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11. 发明申请

WO2006010591A3 QUINAZOLINE DERIVATIVES 审中-公开
标题翻译：喹诺酮衍生物
公开(公告)号：WO2006010591A3
公开(公告)日：2006-10-12
申请号：PCT/EP2005008113
申请日：2005-07-26
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , ALLGEIER HANS , FROESTL WOLFGANG , KOLLER MANUEL , MATTES HENRI , NOZULAK JOACHIM , OFNER SILVIO , ORAIN DAVID , RASETTI VITTORIO , RENAUD JOHANNE , SOLDERMANN NICOLAS , FLOERSHEIM PHILIPP
发明人： ALLGEIER HANS , FROESTL WOLFGANG , KOLLER MANUEL , MATTES HENRI , NOZULAK JOACHIM , OFNER SILVIO , ORAIN DAVID , RASETTI VITTORIO , RENAUD JOHANNE , SOLDERMANN NICOLAS , FLOERSHEIM PHILIPP
IPC分类号： C07D239/96 , A61K31/517 , A61P25/00 , A61P25/18 , A61P25/28 , C07D401/12 , C07D403/04 , C07D409/12
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula (I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮衍生物，其中取代基如说明书中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。

12. 发明申请

WO9902497A3 PYRIDINE DERIVATIVES 审中-公开
标题翻译：吡啶衍生物
公开(公告)号：WO9902497A3
公开(公告)日：1999-04-01
申请号：PCT/EP9804266
申请日：1998-07-09
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , SIBIA NEUROSCIENCES INC , ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , COSFORD NICHOLAS DAVID , GASPARINI FABRIZIO , HECKENDORN ROLAND , JOHNSON EDWIN CARL , KUHN RAINER , VARNEY MARK ANDREW , VELICELEBI GOENUEL
发明人： ALLGEIER HANS , AUBERSON YVES , BIOLLAZ MICHEL , COSFORD NICHOLAS DAVID , GASPARINI FABRIZIO , HECKENDORN ROLAND , JOHNSON EDWIN CARL , KUHN RAINER , VARNEY MARK ANDREW , VELICELEBI GOENUEL
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61P9/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07F7/08
CPC分类号： C07D213/06 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D405/06 , C07D409/06 , C07F7/0812
摘要： Compounds of the formula (I), wherein X and R1 to R5 are as defined in the description, are useful for treating disorders mediated full or in part by mGluR5.
摘要翻译：式（I）化合物，其中X和R 1至R 5如说明书中所定义，可用于治疗全部或部分由mGluR5介导的病症。

13. 发明申请

WO2012059442A3 NEUROTRYPSIN INHIBITORS 审中-公开
公开(公告)号：WO2012059442A3
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069074
申请日：2011-10-31
申请人： NEUROTUNE AG , AHMED, Shaheen , HETTWER, Stefan , VRIJBLOED, Jan Willem , FARINA, Carlo , ALLGEIER, Hans
发明人： AHMED, Shaheen , HETTWER, Stefan , VRIJBLOED, Jan Willem , FARINA, Carlo , ALLGEIER, Hans
IPC分类号： C07D235/18 , C07D277/56 , C07D333/38 , C07D333/70 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07C237/42 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/4184 , A61P25/00
摘要： The invention relates to acylamino-phthalic acid amides and related compounds of formula (I) wherein A is -CONR 3 R 4 , -NR 5 COR 6 , -NHR 7 , -OR 8 , -SR 9 , -CH 2 NR 10 R 11 , -(CH2)2-R 12 , -CH=CH-R 12 , -C≡C-R 12 , optionally substituted phenyl, optionally substituted thiophenyl, or optionally substituted 1,2,3-triazol-4-yl, W is hydrogen, hydroxy or carboxymethoxy, Y is carboxy, methoxycarbonyl or 2 H -tetrazol-5-yl, and the various substituents R have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer's disease, and as cognitive enhancers.

14. 发明申请

WO2012059442A2 NEUROTRYPSIN INHIBITORS 审中-公开
标题翻译：神经营养素抑制剂
公开(公告)号：WO2012059442A2
公开(公告)日：2012-05-10
申请号：PCT/EP2011069074
申请日：2011-10-31
申请人： NEUROTUNE AG , AHMED SHAHEEN , HETTWER STEFAN , VRIJBLOED JAN WILLEM , FARINA CARLO , ALLGEIER HANS
发明人： AHMED SHAHEEN , HETTWER STEFAN , VRIJBLOED JAN WILLEM , FARINA CARLO , ALLGEIER HANS
IPC分类号： C07D235/18 , A61K31/381 , A61K31/4184 , A61K31/426 , A61K31/427 , A61P25/00 , C07C237/42 , C07D277/56 , C07D333/38 , C07D333/70 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
CPC分类号： C07D409/12 , C07C231/02 , C07C237/42 , C07C2601/06 , C07C2602/08 , C07D209/42 , C07D235/18 , C07D277/56 , C07D333/38 , C07D333/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to acylamino-phthalic acid amides and related compounds of formula (I) wherein A is -CONR3R4, -NR5COR6, -NHR7, -OR8, -SR9, -CH2NR10R11, -(CH2)2-R12, -CH=CH-R12, -C=C-R12, optionally substituted phenyl, optionally substituted thiophenyl, or optionally substituted 1,2,3-triazol-4-yl, W is hydrogen, hydroxy or carboxymethoxy, Y is carboxy, methoxycarbonyl or 2H-tetrazol-5-yl, and the various substituents R have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer's disease, and as cognitive enhancers.
摘要翻译：本发明涉及式（I）的酰氨基 - 邻苯二甲酸酰胺和相关化合物，其中A是-CONR 3 R 4，-NR 5 COR 6，-NHR 7，-OR 8，-SR 9，-CH 2 NR 10 R 11， - （CH 2）2 -R 12，-CH = CH -R12，-C = C-R12，任选取代的苯基，任选取代的噻吩基或任选取代的1,2,3-三唑-4-基，W为氢，羟基或羧甲氧基，Y为羧基，甲氧基羰基或2H-四唑 -5-基，并且各种取代基R具有说明书中指出的含义。这些化合物可用于治疗和/或预防骨骼肌萎缩，精神分裂症和阿尔茨海默病，以及作为认知增强剂。

15. 发明申请

WO2008049856A3 METHODS OF TREATING PAIN USING CDK INHIBITORS 审中-公开
标题翻译：使用CDK抑制剂治疗疼痛的方法
公开(公告)号：WO2008049856A3
公开(公告)日：2009-05-07
申请号：PCT/EP2007061415
申请日：2007-10-24
申请人： INGENIUM PHARMACEUTICALS GMBH , AUGUSTIN MARTIN , ZEITLMANN LUTZ , STUMM GABRIELE , PLEISS MICHAEL A , WABNITZ PHILIPP , ALLGEIER HANS
发明人： AUGUSTIN MARTIN , ZEITLMANN LUTZ , STUMM GABRIELE , PLEISS MICHAEL A , WABNITZ PHILIPP , ALLGEIER HANS
IPC分类号： A61K31/427 , A61K31/4439 , A61K31/454 , A61P29/00
CPC分类号： A61K31/427 , A61K31/4439 , A61K31/454
摘要： The present invention relates to inhibitors of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to methods of preventing and/or treating any type of pain comprising the administration of an effective amount of at least one inhibitor of cyclin-dependent kinases.
摘要翻译：本发明涉及细胞周期蛋白依赖性激酶的抑制剂及其治疗应用。此外，本发明涉及预防和/或治疗任何类型的疼痛的方法，包括施用有效量的至少一种细胞周期蛋白依赖性激酶抑制剂。

16. 发明申请

WO2008129071A1 INHIBITORS OF PROTEIN KINASES 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：WO2008129071A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054977
申请日：2008-04-24
申请人： INGENIUM PHARMACEUTICALS GMBH , SCHAUERTE, Heike , ALLGEIER, Hans , PLEISS, Michael A. , AUGUSTIN, Martin , PERAUS, Gisela , STUMM, Gabriele , WABNITZ, Philipp
发明人： SCHAUERTE, Heike , ALLGEIER, Hans , PLEISS, Michael A. , AUGUSTIN, Martin , PERAUS, Gisela , STUMM, Gabriele , WABNITZ, Philipp
IPC分类号： C07D239/42 , A61K31/505 , A61P29/00
CPC分类号： C07D239/42
摘要： The present invention relates to inhibitors of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to methods of preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases comprising the administration of an effective amount of at least one inhibitor of cyclin-dependent kinases. formula (I).
摘要翻译：本发明涉及细胞周期蛋白依赖性激酶的抑制剂及其治疗应用。此外，本发明涉及预防和/或治疗任何类型的疼痛，炎性疾病，免疫疾病，增殖性疾病，感染性疾病，心血管疾病和神经变性疾病的方法，包括施用有效量的至少一种细胞周期蛋白抑制剂，依赖性激酶。式（I）。

17. 发明申请

WO2008129069A1 INHIBITORS OF PROTEIN KINASES 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：WO2008129069A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054972
申请日：2008-04-24
申请人： INGENIUM PHARMACEUTICALS GMBH , SCHAUERTE, Heike , ALLGEIER, Hans , PLEISS, Michael, A. , AUGUSTIN, Martin , PERAUS, Gisela , STUMM, Gabriele , WABNITZ, Philipp
发明人： SCHAUERTE, Heike , ALLGEIER, Hans , PLEISS, Michael, A. , AUGUSTIN, Martin , PERAUS, Gisela , STUMM, Gabriele , WABNITZ, Philipp
IPC分类号： C07D239/42 , C07D403/10 , A61K31/505 , A61P29/00
CPC分类号： C07D239/42 , C07D403/10
摘要： The present invention provides new compounds. The compounds are useful as CDK5 inhibitors, and accordingly they can be included in pharmaceuticals compositions for treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases. formula (I).
摘要翻译：本发明提供新的化合物。这些化合物可用作CDK5抑制剂，因此它们可以包括在用于治疗任何类型的疼痛，炎性疾病，免疫疾病，增殖性疾病，感染性疾病，心血管疾病和神经变性疾病的药物组合物中。式（I）。

18. 发明申请

WO2006010591A2 QUINAZOLINE DERIVATIVES 审中-公开
标题翻译：喹唑啉衍生物
公开(公告)号：WO2006010591A2
公开(公告)日：2006-02-02
申请号：PCT/EP2005/008113
申请日：2005-07-26
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , ALLGEIER, Hans , FROESTL, Wolfgang , KOLLER, Manuel , MATTES, Henri , NOZULAK, Joachim , OFNER, Silvio , ORAIN, David , RASETTI, Vittorio , RENAUD, Johanne , SOLDERMANN, Nicolas , FLOERSHEIM, Philipp
发明人： ALLGEIER, Hans , FROESTL, Wolfgang , KOLLER, Manuel , MATTES, Henri , NOZULAK, Joachim , OFNER, Silvio , ORAIN, David , RASETTI, Vittorio , RENAUD, Johanne , SOLDERMANN, Nicolas , FLOERSHEIM, Philipp
IPC分类号： C07D239/96 , C07D403/04 , C07D409/12 , C07D401/12 , A61K31/517 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula (I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译：本发明涉及其中取代基如说明书中所定义的式（I）的1H-喹唑啉-2,4-二酮衍生物，它们的制备，它们作为药物的用途和药物组合物，其含有它们。

19. 发明申请

WO1997003079A1 NOVEL QUINOXALINE- AND QUINOXALINYLALKANE-PHOSPHONIC ACIDS 审中-公开
标题翻译：新型喹喔啉 - 和喹喔啉酮 - 磷酸
公开(公告)号：WO1997003079A1
公开(公告)日：1997-01-30
申请号：PCT/EP1996002866
申请日：1996-07-01
申请人： CIBA-GEIGY AG , MORETTI, Robert , ALLGEIER, Hans
发明人： CIBA-GEIGY AG
IPC分类号： C07F09/6509
CPC分类号： C07F9/650994 , C07D241/44
摘要： Quinoxaline- and quinoxalinylalkane-phosphonic acids of formula (I), wherein R1 is free or esterified carboxy or free or partially esterified phosphono, R2 and R3 are each independently of the other hydrogen or an aliphatic radical, the radicals R4, R5 and R6 are each independently of the others hydrogen, an aliphatic hydrocarbon radical, free or etherified hydroxy, free or etherified mercapto or oxidised free or etherified mercapto, unsubstituted or aliphatically substituted amino, nitro, free or esterified or amidated carboxy, cyano, free or amidated sulfamoyl, halogen or trifluoromethyl and X is a divalent aliphatic radical, and their tautomers and/or salts have NMDA-antagonistic properties and can be used in the treatment of pathological conditions that are responsive to blocking of NMDA-sensitive receptors.
摘要翻译：式（I）的喹喔啉和喹喔啉基烷烃膦酸，其中R1是游离的或酯化的羧基或游离的或部分酯化的膦酰基，R2和R3各自独立地是另一个氢或脂族基团，基团R4，R5和R6是游离或醚化的羟基，游离的或醚化的巯基或被氧化的游离的或醚化的巯基，未取代或脂族取代的氨基，硝基，游离或酯化或酰胺化的羧基，氰基，游离或酰胺基氨磺酰基，卤素或三氟甲基，X是二价脂族基团，其互变异构体和/或盐具有NMDA-拮抗性质，并且可用于治疗对阻断NMDA敏感受体有反应的病理状况。

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