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101. 发明申请

WO1994003598A1 ANTIALLERGIC AGENT 审中-公开
标题翻译：抗真菌剂
公开(公告)号：WO1994003598A1
公开(公告)日：1994-02-17
申请号：PCT/JP1993001085
申请日：1993-08-03
申请人： THE GREEN CROSS CORPORATION , RA, Chisei
发明人： THE GREEN CROSS CORPORATION , NAITO, Koji , HIRAMA, Minoru , OKUMURA, Ko
IPC分类号： C12N15/12
CPC分类号： A61K38/1709 , C07K14/47 , C07K14/70535 , Y10S424/805 , Y10S424/81 , Y10S514/885
摘要： An antiallergic agent containing an active ingredient comprising a peptide capable of combining with human IgE, more specifically the (alpha)-chain of a high-affinity immunoglobulin E receptor or a soluble fragment of the (alpha)-chain of a high-affinity immunoglobulin E receptor capable of combining with human IgE; an animal cell (1) transformed with a plasmid containing, integrated thereinto, both of sFc(epsilon)RI(alpha) having, added to the upstream region thereof, a promoter capable of controlling the expression in an animal cell and DHFR having, added thereto, a UK promoter; an animal cell (2) transformed with both of a plasmid containing, carried thereon, a DNA coding for an sFc(epsilon)RI(alpha) gene having, added to the upstream region thereof, a promoter capable of controlling the expression in an animal cell and another plasmid containing, carried thereon, a DNA coding for DHFR having, added to the upstream region thereof, a UK promoter; and a process for mass-producing sFc(epsilon)RI(alpha) by culturing the animal cell (1) or (2). The invention can provide a clinically useful antiallergic agent which shuts off allergic reaction in its origin.
摘要翻译：含有活性成分的抗过敏剂包含能够与人IgE结合的肽，更具体地说是高亲和力免疫球蛋白E受体的（α）链或高亲和力免疫球蛋白（α）链的可溶性片段 E受体能与人IgE结合; 用含有其中整合有sFc（ε）RI（α）的质粒转化的动物细胞（1），其具有添加到其上游区域的能够控制动物细胞中的表达的启动子和具有添加的DHFR 英国推动者; 用含有载体上载有编码sFc（ε）RI（α）基因的DNA的质粒转化的动物细胞（2），其具有加入其上游区域的能够控制动物表达的启动子细胞和另外一种质粒，其携带有编码DHFR的DNA，其上游区域加入英国启动子; 以及通过培养动物细胞（1）或（2）来大规模生产sFc（ε）RI（α）的方法。本发明可以提供临床有用的抗过敏剂，其在其起源处关闭过敏反应。

102. 发明申请

WO1994001393A1 NOVEL CHELATING AGENT, COMPLEX COMPOUND COMPOSED OF SAID AGENT AND METALLIC ATOM, AND DIAGNOSTIC AGENT CONTAINING SAID COMPOUND 审中-公开
标题翻译：新型螯合剂，由化合物和金属原子组成的复合化合物，以及含有化合物的诊断试剂
公开(公告)号：WO1994001393A1
公开(公告)日：1994-01-20
申请号：PCT/JP1993000331
申请日：1993-03-22
申请人： THE GREEN CROSS CORPORATION , MORI, Fumio , OKANO, Tadashi , MURAKAMI, Kazuki , SHINTOME, Masakazu , MUKAI, Hiromichi , MIYAGI, Ikuko , IMAGAWA, Takashi , KIM, Sang-Won , MARUKAWA, Taro , KOZUKA, Takahiro
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C07C229/06
CPC分类号： C07C229/16 , A61K49/06 , C07C237/04 , Y10T436/24
摘要： A compound represented by general formula (I), a complex compound composed of the above compound and a metallic atom, and a diagnostic agent containing the complex compound, wherein m represents an integer of 1 to 3, R1 and R2 may be the same or different from each other and each represents hydrogen or lower alkyl, and R3, R4, R5 and R6 may be the same or different from one another and each represents hydroxy or (II), wherein n represents 0 or 1, X represents -NH- or -O-, Y represents alkylene, A represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and B represents alkyl or alkenyl, provided that two or three of the groups R3, R4, R5 and R6 are hydroxy and that when two of them are hydroxy groups, then the cases where R3 and R5 are hydroxy and where R4 and R6 are hydroxy are excluded. The first-mentioned compound is useful as a chelating agent and the complex compound has excellent characteristics as a contrast medium for diagnostic imaging.
摘要翻译：由通式（I）表示的化合物，由上述化合物和金属原子组成的络合物和含有配位化合物的诊断剂，其中m表示1〜3的整数，R1和R2可以相同或相同，彼此不同，各自表示氢或低级烷基，R 3，R 4，R 5和R 6可以彼此相同或不同，并且各自表示羟基或（II），其中n表示0或1，X表示-NH- 或-O-，Y表示亚烷基，A表示氢，低级烷基，低级烷氧基，卤素或三氟甲基，B表示烷基或烯基，条件是R3，R4，R5和R6中的两个或三个为羟基，其中两个是羟基，则排除R3和R5是羟基，R4和R6是羟基的情况。首先提及的化合物可用作螯合剂，并且络合物具有作为诊断成像的造影剂的优异特性。

103. 发明申请

WO1991007493A1 CHIMERIC MOUSE HUMAN ANTIBODIES WITH SPECIFICITY TO HIV ANTIGENS 审中-公开
标题翻译：对HIV抗原具有特异性的嵌合体小鼠人类抗体
公开(公告)号：WO1991007493A1
公开(公告)日：1991-05-30
申请号：PCT/US1990006615
申请日：1990-11-13
申请人： XOMA CORPORATION , GREEN CROSS CORPORATION
发明人： XOMA CORPORATION , GREEN CROSS CORPORATION , BETTER, Marc, D. , HORWITZ, Arnold, H. , GHOSH-DASTIDAR, Pradip , ROBINSON, Randy, R.
IPC分类号： C12N15/13
CPC分类号： C07K16/1072 , A61K38/00 , C07K16/1054 , C07K16/1063 , C07K16/462 , C07K2317/24 , C07K2319/00 , C07K2319/036
摘要： Chimeric immunoglobulins, fragments or derivatives with all or a portion of a human immunoglobulin constant region and a murine variable region, having specificity for human immunodeficiency virus-1 (HIV-1) antigens, methods of their production, and their uses, have been described.
摘要翻译：描述了具有对人类免疫缺陷病毒-1抗原具有特异性的具有人免疫球蛋白和鼠可变区的全部或部分恒定区的免疫球蛋白，片段或嵌合衍生物。（HIV-1）及其生产过程和工作。

104. 发明申请

WO1990015617A1 ALBUMIN PREPARATION AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：铝制备及其制备方法
公开(公告)号：WO1990015617A1
公开(公告)日：1990-12-27
申请号：PCT/JP1990000788
申请日：1990-06-15
申请人： THE GREEN CROSS CORPORATION , MATSUOKA, Yasushi , HASE, Shinichiro , TAKECHI, Kazuo , TOMIOKA, Shinji , YOKOYAMA, Kazumasa
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K37/02
CPC分类号： C07K14/76 , A61K38/00 , A61L2/0023 , C07K14/765
摘要： The invention is directed to solving the problem that an aggregate of, supposedly, albumin or contaminant proteins such as transferrin remain unremoved in an albumin preparation, and provides an albumin preparation containing the aggregate in an amount which cannot be detected by gel filtration analysis and an albumin preparation containing transferrin in an amount which cannot be detected by Mancini's test. These preparations can be produced by treating an aqueous solution of serum albumin with an anion exchanger and then with a cation exchanger, followed by heat treatment.

105. 发明申请

WO1990012576A1 LIQUID PROSTAGLANDIN COMPOSITION 审中-公开
标题翻译：液体PROSTAGLANDIN组合物
公开(公告)号：WO1990012576A1
公开(公告)日：1990-11-01
申请号：PCT/JP1990000525
申请日：1990-04-23
申请人： THE GREEN CROSS CORPORATION , IMAGAWA, Takashi;
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K31/557
CPC分类号： A61K9/0019 , A61K9/1075 , A61K31/557 , A61K47/10
摘要： A liquid composition comprising prostaglandin and a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 1,000 to 20,000. The stability of the prostaglandin can be remarkably improved by the use of the above-specified copolymer.
摘要翻译：包含前列腺素的液体组合物和分子量为1,000〜20,000的聚氧乙烯 - 聚氧丙烯共聚物。通过使用上述规定的共聚物可以显着提高前列腺素的稳定性。

106. 发明申请

WO1987000553A1 PROCESS FOR PREPARING HETERO-PROTEIN 审中-公开
标题翻译：制备HETERO-PROTEIN的方法
公开(公告)号：WO1987000553A1
公开(公告)日：1987-01-29
申请号：PCT/JP1985000399
申请日：1985-07-16
申请人： THE GREEN CROSS CORPORATION , WATANABE, Hironobu , ISHIKAWA, Hideyuki , NAGAI, Masanori , ARIMURA, Hirofumi
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C12P21/00
CPC分类号： C12P21/02 , C07K1/113
摘要： A process for preparing hetero-protein by culturing hetero-protein-producing transformant obtained by genetic engineering techniques and recovering produced hetero-protein, which comprises recovering the hetero-protein from the transformant containing the hetero-protein therein in the presence of chloride ion. Thus, the hetero-protein deposited within the transformant cells is solubilized, restored to the form which is active in bioassay, and obtained in a high yield.

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