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111. 发明申请

WO2005113788A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR KINASE 6 (GRK6) 审中-公开
标题翻译：与G蛋白偶联受体激酶6（GRK6）相关的疾病的诊断和治疗
公开(公告)号：WO2005113788A3
公开(公告)日：2006-03-23
申请号：PCT/EP2005004902
申请日：2005-05-06
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , C12Q1/00 , C12Q1/48 , G01N33/68
CPC分类号： C12Q1/485 , G01N2333/726 , G01N2500/04
摘要： The invention provides a human GRK6 which is associated with cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases, inflammation, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases, inflammation, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK6 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，血液疾病，呼吸系统疾病，炎症，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人GRK6。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，血液疾病，呼吸系统疾病，炎症，肌肉骨骼疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GRK6活性的化合物以及包含这些化合物的药物组合物。

112. 发明申请

WO2005101011A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH LXR-ALPHA (LXRA) 审中-公开
标题翻译：与LXR-ALPHA（LXR）相关的疾病的诊断和治疗
公开(公告)号：WO2005101011A3
公开(公告)日：2006-03-16
申请号：PCT/EP2005003547
申请日：2005-04-05
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： G01N33/6875 , C12Q1/6883 , G01N2500/00
摘要： The invention provides a human LXRA which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton disorders, neurologische Erkrankungen and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton disordes, neurologische Erkrankungen and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LXRA as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经病学和泌尿系疾病有关的人LXRA。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠病，血液疾病，呼吸系统疾病，肌肉骨骼紊乱，神经病学和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制LXRA活性的化合物以及包含这些化合物的药物组合物。

113. 发明申请

WO2005083105A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3B) 审中-公开
标题翻译：与GLYCOGEN SYNTHASE KINASE 3 BETA（GSK3B）相关的疾病诊断和治疗
公开(公告)号：WO2005083105A3
公开(公告)日：2006-03-09
申请号：PCT/EP2005001420
申请日：2005-02-12
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , WEINGAERTNER BERNHARD
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , WEINGAERTNER BERNHARD
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N2333/9121
摘要： The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GSK3B as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类GSK3B。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GSK3B活性的化合物以及包含这些化合物的药物组合物。

114. 发明申请

WO2005090993A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH LUNG SEVEN TRANSMEMBRANE RECEPTOR 1 (LUSTR1) 审中-公开
标题翻译：与肺癌患者相关的疾病诊断和治疗方法（LUSTR1）
公开(公告)号：WO2005090993A3
公开(公告)日：2006-02-09
申请号：PCT/EP2005001980
申请日：2005-02-25
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N33/6893 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human LUSTR1 which is associated with the cardiovascular diseases, infections, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LUSTR1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，血液病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病相关的人LUSTR1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，血液疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物，以及泌尿系疾病本发明还涉及结合和/或活化或抑制LUSTR1的活性的化合物以及包含这些化合物的药物组合物。

115. 发明申请

WO2005106486A3 DIAGNOSTIC AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH DIPEPTIDYL-PEPTIDASE 3(DPP3) 审中-公开
标题翻译：与DIPEPTIDYL-PEPTIDASE 3（DPP3）相关的疾病的诊断和治疗
公开(公告)号：WO2005106486A3
公开(公告)日：2006-02-02
申请号：PCT/EP2005004008
申请日：2005-04-15
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , G01N33/573 , G01N33/68
CPC分类号： G01N33/57484 , G01N33/573 , G01N33/6893 , G01N2333/96425
摘要： The invention provides a human DPP3 which is associated with the cardiovascular diseases, infections, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. tHe invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, cancer, endocrinological diseases, metaboic diseases, gastroenterogical diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类DPP3。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，呼吸系统疾病，癌症，内分泌疾病，代谢组学疾病，胃肠病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制DPP3的活性的化合物以及包含这些化合物的药物组合物。

116. 发明申请

WO2005075990A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN NUCLEAR RECEPTOR NR4A2 (NR4A2) 审中-公开
标题翻译：与人类受体NR4A2（NR4A2）相关的疾病的诊断和治疗方法
公开(公告)号：WO2005075990A3
公开(公告)日：2005-10-06
申请号：PCT/EP2005000679
申请日：2005-01-25
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6875
摘要： The invention provides a human NR4A2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton disorders, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton disorders, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NR4A2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类NR4A2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物的测定。泌尿系疾病本发明还涉及结合和/或活化或抑制NR4A2的活性的化合物以及包含这些化合物的药物组合物。

117. 发明申请

WO2005054867A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 5 (KCNK5) 审中-公开
标题翻译：与钾通道相关的疾病诊断和治疗药物，K型成员5（KCNK5）
公开(公告)号：WO2005054867A3
公开(公告)日：2005-10-06
申请号：PCT/EP2004012825
申请日：2004-11-12
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6872
摘要： The invention provides a human KCNK5 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KCNK5 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液病，神经疾病和泌尿系疾病有关的人类KCNK5。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠病，血液疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制KCNK5活性的化合物以及包含这些化合物的药物组合物。

118. 发明申请

WO2004071393A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH GLUCAGON-LIKE PEPTIDE 1 RECEPTOR (GLP1R) 审中-公开
标题翻译：与GLUCAGON-like肽1受体（GLP1R）相关的疾病的诊断和治疗
公开(公告)号：WO2004071393A3
公开(公告)日：2005-08-04
申请号：PCT/EP2004000877
申请日：2004-01-31
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/566 , G01N33/74 , G01N33/68
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human GLP1R which is associated with the hematological diseases, disorders of the peripheral and central nervous system, gastrointestinal diseases, respiratory diseases, metabolic disease, cardiovascular diseases, endocrinological diseases, inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, disorders of the peripheral and central nervous system, gastrointestinal diseases, respiratory diseases, metabolic disease, cardiovascular diseases, endocrinological diseases, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GLP1R as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，外周和中枢神经系统疾病，胃肠道疾病，呼吸系统疾病，代谢疾病，心血管疾病，内分泌疾病，炎症和泌尿疾病有关的人GLP1R。本发明还提供了用于鉴定可用于治疗或预防血液疾病，外周和中枢神经系统疾病，胃肠道疾病，呼吸系统疾病，代谢疾病，心血管疾病，内分泌疾病，炎症和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GLP1R活性的化合物以及包含这些化合物的药物组合物。

119. 发明申请

WO2004098487A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN TRANSMEMBRANE SERINE PROTEASE 5 (TMPRSS5) 审中-公开
标题翻译：与人类转铁丝氨酸蛋白酶5（TMPRSS5）相关疾病的诊断和治疗方法
公开(公告)号：WO2004098487A3
公开(公告)日：2005-04-14
申请号：PCT/EP2004004272
申请日：2004-04-22
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
IPC分类号： A61K20060101 , C12Q1/37 , G01N33/574
CPC分类号： C12Q1/37 , A61K38/1703 , G01N2333/96433
摘要： The invention provides a human TMPRSS5 which is associated with the cardiovascular disorders, respiratory diseases, neurological disorders, dermatological diseases, gastroenterological disorders and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, respiratory diseases, neurological disorders, dermatological diseases, gastroenterological disorders and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of TMPRSS5 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，呼吸系统疾病，神经障碍，皮肤病，胃肠疾病和癌症有关的人TMPRSS5。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，呼吸系统疾病，神经障碍，皮肤病，胃肠疾病和癌症的化合物的测定。本发明还涉及结合和/或活化或抑制TMPRSS5的活性的化合物以及包含这些化合物的药物组合物。

120. 发明申请

WO2004086052A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN-COUPLED RECEPTOR ADENOSINE A2B (ADORA2B) 审中-公开
标题翻译：与G蛋白偶联受体腺苷A2B（ADORA2B）相关的疾病的诊断和治疗
公开(公告)号：WO2004086052A3
公开(公告)日：2005-03-17
申请号：PCT/EP2004002735
申请日：2004-03-17
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , THIELE RALF
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , THIELE RALF
IPC分类号： C07K14/705 , G01N33/74 , G01N33/68
CPC分类号： G01N33/74 , C07K14/705 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human ADORA2B which is associated with the cardiovascular disorders, dermatological disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of ADORA2B as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤疾病，代谢疾病，胃肠和肝脏疾病，血液学疾病，癌症病症，呼吸系统疾病，神经障碍和泌尿系统疾病相关的人ADORA2B。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，代谢疾病，胃肠和肝脏疾病，血液病症，癌症疾病，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制ADORA2B的活性的化合物以及包含这些化合物的药物组合物。

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