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11. 发明申请

WO0107622A3 DNA SEQUENCES THAT ENCODE TYPE II (xcp) SECRETION SYSTEMS 审中-公开
标题翻译：编码TYPII（xcp）分泌系统的DNA序列
公开(公告)号：WO0107622A3
公开(公告)日：2001-08-09
申请号：PCT/EP0007112
申请日：2000-07-25
申请人： INST GENOMIC RES TIGR , QUIAGEN GMBH , BIOTECHNOLOG FORSCHUNG GMBH , DEUTSCHES KREBSFORSCH , HANNOVER MED HOCHSCHULE , FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
发明人： FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
IPC分类号： A01N63/00 , A01N63/02 , C07K14/21 , C12N1/21 , C12N15/31 , C12N15/82 , C07K16/12 , C12N5/10 , C12N15/78 , C12Q1/68 , G01N33/577
CPC分类号： C12N15/8261 , A01N63/00 , A01N63/02 , C07K14/21 , Y02A40/146
摘要： The invention relates to DNA sequences that encode type II (xcp) secretion systems, especially type II (xcp) secretion systems of the bacteria of the genus Pseudomonas , for example of the Pseudomonas putida and Pseudomonas fluorescens group.
摘要翻译：本发明涉及编码假单胞菌属细菌的II型（xcp）分泌系统，特别是II型（xcp）分泌系统的DNA序列，例如伪麻疹假单胞菌 荧光假单胞菌的基团。

12. 发明申请

WO0107587A3 DNA SEQUENCES CODING FOR IRON AND HEAVY METAL TRANSPORTERS 审中-公开
标题翻译：编码铁和重金属转运蛋白的DNA序列
公开(公告)号：WO0107587A3
公开(公告)日：2001-08-09
申请号：PCT/EP0007000
申请日：2000-07-21
申请人： INST GENOMIC RES TIGR , QIAGEN GMBH , BIOTECHNOLOG FORSCHUNG GMBH , DEUTSCHES KREBSFORSCH , HANNOVER MED HOCHSCHULE , FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
发明人： FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
IPC分类号： C07K14/21 , C12N1/21 , C12N15/31 , C12N15/82 , A01H5/00 , A01N63/02 , C07K16/12 , C12N5/14 , C12N15/63
CPC分类号： C12N15/8261 , C07K14/21 , C12N15/8271 , Y02A40/146
摘要： The invention relates to DNA sequences coding for iron and heavy metal transporters, especially iron and heavy metal transporters of bacteria of the genus Pseudomonas , for instance, of the Pseudomonas putida and fluorescent Pseudomonas group.
摘要翻译：本发明涉及编码铁和重金属转运蛋白的DNA序列，特别是假单胞菌属细菌的铁和重金属转运蛋白，例如恶臭假单胞菌和假单胞菌荧光的基团。

13. 发明申请

WO2005118617A3 METHOD FOR THE PURIFICATION OF POLYMERS CARRYING A LIPOPHILIC GROUP 审中-公开
标题翻译：纯化聚合物的方法
公开(公告)号：WO2005118617A3
公开(公告)日：2006-02-16
申请号：PCT/EP2005005807
申请日：2005-05-30
申请人： DEUTSCHES KREBSFORSCH , JACOB ANETTE , HOHEISEL JOERG , BRANDT OLE
发明人： JACOB ANETTE , HOHEISEL JOERG , BRANDT OLE
IPC分类号： C07K1/20 , C07K1/22 , C07K14/00
CPC分类号： C07K14/003 , C07K1/22
摘要： This invention relates to a method of producing a purified polymer selected from the group consisting of PNAs, (poly)peptides, PNA chimera, peptide-DNA chimera, and derivatives thereof, wherein the polymer carries at least one lipophilic group and wherein the method comprises the following steps: (a) transferring a solution comprising the polymer carrying a lipophilic group to a lipophilic surface under conditions that allow binding of said lipophilic group to said lipophilic surface; (b) washing said surface under conditions that allow said binding to be maintained, wherein polymers not carrying said lipophilic group are removed; (c) washing said surface under conditions that break said binding; (d) collecting the washing solution from step (c); and (e) obtaining said purified polymer from said washing solution. Preferably, the lipophilic group is a protection group, or a label such as a fluorescent dye, or a linker, for example a linker suitable for immobilization on a support.
摘要翻译：本发明涉及一种制备纯化聚合物的方法，该纯化聚合物选自PNA，（poly）肽，PNA嵌合体，肽-DNA嵌合体及其衍生物，其中聚合物携带至少一个亲脂基团，其中该方法包括以下步骤：（a）在允许所述亲脂基团与所述亲脂性表面结合的条件下将包含携带亲脂基团的聚合物的溶液转移到亲脂性表面; （b）在允许所述结合保持的条件下洗涤所述表面，其中除去不携带所述亲脂基团的聚合物; （c）在破坏所述结合的条件下洗涤所述表面; （d）从步骤（c）收集洗涤溶液; 和（e）从所述洗涤溶液中获得所述纯化的聚合物。优选地，亲油基团是保护基团，或诸如荧光染料的标记或接头，例如适于固定在载体上的接头。

14. 发明申请

WO03054541A2 INHIBITION OF TRISTETRAPROLINE FOR PROTECTION OF THE HEART FROM CARDIAC INJURIES 审中-公开
标题翻译： TRISTETRAPROLINE抑制心脏损伤心脏的保护作用
公开(公告)号：WO03054541A2
公开(公告)日：2003-07-03
申请号：PCT/EP0213545
申请日：2002-11-30
申请人： MERCK PATENT GMBH , KLUXEN FRANZ-WERNER , HENTSCH BERND , EHRING THOMAS , BRAENDLE MARIAN , HOHEISEL JOERG DIETRICH , FROHME MARCUS , ZUBAKOV DIMITRI
发明人： KLUXEN FRANZ-WERNER , HENTSCH BERND , EHRING THOMAS , BRAENDLE MARIAN , HOHEISEL JOERG DIETRICH , FROHME MARCUS , ZUBAKOV DIMITRI
IPC分类号： G01N33/53 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P9/04 , A61P9/10 , A61P43/00 , C07K16/18 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/68
CPC分类号： G01N33/6863 , G01N2333/525
摘要： The present invention relates to compounds suitable for the treatment of conditions which may be improved, at least in part, by increasing TNF alpha production. The invention further relates to assays for the identification of an individual at increased risk for or suffering from such conditions and to methods of screening compounds for their ability to enhance TNF alpha biosysthesis.
摘要翻译：本发明涉及适用于治疗可至少部分通过增加TNFα产生来改善的病症的化合物。本发明进一步涉及用于鉴定处于这种病症的风险增高或遭受这种病症的个体的测定法以及筛选化合物增强TNFα生物合成能力的方法。

15. 发明申请

WO0107621A3 DNA SEQUENCES CODING FOR ABC TRANSPORTERS 审中-公开
标题翻译：编码ABC转运蛋白的DNA序列
公开(公告)号：WO0107621A3
公开(公告)日：2001-10-11
申请号：PCT/EP0006999
申请日：2000-07-21
申请人： INST GENOMIC RES TIGR , QIAGEN GMBH , BIOTECHNOLOG FORSCHUNG GMBH , DEUTSCHES KREBSFORSCH , HANNOVER MED HOCHSCHULE , FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
发明人： FRASER CLAIRE M , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
IPC分类号： A01N37/46 , A01N63/00 , C07K14/21 , C12N1/21 , C12N15/31 , C12N15/82 , A01H5/00 , C07K16/12
CPC分类号： C12N15/8261 , A01N37/46 , A01N63/00 , C07K14/21 , C12N15/8271 , Y02A40/146
摘要： The invention relates to DNA sequences coding for ABC transporters, especially ABC transporters of bacteria of the genus Pseudomonas , for instance, of the Pseudomonas putida and fluorescent Pseudomonas group.
摘要翻译：本发明涉及编码ABC转运蛋白的DNA序列，特别是假单胞菌属细菌的ABC转运蛋白，例如恶臭假单胞菌（Pseudomonas putida）假单胞菌和荧光假单胞菌（Pseudomonas）荧光的基团。

16. 发明申请

WO0107591A3 DNA SEQUENCES WHICH CODE EXPORT SYSTEMS 审中-公开
标题翻译： DNA序列出口系统规范
公开(公告)号：WO0107591A3
公开(公告)日：2001-08-16
申请号：PCT/EP0007243
申请日：2000-07-27
申请人： INST GENOMIC RES TIGR , QIAGEN GMBH , BIOTECHNOLOG FORSCHUNG GMBH , DEUTSCHES KREBSFORSCH , HANNOVER MED HOCHSCHULE , FRASER CLAIRE M , VENTER CRAIG , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
发明人： FRASER CLAIRE M , VENTER CRAIG , TUEMMLER BURKHARD , HOHEISEL JOERG , DUESTERHOEFT ANDREAS , HILBERT HELMUT , TIMMIS KENNETH N , MOORE EDWARD , STRAETZ MICHAEL , HEIM SABINA , NELSON KAREN E , HICKEY ERIN , PETERSON JEREMY
IPC分类号： C07K14/21 , C12N15/31 , C12N15/82 , A01H5/00 , A01N63/02 , C07K16/12 , C12N1/21 , C12N5/14 , C12N15/63
CPC分类号： C07K14/21 , C12N15/8261 , Y02A40/146
摘要： The invention relates to DNA sequences which code export systems, especially export systems of bacteria of the genus Pseudomonas , for example, the Pseudomonas-putida group and Pseudomonas-fluorescens group.
摘要翻译：本发明涉及的DNA序列编码该出口系统，在属于埃希假单胞菌的，例如，所述的恶臭假单胞菌的细菌的特定出口系统 - 和荧光假单胞菌的组。

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