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11. 发明申请

WO2006008506A1 SCALE INHIBITION METHOD 审中-公开
标题翻译：规模抑制方法
公开(公告)号：WO2006008506A1
公开(公告)日：2006-01-26
申请号：PCT/GB2005/002821
申请日：2005-07-19
申请人： BP EXPLORATION OPERATING COMPANY LIMITED , COLLINS, Ian, Ralph , SERMON, Paul, Anthony
发明人： COLLINS, Ian, Ralph , SERMON, Paul, Anthony
IPC分类号： E21B37/06
CPC分类号： C09K8/528 , B01D61/002 , B01D61/005 , B01D2311/04 , B01D2311/2626 , B01D2311/2649 , B01D2311/2657 , B01D2317/04 , C09K8/58 , E21B37/06 , E21B43/20 , Y02A20/131
摘要： A scale inhibition method comprising: (a) injecting a dispersion of seed particles of an insoluble mineral salt in an aqueous medium into a formation through an injection well wherein the seed particles have an equivalent spherical diameter of 100% less than 100 nm, preferably 100% less than 50 nm, more preferably 100% less than 25 nm and the aqueous medium has dissolved therein precipitate precursor ions that form a precipitate of the insoluble mineral salt when contacted with resident ions in the formation; (b) allowing the dispersion to percolate through the subterranean formation towards production well and producing the dispersion from the production well; and (c) controllably precipitating the insoluble mineral salt onto the seed particles so as to reduce the deposition of the insoluble mineral salt onto the walls of the porous formation and/or onto the surface in the production well and/or onto the surface downstream of the production well.
摘要翻译：一种防垢方法，包括：（a）通过注射井将不溶性矿物质盐的种子颗粒分散在水性介质中注入到地层中，其中种子颗粒的当量球直径为100％小于100nm，优选为100 小于50nm，更优选100％小于25nm，并且水性介质中溶解有沉淀的前体离子，当与地层中的驻留离子接触时，其形成不溶性矿物盐的沉淀物; （b）允许分散体渗透穿过地层以生产良好并从生产井中产生分散体; 和（c）可控地将不溶性矿物盐沉淀到种子颗粒上，以便减少不溶性矿物盐沉积到多孔地层的壁上和/或沉积在生产井和/或表面下游的表面上生产良好。

12. 发明申请

WO2005030731A1 GAMMA-SECRETASE INHIBITORS 审中-公开
标题翻译： GAMMA-分泌酶抑制剂
公开(公告)号：WO2005030731A1
公开(公告)日：2005-04-07
申请号：PCT/GB2004/003973
申请日：2004-09-16
申请人： MERCK SHARP & DOHME LIMITED , COLLINS, Ian, James , HANNAM, Joanne, Clare , MADIN, Andrew , RIDGILL, Mark, Peter
发明人： COLLINS, Ian, James , HANNAM, Joanne, Clare , MADIN, Andrew , RIDGILL, Mark, Peter
IPC分类号： C07D233/54
CPC分类号： C07D233/64 , C07D249/08 , C07D409/12 , C07D417/04 , C07D417/12
摘要： Compounds of formula: (I) are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid.
摘要翻译：式（I）化合物是γ-分泌酶的有效抑制剂，因此可用于治疗或预防与β-淀粉样蛋白沉积相关的疾病。

13. 发明申请

WO2003106809A1 METHOD OF PREPARING MICROPARTICLES 审中-公开
标题翻译：制备微生物的方法
公开(公告)号：WO2003106809A1
公开(公告)日：2003-12-24
申请号：PCT/GB2003/002091
申请日：2003-05-15
申请人： BP EXPLORATION OPERATING COMPANY LIMITED , COLLINS, Ian, Ralph , DUNCUM, Simon, Neil
发明人： COLLINS, Ian, Ralph , DUNCUM, Simon, Neil
IPC分类号： E21B37/06
CPC分类号： C09K8/92 , B01J13/125 , C09K8/536 , C09K8/54
摘要： A method of preparing microparticles comprising an aqueous solution or dispersion of an oil or gas field production chemical encapsulated in a continuous polymeric phase comprising a degradable polymer, which method comprises: (a) preparing a water in oil in water double emulsion or a water in oil in oil double emulsion having an internal aqueous phase comprising an aqueous solution or dispersion of the production chemical and an internal oil phase comprising a solution of a degradable polymer dissolved in a volatile organic solvent wherein the internal aqueous phase is dispersed in the internal oil phase of the double emulsion in the form of droplets having a mean diameter of less than 10 microns; and (b) at least in part evaporating the volatile organic solvent from the double emulsion such that the degradable polymer accumulates around the droplets of the internal aqueous phase and hardens to form microparticles comprising a continuous polymeric phase encapsulating the internal aqueous phase having a mean particle diameter of less than 10 microns.
摘要翻译：一种制备微粒的方法，其包括包封在包含可降解聚合物的连续聚合物相中的油或气田生产化学品的水溶液或分散体，该方法包括：（a）在水中制备水包油双乳液或水油包水乳液，其具有包含生产化学品的水溶液或分散体的内部水相和包含溶解在挥发性有机溶剂中的可降解聚合物溶液的内部油相，其中内部水相分散在内部油相中的平均直径小于10微米的液滴形式的双重乳液; 和（b）至少部分地从双重乳液中蒸发挥发性有机溶剂，使得可降解聚合物在内部水相的液滴周围积聚并硬化以形成包含连续聚合物相的微粒，所述微粒包封具有平均粒子的内部水相直径小于10微米。

14. 发明申请

WO2003093264A1 OXADIAZOLE DERIVATIVES FOR INHIBITION OF GAMMA SECRETASE 审中-公开
标题翻译：用于抑制GAMMA分泌酶的OXADIAZOLE衍生物
公开(公告)号：WO2003093264A1
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001777
申请日：2003-04-24
申请人： MERCK SHARP & DOHME LIMITED , COLLINS, Ian, James , COOPER, Laura, Catherine
发明人： COLLINS, Ian, James , COOPER, Laura, Catherine
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： Compounds of formula I: wherein X represents a 5-(R-substituted)-1,2,4-oxadiazole-3-yl moiety are inhibitors of gamma-secretase, and hence useful for treating Alzheimer's disease.
摘要翻译：式I化合物：其中X表示5-（R-取代的）-1,2,4-恶二唑-3-基部分是γ-分泌酶的抑制剂，因此可用于治疗阿尔茨海默氏病。

15. 发明申请

WO2003093252A1 HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE 审中-公开
标题翻译：用于抑制GAMMA分泌酶的HETEROARYL取代的螺旋硫代氨基酸
公开(公告)号：WO2003093252A1
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001763
申请日：2003-04-24
申请人： MERCK SHARP & DOHME LIMITED , COLLINS, Ian, James , COOPER, Laura, Catherine , HARRISON, Timothy , KEOWN, Linda, Elizabeth , MADIN, Andrew , RIDGILL, Mark, Peter
发明人： COLLINS, Ian, James , COOPER, Laura, Catherine , HARRISON, Timothy , KEOWN, Linda, Elizabeth , MADIN, Andrew , RIDGILL, Mark, Peter
IPC分类号： C07D285/14
CPC分类号： C07D285/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译：公开了式I的化合物：其中X是5元杂芳基环，R如本文所定义。这些化合物是通过γ-分泌酶处理APP的抑制剂，因此可用于治疗或预防阿尔茨海默氏病。

16. 发明申请

WO1994026733A1 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡嗪衍生物
公开(公告)号：WO1994026733A1
公开(公告)日：1994-11-24
申请号：PCT/GB1994000999
申请日：1994-05-09
申请人： MERCK SHARP & DOHME LIMITED , CARLING, William, Robert , COLLINS, Ian, James , LEESON, Paul, David , ROWLEY, Michael
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D409/14
摘要： A class of substituted pyrimidine derivatives are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular schizophrenia.
摘要翻译：一类取代的嘧啶衍生物是体内多巴胺受体亚型的配体，因此可用于治疗多巴胺系统，特别是精神分裂症的病症。

17. 发明申请

WO2012125626A2 DECORIN COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：装饰组合物及其用途
公开(公告)号：WO2012125626A2
公开(公告)日：2012-09-20
申请号：PCT/US2012028911
申请日：2012-03-13
申请人： CATALENT PHARMA SOLUTIONS LLC , BLECK GREGORY THOMAS , COLLINS IAN JOHN , FREY MARK JOSEPH
发明人： BLECK GREGORY THOMAS , COLLINS IAN JOHN , FREY MARK JOSEPH
IPC分类号： C07K1/36 , C07K14/435 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/00
CPC分类号： C07K14/4725 , C07K2319/036
摘要： The present invention relates to improved decorin compositions and methods of their production.
摘要翻译：本发明涉及改良的核心蛋白聚糖组合物及其生产方法。

18. 发明申请

WO2012045124A1 BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS 审中-公开
标题翻译：细菌淀粉样蛋白酶II抑制2-乙酰基氨基甲酰基-1,3-苯并噻唑-5-YLS
公开(公告)号：WO2012045124A1
公开(公告)日：2012-04-12
申请号：PCT/AU2011/001284
申请日：2011-10-07
申请人： BIOTA EUROPE LTD , PALMER, James T , LUNNISS, Christopher James , OFFERMANN, Daniel A , AXFORD, Lorraine Claire , BLAIR, Michael , MITCHELL, Dale , PALMER, Nicholas , STEELE, Christopher , ATHERALL, John , WATSON, David , HAYDON, David , CZAPLEWSKI, Lloyd , DAVIES, David , COLLINS, Ian , TYNDALL, Edward Malcolm , ANDRAU, Laura , PITT, Gary Robert William
发明人： PALMER, James T , LUNNISS, Christopher James , OFFERMANN, Daniel A , AXFORD, Lorraine Claire , BLAIR, Michael , MITCHELL, Dale , PALMER, Nicholas , STEELE, Christopher , ATHERALL, John , WATSON, David , HAYDON, David , CZAPLEWSKI, Lloyd , DAVIES, David , COLLINS, Ian , TYNDALL, Edward Malcolm , ANDRAU, Laura , PITT, Gary Robert William
IPC分类号： C07D417/14 , A61K31/429 , C07D403/14 , A61K31/428 , A61P31/04 , C07D413/14 , C07D471/04
CPC分类号： C07D417/14 , A01N47/36 , C07D491/04 , C07D513/04
摘要： The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.
摘要翻译：本发明提供下式的化合物及其盐：还提供了这些化合物作为抗菌剂的用途，包含它们的组合物及其制备方法。

19. 发明申请

WO2010139932A2 METHOD AND SYSTEM FOR CONFIGURING CRUDE OIL DISPLACEMENT SYSTEM 审中-公开
标题翻译：用于配置原油排放系统的方法和系统
公开(公告)号：WO2010139932A2
公开(公告)日：2010-12-09
申请号：PCT/GB2010/001038
申请日：2010-05-26
申请人： BP EXPLORATION OPERATING COMPANY LIMITED , COLLINS, Ian, Ralph , HOUSTON, Stephanie, Jane , WEBB, Kevin, John
发明人： COLLINS, Ian, Ralph , HOUSTON, Stephanie, Jane , WEBB, Kevin, John
IPC分类号： E21B43/20
CPC分类号： E21B44/00 , C09K8/58 , E21B43/16 , E21B43/20 , G05B17/02
摘要： A computer-implemented method for determining one or more operating modes for a crude oil displacement system is provided. The crude oil displacement system is arranged to inject an aqueous displacement fluid into one or more reservoirs, each reservoir comprising a porous and permeable rock formation, wherein crude oil and formation water are contained within a pore space of the rock formation. The crude oil displacement system is for use in displacing crude oil from the pore space of the rock formation. The computer-implemented method comprises the steps of receiving measurement data associated with one or more chemical characteristics of the displacement fluid and one or more chemical characteristics of the rock formation, the crude oil and the formation water of the one or more reservoirs, and inputting the measurement data and data representing a predetermined volume of oil into a computer-implemented predictive model. The predictive model is operated so as to generate predicted data indicative of a predicted additional amount of oil, compared to the predetermined volume of oil, that will be displaced by configuring the crude oil displacement system so as to inject the displacement fluid having the chemical characteristics into the one or more reservoirs. On the basis of the predicted data, the one or more operating modes of the crude oil displacement system are determined. A further computer-implemented method employing the predictive model in which predicted data indicative of one or more predicted chemical characteristics of the displacement fluid are generated is also provided. Additionally, a system for configuring a crude oil displacement system is provided.
摘要翻译：提供了一种用于确定原油排放系统的一种或多种操作模式的计算机实现的方法。原油置换系统被布置成将含水置换流体注入到一个或多个储存器中，每个储存器包括多孔和可渗透的岩层，其中原油和地层水被包含在岩层的孔隙空间内。原油排放系统用于从岩层孔隙空间中排除原油。计算机实现的方法包括以下步骤：接收与位移流体的一种或多种化学特性相关联的测量数据和一个或多个储层的岩层，原油和地层水的一种或多种化学特征，以及输入测量数据和表示预定油量的数据转换成计算机实现的预测模型。操作该预测模型，以产生指示与预定体积的油相比预测的附加量的油的预测数据，其将通过配置原油排出系统而移位，以便注入具有化学特性的置换流体进入一个或多个储层。根据预测数据，确定原油排放系统的一个或多个运行模式。还提供了采用预测模型的进一步的计算机实现的方法，其中产生指示位移流体的一种或多种预测化学特性的预测数据。另外，提供了一种用于配置原油排放系统的系统。

20. 发明申请

WO2009044162A1 PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：吡嗪-2-基-L-吡啶-2-基胺和吡嗪-2-基-L-吡啶基-4-甲酰胺化合物及其用途
公开(公告)号：WO2009044162A1
公开(公告)日：2009-04-09
申请号：PCT/GB2008/003362
申请日：2008-10-06
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , COLLINS, Ian , READER, John, Charles , MATTHEWS, Thomas, Peter , CHEUNG, Kwai Ming , PROISY, Nicolas , WILLIAMS, David, Hugh , KLAIR, Sukhbinder, Singh , SCANLON, Jane, Elizabeth , PITON, Nelly , ADDISON, Glynn, Jonathan , CHERRY, Michael
发明人： COLLINS, Ian , READER, John, Charles , MATTHEWS, Thomas, Peter , CHEUNG, Kwai Ming , PROISY, Nicolas , WILLIAMS, David, Hugh , KLAIR, Sukhbinder, Singh , SCANLON, Jane, Elizabeth , PITON, Nelly , ADDISON, Glynn, Jonathan , CHERRY, Michael
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/497 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain biarylamine compounds (referred to herein as BAA compounds), and especially certain pyrazin- 2 - yl -pyridin- 2 -yl -amine and pyrazine - 2 - yl -pyrimidin- 4 - yl -amine compounds of formula (I), which, inter alia, inhibit Checkpoint Kinase 1 (CHK1 ) kinase function The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1. that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or Il inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionisiπq radiation. wherein: -X= is independently -CR A5 = or -N=; and the rest of the substituents are as specified in the claims.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及某些联芳基胺化合物（本文称为BAA化合物），特别是某些吡嗪-2-基 - 吡啶-2-基胺和吡嗪-2-基（I）的嘧啶-4-基 - 胺化合物，其特别是抑制检测点激酶1（CHK1）激酶功能。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物的用途，在体外和体内都抑制CHK1激酶功能，以及治疗由CHK1介导的疾病和病症。通过抑制CHK1激酶功能等改善，包括增殖条件如癌症等，任选地与另一种试剂组合，例如（a）DNA拓扑异构酶I或II抑制剂; （b）DNA损伤剂; （c）抗代谢物或TS抑制剂; （d）微管靶向剂; 和（e）ionisipq辐射。其中：-X =独立地是-CRA5 =或-N =; 并且其余的取代基如权利要求中所述。

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