaces is defined by a non-planar surface to define a plurality of passages. A fan is positioned to move air through the passages. Preferably, the non-planar surface comprises a plurality of protrusions (e.g., a convoluted surface). The body support can further comprise a sensor that detects a parameter and produces a signal, and a controller coupled to the sensor and programmed to control the fan. Multiple fans and sensors can be provided, and the controller can control the fans to provide different air flows through different locations of the body support assembly. A user interface can be coupled to the controller to allow selection of a desired parameter of the body support assembly.
摘要翻译：一种身体支撑组件，包括具有下表面的第一层（例如粘弹性泡沫）和支撑第一层并具有上表面的第二层。上表面和下表面中的一个由非平面表面限定多个通道。风扇定位成使空气通过通道。优选地，非平面表面包括多个突起（例如，回旋表面）。身体支撑件还可以包括检测参数并产生信号的传感器，以及耦合到传感器并被编程以控制风扇的控制器。可以提供多个风扇和传感器，并且控制器可以控制风扇以通过身体支撑组件的不同位置提供不同的空气流。用户界面可以耦合到控制器以允许选择身体支撑组件的期望参数。

14. 发明申请

WO2007084670A2 SPECIFIC THERAPY USING INTEGRIN LIGANDS FOR TREATING CANCER 审中-公开
标题翻译：使用INTEGRIN LIGANDS治疗癌症的具体治疗方法
公开(公告)号：WO2007084670A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001446
申请日：2007-01-18
申请人： MERCK PATENT GMBH , GOODMAN, Simon , PICARD, Martin, Andreas , MIKKELSEN, Tom , NIPPGEN, Johannes , GRIMM, Ulrike , STUPP, Roger , WELLER, Michael , HARSTRICK, Andreas
发明人： GOODMAN, Simon , PICARD, Martin, Andreas , MIKKELSEN, Tom , NIPPGEN, Johannes , GRIMM, Ulrike , STUPP, Roger , WELLER, Michael , HARSTRICK, Andreas
IPC分类号： A61K45/06 , A61K38/08 , A61K31/4188 , A61K41/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K38/12 , A61K41/00 , A61K2300/00
摘要： The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.
摘要翻译：本发明涉及用于治疗肿瘤和肿瘤转移的组合疗法，其包括将整联蛋白配体，优选整联蛋白拮抗剂，以及当与所述配体连续施用时具有协同疗效的共同治疗剂或治疗形式，例如化学治疗剂和或放射治疗。该治疗导致每个单独治疗剂对肿瘤细胞增殖的抑制作用的协同增加，产生比在本发明的剂量方案中同时或不同时单独施用单独组分的治疗更有效的治疗。

15. 发明申请

WO2013040543A3 BODY SUPPORT MODIFIED WITH VISCOUS GEL AND METHOD OF MANUFACTURING A BODY SUPPORT USING THE SAME 审中-公开
标题翻译：用粘性凝胶改性的身体支持物和使用该物质支持物制造身体支持物的方法
公开(公告)号：WO2013040543A3
公开(公告)日：2013-05-10
申请号：PCT/US2012055730
申请日：2012-09-17
申请人： TEMPUR PEDIC MAN INC , MIKKELSEN TOM
发明人： MIKKELSEN TOM
IPC分类号： A47C27/15 , A47C27/00
CPC分类号： A47C27/15 , A47C27/085
摘要： A body support cushion, such as a mattress, mattress topper or overlay, or pillow, is comprised of a layer of flexible foam and further has a volume of gelatinous material, e.g., elastomer gel, applied to a surface thereof. The gelatinous material alters a physical property, such as firmness or feel, of the layer of flexible foam. The gelatinous material can be applied in a number of ways including, but not limited to a spray application whereupon the spray force can be used to control how much gelatinous material penetrates into the layer of foam. The foam layer may be comprised of reticulated or non-reticulated foam. The foam layer may also be comprised of viscoelastic or non-viscoelastic foam.
摘要翻译：诸如床垫，床垫罩或覆盖物或枕头之类的身体支撑垫由一层柔性泡沫构成，并且还具有施加到其表面上的一定体积的凝胶状材料，例如弹性体凝胶。凝胶状材料改变柔性泡沫层的物理性质，例如坚硬度或感觉。凝胶材料可以以多种方式施用，包括但不限于喷涂应用，由此可以使用喷涂力来控制有多少凝胶状材料渗透到泡沫层中。泡沫层可以由网状或非网状泡沫组成。泡沫层也可以由粘弹性或非粘弹性泡沫组成。

16. 发明申请

WO2010075291A1 ADJUSTABLE-FIRMNESS BODY SUPPORT AND METHOD 审中-公开
标题翻译：可调节的身体支持和方法
公开(公告)号：WO2010075291A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069013
申请日：2009-12-21
申请人： TEMPUR-PEDIC MANAGEMENT, INC. , MIKKELSEN, Tom, D. , CHANDLER, Kelly, W.
发明人： MIKKELSEN, Tom, D. , CHANDLER, Kelly, W.
IPC分类号： A47C27/00
CPC分类号： A47C21/048 , A47C21/042 , A47C27/14 , A47C27/15
摘要： A body support assembly includes a layer including a visco-elastic foam, a heating element in thermal communication with the foam, a temperature sensor, such as a Peltier device, in thermal communication with the foam, and a controller coupled to the sensor and programmed to control the heating element based on input from the sensor, wherein the Peltier device is operable to heat and cool the foam.
摘要翻译：身体支撑组件包括包括粘弹性泡沫，与泡沫热连通的加热元件的层，与泡沫热连通的温度传感器，例如珀耳帖装置，以及耦合到传感器的控制器，并被编程以基于来自传感器的输入来控制加热元件，其中珀耳帖装置可操作以加热和冷却泡沫。

17. 发明申请

WO2010075229A1 INTER-LAYER GELATINOUS BODY SUPPORT ADHESIVE AND METHOD OF MANUFACTURING A BODY SUPPORT USING THE SAME 审中-公开
标题翻译：层间胶体支持胶粘剂及使用其制造身体支持的方法
公开(公告)号：WO2010075229A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/068812
申请日：2009-12-18
申请人： TEMPUR-PEDIC MANAGEMENT, INC. , CHANDLER, Kelly, W. , MIKKELSEN, Tom, D.
发明人： CHANDLER, Kelly, W. , MIKKELSEN, Tom, D.
IPC分类号： B32B3/00
CPC分类号： B32B5/18 , A47C27/085 , A47C27/15 , A47G9/10 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/245 , B32B7/12 , B32B2255/02 , B32B2255/26 , B32B2262/0261 , B32B2262/0276 , B32B2262/062 , B32B2262/08 , B32B2266/0207 , B32B2266/0221 , B32B2266/025 , B32B2266/0278 , B32B2307/72 , B32B2307/724 , B32B2307/7242 , B32B2307/726 , B32B2307/7265 , Y10T156/10 , Y10T428/249981 , Y10T428/249982
摘要： A body support assembly including a first layer, a second layer, at least one of the first and second layers comprises a visco-elastic foam, and a gel adhesive bonding the first layer to the second layer. A method of assembling the body support assembly including applying a gelatinous adhesive on at least one of a top surface of the first layer of foam and a bottom surface of the second layer of foam, positioning the second layer of foam on the first layer of foam, and coupling the second layer of foam to the first layer of foam with the gelatinous adhesive.
摘要翻译：包括第一层，第二层，第一层和第二层中的至少一层的主体支撑组件包括粘弹性泡沫和将第一层粘合到第二层的凝胶粘合剂。一种组装身体支撑组件的方法，包括在第一泡沫层的顶表面和第二泡沫层的底表面中的至少一个上施加凝胶状粘合剂，将第二层泡沫定位在第一泡沫层上并且用胶状粘合剂将第二泡沫层与第一泡沫层结合。

18. 发明申请

WO2007002290A3 RETICULATED MATERIAL BODY SUPPORT AND METHOD 审中-公开
公开(公告)号：WO2007002290A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024310
申请日：2006-06-22
申请人： TEMPUR WORLD, LLC , MIKKELSEN, Tom, D. , MITCHELL, Kenneth, E.
发明人： MIKKELSEN, Tom, D. , MITCHELL, Kenneth, E.
IPC分类号： A47C27/16 , A47C27/14
摘要： A body support comprising a top layer of flexible visco-elastic material having an exposed convoluted top surface is disclosed. The flexible visco-elastic material can have a reticulated or non-reticulated cellular structure. In some embodiments, one or more other layers of the body support comprises reticulated visco-elastic foam, and can have at least one material property responsive to temperatures in the range of a user's body heat. In these and other embodiments, one or more of the other layers of flexible material comprises non- visco- elastic foam, and can be combined in a body support with one or more layers of visco-elastic foam. The body support can include one or more layers of other material types, including one or more layers of high-resilience polyurethane foam.

19. 发明申请

WO2007002290A2 RETICULATED MATERIAL BODY SUPPORT AND METHOD 审中-公开
标题翻译：材料支撑和方法
公开(公告)号：WO2007002290A2
公开(公告)日：2007-01-04
申请号：PCT/US2006024310
申请日：2006-06-22
申请人： TEMPUR WORLD LLC , MIKKELSEN TOM D , MITCHELL KENNETH E
发明人： MIKKELSEN TOM D , MITCHELL KENNETH E
IPC分类号： A47C27/14 , A47C27/15
CPC分类号： A47C27/144 , A47C7/022 , A47C7/742 , A47C27/122 , A47C27/148 , A47C27/15 , A47G9/10 , Y10T428/233
摘要： A body support comprising a top layer of flexible visco-elastic material having an exposed convoluted top surface is disclosed. The flexible visco-elastic material can have a reticulated or non-reticulated cellular structure. In some embodiments, one or more other layers of the body support comprises reticulated visco-elastic foam, and can have at least one material property responsive to temperatures in the range of a user's body heat. In these and other embodiments, one or more of the other layers of flexible material comprises non- visco- elastic foam, and can be combined in a body support with one or more layers of visco-elastic foam. The body support can include one or more layers of other material types, including one or more layers of high-resilience polyurethane foam.
摘要翻译：公开了一种主体支撑件，其包括具有暴露的卷积顶表面的柔性粘弹性材料的顶层。柔性粘弹性材料可以具有网状或非网状的细胞结构。在一些实施例中，身体支撑体的一个或多个其它层包括网状粘弹性泡沫，并且可以具有响应于使用者身体热量范围内的温度的至少一种材料性质。在这些和其它实施例中，柔性材料的一个或多个其它层包括非粘弹性泡沫，并且可以将其与一层或多层粘弹性泡沫结合在一体式支撑体中。主体支撑件可以包括一层或多层其他材料类型，包括一层或多层高弹性聚氨酯泡沫。

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