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11. 发明申请

WO2004034767A2 APPARTUS AND METHOD FOR INSERTING AN INTRA-AORTA CATHETER TROUGH A DELIVERY SHEATH 审中-公开
标题翻译：通过输送管插入入口管的插座和方法
公开(公告)号：WO2004034767A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/029585
申请日：2003-09-22
申请人： FLOWMEDICA, INC. , ELKINS, Jeffrey, M. , GOODSON, Harry, B., IV , MAGUIRE, Mark, A. , VALENCIA, Aurelio , PATEL, Samir R
发明人： ELKINS, Jeffrey, M. , GOODSON, Harry, B., IV , MAGUIRE, Mark, A. , VALENCIA, Aurelio , PATEL, Samir R
IPC分类号： A61M25/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
摘要翻译：导引器系统将局部给予患者的肾系统治疗。近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘并且基本上与护套的纵向轴线对准。一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组分与另一装置结合引入导引鞘中。提供了新的插入装置来协调多个装置的耦合。

12. 发明申请

WO2009114826A3 TREATMENT SYSTEMS AND METHODS FOR RENAL-RELATED DISEASES 审中-公开
标题翻译：治疗系统与方法相关的疾病
公开(公告)号：WO2009114826A3
公开(公告)日：2010-02-18
申请号：PCT/US2009037190
申请日：2009-03-13
申请人： ANGIODYNAMICS INC , PEREIRA-KAMATH NIKHIL , GOODSON HARRY B , ELKINS JEFFREY M , PATEL SAMIR R
发明人： PEREIRA-KAMATH NIKHIL , GOODSON HARRY B , ELKINS JEFFREY M , PATEL SAMIR R
IPC分类号： A61K38/21 , A61K31/436 , A61K35/12 , A61K38/18 , A61K38/20 , A61K39/395 , A61P13/12 , A61P35/00
CPC分类号： A61K31/436 , A61B5/201 , A61B5/412 , A61K35/28 , A61K35/545 , A61K38/18 , A61K38/2013 , A61K38/212 , A61M25/0067 , A61M25/0071 , A61M2025/1045 , A61M2210/1082
摘要： Systems and methods are provided for locally delivering specific prophylactic, regenerative, or therapeutic agents within the body of a patient. Systems and methods can involve direct delivery of prophylactic, regenerative, or therapeutic agents into branch blood vessels or body lumens from a main vessel or lumen, respectively, and in particular into renal arteries extending from an aorta in a patient. Drug infusion techniques encompass specific treatment and prevention regimes for renal diseases including, but not limited to, Acute Kidney Injury, Renal Cell Carcinoma, Polycystic Kidney Disease, and Chronic Kidney Disease.
摘要翻译：提供的系统和方法用于在患者体内局部递送特定的预防，再生或治疗剂。系统和方法可以包括将预防性，再生的或治疗剂分别直接递送到分支血管或来自主血管或内腔的体腔，特别是从病人主动脉延伸的肾动脉。药物输注技术包括肾脏疾病的具体治疗和预防方案，包括但不限于急性肾损伤，肾细胞癌，多囊肾病和慢性肾脏疾病。

13. 发明申请

WO2008112563A1 ACUTE KIDNEY INJURY TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：急性KIDNEY伤害治疗系统和方法
公开(公告)号：WO2008112563A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056263
申请日：2008-03-07
申请人： FLOWMEDICA, INC. , GOODSON IV, Harry, B. , ELKINS, Jeffrey, M. , PATEL, Samir, R.
发明人： GOODSON IV, Harry, B. , ELKINS, Jeffrey, M. , PATEL, Samir, R.
IPC分类号： A61M31/00 , A61M1/00
CPC分类号： A61M25/0068 , A61B5/201 , A61B5/412 , A61M25/0071
摘要： Systems and methods for the clinical treatment of individuals susceptible to or suffering from acute kidney injury are provided. Drugs, biologics, or other therapies or treatments are administered by fluid agent delivery directly to the kidneys via their arterial blood supply. Bifurcated renal artery infusion catheter devices and methods can treat kidney injury in patients with locally-delivered drugs, biologics, and other agents, so as to increase the ability of the kidneys to excrete nitrogenous waste products from the blood, and prevent or ameliorate azotemia.
摘要翻译：提供了对急性肾损伤或患有急性肾损伤的个体进行临床治疗的系统和方法。药物，生物制剂或其他疗法或治疗通过流体剂通过其动脉血供给直接递送至肾来施用。分叉的肾动脉输液导管装置和方法可以治疗局部输送的药物，生物制剂和其他药物的患者的肾损伤，以增加肾脏从血液中排出含氮废物的能力，并预防或改善氮血症。

14. 发明申请

WO2007146825A3 SELECTIVE RENAL CANNULATION AND INFUSION SYSTEMS AND METHODS 审中-公开
标题翻译：选择性肾移植和输注系统和方法
公开(公告)号：WO2007146825A3
公开(公告)日：2008-07-31
申请号：PCT/US2007070788
申请日：2007-06-08
申请人： FLOWMEDICA INC , HEKMAT NEEMA , GOODSON HARRY B , VALENCIA AURELIO , ELKINS JEFFREY M
发明人： HEKMAT NEEMA , GOODSON HARRY B , VALENCIA AURELIO , ELKINS JEFFREY M
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/0028 , A61M25/0029 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/008 , A61M25/02 , A61M2025/0034 , A61M2025/0037 , A61M2025/0073 , A61M2025/024 , A61M2025/1045
摘要： Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch,. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.
摘要翻译：肾输液系统包括具有分叉远端的输注导管，其具有第一分支和第二分支，所述分支被偏置以在无约束时横向展开。系统还包括具有接收输注导管并限制第一分支和第二分支的内腔的输送鞘。输送护套的远端开口不对称地形成，以允许第一和第二分支中的一个横向打开，而另一个分支保持约束。还提供了使用肾输注系统的方法。

15. 发明申请

WO2007041031A2 RENAL INFUSION SYSTEMS AND METHODS 审中-公开
标题翻译：肾输入系统和方法
公开(公告)号：WO2007041031A2
公开(公告)日：2007-04-12
申请号：PCT/US2006037025
申请日：2006-09-21
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
发明人： ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
IPC分类号： A61M31/00 , A61F2/958 , A61M20060101 , A61M25/00 , A61M29/00 , A61M29/02 , A61M37/00 , A61N1/362
CPC分类号： A61M25/00 , A61M25/0068 , A61M25/0074 , A61M25/008 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0057 , A61M2025/0183 , A61M2025/0681 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1095 , A61M2029/025 , A61M2210/127
摘要： Systems, devices, and methods for delivering treatment to the renal arteries are provided. Exemplary systems include a delivery catheter having a distal bifurcation, an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter, and a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.
摘要翻译：提供了用于向肾动脉输送治疗的系统，装置和方法。示例性系统包括具有远侧分叉的输送导管，包括与Y轴可操作地相关联的导引器鞘的导引器组件，其中Y轴包括用于接收输送导管的第一端口和用于接收第二导管的第二端口，以及约束组件，用于当输送导管远端分叉超过导引器鞘时，将输送导管的远端分叉保持在低轮廓构造中。

16. 发明申请

WO2005091910A3 SHEATH FOR USE IN PERIPHERAL INTERVENTIONS 审中-公开
标题翻译：用于外围干预的治疗
公开(公告)号：WO2005091910A3
公开(公告)日：2006-08-17
申请号：PCT/US2005006573
申请日：2005-03-04
申请人： FLOWMEDICA INC , GOODSON IV HARRY B , BALL CRAIG A , ELKINS JEFFREY M
发明人： GOODSON IV HARRY B , BALL CRAIG A , ELKINS JEFFREY M
IPC分类号： A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61M25/0662 , A61M25/0032 , A61M25/007
摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.
摘要翻译：双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉导引鞘的插入点进入患者。

17. 发明申请

WO2005112980A2 BI-LATERAL LOCAL RENAL DELIVERY FOR TREATING CONGESTIVE HEART FAILURE AND FOR BNP THERAPY 审中-公开
标题翻译：用于治疗顽固性心脏衰竭和BNP治疗的双向局部肾移植
公开(公告)号：WO2005112980A2
公开(公告)日：2005-12-01
申请号：PCT/US2005017034
申请日：2005-05-13
申请人： FLOWMEDICA INC , GOODSON HARRY BURT IV , PATEL SAMIR R , BALL CRAIG A , ELKINS JEFFREY M
发明人： GOODSON HARRY BURT IV , PATEL SAMIR R , BALL CRAIG A , ELKINS JEFFREY M
IPC分类号： A61K38/17 , A61K38/22 , A61M25/00 , A61M25/04
CPC分类号： A61M25/0041 , A61K38/2242 , A61M25/0054 , A61M25/04 , A61M2025/0681 , A61M2210/1085
摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.
摘要翻译：本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。本发明包括用于肾脏药物递送的装置和使用方法。

18. 发明申请

WO2005091910A2 SHEATH FOR USE IN PERIPHERAL INTERVENTIONS 审中-公开
标题翻译：用于外围干预的治疗
公开(公告)号：WO2005091910A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/006573
申请日：2005-03-04
申请人： FLOWMEDICA, INC. , GOODSON IV, Harry, B. , BALL, Craig, A. , ELKINS, Jeffrey, M.
发明人： GOODSON IV, Harry, B. , BALL, Craig, A. , ELKINS, Jeffrey, M.
IPC分类号： A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61M25/0662 , A61M25/0032 , A61M25/007
摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.
摘要翻译：双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉导引鞘的插入点进入患者。

19. 发明申请

WO2004026371A3 METHOD AND APPARATUS FOR SELECTIVE DRUG INFUSION VIA AN INTRAAORTIC FLOW DIVERTER DELIVERY CATHETER 审中-公开
标题翻译：通过流体流量输送管选择性药物输注的方法和装置
公开(公告)号：WO2004026371A3
公开(公告)日：2004-09-02
申请号：PCT/US0329743
申请日：2003-09-22
申请人： FLOWMEDICA INC , VALENCIA AURELIO , ABOYTES RICARDO , ELKINS JEFFREY M , GOODSON HARRY B IV , PATEL SAMIR R , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
发明人： VALENCIA AURELIO , ABOYTES RICARDO , ELKINS JEFFREY M , GOODSON HARRY B IV , PATEL SAMIR R , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
IPC分类号： A61M20060101 , A61M25/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

20. 发明申请

WO2007044907A3 VASCULAR SHEATH WITH VARIABLE LUMEN CONSTRUCTION 审中-公开
标题翻译：血管结构可变的血管鞘
公开(公告)号：WO2007044907A3
公开(公告)日：2007-09-07
申请号：PCT/US2006040094
申请日：2006-10-11
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
发明人： ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
IPC分类号： A61M25/00 , A61F2/06
CPC分类号： A61M25/0662 , A61F2/07 , A61F2002/065 , A61M25/0668 , A61M2025/0024 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： A system for delivering a renal treatment and a peripheral treatment includes a renal catheter, a peripheral catheter, and an introducer sheath having first and second lumens. The first lumen is configured to receive the renal catheter and is sized to extend from a patient insertion site to a femoral or iliac artery location near or distal to a patient aortic branch. The second lumen is configured to receive the peripheral catheter and is sized to extend from the patient insertion site to an opposite femoral or iliac artery location near or distal to the patient aortic branch. A method of delivering a renal treatment and a peripheral treatment includes positioning an introducer sheath in an iliac artery, advancing a renal catheter and a peripheral catheter through the introducer sheath, where the renal catheter is separated from the peripheral catheter within the introducer sheath by a flap.
摘要翻译：用于递送肾脏治疗和外周治疗的系统包括肾导管，外周导管和具有第一腔和第二腔的导入器鞘。第一内腔被构造成接收肾导管并且被设定尺寸以从患者插入部位延伸到患者主动脉分支附近或远端的股骨或髂动脉位置。第二内腔构造成接收外围导管并且尺寸被设计为从患者插入部位延伸到患者主动脉分支附近或远端的相对的股骨或髂动脉位置。递送肾脏治疗和外周治疗的方法包括将导引鞘定位在髂动脉中，推进肾导管和外周导管穿过导引鞘，其中肾导管与导引鞘内的外周导管分隔开皮瓣。

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