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91. 发明申请

WO1989010969A1 PROCESS FOR PRODUCING L-AMINO ACIDS AND AMINO ACID AMIDES 审中-公开
标题翻译：生产L-氨基酸和氨基酸的方法
公开(公告)号：WO1989010969A1
公开(公告)日：1989-11-16
申请号：PCT/DE1989000232
申请日：1989-04-13
申请人： SCHERING AKTIENGESELLSCHAFT , KLAGES, Uwe , WEBER, Alfred
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12P13/02
摘要： A process for producing L-amino acids of general formula (I), wherein A denotes the residue of an amino acid molecule, from D,L- alpha -aminonitriles of general formula (II), wherein A has the above-mentioned meaning, is characterized in that the alpha -aminonitriles are fermented with a culture of Acinetobacter calcoaceticus DSM 3875, and the D,L-amino acid amides of general formula (III) so obtained, wherein A has the above-mentioned meaning, are reacted with a culture of microorganisms which contains amino acid amide racemases and L-amino acid amide amidases.
摘要翻译：一种制备通式（I）的L-氨基酸的方法，其中A表示通式（II）的D，L-α-氨基腈的氨基酸分子的残基，其中A具有上述含义，其特征在于用α-醋酸不动杆菌DSM3875的培养物发酵α-氨基腈，所得到的通式（III）的D，L-氨基酸酰胺，其中A具有上述含义，与含有氨基酸酰胺消旋酶和L-氨基酸酰胺酰胺酶的微生物培养物。

92. 发明申请

WO1989008454A1 FLUOROBENZOYLPIPERIDINOPROPOXYMETHOXYPHENYLPYRROLIDONE EFFECTIVE AGAINST OBSTRUCTIVE DIFFICULTIES IN URINATING 审中-公开
标题翻译：氟代苯甲酰哌啶磷酸多羟基甲氧基吡咯烷酮有效防止阻塞性阻塞作用
公开(公告)号：WO1989008454A1
公开(公告)日：1989-09-21
申请号：PCT/DE1989000165
申请日：1989-03-15
申请人： SCHERING AKTIENGESELLSCHAFT , BECKMANN, Rolf , El ETREBY, M., Fathy , HABENICHT, Ursula-F. , SCHRÖDER, Gertrud
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： Agent for treating obstructive difficulties in urinating, composed of 4-{3-[3-(4-fluorobenzoylpiperidino)-propoxy]-4-methoxy-phenyl}2-pyrrolidone and ordinary adjuvants and carrier substances.

93. 发明申请

WO1988008422A1 SUBSTITUTED CYCLIC COMPLEX-FORMING SUBSTANCES, COMPLEXES AND COMPLEX SALTS, PROCESS FOR MANUFACTURING SAME, AND PHARMACEUTICAL AGENTS WHICH CONTAIN THEM 审中-公开
标题翻译：取代的环状复合物质，复合物和复合盐，其制造方法和含有它们的药物代理
公开(公告)号：WO1988008422A1
公开(公告)日：1988-11-03
申请号：PCT/DE1988000200
申请日：1988-03-28
申请人： SCHERING AKTIENGESELLSCHAFT , DEUTSCH, Julius , GRIES, Heinz , CONRAD, Jürgen , WEINMANN, Hanns-Joachim
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D257/02
CPC分类号： C07F5/003 , A61K51/0482 , A61K51/1093 , A61K2123/00 , C07D257/02 , C07D403/12 , C07D405/12 , C07D495/04
摘要： Compounds of general formula (I), where q stands for the numbers 0, 1, 2 or 3, A stands for the group (a), in which m = 1, 2, 3, 4 or 5, l = 0, 1, 2, 3, 4 or 5, R1 is a straight-chain, branched, saturated or unsaturated C0-C20 alkylene group which may contain imino, phenylenoxy, phenylenimino, amido, hydrazido, ester groups, oxygen, sulphur and/or nitrogen atoms, possibly substituted by hydroxy, mercapto, imino, epoxy, oxo, thioxo and/or amino groups, having either a terminal ring of general formula (II), where A1 stands for the (b) group, a terminal functional group or a bio- or macromolecule bound to this functional group, B, D, and E, which are the same or different, each stand for the (c) group where R2 is hydrogen or R1, k = 0, 1, 2, 3, 4 or 5, n = 0 or 1, Z stands for hydrogen or CH2X, where X stands for the residues -COOY or -PO3HY where Y is a hydrogen atom and/or a metallic ion equivalent of one of the ordinal numbers 21-29, 31, 32, 37-39, 42-44 or 57-83, provided that B, E, and D each contain not less than 2 and not more than 5 carbon atoms and that at least two Zs stand for CH2X, as well as their salts with inorganic and/or organic bases or amino acids, are useful diagnostic and therapeutic agents.

94. 发明申请

WO1988007050A1 NEW PROCESS FOR THE ANTIPODAL SEPARATION OF BICYCLO[3.3.0]OCTANE-3,7-DION-2-CARBOXYLIC ACID ESTERS AND THEIR 7-MONOCETALS 审中-公开
标题翻译：双氰胺[3.3.0]月桂-3,7-二酮-2-羧酸酯及其7-二醇的抗体分离新工艺
公开(公告)号：WO1988007050A1
公开(公告)日：1988-09-22
申请号：PCT/DE1988000149
申请日：1988-03-11
申请人： SCHERING AKTIENGESELLSCHAFT , VORBRÜGGEN, Helmut
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07J01/00
CPC分类号： C07J1/0074
摘要： Process for the production of (+)-bicyclo-[3.3.0]octane-3-on-2-carboxylic acid steroid esters having the formula (I), in which X represents oxygen or the -O-(CH2)n-O- or the -O-CH2-C(CH3)2-CH2-O- residue; n represents 2 or 3; R2 represents hydrogen or methyl; Y represents the X or X1 residues; X1 represents the OCH3 or OCOR3 residues; and R3 represents methyl, ethyl, phenyl, benzyl or pivalyl.
摘要翻译：制备具有式（I）的（+） - 双环 - [3.3.0]辛烷-3-对2-羧酸类固醇酯的方法，其中X表示氧或-O-（CH 2）n O- 或-O-CH 2 -C（CH 3）2 -CH 2 -O-残基; n表示2或3; R2代表氢或甲基; Y表示X或X 1残基; X1表示OCH3或OCOR3残基; 并且R 3表示甲基，乙基，苯基，苄基或新戊酰基。

95. 发明申请

WO1988006580A1 ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY 审中-公开
标题翻译： ARYL-和ARYLOXY取代的TERT.-ALKYLENAMINES，其制造方法及其在药物中的应用
公开(公告)号：WO1988006580A1
公开(公告)日：1988-09-07
申请号：PCT/DE1988000100
申请日：1988-02-23
申请人： SCHERING AKTIENGESELLSCHAFT , ALBRECHT, Rudolf , SCHÖLLKOPF, Klaus , LEHMANN, Manfred , SCHRÖDER, Gertrud
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C97/10
CPC分类号： C07D295/108 , C07D211/82 , C07D401/06
摘要： Aryl-substituted tert.-alkylenamines, have the formula (I), where R is an alkyl group with 1-6 C-atoms, or the total residue (a) represents the heterocyclic residues (b), (c), (d), (e), or (f), where R5 is hydrogen, methyl, phenyl, 4-chlorphenol or 4-fluorbenzoyl, n = 2 - 4, A is the carbonyl, hydroxymethylene, C2-C4-acyloxymethylene, methylene or oxygen residues, 2 is hydrogen, 2-fluor, 6-fluor, 2-chlor, 5-chlor, 2-methyl or 6-methyl, R1 is hydroxy or C2-C4 acyloxy, amino or NHR3, NH-CHO or NH-CO-NH2, R2 is hydroxy or C2-C4 acyloxy, when R1 is hydroxy, C2-C4 acyloxy, amino or NHR3, R3 is alkyl with 1-4 C-atoms, 4-methoxybenzyl, acetyl, methylsulphonyl or trifluormethylsulphonyl, or the residue (g) forms, by ring closure of R2 and Z, the bicyclic groups (h), (i), (j), (k) or (l), where R4 is hydrogen, methoxycarbonyl or ethoxycarbonyl. The invention also concerns the acid addition salts of these alkylenamines with biocompatible acids, the process for their manufacture and their use in pharmacy.

96. 发明申请

WO1988003526A1 NEW PROCESS FOR MANUFACTURING OPTICALLY ACTIVE CARBOCYCLINE INTERMEDIATES 审中-公开
标题翻译：制造光学活性炭中间体的新工艺
公开(公告)号：WO1988003526A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000515
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , DAHL, Helmut
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07D319/08 , C07C405/0083
摘要： Process for manufacturing cis-bicyclo[3.3.0]octane-2-aldehydes of formula (I), in which R1 and R2 jointly represent the double-bound residue -O-X-O-, with X as straight or branched-chain alkylene with 1-7 C-atoms or R1 and R2 accordingly represent the residue OR with R as a straight or branched-chain alkyl with 1-7 C atoms and R3 represents hydrogen, a saturated alkyl residue with 1-7 C atoms, an aralkyl residu with 7-10 C atoms, a tetrahydropyranyl residue, a trialkylsilyl residue with 1-6 C atoms in the alkyl whereby alkyl also can be substituted by phenyl, a dialkylphenylsilyl residue or alkyldiphenylsilyl residue with 1-16 C atoms in the alkyl, characterized by the fact that the diastereomeric amides of formula (II) are separated, whereby in said formula R1, R2 and R3 have the stated meanings, and in that the enantiomerically pure amide of formula (II) is reduced.
摘要翻译：制备式（I）的顺式 - 双环[3.3.0]辛烷-2-醛的方法，其中R 1和R 2共同代表双键残基-OXO-，X为直链或支链亚烷基， 7个C原子或R 1和R 2相应地表示残基OR，其中R为具有1-7个C原子的直链或支链烷基，R 3表示氢，具有1-7个C原子的饱和烷基残基，残基为7 -10 C原子，四氢吡喃基残基，烷基中含有1-6个C原子的三烷基甲硅烷基残基，其中烷基也可以被苯基，二烷基苯基甲硅烷基残基或烷基中具有1-16个碳原子的烷基二苯基甲硅烷基残基取代，其特征在于分离式（II）的非对映体酰胺，其中在所述式R1中，R2和R3具有所述含义，并且由式（II）的对映体纯的酰胺还原。

97. 发明申请

WO1985005634A1 PROCESS FOR THE PRODUCTION OF FESTUCLAVIN 审中-公开
标题翻译：生产FESTUCLAVIN的方法
公开(公告)号：WO1985005634A1
公开(公告)日：1985-12-19
申请号：PCT/DE1985000189
申请日：1985-05-30
申请人： SCHERING AKTIENGESELLSCHAFT , WILKE, Detlef , WEBER, Alfred
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P17/18
CPC分类号： C12P17/183 , Y10S435/911
摘要： A process for the production of festuclavin characterized by the fact that the micro-organism Claviceps paspali 2838 is cultivated and the festuclavine produced is isolated after fermentation.
摘要翻译：生产festuclavin的方法，其特征在于培养微生物Claviceps paspali 2838，发酵后分离产生的festoklavine。

98. 发明申请

WO1983003248A1 CARBACYCLINE, PREPARATION AND UTILIZATION THEREOF 审中-公开
标题翻译：卡巴肼，其制备和利用
公开(公告)号：WO1983003248A1
公开(公告)日：1983-09-29
申请号：PCT/DE1983000045
申请日：1983-03-11
申请人： SCHERING AKTIENGESELLSCHAFT , VORBRÜGGEN, Helmut , RADÜCHEL, Bernd , SKUBALLA, Werner , SCHWARZ, Norbert , CASALS-STENZEL, Jorge , MANNESMANN, Gerda , TOWN, Michael-Harold
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07D317/72 , C07C45/59 , C07C57/26 , C07C57/60 , C07C405/0083 , C07D263/14 , C07F9/4018 , C07C49/743
摘要： Carbacycline derivatives having the formula I wherein R1 is the residue CH2OH or -C-OR2, R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl, CH2 -C-aryl residue or a heterocyclic residue, or R1 is the residue -C-NHR3, R3 representing an alkanoyl or alkanesulfonyl residue containing each 1 to 10 atoms of carbon or the residue R2 or R1 is the residue wherein m is 1 or 2. X is an oxygen atom or CH2 group, A is a trans -CH=CH- or -C=C- group, W is a free or modified hydrocymethylene group wherein the OH group may be in the position alpha or beta , n represents the integer 1, 2 or 3, D is a straight chain alkylene group with 1 to 3 atoms of carbon, E represents a -C=C- bond or a -CR6=CR7 group, R6 and R7 being different and representing a hydrogen atom or an alkyl group with 1 to 5 atoms of carbon or a hydrogen atom or an a halogen atom, preferably chlorine, R4 represents an alkyl, cycloalkyl group or an optionally substituted aryl group or a heterocyclic group, R5 represents a free or modified hydroxy group. When R2 represents a hydrogen atom, the salts of compounds with pharmaceutically acceptable bases are also involved. The compounds are used as hypotensive agents.
摘要翻译：具有式I的卡巴环素衍生物，其中R 1是残基CH 2 OH或-CON OR 2，R 2表示氢原子，烷基，环烷基，芳基，CH 2 -C芳基或杂环残基，或R 1 是残基，如表示含有1-10个碳原子的链烷酰基或烷磺酰基残基，R 2或R 1为残基，其中m为1或2.X为氧原子或CH 2基团，A是反式-CH = CH-或-C = C-基团，W是游离或修饰的水合甲基基团，其中OH基团可以在α或β位置，n表示整数1,2或 3，D是具有1至3个碳原子的直链亚烷基，E表示-C = C-键或-CR 6 = CR 7基团，R 6和R 7不同，表示氢原子或具有1个至5原子的碳或氢原子或卤素原子，优选氯，R4表示烷基，环烷基或任选取代的芳基或杂环酰基，R5表示游离或改性的羟基。当R 2表示氢原子时，也涉及具有药学上可接受的碱的化合物的盐。这些化合物用作降压剂。

99. 发明申请

WO1998028322A1 BISSTEROIDAL COMPOUNDS AND THEIR USE FOR THE PREPARATION OF CHIRAL COMPLEXES 审中-公开
标题翻译：双组分化合物及其用于制备复合物的用途
公开(公告)号：WO1998028322A1
公开(公告)日：1998-07-02
申请号：PCT/EP1997007098
申请日：1997-12-18
申请人： SCHERING AKTIENGESELLSCHAFT , MOHR, Jörg-Torsten , ENEV, Valentien , EWERS, Christian , HARRE, Michael , HICKISCH, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07J01/00
CPC分类号： C07J31/006 , C07J1/0055 , C07J1/0077 , C07J51/00
摘要： Bissteroidal compounds of general formula (I), in which R1 stands for hydrogen, alkyl, acyl, fluorine, and X1R5, where X1 stands for oxygen and sulfur and R5 can either be hydrogen, alkyl, aryl; R2 stands for hydrogen and alkyl; the stereochemistry of C-13, C-14 and C-17 may either be a or b; X stands for oxygen, hydroxyl, trifluormethylsulfonyloxy, or (R6)2P, where R6 can be aryl, alkyl and cycloalkyl; R3 stands for hydrogen, alkyl, aryl, trialkylsilyl, fluorine and X2R6, where X2 stands for oxygen and sulfur and R6 stands for hydrogen, trifluormethylsulfonyl, alkyl, cycloalkyl or aryl. R4 can either be a substituent in the 6 or 7 position of the steroid with the meaning of hydrogen, alkyl, aryl, fluorine, and X3R7, where X3 stands for oxygen, sulfur or trialkylsilyl and R7 stands for hydrogen, trifluormethylsulfonyl, alkyl or aryl, and the B-ring of the steroid contains none or two double bonds. Enantio- and Diastereomeric derivatives of compounds of general formula (I), metal complexes thereof and their use in enantioselective reactions.
摘要翻译：通式（I）的双星型化合物，其中R1代表氢，烷基，酰基，氟和X1R5，其中X1代表氧和硫，R5可以是氢，烷基，芳基; R2代表氢和烷基; C-13，C-14和C-17的立体化学可能是a或b; X代表氧，羟基，三氟甲基磺酰氧基或（R6）2P，其中R6可以是芳基，烷基和环烷基; R3代表氢，烷基，芳基，三烷基甲硅烷基，氟和X2R6，其中X2代表氧和硫，R6代表氢，三氟甲基磺酰基，烷基，环烷基或芳基。 R4可以是类固醇6或7位的取代基，具有氢，烷基，芳基，氟和X3R7的含义，其中X3表示氧，硫或三烷基甲硅烷基，R7表示氢，三氟甲磺酰基，烷基或芳基，并且类固醇的B环含有无或两个双键。通式（I）化合物的对映异构体和非对映体衍生物，其金属络合物及其在对映选择性反应中的用途。

100. 发明申请

WO1998007730A1 TIN DENDRIMERS, THEIR USE AS X-RAY CONTRAST AGENTS AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译： ZINNDENDRIMERE，其作为X射线造影剂和工艺用自己的
公开(公告)号：WO1998007730A1
公开(公告)日：1998-02-26
申请号：PCT/DE1997001821
申请日：1997-08-18
申请人： SCHERING AKTIENGESELLSCHAFT , KRAUSE, Werner , SCHUMANN, Herbert
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07F07/22
CPC分类号： C07F9/5009 , A61K49/0002 , A61K49/04 , C07F7/2208
摘要： The invention concerns dendrimeric organometallic tin compounds (tin dendrimers) which can advantageously be used as X-ray contrast agents. The invention also concerns processes for their preparation.
摘要翻译：本发明涉及有机金属树枝状锡化合物（Zinndendrimere），其可以有利地用作X-射线造影剂和它们的制备方法。

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