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11. 发明申请

WO2017096281A1 ANTI-OX40 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗OX40抗体及其使用方法
公开(公告)号：WO2017096281A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064794
申请日：2016-12-02
申请人： AGENUS INC. , MEMORIAL SLOAN-KETTERING CANCER CENTER , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
发明人： WILSON, Nicholas S. , WAIGHT, Jeremy D. , BREOUS-NYSTROM, Ekaterina V. , RITTER, Gerd , SCHAER, David , HIRSCHHORN-CYMERMAN, Daniel , MERGHOUB, Taha , SEIBERT, Volker , VAN DIJK, Marc
IPC分类号： C07K16/28 , A61K39/395 , G01N33/68
CPC分类号： C07K16/2878 , C07K2317/34 , C07K2317/35 , C07K2317/76 , G01N2333/70578
摘要： The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g ., reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g ., reduces, deactivates, or inhibits OX40 activity.
摘要翻译：本公开内容提供了特异性结合人OX40受体（OX40）的抗体和包含此类抗体的组合物。在具体方面，抗体特异性结合人OX40并调节OX40活性，例如减少，失活或抑制OX40活性。本公开还提供了通过施用特异性结合人OX40并调节OX40活性（例如减少，减活或抑制OX40活性）的抗体，用于自身免疫或炎性疾病或病症的方法。 p>

12. 发明申请

WO2015148515A1 METHODS FOR OVERCOMING GLUTAMINE DEPRIVATION DURING MAMMALIAN CELL CULTURE 审中-公开
标题翻译：在马马里细胞培养过程中使谷氨酰胺转运的方法
公开(公告)号：WO2015148515A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022259
申请日：2015-03-24
申请人： BIOGEN MA INC.
发明人： YANG, William , HUANG, Yao-Ming , MARTY, Sinacore , RYLL, Thomas , LU, Jiuyi
IPC分类号： C12N5/00
CPC分类号： C12N5/0018 , C12N2500/40 , C12N2500/60 , C12P21/00
摘要： The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
摘要翻译：本发明涉及在缺乏谷氨酰胺的细胞培养物中产生感兴趣的多肽的方法。本发明还涉及在大规模细胞培养物中生产感兴趣的蛋白质的方法，其包括用核酸合成前体和/或皮质类固醇补充细胞培养物。

13. 发明申请

WO2014186403A2 ANTI-FOLR1 IMMUNOCONJUGATE DOSING REGIMENS 审中-公开
标题翻译： ANTI-FOLR1免疫调节剂量方案
公开(公告)号：WO2014186403A2
公开(公告)日：2014-11-20
申请号：PCT/US2014/037911
申请日：2014-05-13
申请人： IMMUNOGEN INC.
发明人： RUNNING, Kelli , MASTICO, Robert A. , O'LEARY, James J. , AB, Olga , WOLF, Beni B.
IPC分类号： A61K47/48 , A61K31/573 , C07K16/28 , A61K39/395
CPC分类号： A61K9/0019 , A61K31/5365 , A61K31/573 , A61K45/06 , A61K47/48384 , A61K47/48592 , A61K47/48638 , A61K47/6803 , A61K47/6849 , A61K47/6857 , A61K47/6869 , A61K2039/505 , A61K2039/545 , C07K16/28 , C07K16/2857 , C07K2317/94 , A61K2300/00
摘要： Methods of administering immunoconjugates that bind to FOLR1 are provided. The methods comprise administering an anti-FOLR1 immunoconjugate to a person in need thereof, for example, a cancer patient, at a therapeutically effective dosing regimen that results in minimal adverse effects.
摘要翻译：提供了与FOLR1结合的免疫缀合物的给药方法。所述方法包括以有效的给药方案向有需要的人（例如癌症患者）施用抗FOLR1免疫偶联物，其导致最小的不良反应。

14. 发明申请

WO2014070953A1 Methods of Using FVIII Polypeptide 审中-公开
标题翻译： FVIII多肽的使用方法
公开(公告)号：WO2014070953A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067613
申请日：2013-10-30
申请人： BIOGEN IDEC MA INC.
发明人： JIANG, Haiyan , NEELAKANTAN, Srividya , NESTOROV, Ivan , LI, Shuanglian
IPC分类号： A61K39/395
CPC分类号： C07K14/755 , A61K38/00 , C07K2319/21 , C07K2319/30 , C07K2319/43
摘要： The present invention provides methods of reducing or decreasing the annualized bleeding rate of a human subject having hemophilia by administering a long acting Factor VIII polypeptide. The long-acting FVIII polypeptide can be used for individual prophylaxis, weekly prophylaxis, episodic (on-demand) treatment, or perioperative management of hemophilia. The present invention relates generally to the field of therapeutics for hemostatic disorders.
摘要翻译：本发明提供通过施用长效因子VIII多肽来降低或降低具有血友病的人类受试者的年化出血率的方法。长效FVIII多肽可用于个体预防，每周预防，发作（按需）治疗或血友病围手术期管理。本发明一般涉及止血障碍治疗领域。

15. 发明申请

WO2014018777A3 BLOOD FACTOR MONITORING ASSAY AND USES THEREOF 审中-公开
标题翻译：血液因子监测分析及其用途
公开(公告)号：WO2014018777A3
公开(公告)日：2014-01-30
申请号：PCT/US2013/052101
申请日：2013-07-25
申请人： BIOGEN IDEC MA INC.
发明人： SOMMER, Jurg
IPC分类号： A61K38/37 , A61K38/36 , C07K14/755
摘要： The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g. , a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.
摘要翻译：本公开提供了用于诊断和治疗患有出血性疾病的对象的方法和组合物。所公开的方法包括使样品（例如从患者获得的血液或血浆样品）与包含活化的凝血因子和磷脂混合物的活化混合物接触，其中将活化混合物干燥到固体上基质。还提供了基于凝血时间（Ct）和药代动力学数据的整合的全面止血测试。所呈现的方法和组合物可以应用于护理点诊断系统。

16. 发明申请

WO2013123457A1 RECOMBINANT FACTOR VIII PROTEINS 审中-公开
标题翻译：重组因子VIII蛋白
公开(公告)号：WO2013123457A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/026521
申请日：2013-02-15
申请人： BIOGEN IDEC MA INC.
发明人： KULMAN, John
IPC分类号： A61K38/37 , A61K35/14
CPC分类号： C07K14/755 , A61K35/14 , A61K38/00 , A61K38/37 , C07K14/00 , C07K14/43504 , C07K14/59 , C07K14/705 , C07K14/76 , C07K14/79 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/60 , Y02A50/465 , Y02A50/467
摘要： Provided are recombinant Factor VIII proteins, e.g., human Factor VIII proteins with heterologous moieties inserted into flexible permissive loops located in the Factor VIII A domains, while retaining the procoagulant activity of Factor VIII.
摘要翻译：提供重组因子VIII蛋白，例如具有插入到因子VIIIA结构域中的柔性允许循环中的异源部分的人因子VIII蛋白质，同时保留因子VIII的促凝血活性。

17. 发明申请

WO2010048313A2 RECOMBINANT FCRN AND VARIANTS THEREOF FOR PURIFICATION OF FC-CONTAINING FUSION PROTEINS 审中-公开
标题翻译：重组FCRN及其变体用于纯化含FC的融合蛋白
公开(公告)号：WO2010048313A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/061517
申请日：2009-10-21
申请人： BIOGEN IDEC MA INC. , MCDONNELL, Kevin, Andrew
发明人： MCDONNELL, Kevin, Andrew
IPC分类号： C07K16/00
CPC分类号： C07K1/22 , C07K14/755 , C07K2319/30
摘要： The invention is directed to methods of purifying Fc-containing molecules using a soluble neonatal Fc receptor (sFcRn). Native FcRn binds Fc-containing proteins at or below about pH 6.5 and releases them at or above about pH 7 and provides a much milder approach for capturing and purifying Fc-containing proteins, in particular, therapeutic Fc-containing proteins. Other embodiments of the invention provide modifications to alter the pH for binding and elution to the sFcRn, to modulate Fc-containing protein binding affinity, to affect sFcRn linkage to a support surface, or to improve the stability of sFcRn to conditions utilized in the methods of the invention.
摘要翻译：本发明涉及使用可溶性新生儿Fc受体（sFcRn）纯化含Fc分子的方法。天然FcRn在约pH6.5或低于约pH6.5下结合含Fc蛋白质，并在约pH7或高于约pH7下释放它们，并为捕获和纯化含Fc的蛋白质，特别是含治疗性Fc的蛋白质提供了更温和的方法。本发明的其他实施方案提供改变以改变结合和洗脱至sFcRn的pH，调节含Fc的蛋白质结合亲和力，影响与载体表面的sFcRn连接或改善sFcRn对方法中所用条件的稳定性的发明。

18. 发明申请

WO2010019814A1 METHODS FOR EVALUATING CHROMATOGRAPHY COLUMN PERFORMANCE 审中-公开
标题翻译：评估色谱柱性能的方法
公开(公告)号：WO2010019814A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/053773
申请日：2009-08-13
申请人： BIOGEN IDEC MA INC. , GANGULY, Joydeep , THOMMES, Jorg
发明人： GANGULY, Joydeep , THOMMES, Jorg
IPC分类号： G01N30/86 , B01J19/00 , G06F19/00 , G01N30/50
CPC分类号： G01N30/8693 , G01N30/50 , G01N2030/889
摘要： Methods for evaluating and/or monitoring chromatography column performance are provided. Embodiments apply multivariate analysis (MVA) methods to process data as well as transition analysis data to provide a comprehensive evaluation of chromatography column performance. In embodiments, transition analysis data generated over extended periods of time can be analyzed together with process data to evaluate column performance. Further, embodiments enable a compact and robust tool for combining and presenting performance evaluation results, which allows for time-efficient performance examination. According to embodiments, MVA methods applied on transition analysis and process data provide (1) near real-time ability to comprehensively monitor column packing quality; (2) sensitive detection of column integrity breaches; (3) sensitive detection of subtle changes in column packing; (4) sensitive detection of different types of changes in column packing; (5) sensitive detection of fronting/tailing; and (6) sensitive detection of changes in process performance.
摘要翻译：提供了评估和/或监测色谱柱性能的方法。实施例应用多变量分析（MVA）方法处理数据以及过渡分析数据，以提供色谱柱性能的综合评估。在实施例中，可以在延长的时间段内生成的过渡分析数据与过程数据一起分析以评估列性能。此外，实施例使得能够组合和呈现性能评估结果的紧凑且鲁棒的工具，这允许进行时间效率的性能检查。根据实施例，应用于过渡分析和过程数据的MVA方法提供（1）近实时能力以全面监测柱填充质量; （2）敏感检测柱完整性违规; （3）柱包装微妙变化的敏感检测; （4）敏感检测不同类型的柱包装变化; （5）前端/尾部的敏感检测; 和（6）敏感检测过程性能变化。

19. 发明申请

WO2008091535A3 ANTIBODIES TO PHOSPHORYLATED-IRAK4 审中-公开
公开(公告)号：WO2008091535A3
公开(公告)日：2008-07-31
申请号：PCT/US2008/000639
申请日：2008-01-18
申请人： BIOGEN IDEC MA INC. , GORELIK, Leonid , BAKER, Darren, P. , HESSION, Catherine, A. , VAN DE MARK, Karyn , ARDUNINI, Robert, M. , WILDES, Craig
发明人： GORELIK, Leonid , BAKER, Darren, P. , HESSION, Catherine, A. , VAN DE MARK, Karyn , ARDUNINI, Robert, M. , WILDES, Craig
IPC分类号： C07K16/18 , C07K16/40 , G01N33/53 , G01N33/566 , G01N33/573 , G01N33/68 , C12N5/12
摘要： The present invention relates to antibodies that bind phosphorylated forms of IRAK4, methods of using such antibodies to detect IRAK4 biological activity, and methods for the detection, diagnosis, and prognostication of pathological conditions related to IRAK4 biological activity. ERAK4 is one member of a small family of highly conserved cytoplasmic signal transduction proteins characterized by the presence of an N-terminal "death domain" and a C- terminal serine-threonine kinase domain. IRAK4 functions in cytoplasmic signal transduction pathways by interacting with membrane spanning proteins which play, inter alia , critical roles in vertebrate immune system function.

20. 发明申请

WO2008073348A2 MICROGRAVITY BIOREACTOR SYSTEMS FOR PRODUCTION OF BIOACTIVE COMPOUNDS AND BIOLOGICAL MACROMOLECULES 审中-公开
标题翻译：用于生产生物活性化合物和生物大分子的微生物生物反应器系统
公开(公告)号：WO2008073348A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/025173
申请日：2007-12-10
申请人： MARSHALL UNIVERSITY RESEARCH CORPORATION , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION , VALLURI, Jagan, V. , GONDA, Steven, R.
发明人： VALLURI, Jagan, V. , GONDA, Steven, R.
IPC分类号： C12N1/00 , C12N1/20 , C12N5/00 , C12P21/00 , G01N33/53
CPC分类号： C12P17/06 , A01H3/00 , A01H4/001 , C12N5/04
摘要： The present invention relates to compositions and methods of plant, fungal and bacterial cell culture that can be effectively utilized for three-dimensional plant, fungal, and bacterial cell growth and production of bioactive compounds of interest. The culture methods employ a microgravity environment such that rapid establishment and expansion of cells into tissue constructs occurs influencing expression of biological macromolecules and biopharmaceuticals. The present invention is further directed to a method for the in vitro cultivation of plant, fungal, and bacterial cells in a liquid nutrient medium in modeled microgravity with potential for large scale manipulations.
摘要翻译：本发明涉及植物，真菌和细菌细胞培养物的组合物和方法，其可以有效地用于三维植物，真菌和细菌细胞生长和生产感兴趣的生物活性化合物。培养方法采用微重力环境，使得细胞进入组织构建体的快速建立和扩增会影响生物大分子和生物药物的表达。本发明还涉及一种用于在具有潜在的大规模操作的建模微重力中的液体营养培养基中体外培养植物，真菌和细菌细胞的方法。

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