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91. 发明申请

WO2007139776A1 DIAGNOSTIC SCREENING METHODS FOR DISORDERS OF THE ENDOPLASMIC RETICULUM-to-GOLGI TRAFFICKING OF PROTEINS 审中-公开
标题翻译：蛋白质内皮细胞向高尔基体运动障碍的诊断筛查方法
公开(公告)号：WO2007139776A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/012154
申请日：2007-05-22
申请人： THE JOHNS HOPKINS UNIVERSITY , BOYD, Simeon
发明人： BOYD, Simeon
IPC分类号： G01N33/53
CPC分类号： G01N33/573 , G01N33/5091 , G01N2800/00
摘要： The invention relates to methods of diagnosing Cranio-lenticulo-sutural dysplasia and other disorders that occur as a result of defective endoplasmic reticulum-to-Golgi trafficking using immunofluorescence based screening tests using antibodies against protein disulfide isomerase.
摘要翻译：本发明涉及使用基于蛋白质二硫键异构酶的抗体的基于免疫荧光的筛选试验来诊断颅内 - 皮肤结肠发育不良和其他疾病的方法，所述疾病是由于内质网到高尔基体的缺陷而导致的。

92. 发明申请

WO2007070021A1 DETECTION OF CALCIFYING NANO-PARTICLES, AND ASSOCIATED PROTEINS THEREON 审中-公开
标题翻译：计算纳米颗粒及其相关蛋白质的检测
公开(公告)号：WO2007070021A1
公开(公告)日：2007-06-21
申请号：PCT/US2005/044589
申请日：2005-12-09
申请人： NANOBAC LIFE SCIENCES, INC. , KAJANDER, E., Olavia , AHO, Katja , CIFTIOGLU, Neve
发明人： KAJANDER, E., Olavia , AHO, Katja , CIFTIOGLU, Neve
IPC分类号： G01N33/569 , C12Q1/04
CPC分类号： G01N33/6893 , G01N33/5082 , G01N33/5091 , G01N33/54346 , G01N2800/00 , G01N2800/52
摘要： Disclosed are methods and compositions for detecting, analyzing and assessing the significance of calcifying nano-particles. The disclosed methods and compositions generally involve detecting one or more proteins present on a calcifying nano-particle. It has been discovered that particular proteins become associated with calcifying nano-particles. This association provides a means for detecting, classifying, analyzing, categorizing, and assessing calcifying nano-particles. Detecting particular proteins while associated with a calcifying nano-particle can be used to indicate the presence and type of calcifying nano-particle, which can be used to indicate the presence of, or disposition to, diseases or conditions. Multiple proteins on a calcifying particle can be detected. The presence or absence of particular proteins and the pattern of the presence and absence of particular proteins can be used to indicate the presence and type of calcifying nano-particle.
摘要翻译：公开了用于检测，分析和评估钙化纳米颗粒的意义的方法和组合物。所公开的方法和组合物通常涉及检测存在于钙化纳米颗粒上的一种或多种蛋白质。已经发现特定的蛋白质与钙化纳米颗粒相关。该协会提供了一种检测，分类，分析，分类和评估纳米颗粒的方法。检测与钙化纳米颗粒相关的特定蛋白质可用于指示钙化纳米颗粒的存在和类型，其可用于指示疾病或病症的存在或处置。可以检测钙化颗粒上的多种蛋白质。特定蛋白质的存在或不存在以及特定蛋白质的存在和不存在的模式可用于指示钙化纳米颗粒的存在和类型。

93. 发明申请

WO2007035405A2 IN VIVO OR IN VITRO METHOD FOR DETECTING AMYLOID DEPOSITS HAVING AT LEAST ONE AMYLOIDOGENIC PROTEIN 审中-公开
标题翻译：用于检测具有至少一种淀粉样蛋白的淀粉样沉积物的体内或体外方法
公开(公告)号：WO2007035405A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/035823
申请日：2006-09-14
申请人： UNIVERSITY OF PITTSBURGH , KLUNK, William, E. , MATHIS, Chester, A., Jr.
发明人： KLUNK, William, E. , MATHIS, Chester, A., Jr.
CPC分类号： G01N33/5088 , G01N33/582 , G01N33/60 , G01N2800/00
摘要： An amyloid deposit can be detected by administering to a subject or applying to a sample a compound of Formula (I) or Formula (II) or structures 1-45, as described, and then imaging to detect binding of the compound to an amyloid deposit, where the amyloido genie protein of the deposit can be AL, AH, ATTR, Aβ2M, AA, AApoAI, AApoAII, AGeI, ALys, AFib, ACys, ABri, ADan, APrP, ACaI, AlAPP, AANF, APro, AIns, AMed, AKer, A(tbn), and/or ALac.
摘要翻译：淀粉样沉积物可以通过向受试者施用或向所述样品施用如所述的式（I）或式（II）或结构1-45的化合物，然后成像以检测所述化合物与淀粉样沉积物的结合来检测，其中沉积物的淀粉样蛋白蛋白可以是AL，AH，ATTR，Aß2M，AA，AApoAI，AApoAII，AGeI，ALys，AFib，ACys，ABri，ADan，APrP，ACaI，AlAPP，AANF，APro，AIns，AMed ，AKer，A（tbn）和/或ALAC。

94. 发明申请

WO2005072470A3 MBMS AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE 审中-公开
标题翻译： MBMS作为分枝形态发生的改良剂及其使用方法
公开(公告)号：WO2005072470A3
公开(公告)日：2006-03-23
申请号：PCT/US2005003526
申请日：2005-01-27
申请人： EXELIXIS INC , PLOWMAN GREGORY D , KARIM FELIX D , SWIMMER CANDACE , HABECK HINRICH ALEXANDER , KOBLIZEK THOMAS I , SCHULTE-MERKER STEFAN , LANGHEINRICH ULRIKE , STOTT GORDON MARK , TROWE TORSTEN , VOGEL ANDREAS MICHAEL , ODENTHAL JOERG HEINRICH , SCHEEL JOCHEN KONRAD , WILL TORSTEN TILMANN , JIN YISHENG , BJERKE LYNN MARGARET
发明人： PLOWMAN GREGORY D , KARIM FELIX D , SWIMMER CANDACE , HABECK HINRICH ALEXANDER , KOBLIZEK THOMAS I , SCHULTE-MERKER STEFAN , LANGHEINRICH ULRIKE , STOTT GORDON MARK , TROWE TORSTEN , VOGEL ANDREAS MICHAEL , ODENTHAL JOERG HEINRICH , SCHEEL JOCHEN KONRAD , WILL TORSTEN TILMANN , JIN YISHENG , BJERKE LYNN MARGARET
IPC分类号： G01N33/50 , G01N33/574 , C12N5/06 , C12N5/16 , C12N11/04 , C12P1/00 , C12P21/04 , C12Q1/00 , C12Q1/68 , G01N33/48
CPC分类号： G01N33/5032 , G01N33/574 , G01N2800/00
摘要： Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
摘要翻译：人类MBM基因被鉴定为分支形态发生的调节剂，因此是与分支形态发生功能缺陷相关的疾病的治疗靶标。提供了鉴定分支形态发生调节剂的方法，包括筛选调节MBM活性的试剂。

95. 发明申请

WO2005000229A2 COMPOSITIONS AND METHODS FOR MODULATING S-NITROSOGLUTATHIONE REDUCTASE 审中-公开
标题翻译：用于调节S-硝基脱氨酶的组合物和方法
公开(公告)号：WO2005000229A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/017758
申请日：2004-06-04
申请人： DUKE UNIVERSITY , STAMLER, Jonathan, S. , LIMIN, Lin
发明人： STAMLER, Jonathan, S. , LIMIN, Lin
IPC分类号： A61K
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S -nitrosoglutathione reductase (GSNOR) in vivo or in vitro . Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S -nitrosothiol levels) in connection with various medical conditions.
摘要翻译：本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。

96. 发明申请

WO01059107A1 NOVEL SCAVENGER RECEPTORS 审中-公开
标题翻译：新的SCAVENGER受体
公开(公告)号：WO01059107A1
公开(公告)日：2001-08-16
申请号：PCT/JP2001/000874
申请日：2001-02-08
IPC分类号： A61K38/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07K14/705 , C12N1/21 , C12N15/12 , C12P21/08 , A01K67/027 , A61K45/00 , C07K14/47 , C07K16/28 , C12N5/10 , C12P21/02
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , C07K14/705 , G01N2500/00 , G01N2800/00 , G01N2800/32
摘要： Novel scavenger receptors having an SR structure and a collectin-like structure which are proteins having the amino acid sequences of SEQ ID NOS:2, 4 and 24 or proteins having comparable properties thereto, which are usable in clarifying the functions of macrophages and basal immunity, in clarifying the onset mechanisms of various diseases such as arteriosclerosis, diabetic complications, re-constriction after angioplasty and bacterial infection, in diagnosing, preventing and treating these diseases and in developing reagents and drugs therefor; and molecules related thereto such as derivatives or fragments thereof, isolated polynucleotides containing base sequences encoding the same, antibodies and antagonists. A treatment method by using these receptors is also disclosed.
摘要翻译：具有SR结构和集合蛋白样结构的新型清道夫受体是具有SEQ ID NO：2,4和24的氨基酸序列的蛋白质或具有可比性质的蛋白质，其可用于澄清巨噬细胞和基础免疫功能阐明动脉硬化，糖尿病并发症，血管成形术和细菌感染后再狭窄等各种疾病的发病机制，诊断，预防和治疗这些疾病以及开发试剂和药物; 与其相关的分子，例如衍生物或其片段，含有编码其的碱基序列的分离的多核苷酸，抗体和拮抗剂。还公开了使用这些受体的治疗方法。

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