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91. 发明申请

WO2005076003A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PLASMA GLUTAMATE CARBOXYPEPTIDASE (PGCP) 审中-公开
公开(公告)号：WO2005076003A3
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000611
申请日：2005-01-22
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/573
摘要： The invention provides a human PGCP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PGCP as well as pharmaceutical compositions comprising such compounds.

92. 发明申请

WO2005075665A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PLASMA KALLIKREIN (KLKB1) 审中-公开
标题翻译：与血浆Kallikrein有关的疾病的诊断和治疗（KLKB1）
公开(公告)号：WO2005075665A2
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000607
申请日：2005-01-22
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/6893
摘要： The invention provides a human KLKB1 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLKB1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了一种人类KLKB1，其与心血管疾病，内分泌系统和激素失调，代谢疾病，胃肠和肝脏疾病，炎性疾病，癌症疾病，肌肉骨骼疾病，神经疾病和泌尿系统疾病。本发明还提供了用于鉴定可用于治疗或预防心血管病症，内分泌系统和激素失调，代谢性疾病，胃肠和肝脏疾病，炎性疾病，癌症病症，肌肉骨骼病症，神经病症和泌尿系统疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制KLKB1活性的化合物以及包含这些化合物的药物组合物。

93. 发明申请

WO2005075664A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 15 (KLK15) 审中-公开
标题翻译：与KALLIKREIN 15（KLK15）相关的疾病诊断和治疗
公开(公告)号：WO2005075664A1
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000340
申请日：2005-01-15
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2500/10
摘要： The invention provides a human KLK15 which is associated with the cardiovascular diseases, cancer, gastroenterological diseases, inflammation, metabolic diseases, hematological diseases, respiratory diseases, neurological diseases, reproduction disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, gastroenterological diseases, inflammation, metabolic diseases, hematological diseases, respiratory diseases, neurological diseases, reproduction disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK15 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，胃肠疾病，炎症，代谢疾病，血液疾病，呼吸系统疾病，神经系统疾病，繁殖障碍和泌尿系疾病有关的人类KLK15。本发明还提供用于鉴定可用于治疗或预防心血管疾病，癌症，胃肠疾病，炎症，代谢疾病，血液疾病，呼吸系统疾病，神经疾病，繁殖障碍和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制KLK15活性的化合物以及包含这些化合物的药物组合物。

94. 发明申请

WO2005073397A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH TRIPEPTIDYL-PEPTIDASE 2(TPP2) 审中-公开
标题翻译：与三磷酸腺苷二磷酸（TPP2）相关的疾病的诊断和治疗
公开(公告)号：WO2005073397A1
公开(公告)日：2005-08-11
申请号：PCT/EP2005/000472
申请日：2005-01-19
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： C12Q1/37
CPC分类号： G01N33/57449 , C12Q1/37 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/6893 , G01N33/6896 , G01N2500/00
摘要： The invention provides a human TPP2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TPP2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类TPP2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物和泌尿系疾病本发明还涉及结合和/或活化或抑制TPP2活性的化合物以及包含这些化合物的药物组合物。

95. 发明申请

WO2005069010A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN METABOTROPIC GLUTAMATE RECEPTOR 4 (MGLUR4) 审中-公开
标题翻译：与人类代谢谷氨酸受体4（MGLUR4）相关的疾病的诊断和治疗
公开(公告)号：WO2005069010A1
公开(公告)日：2005-07-28
申请号：PCT/EP2005/000074
申请日：2005-01-07
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/68
CPC分类号： G01N33/566 , A61K38/1787 , G01N2333/726 , G01N2500/04
摘要： The invention provides a human mGluR4 which is associated with the neurological diseases, urological diseases, respiratory diseases, cancer, reproduction disorders and cardiovascular diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of neurological diseases, urological diseases, respiratory diseases, cancer, reproduction disorders and cardiovascular diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of mGluR4 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与神经疾病，泌尿科疾病，呼吸系统疾病，癌症，繁殖障碍和心血管疾病相关的人mGluR4。本发明还提供了用于鉴定可用于治疗或预防神经疾病，泌尿疾病，呼吸系统疾病，癌症，繁殖障碍和心血管疾病的化合物的测定。本发明还涉及结合和/或活化或抑制mGluR4的活性的化合物以及包含这些化合物的药物组合物。

96. 发明申请

WO2005059560A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR MC2 (MC2) 审中-公开
标题翻译：与G蛋白偶联受体MC2（MC2）相关的疾病诊断和治疗
公开(公告)号：WO2005059560A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004/013486
申请日：2004-11-27
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/68
CPC分类号： G01N33/566
摘要： The invention provides a human MC2 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of MC2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌系统和激素失调，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍，泌尿系统疾病和癌症疾病有关的人类MC2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素失调，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍，泌尿系统疾病和癌症的化合物的测定障碍。本发明还涉及结合和/或活化或抑制MC2活性的化合物以及包含这些化合物的药物组合物。

97. 发明申请

WO2005050199A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN- COUPLED RECEPTOR 77 (GPR77) 审中-公开
标题翻译：与G蛋白偶联受体77相关的疾病的诊断和治疗（GPR77）
公开(公告)号：WO2005050199A1
公开(公告)日：2005-06-02
申请号：PCT/EP2004/011806
申请日：2004-10-19
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/50
CPC分类号： G01N33/57438 , G01N33/566 , G01N33/57419 , G01N33/57423 , G01N33/6896 , G01N2021/6439 , G01N2333/726
摘要： The invention provides a human GPR77 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR77 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，癌症疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病相关的人GPR77。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，癌症疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GPR77活性的化合物以及包含这些化合物的药物组合物。

98. 发明申请

WO2005040825A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 20 (GPR20) 审中-公开
标题翻译： G蛋白偶联受体20（GPR20）相关疾病的诊断和治疗
公开(公告)号：WO2005040825A2
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011393
申请日：2004-10-12
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/68
CPC分类号： G01N33/57423 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N33/6896
摘要： The invention provides a human GPR20 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR20 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和癌症疾病有关的人GPR20。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝疾病，炎性疾病，代谢疾病，血液病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和癌症疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制GPR20活性的化合物以及包含此类化合物的药物组合物。

99. 发明申请

WO2005040821A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 18 (GPR18) 审中-公开
标题翻译：与G蛋白偶联受体18（GPR18）相关的疾病的诊断和治疗
公开(公告)号：WO2005040821A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011330
申请日：2004-10-09
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , SUMMER, Holger
IPC分类号： G01N33/68
CPC分类号： G01N33/74 , G01N2333/726
摘要： The invention provides a human GPR18 which is associated with the cardiovascular disorders, developmental disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, developmental disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR18 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，发育障碍，皮肤病，内分泌系统和激素紊乱，代谢疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病，肌肉骨骼疾病，神经障碍和泌尿系统疾病。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，发育障碍，皮肤病，内分泌系统和激素障碍，代谢疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病，肌肉的化合物的测定骨骼疾病，神经障碍和泌尿系统疾病。本发明还涉及结合和/或活化或抑制GPR18活性的化合物以及包含这些化合物的药物组合物。

100. 发明申请

WO2008046509A1 LTBP2 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： LTBP2作为生物标志物，治疗和诊断目标
公开(公告)号：WO2008046509A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008558
申请日：2007-10-02
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。本发明还提供LTBP2作为心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病的疾病的生物标志物

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