专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO03027137A2 POLYMERIC COMPOUNDS 审中-公开
标题翻译：聚合物
公开(公告)号：WO03027137A2
公开(公告)日：2003-04-03
申请号：PCT/GB0204352
申请日：2002-09-26
申请人： ADPROTECH LTD , SMITH RICHARD ANDREW GODWIN , BETLEY JASON RICHARD , ESSER DIRK
发明人： SMITH RICHARD ANDREW GODWIN , BETLEY JASON RICHARD , ESSER DIRK
IPC分类号： C07K1/04 , C07K1/107 , C07K14/705 , C07K14/815 , A61K47/48
CPC分类号： C07K14/70596 , C07K1/047 , C07K1/1075 , C07K1/1077 , C07K14/815
摘要： The invention provides a process for forming a compound having the formula (I): from chemical entities native [A], native [B] and native [C], where native [A] has a thioester group, native [B] had a 1-amino-2-thiol group with an unoxidised sulfhydryl side chain, and native [C] had a thiol reactive function (TRF) group, wherein chemical entities [A], [B] and [C] are covalently linked by linker group L, comprising the steps of: (i) admixing native [A] and native [B] in a reaction solution; (ii) condensing the unoxidised sulfydryl side chain of native [B] with the thioester group of native [A] for producing a first intermediate compound wherein [A] and [B] are linked with a beta -aminothioester bond; (iii) rearranging the beta -aminothioester bond for producing a second intermediate compound wherein [A] and [B] are linked with an amide bond having attached thereto a free thiol group; (iv) admixing native [C] with the second intermediate compound in a reaction solution; and (v) reacting the thiol reactive function (TRF) group of native [C] with the free thiol group of the second intermediate compound for producing a compound having the formula (I).
摘要翻译：本发明提供了一种用于形成具有式（I）的化合物的方法：从天然[A]，天然[B]和天然[C]的化学实体，其中天然[A]具有硫酯基，天然[B]具有具有未氧化巯基侧链的1-氨基-2-硫醇基团，天然[C]具有硫醇反应性功能（TRF）基团，其中化学实体[A]，[B]和[C]通过连接基团共价连接 L，包括以下步骤：（i）将天然[A]和天然[B]混合在反应溶液中; （ii）将天然[B]的未氧化硫辛酸侧链与天然[A]的硫酯基缩合，以制备其中[A]和[B]与β-氨基硫酯键连接的第一中间体化合物; （iii）重排β-氨基硫酯键以制备第二中间体化合物，其中[A]和[B]与其上附着有游离巯基的酰胺键连接; （iv）将天然[C]与第二中间体化合物在反应溶液中混合; 和（v）使天然[C]的硫醇反应性官能团（TRF）基团与第二中间体化合物的游离巯基反应，以制备具有式（I）的化合物。

12. 发明申请

WO2003006433A1 PROTEIN MODIFICATION REAGENTS 审中-公开
标题翻译：蛋白质修饰试剂
公开(公告)号：WO2003006433A1
公开(公告)日：2003-01-23
申请号：PCT/GB2002/003210
申请日：2002-07-15
申请人： ADPROTECH LIMITED , SMITH, Richard, Anthony, Godwin , BETLEY, Jason, Richard
发明人： SMITH, Richard, Anthony, Godwin , BETLEY, Jason, Richard
IPC分类号： C07D213/71
CPC分类号： C07D213/71 , C07K1/1077
摘要： The invention relates to a protein modification reagent capable of introducing aldehyde or ketone functions into proteins. These compounds can be used to modify peptides in a site-specific and pharmaceutically acceptable manner. Also described are methods for modifying peptides and their use in pharmaceutical compositions.
摘要翻译：本发明涉及能够将醛或酮功能引入蛋白质的蛋白质修饰试剂。这些化合物可用于以位点特异性和药学上可接受的方式修饰肽。还描述了用于修饰肽及其在药物组合物中的用途的方法。

13. 发明申请

WO2010127304A3 SEQUENCING METHODS 审中-公开
公开(公告)号：WO2010127304A3
公开(公告)日：2010-11-04
申请号：PCT/US2010/033272
申请日：2010-04-30
申请人： ILLUMINA, INC. , RONAGHI, Mostafa , EVERS, Dirk , BETLEY, Jason, Richard
发明人： RONAGHI, Mostafa , EVERS, Dirk , BETLEY, Jason, Richard
IPC分类号： C12Q1/68 , C12N15/11 , C40B40/06
摘要： The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to nucleic acid sequencing.

14. 发明申请

WO2010127304A2 SEQUENCING METHODS 审中-公开
标题翻译：序列方法
公开(公告)号：WO2010127304A2
公开(公告)日：2010-11-04
申请号：PCT/US2010033272
申请日：2010-04-30
申请人： ILLUMINA INC , RONAGHI MOSTAFA , EVERS DIRK , BETLEY JASON RICHARD
发明人： RONAGHI MOSTAFA , EVERS DIRK , BETLEY JASON RICHARD
IPC分类号： C12Q1/68 , C12N15/11 , C40B40/06
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2525/186 , C12Q2525/197
摘要： The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to nucleic acid sequencing.
摘要翻译：本技术涉及分子科学，如基因组学。更具体地，本技术涉及核酸测序。

15. 发明申请

WO2006131768A2 PROTEIN BINDING LIGANDS 审中-公开
标题翻译：蛋白结合配体
公开(公告)号：WO2006131768A2
公开(公告)日：2006-12-14
申请号：PCT/GB2006050146
申请日：2006-06-08
申请人： PROMETIC BIOSCIENCES LTD , BETLEY JASON RICHARD , PEARSON JAMES CHRISTOPHER , TATTON HELEN ROSEMARY , BEACOM BEN MARTIN
发明人： BETLEY JASON RICHARD , PEARSON JAMES CHRISTOPHER , TATTON HELEN ROSEMARY , BEACOM BEN MARTIN
CPC分类号： C07D251/70 , B01D15/327 , B01D15/3804 , B01J20/3242 , B01J20/3255 , C07B2200/11 , C07D251/44 , C07D251/50 , C07K1/20 , C40B40/00 , Y10T436/255
摘要： Compounds of the general formula (I): in which inter alia Q 1 represents -NR 1 R 3 , -OR 1 or -SR 1 and Q 2 represents -NR 2 R 4 , -OR 2 or -SR 2 , and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R 1 , R 2 , R 3 and R 4 includes an alkyl group -C n H 2n+1 in which n is greater than or equal to 7; (b) at least two of R 1 , R 2 , R 3 and R 4 independently include an alkyl group -C n H 2n+1 or a cycloalkyl group -C n H 2n-1 in which n is greater than or equal to 4; or (c) at least three of R 1 , R 2 , R 3 and R 4 independently include a C 1-12 alkyl group substituted by -NR 5 R 6 or aryl.
摘要翻译：通式（I）的化合物：其中尤其是Q 1是-NR 1，R 3，-OR 1， / SUP>或-SR 1和Q 2代表-NR 2 R 4，-OR， 2或-SR 2 2，并且A表示与载体基质的连接点，当（a）R 1〜R 2中的至少一个时，可用作蛋白质结合配体，其中，R 2，R 3，R 3和R 4包括烷基-C≡N<！ - SIPO 其中n大于或等于7; （b）R 1，R 2，R 3和R 4中的至少两个独立地包括烷基基团-C n H 2n + 1或环烷基-C≡NH 2n-1 N，其中n 大于或等于4; 或（c）R 1，R 2，R 3和R 4中的至少3个独立地包括被-NR 5 R 6取代的C 1-12烷基或芳基。

16. 发明申请

WO2003080650A1 COMPOUNDS COMPRISING PSEUDO-AMINO ACIDS 审中-公开
标题翻译：包含PSEUDO-AMINO酸的化合物
公开(公告)号：WO2003080650A1
公开(公告)日：2003-10-02
申请号：PCT/GB2003/001270
申请日：2003-03-25
申请人： ADPROTECH LIMITED , BETLEY, Jason, Richard
发明人： BETLEY, Jason, Richard
IPC分类号： C07K1/107
CPC分类号： C07K2/00 , C07K1/1075
摘要： This invention relates to compounds, and in particular to polypeptides, their use and methods for their production. These polypeptides are produced from "pseudo-cysteine" amino acids that facilitate the assembly of polypeptides by native chemical ligation. The invention provides a compound comprising a polypeptide, the polypeptide having at a C-terminal end a pseudo amino acid, the pseudo amino acid having a side chain containing a 1-amino-2-thiol moiety. For example the polypeptide comprises the structure: formula (I) wherein : R is a polypeptide chain; X is a linker.
摘要翻译：本发明涉及化合物，特别是涉及多肽，其用途及其制备方法。这些多肽由“假半胱氨酸”氨基酸产生，其通过天然化学连接促进多肽的组装。本发明提供了包含多肽的化合物，所述多肽在C末端具有假氨基酸，所述假氨基酸具有含有1-氨基-2-硫醇部分的侧链。例如，多肽包含结构式（I）其中：R是多肽链; X是一个链接器。

17. 发明申请

WO2003027137A3 TRIMERIC CONJUGATES OF PEPTIDIC DERIVATIVE 审中-公开
公开(公告)号：WO2003027137A3
公开(公告)日：2003-04-03
申请号：PCT/GB2002/004352
申请日：2002-09-26
申请人： ADPROTECH LIMITED , SMITH, Richard, Andrew, Godwin , BETLEY, Jason, Richard , ESSER, Dirk
发明人： SMITH, Richard, Andrew, Godwin , BETLEY, Jason, Richard , ESSER, Dirk
IPC分类号： C07K1/107
摘要： The invention provides a process for forming a compound having the formula (I): from chemical entities native [A], native [B] and native [C], where native [A] has a thioester group, native [B] had a 1-amino-2-thiol group with an unoxidised sulfhydryl side chain, and native [C] had a thiol reactive function (TRF) group, wherein chemical entities [A], [B] and [C] are covalently linked by linker group L, comprising the steps of: (i) admixing native [A] and native [B] in a reaction solution; (ii) condensing the unoxidised sulfydryl side chain of native [B] with the thioester group of native [A] for producing a first intermediate compound wherein [A] and [B] are linked with a β-aminothioester bond; (iii) rearranging the β-aminothioester bond for producing a second intermediate compound wherein [A] and [B] are linked with an amide bond having attached thereto a free thiol group; (iv) admixing native [C] with the second intermediate compound in a reaction solution; and (v) reacting the thiol reactive function (TRF) group of native [C] with the free thiol group of the second intermediate compound for producing a compound having the formula (I).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式