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91. 发明申请

WO2013068650A2 METHOD AND SYSTEM FOR EVALUATING A PHYSIOLOGICAL STATE DEPICTING A PERSON'S RESOURCES 审中-公开
标题翻译：用于评估描绘个人资源的生理状态的方法和系统
公开(公告)号：WO2013068650A2
公开(公告)日：2013-05-16
申请号：PCT/FI2012/051094
申请日：2012-11-09
申请人： FIRSTBEAT TECHNOLOGIES OY
发明人： SAALASTI, Sami , KETTUNEN, Joni , TUOMINEN, Satu , KOTISAARI, Jaakko
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3431 , A61B5/0022 , A61B5/02405 , A61B5/1118 , G06F19/00 , G06F19/345 , G06F19/3481 , G16H50/20 , G16H50/30
摘要： The invention relates to a method for evaluating a physiological state depicting a person's resources, in which method the alternatives (1, 2, 3, 4, 5, 6, 7, 8) of physiological states (10) depicting resources are determined, one or more contexts (11) are selected, one or more variables (12) are selected for each context (11), in which case in the evaluation the person's physiological information (20) is measured and recorded, the measurement-background data (22) of the measurement are determined and recorded, a value (26) is defined for a variable (12) of the context (11), corresponding temporal periods are defined for each context (11), and - the person's physiological state (10) is determined. Further, in the method a preselected correlation function (24) is defined, a value (14) is computed for the correlation function (24), - a reference value (16) is computed for each physiological state ( 10), and the physiological state (10) of the person is determined. The invention also relates to a corresponding system for evaluating a person's physiological state.
摘要翻译：本发明涉及一种用于评估描绘个人资源的生理状态的方法，在该方法中，生理状态（1，2，3，4，5，6，7， 10）描绘资源，选择一个或多个上下文（11），为每个上下文（11）选择一个或多个变量（12），在这种情况下，在评估中测量和记录人的生理信息，确定并记录测量的测量背景数据（22），为上下文（11）的变量（12）定义值（26），为每个上下文（11）定义相应的时间段，以及 - 确定人的生理状态（10）。此外，在该方法中，定义预先选择的相关函数（24），为相关函数（24）计算值（14）， - 为每个生理状态（10）计算参考值（16）状态（10）被确定。本发明还涉及用于评估人的生理状态的相应系统。

92. 发明申请

WO2013039574A1 BODILY SELF-IMAGE AND METHODS FOR PREDICTING PLACEBO RESPONSE OR RESPONSE SHIFT 审中-公开
标题翻译：用于预测平台响应或响应移位的自身自身图像和方法
公开(公告)号：WO2013039574A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/038014
申请日：2012-05-15
申请人： STEVEN PASHKO, LLC , PASHKO, Steven, Michael
发明人： PASHKO, Steven, Michael
IPC分类号： G06F19/00
CPC分类号： G06F19/3431 , A61B5/0042 , A61B5/04001 , A61B5/04009 , A61B5/04842 , A61B5/0496 , A61B5/16 , A61B6/032 , A61B6/037 , G01R33/4806 , G06F19/00 , G16H10/20 , G16H50/30 , G16H50/50
摘要： Methods for determining the likelihood that a subject will be a placebo responder in a clinical study are provided. Also provided are methods for eliminating likely placebo responders from a clinical study a priori, thereby simplifying data analysis and minimizing or eliminating any confound that arises in the analysis as a result of placebo response. Databases and computer systems using the methods are also disclosed herein. Methods for assessing likelihood of a subject experiencing a response shift are also provided.
摘要翻译：提供了确定受试者在临床研究中作为安慰剂应答者的可能性的方法。还提供了用于从先验临床研究中消除可能的安慰剂应答者的方法，从而简化数据分析并最小化或消除由于安慰剂反应而在分析中产生的任何混淆。使用这些方法的数据库和计算机系统也在此公开。还提供了评估经历反应转移的受试者的可能性的方法。

93. 发明申请

WO2012127199A2 METHODS AND SYSTEMS FOR MONITORING THE SEVERITY OF INFECTION IN A GROUP OF INDIVIDUALS 审中-公开
标题翻译：监测一组个体感染严重程度的方法和系统
公开(公告)号：WO2012127199A2
公开(公告)日：2012-09-27
申请号：PCT/GB2012/050312
申请日：2012-02-13
申请人： ISIS INNOVATION LIMITED , WYLLIE, David Hamilton , WALKER, Ann Sarah , SCHLACKOW, Iryna , CROOK, Derrick , PETO, Tim
发明人： WYLLIE, David Hamilton , WALKER, Ann Sarah , SCHLACKOW, Iryna , CROOK, Derrick , PETO, Tim
IPC分类号： G06F19/00
CPC分类号： G06F19/3431 , G06F17/30312 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/70 , G16H50/80
摘要： A computer-implemented method of monitoring the severity of infection in a group of individuals. A set of data for each individual is obtained, the data comprising at least one piece of diagnostic test data indicating the level of a biomarker associated with the individuals response to infection. The data is then split into a plurality of segments, each segment comprising all data for each individual within a corresponding one of a plurality of time periods. For each segment, a level of the biomarker across the group of individuals during the time period is estimated. The level of the biomarker for each segment to is then determined provide an indication of the change in severity of infection in the group of individuals over time.
摘要翻译：一种监测一组个体感染严重程度的计算机实现方法。获得每个个体的一组数据，该数据包括至少一个诊断测试数据，其指示与个体对感染的反应相关联的生物标志物的水平。然后将数据分割成多个段，每个段包括在多个时间段内的相应一个中的每个个体的所有数据。对于每个部分，估计在该时间段期间该组个体的生物标志物的水平。然后确定每个部分的生物标志物的水平提供随着时间的推移，个体组中感染的严重程度的变化的指示。

94. 发明申请

WO2012106194A2 BIOMARKER MONITORING DEVICE AND METHOD 审中-公开
标题翻译：生物标记监测装置和方法
公开(公告)号：WO2012106194A2
公开(公告)日：2012-08-09
申请号：PCT/US2012022862
申请日：2012-01-27
申请人： BOSCH GMBH ROBERT , KAVUSI SAM , LANG CHRISTOPH
发明人： KAVUSI SAM , LANG CHRISTOPH
IPC分类号： G06F19/28
CPC分类号： G06F19/28 , G06F19/3431 , G06F19/3487 , G06F19/366 , G16H10/40 , G16H15/00 , G16H50/30
摘要： A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.
摘要翻译：在一个实施方案中的生物标志物监测方法和系统包括通信网络，配置为与通信网络形成通信链路的便携式健康设备，便携式健康设备包括被配置成检测生物样品中的至少一种生物标志物的检测器，存储器，存储在第一存储器中的多个程序指令以及可操作地连接到第一存储器并且被配置为执行程序指令以基于生物样本中的至少一个生物标志物的检测来生成健康数据的处理电路，以及远程用户界面可操作地连接到通信网络并且被配置为呈现健康数据。

95. 发明申请

WO2012082994A2 METHOD FOR ASSESSING BREAST DENSITY 审中-公开
标题翻译：评估乳房密度的方法
公开(公告)号：WO2012082994A2
公开(公告)日：2012-06-21
申请号：PCT/US2011065091
申请日：2011-12-15
申请人： H LEE MOFFITT CANCER CT & RES , HEINE JOHN J , SELLERS THOMAS A
发明人： HEINE JOHN J , SELLERS THOMAS A
IPC分类号： A61B6/03 , A61B5/00 , G06F19/00 , G06T1/00
CPC分类号： G06F17/18 , A61B5/4312 , A61B6/502 , A61B6/5217 , A61B6/583 , G06F19/3431 , G06F19/345 , G06K9/00496 , G06K9/623 , G06T7/0012 , G06T2207/10116 , G06T2207/20076 , G06T2207/30068 , G16H50/20 , G16H50/30
摘要： Breast density is a significant breast cancer risk factor measured from mammograms. Evidence suggests that the spatial variation in mammograms may also be associated with risk. The variation in calibrated mammograms as a breast cancer risk factor was investigated and its relationship with other measures of breast density was explored using full field digital mammography (FFDM) as described herein. A matched case-control analysis was used to assess a spatial variation breast density measure in calibrated FFDM images, normalized for the image acquisition technique variation. The findings indicate the variation measure is a viable automated method for assessing breast density. Insights gained by this work may be used to develop a standard for measuring breast density.
摘要翻译：乳房密度是乳房X线照片测量的显着乳腺癌危险因素。有证据表明，乳房X线照片的空间变化也可能与风险有关。作为乳腺癌危险因素的校准的乳房X线照片的变化进行了调查，并且使用如本文所述的全场数字乳房X线照相术（FFDM）探索了与其他乳房密度测量的关系。使用匹配的病例对照分析来评估校准的FFDM图像中的空间变化乳房密度测量值，其针对图像采集技术变化进行归一化。研究结果表明，变异测量是评估乳房密度的可行的自动化方法。通过这项工作获得的见解可以用来制定测量乳房密度的标准。

96. 发明申请

WO2011139733A3 IMMUNE AND OXYGEN SYSTEM MEASURING AND DRUG SCREENING METHOD AND APPARATUS 审中-公开
标题翻译：免疫和氧气系统测量和药物筛选方法和装置
公开(公告)号：WO2011139733A3
公开(公告)日：2012-03-29
申请号：PCT/US2011034051
申请日：2011-04-27
申请人： SOFER SAMIR
发明人： SOFER SAMIR
IPC分类号： G01N33/84 , G01N33/15
CPC分类号： G06F19/3431 , A61B5/145 , A61B5/1455 , A61K31/60 , A61K33/00 , A61K33/22 , A61K35/14 , G01N33/48 , G01N33/84 , G16H50/30
摘要： Method and apparatus for monitoring health as related to immune system function, and for measuring the effects of toxins and other stresses. A method for pre-screening drugs for the pharmaceutical pipeline. A method for using an Immunogram as a research tool. A method for preparing compounds or drugs for treatment, therapy, or cure of diseases.
摘要翻译：用于监测与免疫系统功能相关的健康的方法和装置，以及用于测量毒素和其他压力的影响。用于药物管道预筛选药物的方法。一种使用Immunogram作为研究工具的方法。一种制备用于治疗，治疗或治愈疾病的化合物或药物的方法。

97. 发明申请

WO2011144676A1 SYSTEM AND METHOD OF ASSESSING ALLERGIC STATUS IN A SUBJECT 审中-公开
标题翻译：评估受试者过敏状态的系统和方法
公开(公告)号：WO2011144676A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/058085
申请日：2011-05-18
申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK , DUNN-GALVIN, Audrey , O'HOURIHANE, Jonathan B.
发明人： DUNN-GALVIN, Audrey , O'HOURIHANE, Jonathan B.
IPC分类号： G06F19/00
CPC分类号： G06F19/3431 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： A method of assessing the allergic status of a subject to a specific allergen, comprises the steps of determining a subject-specific numeric value for a plurality of variables comprising age, sex, SPT, IgE, (sIgE or tIgE minus sIgE) and allergic symptoms, applying an allergen-specific weighting to the numeric value for each variable, and correlating the weighted numeric values with allergic status for the subject. The weighted numeric values is correlated with allergenicity status using a deterministic probability function.
摘要翻译：评估受试者对特定变应原的过敏状态的方法包括以下步骤：确定包括年龄，性别，SPT，IgE，（sIgE或tIgE减去sIgE）和变态反应症状的多种变量的受试者特异性数值对每个变量对数值应用变应原特异性权重，并将加权数值与受试者的过敏状态相关联。加权数值与使用确定性概率函数的变应原性状态相关。

98. 发明申请

WO2011139733A2 IMMUNE AND OXYGEN SYSTEM MEASURING AND DRUG SCREENING METHOD AND APPARATUS 审中-公开
标题翻译：免疫和氧气系统测量和药物筛选方法和装置
公开(公告)号：WO2011139733A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034051
申请日：2011-04-27
申请人： SOFER, Samir
发明人： SOFER, Samir
IPC分类号： G01N33/84 , G01N33/15
CPC分类号： G06F19/3431 , A61B5/145 , A61B5/1455 , A61K31/60 , A61K33/00 , A61K33/22 , A61K35/14 , G01N33/48 , G01N33/84 , G06F19/00 , G16H50/30
摘要： Method and apparatus for monitoring health as related to immune system function, and for measuring the effects of toxins and other stresses. A method for pre-screening drugs for the pharmaceutical pipeline. A method for using an Immunogram as a research tool. A method for preparing compounds or drugs for treatment, therapy, or cure of diseases.
摘要翻译：用于监测与免疫系统功能相关的健康的方法和装置，以及用于测量毒素和其他压力的影响。用于药物管道预筛选药物的方法。一种使用Immunogram作为研究工具的方法。一种制备用于治疗，治疗或治愈疾病的化合物或药物的方法。

99. 发明申请

WO2010064223A2 CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY 审中-公开
标题翻译：细胞因子作为主要手术后呼吸道感染的预防标记
公开(公告)号：WO2010064223A2
公开(公告)日：2010-06-10
申请号：PCT/IE2009000085
申请日：2009-11-30
申请人： TRINITY COLLEGE DUBLIN , RYAN THOMAS , WHITE MARY , MCMANUS OWEN ROSS , KELLEHER DERMOT , STORDEUR PATRICK , YOUNG VINCENT
发明人： RYAN THOMAS , WHITE MARY , MCMANUS OWEN ROSS , KELLEHER DERMOT , STORDEUR PATRICK , YOUNG VINCENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G06F19/18 , G06F19/3431 , G16H50/30
摘要： The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-? (INF?) and Tissue Necrosis Factor-a (TNFa). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA.
摘要翻译：本发明涉及某些亚细胞因子标记物在个体中作为感染状态的预后变量的用途，特别是作为手术后发生严重感染如肺炎和呼吸道感染的患者的预后标志物。细胞因子标志物的亚组由IL-2，IL-7，IL-23，IL-27和IL-10以及干扰素（INF？）和组织坏死因子-α（TNFa）。标记物可以用作感染状态的个体预后变量，或者它们可以成对使用或其它组合使用。通常，标记物的丰度与生物标志物丰度的绝对术前价值，手术前与术后生物标志物丰度的比值或子集内特定生物标志物对的比值相关联于感染状态。通常，细胞因子丰度以mRNA拷贝数表示，其中拷贝数理想地归一化为保存基因，并且通过含有细胞因子特异性cDNA的参考连续稀释度的RT-PCR测定mRNA拷贝数的定量。

100. 发明申请

WO2008048662A3 INFORMATION MANAGEMENT AND COMMUNICATIONS SYSTEM FOR COMMUNICATION BETWEEN PATIENTS AND HEALTHCARE PROVIDERS 审中-公开
标题翻译：信息管理和通信系统，用于病人和医疗保健提供者之间的沟通
公开(公告)号：WO2008048662A3
公开(公告)日：2008-06-26
申请号：PCT/US2007022224
申请日：2007-10-18
申请人： HEALTHCALL LLC , HAYES DANIEL C
发明人： HAYES DANIEL C
IPC分类号： G06Q50/00
CPC分类号： G06F19/3406 , G06F19/322 , G06F19/3418 , G06F19/3431 , G06F19/363 , G06Q10/10 , G06Q50/22 , G16H10/20 , G16H10/60 , G16H40/63 , G16H50/30
摘要： An information management and communications system for communication between patients and healthcares providers, including an automated interactive patient response system, and apparatus and software to create, configure, and manage the content and structure of the patient response system to provide secure standards-based outpatient health assessment monitoring, to include disease management, medication compliance, wellness program compliance, and general health screening.
摘要翻译：用于患者和医疗保健提供者之间通信的信息管理和通信系统，包括自动交互式患者响应系统，以及创建，配置和管理患者应答系统的内容和结构以提供安全的基于标准的门诊健康的设备和软件评估监测，包括疾病管理，用药依从性，健康计划合规性和一般健康筛查。

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