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11. 发明申请

WO2013142201A1 APPARATUS AND METHODS FOR FILTERING EMBOLI DURING PERCUTANEOUS AORTIC VALVE REPLACEMENT AND REPAIR PROCEDURES WITH FILTRATION SYSTEM COUPLED IN-SITU TO DISTAL END OF SHEATH 审中-公开
标题翻译：装置和方法，用于过滤动脉瓣置换和修复过程中的过滤与过滤系统联合在一起的远端
公开(公告)号：WO2013142201A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/030931
申请日：2013-03-13
申请人： NEXEON MEDSYSTEMS, INC. , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2/2427
摘要： Embodiments of the present invention provide apparatus and methods for embolic filtering during percutaneous valve replacement and repair procedures. Under one aspect, an apparatus comprises a sheath and a filter. The sheath has proximal and distal ends and a lumen therebetween. The distal end may be introduced into the aortic arch via the peripheral arteries and ascending aorta, while the proximal end may be disposed outside of the body. The lumen permits percutaneous aortic valve replacement or repair therethrough. The filter has a frame with an inlet and an outlet and an emboli-filtering mesh attached to the frame. The inlet is substantially spans the aortic arch in a region between the aortic valve and the great arteries. The outlet couples to the distal end of the sheath without leaving any gaps through which emboli could pass and without obstructing the lumen at the distal end of the sheath.
摘要翻译：本发明的实施例提供了在经皮瓣膜置换和修复过程期间用于栓塞过滤的装置和方法。在一个方面，一种装置包括护套和过滤器。护套具有近端和远端以及其间的管腔。远端可以通过外周动脉和升主动脉引入主动脉弓，而近端可以设置在身体的外部。管腔允许经皮主动脉瓣置换或修复。过滤器具有带入口和出口的框架，以及连接到框架的栓塞过滤网。入口基本跨过主动脉瓣和大动脉之间的区域中的主动脉弓。出口连接到护套的远端，而不留下任何间隙，栓塞通过该间隙，而不会阻塞鞘的远端处的内腔。

12. 发明申请

WO2007126729A3 FRACTURE-RESISTANT HELICAL STENT INCORPORATING BISTABLE CELLS AND METHODS OF USE 审中-公开
标题翻译：抗破坏性螺旋固定治疗双胞胎细胞及其使用方法
公开(公告)号：WO2007126729A3
公开(公告)日：2008-11-20
申请号：PCT/US2007007377
申请日：2007-03-23
申请人： PARAGON INTELLECTUAL PROPERTIE , BESSELINK PETRUS ANTONIUS , BATES MARK C
发明人： BESSELINK PETRUS ANTONIUS , BATES MARK C
IPC分类号： A61B17/11 , A61F2/00 , A61F2/06
CPC分类号： A61F2/88 , A61B17/11 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91541
摘要： Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.
摘要翻译：提供了血管假体和使用方法，其中血管假体包括构造成形成螺旋结构的多个双稳态单位电池。还提供了可视化导管，用于确保对病变进行精确测量并确保血管假体的传送和放置。

13. 发明申请

WO2007126729A2 FRACTURE-RESISTANT HELICAL STENT INCORPORATING BISTABLE CELLS AND METHODS OF USE 审中-公开
标题翻译：耐破伤性螺旋固定治疗双胞胎细胞及其使用方法
公开(公告)号：WO2007126729A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007377
申请日：2007-03-23
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BESSELINK, Petrus, Antonius , BATES, Mark, C.
发明人： BESSELINK, Petrus, Antonius , BATES, Mark, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61B17/11 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91541
摘要： Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.
摘要翻译：提供了血管假体和使用方法，其中血管假体包括构造成形成螺旋结构的多个双稳态单位电池。还提供了一种可视化导管，用于确保对病变的准确测量并确保血管假体的传送和放置。

14. 发明申请

WO2004068293A3 MICROPAYMENT PROCESSING METHOD AND SYSTEM 审中-公开
标题翻译：微处理处理方法与系统
公开(公告)号：WO2004068293A3
公开(公告)日：2005-05-06
申请号：PCT/US2004001845
申请日：2004-01-23
申请人： PEPPERCOIN INC , RIVEST RONALD L , MICALI SILVIO , SOLOMON PERRY , NIX ROBERT P , CARNEY ROBERT , JONNALAGADDA VARAPRASAD , BERGERON JOSEPH III , BATES MARK
发明人： RIVEST RONALD L , MICALI SILVIO , SOLOMON PERRY , NIX ROBERT P , CARNEY ROBERT , JONNALAGADDA VARAPRASAD , BERGERON JOSEPH III , BATES MARK
IPC分类号： G06Q20/40 , G06Q30/02 , G06F17/60
CPC分类号： G06Q30/02 , G06Q20/401
摘要： A method of producing an offer package (150) includes defining, within the offer package (156), a description of an offered product. The cost of the offered product and the merchant (154) making the offer are also defined within the offer package (158), which includes an encrypted version of the offered product (158, 160, 164).
摘要翻译：提供报价包（150）的方法包括在报价包（156）内定义所提供产品的描述。提供的产品和提供商品的商品（154）的成本也在提供包（158）内定义，其包括所提供产品的加密版本（158,160,164）。

15. 发明申请

WO2013142204A3 APPARATUS FOR FILTERING EMBOLI DURING PERCUTANEOUS AORTIC VALVE REPLACEMENT AND REPAIR PROCEDURES WITH FILTRATION SYSTEM COUPLED TO DISTAL END OF SHEATH 审中-公开
标题翻译：用于在超声波阀门更换过程中的装置和与过滤系统相连的修复程序
公开(公告)号：WO2013142204A3
公开(公告)日：2014-03-13
申请号：PCT/US2013030943
申请日：2013-03-13
申请人： NEXEON MEDSYSTEMS INC , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/01 , A61F2/24
CPC分类号： A61F2/013 , A61F2/2427 , A61F2002/011
摘要： The present invention provides several embodiments of an apparatus for embolic filtering during percutaneous valve replacement and repair procedures. Under one aspect, an apparatus (100) comprises a sheath (110)and a filter (120). The sheath has proximal (111) and distal (112) ends and a lumen (113) therebetween. The distal end may be introduced into the aortic arch via the peripheral arteries and ascending aorta, while the proximal end may be disposed outside of the body. The lumen permits percutaneous aortic valve replacement or repair therethrough. The filter has a frame (121) with an inlet and an outlet and an emboli-filtering mesh (122) attached to the frame. The inlet substantially spans the aortic arch in a region between the aortic valve and the great arteries. The outlet is coupled to the distal end of the sheath without leaving any gaps through which emboli could pass and without obstructing the lumen at the distal end of the sheath.
摘要翻译：本发明提供了在经皮瓣膜置换和修复过程期间用于栓塞过滤的装置的几个实施例。在一个方面，装置（100）包括护套（110）和过滤器（120）。护套具有近端（111）和远端（112）端部以及其间的内腔（113）。远端可以通过外周动脉和升主动脉引入主动脉弓，而近端可以设置在身体的外部。管腔允许经皮主动脉瓣置换或修复。过滤器具有带入口和出口的框架（121）和附接到框架的栓塞过滤网（122）。入口基本跨越主动脉瓣和主动脉瓣之间的区域。出口连接到护套的远端，而不留下任何间隙，栓塞通过该间隙，而不会阻塞鞘的远端处的内腔。

16. 发明申请

WO2007075959A3 INTERVENTIONAL CATHETER FOR RETROGRADE USE HAVING EMBOLIC PROTECTION CAPABILITY AND METHODS OF USE 审中-公开
标题翻译：用于具有刺激保护能力和使用方法的改造用传统导管
公开(公告)号：WO2007075959A3
公开(公告)日：2008-12-24
申请号：PCT/US2006048921
申请日：2006-12-20
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/90 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0097 , A61F2250/0039
摘要： Interventional catheters are disclosed for use in performing diagnostic and therapeutic procedures in vessels that are accessed retrograde to blood flow. The catheters include an elongated shaft slidably disposed within a sheath, a distal region having an end effector and a filter disposed proximal to the end effector to capture emboli liberated during the diagnostic or therapeutic procedure. The filter includes a plurality of struts that cooperate with an exterior surface of the catheter to define a reservoir to retain captured emboli, the reservoir configured so that advancement of the sheath contracts the filter without squeezing or dislodging captured emboli beyond a distal end of the filter.
摘要翻译：公开了介入导管用于在逆行到血液流动的血管中进行诊断和治疗程序。导管包括可滑动地设置在护套内的细长轴，具有末端执行器的远侧区域和设置在末端执行器附近的过滤器，以捕获在诊断或治疗过程期间释放的栓塞。过滤器包括多个支柱，其与导管的外表面协作以限定储存器以保持被捕获的栓塞，储存器构造成使得护套的前进收缩过滤器而不挤压或移除超过过滤器的远端的捕获的栓塞。

17. 发明申请

WO2006050063A3 METHODS AND APPARATUS FOR TREATING AN INJURED NERVE PATHWAY 审中-公开
标题翻译：治疗神经病变途径的方法和装置
公开(公告)号：WO2006050063A3
公开(公告)日：2007-12-21
申请号：PCT/US2005038876
申请日：2005-10-26
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/00 , A01N63/00 , A61F2/02
CPC分类号： A61M37/0069
摘要： Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration.
摘要翻译：提供了用于治疗受伤或切断的神经通路的方法和装置，其中将一个或多个微孔管植入神经通路以桥接受伤或切断的区域。将包含干细胞和营养物质的生物活性基质置于微孔管内，以促进干细胞的生长和通过受伤或切断的区域重新建立感官和运动导电通路。微孔管在干细胞发育过程中保护生物活性基质，并且在神经通路再生过程中也保持端区正确对准。

18. 发明申请

WO2007075959A2 INTERVENTIONAL CATHETER FOR RETROGRADE USE HAVING EMBOLIC PROTECTION CAPABILITY AND METHODS OF USE 审中-公开
标题翻译：用于具有刺激保护能力和使用方法的改造用传统导管
公开(公告)号：WO2007075959A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048921
申请日：2006-12-20
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/90 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0097 , A61F2250/0039
摘要： Interventional catheters are disclosed for use in performing diagnostic and therapeutic procedures in vessels that are accessed retrograde to blood flow. The catheters include an elongated shaft slidably disposed within a sheath, a distal region having an end effector and a filter disposed proximal to the end effector to capture emboli liberated during the diagnostic or therapeutic procedure. The filter includes a plurality of struts that cooperate with an exterior surface of the catheter to define a reservoir to retain captured emboli, the reservoir configured so that advancement of the sheath contracts the filter without squeezing or dislodging captured emboli beyond a distal end of the filter.
摘要翻译：公开了介入导管用于在逆行到血液流动的血管中进行诊断和治疗程序。导管包括可滑动地设置在护套内的细长轴，具有末端执行器的远侧区域和设置在末端执行器附近的过滤器，以捕获在诊断或治疗过程期间释放的栓塞。过滤器包括多个支柱，其与导管的外表面协作以限定储存器以保持被捕获的栓塞，储存器构造成使得护套的前进收缩过滤器而不挤压或移除超过过滤器的远端的捕获的栓塞。

19. 发明申请

WO2006020256B1 SYSTEMS AND METHODS FOR ATRAUMATIC IMPLANTATION OF BIO-ACTIVE AGENTS 审中-公开
标题翻译：用于生物活性剂的ATRAUMATIC植入物的系统和方法
公开(公告)号：WO2006020256B1
公开(公告)日：2007-01-25
申请号：PCT/US2005025470
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00398 , A61B2017/00871 , A61B2017/3411 , A61B2017/3484 , A61B2018/00392 , A61M5/3287
摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter (31) and a needle (37) disposed within the catheter (31) and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle (37) may be configured to create a tissue space surrounding a distal or lateral surface of the needle (37), into which the bioactive agent to be infused.
摘要翻译：提供了方法和装置，用于在形成针迹后，在形成于靶组织块中的针迹中递送生物活性剂，方法是避免药物以高速度撞击目标组织，或通过使用毛细管作用来吸引生物活性剂拔针时出针。该装置包括导管（31）和设置在导管（31）内的针（37），并且被配置为选择性地延伸到组织块中至预定深度，同时在沿针针回缩针的同时分配药剂。或者或另外，针（37）可以被配置为产生围绕针（37）的远侧或侧表面的组织空间，待注入的生物活性剂。

20. 发明申请

WO2005123044A3 IMPLANTABLE DEVICE FOR TREATING DISEASE STATES AND METHODS OF USING SAME 审中-公开
标题翻译：用于治疗疾病状态的可植入装置及其使用方法
公开(公告)号：WO2005123044A3
公开(公告)日：2006-08-24
申请号：PCT/US2005019934
申请日：2005-06-07
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/02 , A61B17/12 , A61F2/86 , A61K9/22 , A61L29/16 , A61L31/16 , A61M25/04 , A61M31/00
CPC分类号： A61M31/002 , A61B17/12109 , A61B17/12172 , A61B17/12177 , A61B17/12181 , A61B17/1219 , A61B2017/00889 , A61F2/022 , A61F2/86 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/64 , A61M25/04
摘要： Methods and apparatus are provided for delivering drugs, gene vectors, naturally-occurring or synthetic hormones or proteins or other bioactive agents within a patient's vasculature. In a preferred embodiment, the apparatus comprises a material that elutes or secretes a bioactive agent and is held in place within the patient's vessel by an anchor. The material may comprise a biocompatible, and optionally, absorbable matrix, or a culture medium that sustains and nourishes stem cells, spleen cells or pancreatic islets or other beneficial cells. The anchor and material are sized and/or collapsible from a delivery configuration, in which the anchor and material may be delivered into the patient's vasculature within a delivery sheath, to a deployed configuration, wherein the anchor engages an interior wall of the patient's vessel. The apparatus of the invention may be temporarily or permanently implanted, and may in addition self reconfigure after a predetermined period of residency.
摘要翻译：提供了用于在患者的脉管系统内递送药物，基因载体，天然存在的或合成的激素或蛋白质或其他生物活性剂的方法和装置。在优选的实施方案中，该装置包括洗脱或分泌生物活性剂并通过锚定在患者血管内保持就位的材料。该材料可以包含生物相容性和任选的可吸收基质，或维持和滋养干细胞，脾细胞或胰岛或其它有益细胞的培养基。锚和材料的尺寸和/或可从输送构型定尺寸，其中锚固件和材料可以在输送护套内输送到患者的脉管系统中到展开构造，其中锚固件接合患者血管的内壁。本发明的装置可以暂时地或永久地植入，并且可以在预定的居住期间之后再重新配置。

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