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111. 发明申请

WO2005095977A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH P21/CDC42/RAC1-ACTIVATED KINASE 1 (PAK1) 审中-公开
标题翻译：与P21 / CDC42 / RAC1激活的激酶1（PAK1）相关的疾病的诊断和治疗
公开(公告)号：WO2005095977A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/001749
申请日：2005-02-19
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The invention provides a human PAK1 which is associated with cardiovascular diseases, dermatological diseaes, endocrinological diseases, metabolic diseases, inflammation (e.g. liver cirrhosis), gastroenterological diseases, cancer (e.g. stomach, colon, ovary or prostate tumor), hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases (e.g. Alzheimer) and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PAK1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症（例如肝硬化），胃肠病，癌症（例如胃，结肠，卵巢或前列腺肿瘤），血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病（如阿尔茨海默病）和泌尿系疾病。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物和泌尿系疾病本发明还涉及结合和/或活化或抑制PAK1的活性的化合物以及包含这些化合物的药物组合物。

112. 发明申请

WO2005095976A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH P21 (CDKN1A)-ACTIVATED KINASE 3 (PAK3) 审中-公开
标题翻译：与P21（CDKN1A）活化的激酶3（PAK3）相关的疾病的诊断和治疗方法
公开(公告)号：WO2005095976A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/001601
申请日：2005-02-17
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The invention provides a human PAK3 which is associated with cardiovascular diseases, respiratory diseases, (e.g. lung COPD), dermatological diseases, endocrinological diseases, metabolic diseases, cancer (e.g. thyroid, lung, ovary, breast or prostate tumor), inflammation (e.g. liver cirrhosis), gastroenterological diseases, hematological diseases, neurological diseases (e.g. Alzheimer) and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PAK3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，呼吸系统疾病（例如肺COPD），皮肤病，内分泌疾病，代谢疾病，癌症（例如甲状腺，肺，卵巢，乳腺或前列腺肿瘤），炎症（例如肝脏）相关的人类PAK3 肝硬化），胃肠疾病，血液病，神经系统疾病（如阿尔茨海默病）和泌尿系疾病。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，神经系统疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PAK3活性的化合物以及包含这些化合物的药物组合物。

113. 发明申请

WO2005095973A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR 54 (GPR54) 审中-公开
标题翻译： G蛋白偶联受体54（GPR54）相关疾病的诊断和治疗
公开(公告)号：WO2005095973A2
公开(公告)日：2005-10-13
申请号：PCT/EP2005/002595
申请日：2005-03-11
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N33/6893 , G01N33/721
摘要： The invention provides a human GPR54 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR54 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和癌症疾病相关的人类GPR54。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝疾病，炎性疾病，代谢疾病，血液病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和癌症疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制GPR54活性的化合物以及包含此类化合物的药物组合物。

114. 发明申请

WO2005095637A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MIXED LINEAGE KINASE 4 BETA (MLK4 BETA) 审中-公开
标题翻译：与混合线性激酶相关的疾病诊断和治疗4 BETA（MLK4 BETA）
公开(公告)号：WO2005095637A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/001599
申请日：2005-02-17
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/48
CPC分类号： G01N33/6896 , C12Q1/485 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/57484
摘要： The invention provides a human MLK4 beta which is associated with cardiovascular diseases, dermatological diseases, endocrinological disease, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological disease, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MLK4 beta as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，肠胃疾病，癌症，血液疾病，呼吸系统疾病，神经疾病和泌尿系疾病相关的人MLK4β。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制MLK4β的活性的化合物以及包含这些化合物的药物组合物。

115. 发明申请

WO2005078123A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 5 (KLK5) 审中-公开
标题翻译：与KALLIKREIN 5（KLK5）相关的疾病诊断和治疗
公开(公告)号：WO2005078123A1
公开(公告)日：2005-08-25
申请号：PCT/EP2005/001130
申请日：2005-02-04
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/68
CPC分类号： C12N9/6445
摘要： The invention provides a human KLK5 which is associated with the dermatological diseases, cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, inflammation, muscle-skeleton diseases, reproduction disorders, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of dermatological diseases, cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, inflammation, muscle-skeleton diseases, reproduction disorders, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK5 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与皮肤科疾病，心血管疾病，内分泌疾病，代谢疾病，癌症，胃肠病，血液疾病，炎症，肌肉骨骼疾病，繁殖障碍，神经系统疾病和泌尿系疾病有关的人类KLK5。本发明还提供了用于鉴定可用于治疗或预防皮肤病，心血管疾病，内分泌疾病，代谢疾病，癌症，胃肠疾病，血液疾病，炎症，肌肉骨骼疾病，繁殖障碍，神经系统疾病的化合物的测定。泌尿系疾病本发明还涉及结合和/或活化或抑制KLK5活性的化合物以及包含这些化合物的药物组合物。

116. 发明申请

WO2005075675A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES WITH PUTATIVE CYSTEINE PROTEASE 1 (PRSC1) 审中-公开
标题翻译：与胰岛素抵抗1（PRSC1）相关的疾病诊断与治疗
公开(公告)号：WO2005075675A2
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000610
申请日：2005-01-22
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger , THIELE, Ralf
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger , THIELE, Ralf
IPC分类号： C12Q1/68
CPC分类号： C12Q1/37 , C12N9/641 , G01N2500/10
摘要： The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSC1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人PRSC1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PRSC1的活性的化合物以及包含这些化合物的药物组合物。

117. 发明申请

WO2005075667A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 7 (KLK7) 审中-公开
标题翻译：与KALLIKREIN 7（KLK7）相关的疾病诊断和治疗
公开(公告)号：WO2005075667A1
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000634
申请日：2005-01-22
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2500/10
摘要： The invention provides a human KLK7 which is associated with the dermatological disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of dermatological disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK7 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与皮肤病，内分泌系统和激素失调，癌症疾病，代谢疾病，肌肉骨骼疾病，心血管疾病，神经障碍和泌尿系统疾病相关的人类KLK7。本发明还提供了用于鉴定可用于治疗或预防皮肤病，内分泌系统和激素疾病，癌症疾病，代谢疾病，肌肉骨骼疾病，心血管疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制KLK7活性的化合物以及包含这些化合物的药物组合物。

118. 发明申请

WO2005073729A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR P2Y11 (P2Y11) 审中-公开
公开(公告)号：WO2005073729A3
公开(公告)日：2005-08-11
申请号：PCT/EP2005/000470
申请日：2005-01-19
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/68
摘要： The invention provides a human P2Y11 which is associated with the dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, cardiovascular diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, cardiovascular diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y11 as well as pharmaceutical compositions comprising such compounds.

119. 发明申请

WO2005059546A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) 审中-公开
公开(公告)号：WO2005059546A3
公开(公告)日：2005-06-30
申请号：PCT/EP2004/013679
申请日：2004-12-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/53 , C07K14/72 , A61K38/00 , A61K39/395
摘要： The invention provides a human GPR35 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR35 as well as pharmaceutical compositions comprising such compounds.

120. 发明申请

WO2005059545A2 DIAGNOSTICS ANS THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR GPR82 (GPR82) 审中-公开
标题翻译：与G蛋白偶联受体GPR82（GPR82）相关的疾病诊断ANS的治疗方法
公开(公告)号：WO2005059545A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004/013691
申请日：2004-12-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/50
CPC分类号： G01N33/57492 , G01N33/6893 , G01N2333/726
摘要： The invention provides a human GPR82 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR82 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病，炎性疾病，神经障碍和泌尿系统疾病有关的人GPR82。本发明还提供用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病，炎性疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GPR82活性的化合物以及包含这些化合物的药物组合物。

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