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91. 发明申请

WO1989012067A1 COMPOSITIONS HAVING USE AS TREATMENT OF PSORIASIS AND NEUROPSYCHIATRIC DEFICITS 审中-公开
标题翻译：具有治疗PSORIASIS和神经缺血缺陷的组合物
公开(公告)号：WO1989012067A1
公开(公告)日：1989-12-14
申请号：PCT/US1989002205
申请日：1989-05-25
申请人： THE UNITED STATES OF AMERICA, as represented by ...
发明人： THE UNITED STATES OF AMERICA, as represented by ... , BRIDGE, Peter , GOODWIN, Frederick, K.
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K38/162 , C12N2740/16122
摘要： Peptides which inhibit binding of human immunodeficiency virus (HIV) to receptor sites on the cell surface have now been shown to be useful as agents for treatment of psoriasis and neuropsychiatric disorders, including memory deficit and mood disorders. Compositions formulated for administration by sublingual and nasal route have proven particularly useful.
摘要翻译：抑制人体免疫缺陷病毒（HIV）与细胞表面受体位点结合的肽现在已被证明可用作治疗牛皮癣和神经精神障碍（包括记忆缺陷和情绪障碍）的药剂。通过舌下和鼻道给药配制的组合被证明是特别有用的。

92. 发明申请

WO1989006658A1 IMMUNOGENIC PEPTIDES 审中-公开
标题翻译：免疫肽
公开(公告)号：WO1989006658A1
公开(公告)日：1989-07-27
申请号：PCT/US1989000097
申请日：1989-01-13
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEMON, Stanley, M.
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/32422 , Y02A50/464
摘要： The instant invention relates to immunogenic synthetic peptides comprising amino acid sequences corresponding to antigenic determinants of the capsid of HAV, advantageously, linked directly or through a spacer molecule to carrier molecules suitable for vaccination of mammals.
摘要翻译：本发明涉及包含氨基酸序列的免疫原性合成肽，所述氨基酸序列对应于HAV衣壳的抗原决定簇，有利地直接或通过间隔分子连接到适合于哺乳动物接种的载体分子上。

93. 发明申请

WO1988009338A1 SYNTHETIC PEPTIDES AND A METHOD OF TREATING AIDS 审中-公开
标题翻译：合成肽和治疗艾滋病的方法
公开(公告)号：WO1988009338A1
公开(公告)日：1988-12-01
申请号：PCT/US1988001674
申请日：1988-05-20
申请人： SYNTBIOTECH, INC.
发明人： SYNTBIOTECH, INC. , TRAMPOTA, Miroslav , PINCUS, Matthew, R.
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Synthetic linear or cyclic peptides having the formula: [A]x-[B]x-Ser-Ser-Ser-Asn-Tyr-[C]x, wherein A is L-Ala, DL-Ala, D-Ala, Gly, or Val; B is L-Ala, DL-Ala, D-Ala, Gly, or Val; C is L-Met, L-Met (0), Cys, Thr or Gly; and x is an integer of from 0-1. A method of treating AIDS by administering the synthetic peptides is also provided.
摘要翻译：具有下式的合成线性或环状肽：[A] x- [B] x-Ser-Ser-Ser-Asn-Tyr- [C] x，其中A是L-Ala，DL-Ala，D-Ala，Gly ，或Val; B是L-Ala，DL-Ala，D-Ala，Gly或Val; C为L-Met，L-Met（0），Cys，Thr或Gly; x是0-1的整数。还提供了通过施用合成肽治疗AIDS的方法。

94. 发明申请

WO1988000596A1 A PROTEIN ACTIVE IN HUMORAL HYPERCALCEMIA OF MALIGNANCY-PTHrP 审中-公开
标题翻译：一种蛋白质在恶性高血糖症中的活性
公开(公告)号：WO1988000596A1
公开(公告)日：1988-01-28
申请号：PCT/AU1987000165
申请日：1987-06-04
申请人： THE UNIVERSITY OF MELBOURNE , MARTIN, Thomas, John , MOSELEY, Jane, Maries , KEMP, Bruce, Ernest , WETTENHALL, Richard, Edward, Hugh
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C07K07/06
CPC分类号： C07K14/635 , A61K39/00 , C07K16/26 , C07K2317/34 , Y10S435/975
摘要： Substantially pure proteins active in humoral hypercalcemia of malignancy (PTHrP) and sub-units and fragments thereof. Antibody reagents capable of binding to epitopes of PTHrP. Methods and kits for the detection of PTHrP.
摘要翻译：基本上纯的蛋白质在体液性高钙血症（PTHrP）及其亚单位及其片段中活跃。能够结合PTHrP表位的抗体试剂。检测PTHrP的方法和试剂盒。

95. 发明申请

WO1987006940A1 ASSAYS AND ANTIBODIES FOR N-myc PROTEINS 审中-公开
标题翻译： N-myc蛋白的测定和抗体
公开(公告)号：WO1987006940A1
公开(公告)日：1987-11-19
申请号：PCT/US1987001046
申请日：1987-05-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , AMGEN
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , AMGEN , SLAMON, Dennis, J. , SOUZA, Lawrence, M.
IPC分类号： C07K07/06
CPC分类号： C07K14/82 , A61K38/00 , C07K16/32 , G01N33/5748
摘要： Methods and compositions for identifying patients suffering from cancer, particularly neural and neuroendocrine cancers. It has been found that the protein expression product of the human N-myc photo-oncogene may be detected in certain biological specimens, particularly tissue specimens and sputum samples. By obtaining immunogenic N-myc polypeptides, either synthetically or by isolation from a natural source, antibodies specific for the N-myc protein are obtained. Those antibodies may then be used in immunological techniques for detecting the presence of N-myc in the biological samples. In particular, the antibodies may be employed in immunohistochemical techniques to detect the N-myc protein in prepared tissue and sputum samples.
摘要翻译：识别癌症患者的方法和组合物，特别是神经和神经内分泌癌症。已经发现，人类N-myc光致癌基因的蛋白质表达产物可以在某些生物样品，特别是组织标本和痰样品中检测。通过合成或通过从天然来源分离获得免疫原性N-myc多肽，获得对N-myc蛋白特异的抗体。然后可以将这些抗体用于免疫学技术以检测生物样品中N-myc的存在。特别地，抗体可用于免疫组织化学技术以检测制备的组织和痰样品中的N-myc蛋白。

96. 发明申请

WO1998018816A1 PEPTIDE COMPOSITIONS WITH GROWTH FACTOR-LIKE ACTIVITY 审中-公开
标题翻译：具有生长因子活性的肽组合物
公开(公告)号：WO1998018816A1
公开(公告)日：1998-05-07
申请号：PCT/US1997018342
申请日：1997-10-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BHATNAGAR, Rajendra, S. , QIAN, Jing, Jing
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00 , A61L27/227 , C07K14/495
摘要： Small peptide mimics of TGF- beta , having the general sequence AAj-AAj+1-AAj+2 followed by AAi+n shortly thereafter, have been prepared. In this sequence, AAi is alanine, asparagine, or leucine, AAi+1 is valine or isoleucine, AAi+2 is alanine, n is 3, 4 or 5 such that there are n-3 amino acid residues in between AAj+2 and AAi+n, and AAj+n is glutamic acid, aspartic acid, glutamine or asparagine. Because the essential requirement for TGF- beta activity is the peptide's ability to form a stable beta -bend structure under physiologic conditions, the inventive peptides are collectively referred to as beta -bend peptides. Compositions for applications such as tissue repair are also provided that comprise a biocompatible matrix having cytomodulin or a cytomodulin analog admixed with or carried by the matrix.
摘要翻译：已经制备了具有一般序列AAj-AAj + 1-AAj + 2，之后是AAi + n的TGF-β的小肽模拟物。在这个序列中，AAi是丙氨酸，天冬酰胺或亮氨酸，AAi + 1是缬氨酸或异亮氨酸，AAi + 2是丙氨酸，n是3,4或5，使得在AAj + 2之间有n-3个氨基酸残基 AAi + n和AAj + n是谷氨酸，天冬氨酸，谷氨酰胺或天冬酰胺。因为TGF-β活性的基本要求是肽在生理条件下形成稳定的β-末端结构的能力，所以本发明的肽统称为β-末端肽。还提供了诸如组织修复的组合物，其包含具有与基质混合或携带的细胞调节蛋白或细胞模型蛋白类似物的生物相容性基质。

97. 发明申请

WO1998017681A1 MATERIALS AND METHOD FOR THE DETECTION AND TREATMENT OF WEGENER'SGRANULOMATOSIS 审中-公开
标题翻译：食肉动物检测和治疗的材料与方法
公开(公告)号：WO1998017681A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019145
申请日：1997-10-17
申请人： UNIVERSITY OF FLORIDA
发明人： UNIVERSITY OF FLORIDA , STAUD, Roland
IPC分类号： C07K07/06
CPC分类号： C12N9/6467 , A61K38/00 , C07K14/4713 , G01N33/564 , G01N2333/96411 , G01N2800/101 , Y10S435/81
摘要： The subject invention pertains to the identification of peptides useful in the detection and treatment of Wegener's granulomatosis.
摘要翻译：本发明涉及可用于检测和治疗韦格纳肉芽肿病的肽的鉴定。

98. 发明申请

WO1998015572A1 A COMPOSITION COMPRISING AN IMMOBILISED, ACYLATED PEPTIDE 审中-公开
标题翻译：包含固定化的肽的组合物
公开(公告)号：WO1998015572A1
公开(公告)日：1998-04-16
申请号：PCT/EP1997005572
申请日：1997-10-07
申请人： AKZO NOBEL N.V. , LOOMANS, Elma, Elisabeth, Maria, Gerarda , SCHIELEN, Wilhelmus, Joseph, Gerardus
发明人： AKZO NOBEL N.V.
IPC分类号： C07K07/06
CPC分类号： C07K17/06 , G01N33/54353
摘要： A novel generic coating procedure to improve the coating efficienncy of small synthetic peptide antigens in ELISA is described. Inthis invention the binding capacities of several peptides linked to various moieties were compared to their parent counterparts in ELISA. Elongation of an epitope-sequence by an acyl group of the formula: R1-A-R2-CO- wherein R1 is lower alkyl, arly, or aralkyl; R2 is a divalent radical derived from lower alkyl, arly, or aralkyl; and A is a sulfur containing functional group selected from -CO-S-, -S-, -SO-, -SO2- and -S-S- specifically increased the binding reactivity with the monoclonal antibody when adsorbed onto a solid support, preferably polystyrene wells. Elongation is preferably, N-teminally. Several moieties achieved an enormous reduction in peptide coat concentration for all tested peptides of net two to four orders of magnitude. Replacement of an Ata-extension (wherein R1 is methyl; R2 is methylene; and A is -CO-S-) by analogues (i.e. Bta, Atp, Btb) was possible without reducing their enhancing properties to a great extent. Furthermore, direct synthesis of the Ata-group to the N-terminal end of a peptide appears to be a simple and general strategy for effective adsorption of small peptides to polystyrene.
摘要翻译：描述了一种用于改善ELISA中小合成肽抗原的包衣效率的新颖的通用包衣方法。本发明将与多种部分连接的几种肽的结合能力与ELISA中的亲本对应物进行比较。通过下式的酰基延伸表位序列：R1-A-R2-CO-，其中R1是低级烷基，芳基或芳烷基; R2是衍生自低级烷基，芳基或芳烷基的二价基团; 并且A是选自-CO-S-，-S-，-SO-，-SO 2 - 和-SS的含硫官能团 - 当吸附到固体载体上时，特别是增加了与单克隆抗体的结合反应性，优选聚苯乙烯。延伸优选为N末端。对于所有测试的肽的肽数量来说，几个部分实现了肽包衣浓度的极大降低。通过类似物（即Bta，Atp，Btb）替换Ata-延伸（其中R1是甲基; R2是亚甲基; A是-CO-S-））是可能的，而在很大程度上不降低它们的增强性能。此外，将Ata-基团直接合成肽的N-末端似乎是有效吸附小肽至聚苯乙烯的简单且一般的策略。

99. 发明申请

WO1998012218A1 TRI- OR POLYSULPHIDE CONTAINING PEPTIDES HAVING IMMUNOMODULATING ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的含有多聚磷酸的肽
公开(公告)号：WO1998012218A1
公开(公告)日：1998-03-26
申请号：PCT/SE1997001553
申请日：1997-09-15
申请人： ASTRA AKTIEBOLAG (publ) , BERGSTRAND, Håkan , ERIKSSON, Tomas , LINDVALL, Magnus , SÄRNSTRAND, Bengt
发明人： ASTRA AKTIEBOLAG (publ)
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00
摘要： A physiologically active tri- or polysulphide linked peptide homo- or heterodimer or cyclised monomer, derived from one or more monomers of formula (I): A-R2-R3-B (SEQ ID NO:1) wherein R2 is a residue of an amino acid selected from proline (Pro), isoleucine (Ile), alanine (Ala), tyrosine (Tyr), pipecolic acid (Pec), threonine (Thr), arginine (Arg), glycine (Gly), or R8, R3 is R8, and each R8 is independently an amino acid residue of formula (II) or formula (III), wherein each of R5 and R6 is independently selected from H, alkyl, e.g. methyl, aryl and alkoxy, n is selected from 0, 1, 2, 3 and 4, and m is selected from 0, 1, 2, 3 and 4; the entire peptide sequence of each monomer containing 3 to 30 amino acid residues; the dimer being formed by linking of the sulphide group of at least one R8 group of one monomer to the sulphide group of an R8 group of the other monomer via an -(S)p- wherein p is an integer of at least 1, so that a trisulphide or polysulphide link is provided, and the monomer being cyclised by linking of the sulphide group of one R8 group to the sulphide group of another R8 group via an -(S)p-, wherein p is an integer of at least 1, so that a trisulphide or polysulphide cyclising link is provided, is absorbable by the epithelial cell lining in a mammal resulting in a modulated immune response and thereby a therapeutic effect against disease.
摘要翻译：衍生自一种或多种式（I）单体的生理活性三硫或多硫键连接的肽均聚物或异二聚体或环化单体：A-R2-R3-B（SEQ ID NO：1），其中R2是选自脯氨酸（Pro），异亮氨酸（Ile），丙氨酸（Ala），酪氨酸（Tyr），哌啶酸（Pec），苏氨酸（Thr），精氨酸（Arg），甘氨酸（Gly）或R8， R 8和R 8各自独立地为式（II）或式（III）的氨基酸残基，其中R 5和R 6各自独立地选自H，烷基，例如甲基，芳基和烷氧基，n选自0,1,2,3和4，m选自0,1,2,3和4; 每个单体的整个肽序列含有3至30个氨基酸残基; 二聚体通过一个单体的至少一个R 8基团的硫化物基团与其它单体的R 8基团的硫化物基团经由其中p是至少为1的整数连接而形成，因此，提供三硫化物或多硫化物连接，并且单体通过将一个R 8基团的硫化物基团与另一个R 8基团的硫化物基团经由 - （S）p - 键合而环化，其中p是至少为1的整数，使得提供三硫化物或多硫化物环化链接，其可被哺乳动物中的上皮细胞衬里吸收，导致调节的免疫应答，从而对抗疾病的治疗效果。

100. 发明申请

WO1998006743A1 ACYLATED PEPTIDE CYTOLYTIC PEPTIDE INHIBITORS 审中-公开
标题翻译：酰化肽细胞肽抑制剂
公开(公告)号：WO1998006743A1
公开(公告)日：1998-02-19
申请号：PCT/AU1997000511
申请日：1997-08-13
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , BIOMOLECULAR RESEARCH INSTITUTE , CURTAIN, Cyril, Curtis , MATTHEWS, Barry, Ross , BAELL, Jonathan, Bayldon , RIVETT, Donald, Edward , HEWISH, Dean, Raymond , WERKMEISTER, Jerome
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , BIOMOLECULAR RESEARCH INSTITUTE
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , C07K5/0812 , C07K5/0819
摘要： The present invention relates to hybrid molecules and novel peptides which inhibit cytolytic compounds such as melittin. The invention also relates to pharmaceutical compositions including these inhibitors and to methods of inhibiting cytolytic compounds.
摘要翻译：本发明涉及抑制细胞溶解化合物如蜂毒素的杂合分子和新型肽。本发明还涉及包括这些抑制剂的药物组合物和抑制细胞溶解化合物的方法。

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