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91. 发明申请

WO2016078770A1 SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开
标题翻译：具有多种药物活性的SPIRO-ISOQUINOLINE-1,4'-哌啶化合物
公开(公告)号：WO2016078770A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/002332
申请日：2015-11-20
申请人： LABORATORIOS DEL DR. ESTEVE, S.A.
发明人： ALMANSA-ROSALES, Carmen , GARCIA-LOPEZ, Monica , CAAMANO-MOURE, Ana-Maria
IPC分类号： C07D471/10 , C07D471/20 , A61K31/435 , A61K31/438 , A61P25/04
CPC分类号： C07D471/10 , A61P25/04 , C07D471/20
摘要： The present invention relates to spiro-isoquinoline-1,4'-piperidine compounds having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
摘要翻译：本发明涉及对σ（σ）受体和μ-阿片受体两者具有双重药理学活性的这些化合物的制备方法，以及包含它们的药物组合物的螺 - 异喹啉-1,4'-哌啶化合物，以及用于治疗，特别是用于治疗疼痛。

92. 发明申请

WO2015185209A1 ALKYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开
标题翻译：具有多种药物活性的1-OXA-4,9-DIAZASPIRO未分解化合物的烷基衍生物
公开(公告)号：WO2015185209A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/001115
申请日：2015-06-02
申请人： LABORATORIOS DEL DR. ESTEVE, S.A.
发明人： VIRGILI-BERNARDO, Marina , ALONSO-XALMA, Monica , ALEGRET-MOLINA, Carlos , ALMANSA-ROSALES, Carmen , GARCIA LOPEZ, Monica
IPC分类号： C07D498/10 , A61K31/537
CPC分类号： C07D498/10
摘要： The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
摘要翻译：本发明涉及具有对σ（σ）受体和μ-阿片受体的双重药理学活性的化合物，更具体地说涉及具有该药理学活性的二氮杂螺十一烷化合物，这些化合物的制备方法，包括它们的药物组合物，以及它们在治疗中的用途，特别是用于治疗疼痛。

93. 发明申请

WO2015185207A1 ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开
标题翻译：具有多种药物活性的1-OXA-4,9-DIAZASPIRO UNDECANE化合物的烷基衍生物和ARYL衍生物
公开(公告)号：WO2015185207A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/001113
申请日：2015-06-02
申请人： LABORATORIOS DEL DR. ESTEVE, S.A.
发明人： VIRGILI-BERNARDO, Marina , ALONSO-XALMA, Monica , ALEGRET-MOLINA, Carlos , ALMANSA-ROSALES, Carmen , GARCIA LOPEZ, Monica
IPC分类号： C07D498/10 , C07D519/00 , A61K31/5386 , A61P29/00
CPC分类号： C07D498/10 , C07D519/00
摘要： The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
摘要翻译：本发明涉及具有对σ（σ）受体和μ-阿片受体的双重药理学活性的通式（I）的化合物，更具体地说，涉及具有该药理活性的二氮杂螺十一烷化合物对这些化合物的制备方法，包含它们的药物组合物，以及它们在治疗中的用途，特别是用于治疗疼痛。

94. 发明申请

WO2013160852A2 FLOOD PROTECTION SYSTEM 审中-公开
标题翻译：防洪保护系统
公开(公告)号：WO2013160852A2
公开(公告)日：2013-10-31
申请号：PCT/IB2013/053246
申请日：2013-04-24
申请人： GUJER, Rudolf, Heinrich
发明人： GUJER, Rudolf, Heinrich
IPC分类号： E02B3/10
CPC分类号： E02B7/50 , E02B3/104 , E02B7/28 , E02B7/36 , E02B8/00 , E04H9/145 , Y02A50/14
摘要： A flood protection system is provided for protecting an area from flooding water, wherein the area includes a trench defined at least along a portion of the boundaries thereof and a at least one depression on the side of the trench facing away from the area to be protected. The system comprising a barrier, configured for being at least partially fitted in the trench; and a float coupled to the barrier and being configured for at least partially is disposed in the depression. The float is configured for rising in response to a rise in the water level inside the depression and about the boundaries of the area. The float is further configured for lifting the barrier out of the trench therewith, thereby blocking the waters from entering the area.
摘要翻译：提供一种防洪系统，用于保护区域免受淹水的影响，其中该区域包括至少沿其边界的一部分限定的沟槽和在沟槽侧面上远离受保护区域的至少一个凹陷部分。所述系统包括被构造成至少部分地装配在所述沟槽中的屏障; 并且耦合到所述阻挡件并且被配置为至少部分地设置在所述凹部中的浮子。浮子被配置为响应于凹陷内的水位和区域边界的上升而上升。浮子进一步构造成用于将屏障从沟槽中提升出来，从而阻止水进入该区域。

95. 发明申请

WO2013079204A2 4-PHENYLBUTYRIC ACID FOR COSMETIC USE 审中-公开
标题翻译： 4-苯甲酸用于化妆品用途
公开(公告)号：WO2013079204A2
公开(公告)日：2013-06-06
申请号：PCT/EP2012/004935
申请日：2012-11-29
申请人： LUNAMED AG , TRUOG, Peter , BUSCHMANN, Helmut, H.
发明人： TRUOG, Peter , BUSCHMANN, Helmut, H.
CPC分类号： A61K8/36 , A61K8/44 , A61K9/2054 , A61K9/2846 , A61K2800/10 , A61K2800/92 , A61Q19/00
摘要： The present invention relates to a cosmetic use of a phenyl-butyric acid, a derivative or a physiologically acceptable salt thereof, like 4-phenylbutyric acid (4-PB) or its sodium salt. Particularly, the present invention provides cosmetic articles comprising phenyl-butyric acid, a derivative or a physiologically acceptable salt thereof, like 4-phenylbutyric acid (4-PB) or its sodium salt, especially at a low daily dosis for cosmetic use for treatment of various cosmetic problems of body surfaces such as hair, skin etc...
摘要翻译：本发明涉及苯丁酸，其衍生物或其生理学上可接受的盐如4-苯基丁酸（4-PB）或其钠盐的化妆品用途。特别地，本发明提供包含苯基 - 丁酸，其衍生物或其生理上可接受的盐，如4-苯基丁酸（4-PB）或其钠盐的化妆品，特别是在用于治疗身体表面的各种化妆品问题，如头发，皮肤等...

96. 发明申请

WO2013026541A3 STENT GRAFT WITH ALTERNATING RINGS 审中-公开
公开(公告)号：WO2013026541A3
公开(公告)日：2013-02-28
申请号：PCT/EP2012/003464
申请日：2012-08-14
申请人： ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED , BREGULLA, Rainer
发明人： BREGULLA, Rainer
IPC分类号： A61F2/07 , A61F2/90 , A61F2/00 , A61F2/852 , A61F2/89 , A61F2/915
摘要： The invention relates to a stent graft, adapted for being inserted into a blood vessel, and to a method for forming a stent graft. The stent graft (1) comprises a first stent (2) comprising a plurality of first rings (4) being connected by at least one first connector, wherein the first stent (2) is arranged at least partly in an inner part of the stent graft (1), a second stent (3) comprising a plurality of second rings (5) being connected by at least one second connector, wherein the second stent (3) is arranged at least partly in an outer part of the stent graft (1), and a graft layer is arranged at least partly between the first stent (2) and the second stent (3), wherein the first stent (2) and the second stent (3) having each a predetermined length and the plurality of first rings (4) and the plurality of second rings (5) are axially arranged along the length such that the plurality of second rings (5) fit into the plurality of first rings (4). In this way, a possibility is provided to avoid the problem of integrity in connection with having as less as possible interaction between the first stent and the second stent and thus to minimize the risks of shear effects.

97. 发明申请

WO2011147584A1 COMPOSITIONS FOR USE IN GENETIC DISORDERS CAUSATIVE FOR CYSTIC FIBROSIS COMPRISING 4-PHENYL-BUTYRIC ACID AND ITS SALTS 审中-公开
标题翻译：用于遗传性疾病的组合物用于包含4-苯基 - 丁酸及其盐的CYSTIC FIBROSIS的原因
公开(公告)号：WO2011147584A1
公开(公告)日：2011-12-01
申请号：PCT/EP2011/002631
申请日：2011-05-27
申请人： LUNAMED AG , TRUOG, Peter
发明人： TRUOG, Peter
IPC分类号： A61K31/192 , A61P15/02 , A61P9/14 , A61P25/24 , A61P43/00
CPC分类号： A61K31/192
摘要： The present invention refers to pharmaceutical compositions comprising the histone hyperacetylating agent phenyl-butyric acid, a derivative or a physiologically acceptable salt thereof for use in the treatment of a genetic disorder, especially of an epigenetic disorder, which manifests itself in cystic fibrosis.
摘要翻译：本发明涉及包含组蛋白超乙酰化剂苯丁酸，其衍生物或生理上可接受的盐的药物组合物，其用于治疗遗传疾病，特别是表现为囊性纤维化的表观遗传病症。

98. 发明申请

WO2011072861A1 SUPPOSITORY COMPRISING PANTOPRAZOLE 审中-公开
标题翻译：包含潘多普唑的支架
公开(公告)号：WO2011072861A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/007700
申请日：2010-12-15
申请人： BENE-ARZNEIMITTEL GMBH , METZ, Christian
发明人： METZ, Christian
IPC分类号： A61K9/02 , A61K31/4439 , A61K9/48
CPC分类号： A61K9/025 , A61K9/4808 , A61K9/4858 , A61K9/5078 , A61K31/4439
摘要： The present invention concerns the field of pharmaceutical technology and relates to a suppository for rectal administration comprising at least one pellet, in particular, a pellet comprising the proton pump inhibitor pantoprazole. In addition, the present invention concerns a process for preparing such a suppository.
摘要翻译：本发明涉及药物技术领域，涉及用于直肠给药的栓剂，其包含至少一种丸剂，特别是包含质子泵抑制剂泮托拉唑的丸剂。此外，本发明涉及制备这种栓剂的方法。

99. 发明申请

WO2010081723A1 METHOD, APPARATUS AND SOLUTION FOR ELECTROPOLISHING METALLIC STENTS 审中-公开
标题翻译：用于电镀金属制品的方法，装置和解决方案
公开(公告)号：WO2010081723A1
公开(公告)日：2010-07-22
申请号：PCT/EP2010/000216
申请日：2010-01-15
申请人： ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED , WULF, Elena
发明人： WULF, Elena
IPC分类号： C25F3/16 , A61L31/00
CPC分类号： C25F3/16 , A61L31/022 , A61L31/14 , A61L2400/18
摘要： An apparatus and method are described for electropolishing metallic stents. The apparatus may include an electropolishing container made from material of low thermal conductivity. The apparatus may include at least one spiral cathode for optimization of solution agitation and/or voltage distribution in the electrolytic solution. Further, an electrolytic solution is described. A method for improved polishing to consistently produce smooth surfaces is described.
摘要翻译：描述了用于电抛光金属支架的装置和方法。该装置可以包括由导热性低的材料制成的电解抛光容器。该装置可以包括用于优化电解溶液中的溶液搅拌和/或电压分布的至少一个螺旋阴极。另外，对电解液进行说明。描述了一种用于改进抛光以一致地产生光滑表面的方法。

100. 发明申请

WO2010078931A1 SYSTEM AND METHOD FOR CRIMPING BODY LUMEN FILTERS 审中-公开
标题翻译：用于冲击身体过滤器的系统和方法
公开(公告)号：WO2010078931A1
公开(公告)日：2010-07-15
申请号：PCT/EP2009/009048
申请日：2009-12-16
申请人： ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED , BREGULLA, Rainer
发明人： BREGULLA, Rainer
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/9522 , A61F2230/0023 , Y10T29/49908 , Y10T29/49913 , Y10T29/53
摘要： As described herein, a body lumen filter is provided that includes a body configured to move between a pre-deployed state and a deployed state, a filtering structure operatively associated with the body to filter particulates, and a blending structure operatively associated with the body. The blending structure can be configured to break up at least one of the particulates.
摘要翻译：如本文所述，提供了体腔过滤器，其包括构造成在预部署状态和展开状态之间移动的主体，与身体可操作地相关联以过滤微粒的过滤结构，以及与身体可操作地相关联的混合结构。混合结构可以被配置成分解至少一种微粒。

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