专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

131. 发明申请

WO2005007812A2 GENES AS DIAGNOSTIC TOOLS FOR AUTISM 审中-公开
标题翻译：作为诊断工具的使用
公开(公告)号：WO2005007812A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/021301
申请日：2004-07-01
申请人： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , MILLONIG, James, H. , BRZUSTOWICZ, Linda , GHARANI, Neda
发明人： MILLONIG, James, H. , BRZUSTOWICZ, Linda , GHARANI, Neda
IPC分类号： C12N
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The homeobox transcription factor, ENGRAILED 2 EN2) , was investigated for association with autism spectrum disorder (AS) by performing transmission/disequilibrium tests (TDT) for two SNPs ( rs1861972 and rs1861973 ) and was identified as being a likely susceptibility locus for autism and related AS disorders. Initially, TDT was performed using 137 triads of autistic individuals and their parents and significant overtransmission of the A allele of rs1861972 and the C allele or rs1861973 was observed. The analysis was then extended to include other affected and unaffected siblings as well as additional families. Significant association was observed for both SNPs under both the broad and narrow diagnostic schemes.
摘要翻译：通过对两个SNP（rs1861972和rs1861973）进行传输/不平衡测试（TDT），研究同源框转录因子ENGRAILED 2 EN2与自闭症谱系障碍（AS）相关，并被确定为自闭症易感性位点，相关的AS疾病。最初，使用137个自闭症个体及其父母进行TDT，并观察到rs1861972的A等位基因的显着过度传播和C等位基因或rs1861973。然后将分析扩大到包括其他受影响和不受影响的兄弟姐妹以及其他家庭。在广泛和狭窄的诊断方案下，观察到两个SNP的显着关联。

132. 发明申请

WO2004039944A2 TRI-BLOCK POLYMERS FOR NANOSPHERE-BASED DRUG OR GENE DELIVERY 审中-公开
标题翻译：用于基于NANOSPHERE的药物或基因交付的三嵌段聚合物
公开(公告)号：WO2004039944A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/015600
申请日：2003-05-15
申请人： RUTGERS, THE STATE UNIVERSITY , KOHN, Joachim , VEBERT-NARDIN, Corinne , BOLIKAL, Durgadas , SEYDA, Agnieszka
发明人： KOHN, Joachim , VEBERT-NARDIN, Corinne , BOLIKAL, Durgadas , SEYDA, Agnieszka
IPC分类号： C12N
CPC分类号： B82Y5/00 , A61K47/6925 , C12N15/88
摘要： Biocompatible non-toxic polyarylate triblock copolymers having an A-B-A structure wherein each A is a water-soluble, hydrophilic polymer end block and the B middle block is an polyarylate oligomer. The polymers spontaneously self-assemble to form low CAC nanospheres having utility as transfection agents for gene delivery.
摘要翻译：具有A-B-A结构的生物相容性无毒多芳基化合物三嵌段共聚物，其中每个A是水溶性亲水性聚合物端嵌段，B中间嵌段是聚芳基化合物低聚物。聚合物自发地自组装形成低CAC纳米球，其具有用作基因递送的转染剂。

133. 发明申请

WO2004014862A1 NITRO AND AMINO SUBSTITUTED HETEROCYCLES AS TOPOISOMERASE I TARGETING AGENTS 审中-公开
标题翻译： NITRO和AMINO替代替代物作为TOPOISOMERASE I靶向剂
公开(公告)号：WO2004014862A1
公开(公告)日：2004-02-19
申请号：PCT/US2003/025109
申请日：2003-08-11
申请人： RUTGERS, THE STATE UNIVERSITY , LAVOIE, Edmond, J. , SINGH, Sudhir, K. , LIU, Leroy, F.
发明人： LAVOIE, Edmond, J. , SINGH, Sudhir, K. , LIU, Leroy, F.
IPC分类号： C07D221/18
CPC分类号： C07D471/04 , C07D221/18
摘要： The invention provides compounds of formula (I): wherein: R 1 -R 5 , "a" and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating cancer using compounds of formula (I).
摘要翻译：本发明提供式（I）化合物：其中：R1-R5，“a”和X具有本说明书中定义的任何含义及其药学上可接受的盐。本发明还提供了包含式（I）化合物，制备式（I）化合物的方法，用于制备式（I）化合物的中间体和使用式（I）化合物治疗癌症的治疗方法的药物组合物。

134. 发明申请

WO2003107010A1 REAGENTS AND PROCEDURES FOR HIGH-SPECIFICITY LABELING 审中-公开
标题翻译：高特异性标签的试剂和程序
公开(公告)号：WO2003107010A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/018792
申请日：2003-06-13
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： EBRIGHT, Richard, H. , EBRIGHT, Yon, W.
IPC分类号： G01N33/68
CPC分类号： C07F9/78 , C07F9/706 , C07F9/806 , G01N33/533 , G01N33/582 , Y10S436/80
摘要： A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof, wherein: (i) Rl or R2, are each independently O-, S-, OR 3 or SR 3 with the provision that if either Rl or R2 is absent, the other remaining group is =0 or =S; or Rl and R2, together with the arsenic atom, form a ring according to one of the general structural Formulae (II), (III), (IV), or (V), wherein R3 is H, CH(OH)CH20H, or (CH2)y- Y, with q being 1-4 and Y being H, OH, NH2, SH, COOH, OAc, CONH2 or CN, and Z represents a hydrocarbon chain comprising 2-4 singly or doubly bonded carbon atoms each of which may be further substituted with one or more of hydrogen, methyl, ethyl, 1-propyl, 2-propyl, methoxy, hydroxy, amino, carboxy, sulfo, oxo, thio, halo (fluoro, chloro, bromo, or fluoro) and (CH2)„ "SO3, wherein n" is 1 or 2.
摘要翻译：具有根据一般结构式（I）的两个侧链胂基部分的分子和互变异构体，酸和其盐，其中：（i）R 1或R 2各自独立地为O，S-，OR 3或SR 3，其中规定如果R1或R2不存在，另一个剩余的基团为= 0或= S; 或者R 1和R 2与砷原子一起形成根据通式（II），（III），（IV）或（V）之一的环，其中R 3是H，CH（OH）CH 2 OH，或（CH2）y-Y，其中q为1-4，Y为H，OH，NH2，SH，COOH，OAc，CONH2或CN，Z表示包含2-4个单键或双键碳原子的烃链可以进一步被氢，甲基，乙基，1-丙基，2-丙基，甲氧基，羟基，氨基，羧基，磺基，氧代，硫代，卤代（氟，氯，溴或氟）中的一个或多个取代，和（CH 2）“”SO 3，其中n“为1或2。

135. 发明申请

WO2003065928A3 THERAPEUTIC POLYESTERS AND POLYAMIDES 审中-公开
公开(公告)号：WO2003065928A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003718
申请日：2003-02-06
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UHRICH, Kathryn, E.
发明人： UHRICH, Kathryn, E.
IPC分类号： A61F2/02
摘要： Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided. Medical implants based on the polymers of the invention are also provided.

136. 发明申请

WO2003046034A3 IMPROVED SYNTHESIS OF POLYANHYRIDES 审中-公开
公开(公告)号：WO2003046034A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/037799
申请日：2002-11-25
申请人： RUTGERS, THE STATE UNIVERSITY , UHRICH, Kathryn, E. , SCHMELTZER, Robert, C. , ANASTASION, Theodore, James , PUDIL, Bryant, J. , WOOD, Richard, D. , KANAMATHAREDDY, Suseela
发明人： UHRICH, Kathryn, E. , SCHMELTZER, Robert, C. , ANASTASION, Theodore, James , PUDIL, Bryant, J. , WOOD, Richard, D. , KANAMATHAREDDY, Suseela
IPC分类号： A01N25/00
摘要： The present invention provides a method for forming compounds of Formula HO-C(=O)R 1 -X-R 2 -X-R 1 -C(=O)-O-H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R 1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R 2 is a linking group.

137. 发明申请

WO2003041660A2 SOLUBILIZED TOPOISOMERASE POISONS 审中-公开
标题翻译：溶解性TOPOISOMERASE毒素
公开(公告)号：WO2003041660A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036901
申请日：2002-11-14
申请人： RUTGERS, THE STATE UNIVERSITY , LAVOIE, Edmond, J. , RUCHELMAN, Alexander, L. , LIU, Leroy, F.
发明人： LAVOIE, Edmond, J. , RUCHELMAN, Alexander, L. , LIU, Leroy, F.
IPC分类号： A61K
CPC分类号： C07D491/14
摘要： The invention provides compounds of formula (I) wherein A, B, W, Y, Z, and R 1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
摘要翻译：本发明提供式（I）化合物，其中A，B，W，Y，Z和R 1具有本说明书中定义的任何含义及其药学上可接受的盐。本发明还提供包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体，以及使用式I化合物治疗癌症的治疗方法。

138. 发明申请

WO2002102475A1 METHOD AND APPARATUS FOR ANALYZING A GOLF STROKE 审中-公开
标题翻译：用于分析高尔夫球的方法和装置
公开(公告)号：WO2002102475A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/018243
申请日：2002-06-07
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , SHOANE, George, K.
发明人： SHOANE, George, K.
IPC分类号： A63B57/00
CPC分类号： A63B69/3608 , A63B69/3614 , A63B2220/805
摘要： A method of analyzing and practicing golf strokes, such as putting strokes, is provided. A surface is provided, wherein a golfer (20) can practice one or more strokes in an environment simulating components of a golf course, such as a green. A club movement detector embedded in the surface and comprising a plurality of photodetectors and associated circuitry determines the position and velocity of the club face. A head movement sensor (40) detects rotational movement of the golfer's head during the golf stroke. An eye movement sensor (50) detects movement of the eyes of the golfer during the golf stroke. A processor (70) connected to the club movement sensor (60), eye movement sensor (60), and head movements sensor (50) gathers movement data during the golf stroke and produces measurements corresponding to the golf stroke, such as eye, head, and club movement of the golfer. The invention includes measuring head movement data and wirelessly transmitting same for remote analysis during a golf stroke.
摘要翻译：提供了一种分析和练习高尔夫球击的方法，如放置笔画。提供了一种表面，其中高尔夫球手（20）可以在模拟高尔夫球场（例如绿色）的部件的环境中练习一个或多个冲程。嵌入在表面中并包括多个光电检测器和相关电路的球杆运动检测器确定球杆面的位置和速度。头部运动传感器（40）检测高尔夫球打击期间高尔夫球手头部的旋转运动。眼球运动传感器（50）在高尔夫球击中检测高尔夫球手的眼睛的运动。连接到球杆运动传感器（60），眼睛运动传感器（60）和头部移动传感器（50）的处理器（70）在高尔夫球击中收集运动数据并且产生对应于高尔夫球程的测量，例如眼睛，头部，以及高尔夫球手的俱乐部运动。本发明包括测量头部运动数据和在高尔夫中程期间进行远程分析的无线传输。

139. 发明申请

WO2002087321A2 APPARATUS AND METHOD FOR MASS PRODUCTION OF INSECTICIDAL NEMATODES 审中-公开
标题翻译：杀虫剂NEMATODES大量生产的装置和方法
公开(公告)号：WO2002087321A2
公开(公告)日：2002-11-07
申请号：PCT/US2002/013368
申请日：2002-04-25
申请人： RUTGERS, THE STATE UNIVERSITY , GAUGLER, Randy
发明人： GAUGLER, Randy
IPC分类号： A01M
CPC分类号： A01K67/033
摘要： Disclosed are an apparatus and methods for in vivo mass production of insecticidal nematodes, which the efficiency and volume of nematode production. In the method, nematodes are cultured within a natural insect host. The apparatus comprises at least one harvesting area, a water dispensing system that promotes harvest of nematodes from the host organisms, and a water collection and concentration system for nematode collection and storage. The harvesting area comprises reusable stackable perforated trays, which allow passage of dispensed water while retaining the nematode hosts. The perforations are sized to retain the host organisms and facilitate the passage of harvested nematodes carried within the dispensed water.
摘要翻译：公开了一种用于体内大量生产杀虫线虫的装置和方法，其中线虫生产的效率和体积。在该方法中，线虫在天然昆虫宿主体内培养。该装置包括至少一个收获区域，促进从宿主生物体中收获线虫的水分配系统，以及用于线虫收集和储存的集水和浓缩系统。收获区域包括可重复使用的堆叠多孔板，其允许分配的水通过，同时保留线虫主体。这些穿孔的大小适于保持宿主生物体并促进收集的分配水中携带的线虫的通过。

140. 发明申请

WO2002075823A1 HIGH TEMPERATURE STABLE PIEZOELECTRIC POLYMER FILMS 审中-公开
标题翻译：高温稳定压电聚合物薄膜
公开(公告)号：WO2002075823A1
公开(公告)日：2002-09-26
申请号：PCT/US2002/006209
申请日：2002-02-27
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： SCHEINBEIM, Jerry, I. , GAO, Qiong
IPC分类号： H01L41/193
CPC分类号： H01L41/45 , C08L27/16 , C08L77/00 , H01L41/193 , H01L41/257 , C08L2666/14
摘要： Improved polarized materials are formed form dry powder blends of materials that demonstrate piezoelectric properties. Specifically, at least one nylon and at least one vinylidene containing polymer are mixed together to form a blended polarized material. Single-layered and multi-layered films including the blended polarized material, as well as methods for their manufacture are also disclosed.
摘要翻译：改进的极化材料由表现出压电性能的材料的干粉混合物形成。具体地，将至少一种尼龙和至少一种含亚乙烯基的聚合物混合在一起以形成混合的极化材料。还公开了包括共混极化材料的单层和多层膜及其制造方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式