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151. 发明申请

WO2005050197A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL GIRK4 (GIRK4) 审中-公开
标题翻译：与蛋白质相关的疾病相关的疾病诊断和治疗方法与蛋白质偶联的重组通道GIRK4（GIRK4）
公开(公告)号：WO2005050197A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004012587
申请日：2004-11-06
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6872
摘要： The invention provides a human GIRK4 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GIRK4 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人GIRK4。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GIRK4活性的化合物以及包含这些化合物的药物组合物。

152. 发明申请

WO2005054863A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL (GIRK 3) 审中-公开
标题翻译：与G蛋白偶联重复通道通道（GIRK 3）相关的疾病诊断和治疗
公开(公告)号：WO2005054863A3
公开(公告)日：2005-08-25
申请号：PCT/EP2004012784
申请日：2004-11-11
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/57492 , G01N33/6872
摘要： The invention provides a human GIRK3 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GIRK3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，炎症，代谢疾病，血液疾病，神经系统疾病和泌尿系疾病有关的人GIRK3。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，炎症，代谢疾病，血液疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GIRK3活性的化合物以及包含这些化合物的药物组合物。

153. 发明申请

WO2005031346A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR ADIPOR1 (ADIPOR1) 审中-公开
标题翻译：与G蛋白偶联受体ADIPOR1相关的疾病诊断和治疗（ADIPOR1）
公开(公告)号：WO2005031346A3
公开(公告)日：2005-08-25
申请号：PCT/EP2004010384
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68 , G01N33/74
CPC分类号： G01N33/6893 , G01N33/74 , G01N2800/32
摘要： The invention provides a human AdipoR1 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer e.g. stomach, rectum, prostate tumor hematological diseases e.g. liver cirrhosis, inflammation e.g. lung CoPD, respiratory diseases, neurological diseases and urological diseases e.g. prostate BPH. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症等相关的人AdipoR1。胃，直肠，前列腺肿瘤血液病例如肝硬化，炎症等。肺CoPD，呼吸系统疾病，神经系统疾病和泌尿系统疾病，例如前列腺BPH。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还具有结合和/或活化或抑制AdipoR1活性的化合物以及包含这些化合物的药物组合物。

154. 发明申请

WO2005052587A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 7 (KCNK7) 审中-公开
标题翻译：与钾通道，亚科K，成员7（KCNK7）相关的疾病诊断和治疗
公开(公告)号：WO2005052587A3
公开(公告)日：2005-08-04
申请号：PCT/EP2004012900
申请日：2004-11-13
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6872
摘要： Diagnostics and Therapeutics for Diseases Associated with Potassium Channel, Subfamily K, Member 7 (KCNK7) Abstract of Disclosure The invention provides a human KCNK7 which is associated with the cardiovascluar diseases, dermatological diseases, gastroeneterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascluar diseases, dermatological diseases, gastroeneterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KCNK7 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：与钾通道相关的疾病诊断与治疗，次科K，成员7（KCNK7）披露摘要本发明提供了与心脑血管疾病，皮肤病，胃肠病，癌症，血液疾病，呼吸系统疾病，肌肉相关的人类KCNK7 骨骼疾病，神经系统疾病和泌尿科疾病。本发明还提供了用于鉴定可用于治疗或预防心脑血管疾病，皮肤病，胃肠病，癌症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制KCNK7活性的化合物以及包含这些化合物的药物组合物。

155. 发明申请

WO2005003779A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH SENSORY NEURON-SPECIFIC G PROTEIN-COUPLED RECEPTOR 3 (SNSR3) 审中-公开
标题翻译：与感觉神经元特异性G蛋白偶联受体3（SNSR3）相关的疾病的诊断和治疗
公开(公告)号：WO2005003779A3
公开(公告)日：2005-07-07
申请号：PCT/EP2004006060
申请日：2004-06-04
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/566
CPC分类号： G01N33/566
摘要： The invention provides a human SNSR3 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, inflammatory diseases, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, inflammatory diseases, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of SNSR3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌系统和激素失调，炎性疾病，代谢疾病，胃肠和肝脏疾病，癌症疾病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系统疾病相关的人类SNSR3。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素紊乱，炎性疾病，代谢疾病，胃肠和肝脏疾病，癌症疾病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系统疾病障碍。本发明还涉及结合和/或激活或抑制SNSR3活性的化合物以及包含此类化合物的药物组合物。

156. 发明申请

WO2005040401A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MOSAIC SERINE PROTEASE (MSP) 审中-公开
标题翻译：马拉维丝氨酸蛋白酶相关疾病的诊断和治疗
公开(公告)号：WO2005040401A3
公开(公告)日：2005-06-23
申请号：PCT/EP2004011015
申请日：2004-10-02
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C12Q1/00 , C12Q1/37 , G01N33/574 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/574 , G01N33/6893 , G01N33/6896
摘要： The invention provides a human MSP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of MSP as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和生殖疾病有关的人类MSP。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和生殖疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制MSP活性的化合物以及包含这些化合物的药物组合物。

157. 发明申请

WO2005029085A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ORGANIC CATION TRANSPORTER SLC22A11 (SLC22A11) 审中-公开
标题翻译：与有机运输机相关的疾病诊断与治疗SLC22A11（SLC22A11）
公开(公告)号：WO2005029085A3
公开(公告)日：2005-06-23
申请号：PCT/EP2004010112
申请日：2004-09-10
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6872
摘要： The invention provides a human SLC22A11 which is associated with the cardiovascular diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of SLC22A11 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠疾病，炎症，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类SLC22A11。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠疾病，炎症，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制SLC22A11活性的化合物以及包含这些化合物的药物组合物。

158. 发明申请

WO2005022146A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 13 (KLK13) 审中-公开
标题翻译：与KALLIKREIN 13（KLK13）相关的疾病诊断和治疗
公开(公告)号：WO2005022146A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004009200
申请日：2004-08-17
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N2333/96455
摘要： The invention provides a human KLK13 which is associated with the hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK13 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病，肠胃病，泌尿科疾病，癌症病症和炎症有关的人类KLK13。本发明还提供了用于鉴定可用于治疗或预防血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病学，胃肠疾病，泌尿科疾病，癌症病症和炎症的化合物的测定。本发明还涉及结合和/或活化或抑制KLK13活性的化合物以及包含这些化合物的药物组合物。

159. 发明申请

WO2005052586A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 3 (KCNK3) 审中-公开
标题翻译：与钾通道相关的疾病，亚科K，成员3（KCNK3）的诊断和治疗
公开(公告)号：WO2005052586A2
公开(公告)日：2005-06-09
申请号：PCT/EP2004012891
申请日：2004-11-13
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C07K14/705 , G01N33/574 , G01N33/68
CPC分类号： C07K14/705 , G01N33/57492 , G01N33/6872 , G01N33/6896 , G01N2500/00
摘要： The invention provides a human KCNK3 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hernatological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hernatological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KCNK3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌疾病，代谢性疾病，癌症，炎症，胃肠疾病，脑膜炎病，呼吸系统疾病，神经系统疾病和泌尿系统疾病有关的人类KCNK3。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，脑膜炎疾病，呼吸系统疾病，神经疾病和泌尿科疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制KCNK3活性的化合物以及包含此类化合物的药物组合物。

160. 发明申请

WO2004104577A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR 4 (5-HT4) 审中-公开
标题翻译：与5-羟基嘧啶（丝氨酸）受体4（5-HT4）相关的疾病的诊断和治疗
公开(公告)号：WO2004104577A3
公开(公告)日：2005-06-02
申请号：PCT/EP2004005070
申请日：2004-05-12
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C07K14/705 , G01N33/94 , G01N33/50 , G01N33/68
CPC分类号： C07K14/70571 , G01N33/9406 , G01N33/942 , G01N2500/00
摘要： The invention provides a human 5-HT4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of 5-HT4 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供与心血管疾病，胃肠和肝脏疾病，炎性疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病有关的人类5-HT4。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，炎性疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制5-HT4活性的化合物以及包含这些化合物的药物组合物。

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