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1. 发明申请

WO1994007869A1 QUINAZOLINE DERIVATIVES 审中-公开
标题翻译：喹诺酮衍生物
公开(公告)号：WO1994007869A1
公开(公告)日：1994-04-14
申请号：PCT/GB1993002015
申请日：1993-09-28
申请人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD. , BARKER, Andrew, John , BOYLE, Francis, Thomas , HENNEQUIN, Laurent, François, André
发明人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D239/90
CPC分类号： C07D401/12 , C07D239/90 , C07F9/65128
摘要： The invention relates to quinazoline derivatives of formula (I) wherein R1 includes hydrogen, amino, (1-4C)alkyl and (1-4C)alkoxy; R2 includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl and (3-4C)alkynyl; Ar1 is phenylene or a 5- or 6-membered aromatic heterocyclene ring; Ar2 is optionally substituted phenyl or heteroaryl; and Q includes nitro, cyano, carbamoyl, (1-4C)alkylsulphonyl and NŸ ,NŸ -di-((1-4C)alkyl)sulphamoyl; or pharmaceutically acceptable salts thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-tumour agents.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中R 1包括氢，氨基，（1-4C）烷基和（1-4C）烷氧基; R2包括氢，（1-4C）烷基，（3-4C）烯基和（3-4C）炔基; Ar 1是亚苯基或5或6元芳族杂环烯环; Ar 2是任选取代的苯基或杂芳基; 并且Q包括硝基，氰基，氨基甲酰基，（1-4C）烷基磺酰基和N，N， - 二 - （（1-4C）烷基）氨磺酰基; 或其药学上可接受的盐; 制造过程; 含有它们的药物组合物; 并将其用作抗肿瘤剂。

2. 发明申请

WO1994011354A1 TRICYCLIC COMPOUNDS WITH PHARMACEUTICAL ACTIVITY 审中-公开
标题翻译：具有药物活性的三元化合物
公开(公告)号：WO1994011354A1
公开(公告)日：1994-05-26
申请号：PCT/GB1993002281
申请日：1993-11-04
申请人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD. , BOYLE, Francis, Thomas , CROOK, James, William , MATUSIAK, Zbigniew, Stanley
发明人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D239/70
CPC分类号： C07D401/12 , C07D239/70 , C07D403/12
摘要： The invention relates to tricyclic compounds of formula (I) wherein R is hydrogen, amino, (1-4C)alkyl, (1-4C)alkoxy, hydroxy-(1-4C)alkyl or fluoro-(1-4C)alkyl; R is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, hydroxy-(2-4C)alkyl, halogeno-(2-4C)alkyl or cyano-(1-4C)alkyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and R includes a group of the formula -NHCH(CO2H)-A -Y wherein A is (1-6C)alkylene and Y is carboxy, tetrazol-5-yl, N &cir& _-[(1-4C)alkylsulphonyl]carbamoyl, N &cir& _(phenylsulphonyl)carbamoyl, tetrazol-5-ylthio, tetrazol-5-ylsulphinyl or tetrazol-5-ylsulphonyl; or pharmaceutically-acceptable salts or esters thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-cancer agents.
摘要翻译：本发明涉及式（I）的三环化合物，其中R 1是氢，氨基，（1-4C）烷基，（1-4C）烷氧基，羟基 - （1-4C）烷基或氟 - （1-4C））烷基; R 2是氢，（1-4C）烷基，（3-4C）烯基，（3-4C）炔基，羟基 - （2-4C）烷基，卤代 - （2-4C）烷基或氰基 - （1 -4C）烷基; Ar是任选取代的亚苯基，噻吩二基，噻唑二基，吡啶二基或嘧啶二基; 并且R 3包括其中A 1为（1-6C）亚烷基且Y 1为羧基的式-NHCH（CO 2 H）-A 1 -Y 1的基团，四唑-5-基，（1-4C）烷基磺酰基]氨基甲酰基，N，（苯基磺酰基）氨基甲酰基，四唑-5-基硫基，四唑-5-基亚磺酰基或四唑-5-基磺酰基; 或其药学上可接受的盐或酯; 制造过程; 含有它们的药物组合物; 并将其用作抗癌剂。

3. 发明申请

WO1995009158A1 TRICYCLIC DERIVATIVES 审中-公开
标题翻译： TRICYCLIC衍生物
公开(公告)号：WO1995009158A1
公开(公告)日：1995-04-06
申请号：PCT/GB1994002039
申请日：1994-09-20
申请人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD. , BOYLE, Francis, Thomas
发明人： ZENECA LIMITED , BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D239/70
CPC分类号： C07D401/12 , C07D239/70 , C07D401/14
摘要： The invention relates to tricyclic derivatives of formula (I), wherein R includes hydrogen, amino, (1-4C)alkyl and (1-4C)alkoxy; R includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl and (3-4C)alkynyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and Ar is optionally-substituted phenyl or heteroaryl; or a pharmaceutically-acceptable salt thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as thymidylate synthase inhibitors.
摘要翻译：本发明涉及式（I）的三环衍生物，其中R 1包括氢，氨基，（1-4C）烷基和（1-4C）烷氧基; R 2包括氢，（1-4C）烷基，（3-4C）烯基和（3-4C）炔基; Ar 1是任选取代的亚苯基，噻吩二基，噻唑二基，吡啶二基或嘧啶二基; 并且Ar 2是任选取代的苯基或杂芳基; 或其药学上可接受的盐; 制造过程; 含有它们的药物组合物; 并用作胸苷酸合酶抑制剂。

4. 发明申请

WO1997037664A2 USE OF 7 APHA-SUBSTITUTED STEROIDS TO TREAT NEUROPSYCHIATRIC, IMMUNE OR ENDOCRINE DISORDERS 审中-公开
标题翻译：使用7种APHA-替代的甾体来治疗神经病，免疫或内分泌疾病
公开(公告)号：WO1997037664A2
公开(公告)日：1997-10-16
申请号：PCT/GB1997000955
申请日：1997-04-04
申请人： BRITISH TECHNOLOGY GROUP LTD. , LATHE, Richard , ROSE, Kenneth, Andrew , SECKL, Jonathan, Robert , BEST, Ruth , YAU, Joyce, Lai, Wah , LECKIE, Caroline, McKenzie
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： A61K31/565
CPC分类号： A61K31/566 , A61K31/565 , A61K31/5685 , A61K31/57 , A61K38/00 , C07J1/0059 , C07J1/007 , C07J1/0074 , C07J1/0077 , C12N9/0071 , C12P33/06
摘要： Use is provided for a 7 alpha -hydroxy or 7-oxo substituted 3 beta -hydroxy-steroid possessing the carbon skeleton of cholesterol, androsterone, pregnenolone or estradiol, or an analogue thereof substituted independently at one or both of the 7- and 3-positions with an ester or ether group, in the manufacture of a pharmaceutical composition for the therapy of neuropsychiatric, immune and/or endocrine disorders or for inducing cognitive enhancement. Uses for Cyp7b enzymes in producing such steroids is also provided together with various novel steroids and test kits and methods for diagnosing the disorders.
摘要翻译：提供用于具有胆固醇，雄酮，孕烯醇酮或雌二醇的碳骨架的7α-羟基或7-氧代取代的3β-羟基类固醇，或其在7-和3-位的一个或两个上单独取代的类似物，在制备用于治疗神经精神，免疫和/或内分泌紊乱或用于诱导认知增强的药物组合物中具有酯或醚基团的位置。 Cyp7b酶在制备此类类固醇中的应用还与各种新型类固醇和检测试剂盒以及诊断疾病的方法一同提供。

5. 发明申请

WO1997023456A1 INDOLOQUINONE DERIVATIVES AS BIOREDUCTIVE AGENTS 审中-公开
标题翻译：吲哚喹啉衍生物作为生物降解剂
公开(公告)号：WO1997023456A1
公开(公告)日：1997-07-03
申请号：PCT/GB1996003176
申请日：1996-12-20
申请人： BRITISH TECHNOLOGY GROUP LTD. , STRATFORD, Ian, James , NAYLOR, Matthew, Alexander , JAFFAR, Mohammed , ADAMS, Gerald, Edward
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D209/42
CPC分类号： C07D209/12 , A61K31/404
摘要： Use of a compound of general formula (I) or salt thereof wherein R and R are independently selected from hydrogen, halogen and C1-6 alkyl or haloalkyl, C2-6 alkenyl or haloalkenyl, C1-6 alkoxy, phenoxy, C1-6 alkylthio, phenylthio, primary and secondary amino or hydroxy groups and R is hydrogen, hydroxy, a C1-6 alkyl or haloalkyl, C2-6 alkenyl or haloalkenyl or C1-6 alkoxy or haloalkoxy group is provided for the manufacture of a medicament for the treatment of neoplasms, particularly solid cancerous tumours characterised in that R is selected from a C1-6 alkyl or haloalkyl group, -CO2R where R is hydrogen or a C1-6 alkyl or haloalkyl group, or a group -CH2-X where X is selected from groups of formula -S-R , -O-R , and (a) where R is a hydrogen or a leaving group, the acid HR6 of which has a pKa of 10 or less and R and R are the same or different and are selected from C1-6 alkyl or haloalkyl or together with the interjacent nitrogen form a heterocyclic ring of 5 to 7 atoms optionally substituted by C1-4 alkyl or haloalkyl and R is selected from hydrogen, C1-4 alkyl and haloalkyl or groups-(CH2)nCHR R of more than four carbon atoms where n is an integer of 0 to 2 and R and R are independently selected from a C1-4 alkyl or haloalkyl group, or R and R together with the interjacent carbon atom form a C3-7 cycloalkyl or cycloalkenyl ring optionally substituted with one or more C1-4 alkyl or haloalkyl, or C2-4 alkenyl or haloalkenyl groups.
摘要翻译：使用通式（I）的化合物或其盐，其中R和R 4独立地选自氢，卤素和C 1-6烷基或卤代烷基，C 2-6烯基或卤代烯基，C 1-6烷氧基，苯氧基，C 1 -6烷硫基，苯硫基，伯和仲氨基或羟基，R 3为氢，羟基，C 1-6烷基或卤代烷基，C 2-6烯基或卤代链烯基或C 1-6烷氧基或卤代烷氧基，用于制备用于治疗肿瘤，特别是固体癌性肿瘤的药物，其特征在于R 1选自C 1-6烷基或卤代烷基，-CO 2 R 5，其中R 5是氢或C 1-6烷基或卤代烷基，或基团-CH 2 -X（其中X选自式-SR 6，-OR 6）和（a）其中R 6为氢或离去基团的基团，该酸 HR6的pKa为10以下，R 7和R 8相同或不同，选自C 1-6烷基或卤代烷基，或与中间的氮一起形成杂环任选被C 1-4烷基或卤代烷基取代的5至7个原子，R 2选自氢，C 1-4烷基和卤代烷基或多于四个碳原子的基团 - （CH 2）n CHR 9 R 10，其中 n为0〜2的整数，R 9和R 10独立地选自C 1-4烷基或卤代烷基，或R 9和R 10与中间碳原子一起形成C 3 -7环烷基或环烯基，任选被一个或多个C 1-4烷基或卤代烷基取代，或C 2-4链烯基或卤代烯基。

6. 发明申请

WO1994002849A1 ASSAY OF NADH 审中-公开
标题翻译： NADH测定
公开(公告)号：WO1994002849A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001552
申请日：1993-07-22
申请人： BRITISH TECHNOLOGY GROUP LTD. , SHARMA, Ashutosh
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： G01N33/52
CPC分类号： C12Q1/008 , G01N21/6428 , G01N21/7703 , G01N33/52 , G01N2021/6432 , G01N2021/772
摘要： Use of benzopurpurin 4B for the assay of NADH by fluorescence quenching.

7. 发明申请

WO1994002469A1 PYRIMIDINE COMPOUNDS USED IN THE THERAPY 审中-公开
标题翻译：在治疗中使用的吡咯烷酮化合物
公开(公告)号：WO1994002469A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001381
申请日：1993-07-01
申请人： BRITISH TECHNOLOGY GROUP LTD. , STEVENS, Malcolm, Francis, Graham , RATHBONE, Daniel, Lee , O'SHEA, Dennis, Mark
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D239/48
CPC分类号： C07D239/48 , C07D401/12
摘要： Compounds of formula (I), wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl or acyl, R5 is alkyl, X represents a hydrophobic substituent and n is an integer from 1 to 3, and R6 and R7 each represent alkyl, cycloalkyl, or aralkyl, or R6 and R7 together with the nitrogen to which they are attached form a heterocyclic ring, with the proviso that one or both of R6 and R7, or the heterocyclic ring including R6 and R7, carries and/or includes at least one oxygen or sulphur atom, or a salt or N-oxide thereof may be used in the treatment of (P.Carinii) infections.
摘要翻译：式（I）化合物，其中R 1，R 2，R 3和R 4各自独立地为氢，烷基或酰基，R 5为烷基，X为疏水性取代基，n为1〜3的整数，R 6和R 7各自为烷基，环烷基或芳烷基，或者R 6和R 7与它们所连接的氮一起形成杂环，条件是R 6和R 7或包括R 6和R 7的杂环中的一个或两个携带和/或包括至少一种氧或硫原子，或其盐或N-氧化物可用于治疗（P.Carinii）感染。

8. 发明申请

WO1993024676A1 DIAMOND FILM DEPOSITION 审中-公开
标题翻译：金刚石膜沉积
公开(公告)号：WO1993024676A1
公开(公告)日：1993-12-09
申请号：PCT/GB1993001082
申请日：1993-05-26
申请人： BRITISH TECHNOLOGY GROUP LTD. , JOHN, Phillip , WILSON, John, Ivor, Barrett , DRUMMOND, Iain, Cameron
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C23C16/26
CPC分类号： C23C16/274 , B24C3/32 , B24C5/08 , B24C11/00 , C23C16/0254
摘要： The invention provides an improved method and apparatus for pre-treating a substrate surface (19) to prepare it for subsequent deposition upon it of a film of diamond. The method of pre-treating a surface according to the invention comprises the steps of positioning a quantity of diamond dust (16) in relation to the surface, producing a shock wave in gas adjacent the dust, subjecting the dust to the shock wave, and thereby causing the diamond dust to impinge at high velocity on to the surface. The apparatus according to the invention comprises means for holding a charge of diamond dust (15), means for generating a shock wave in gas adjacent the charge of diamond dust (17), and means for directing the shock wave at the diamond dust (12) and causing the diamond dust to be expelled at high velocity for impingement on the substrate surface. The invention also provides a method depositing a diamond film on a substrate, including pre-treatment by the aforesaid method or apparatus.
摘要翻译：本发明提供了一种改进的方法和装置，用于预处理衬底表面（19）以准备其用于随后沉积在金刚石膜上。根据本发明的预处理表面的方法包括以下步骤：相对于表面定位一定数量的金刚石粉尘（16），在靠近灰尘的气体中产生冲击波，使粉尘受到冲击波的影响;以及从而使金刚石粉尘以高速撞击到表面。根据本发明的装置包括用于保持金刚石粉尘（15）的装置的装置，用于在靠近金刚石粉尘（17）的充电的气体中产生冲击波的装置，以及用于将冲击波引导到金刚石粉尘（12））并使金刚石粉尘以高速度排出以冲击衬底表面。本发明还提供了一种在衬底上沉积金刚石膜的方法，包括通过前述方法或装置的预处理。

9. 发明申请

WO1993023780A1 MECHANICAL MOUNTING 审中-公开
标题翻译：机械安装
公开(公告)号：WO1993023780A1
公开(公告)日：1993-11-25
申请号：PCT/GB1993000991
申请日：1993-05-14
申请人： BRITISH TECHNOLOGY GROUP LTD. , DOWNS, Michael, John
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： G02B07/00
CPC分类号： G02B7/00 , G01B9/02049 , G02B7/182
摘要： A substantially kinematic mount for a rigid object comprising planar, linear and point contact constraining means is provided. At least one of the constraining means comprises a rigid body and a resilient body which together are adapted to urge said rigid object into contact with the other two of the constraining means.

10. 发明申请

WO1993021659A1 SEMICONDUCTOR DEVICES WITH A DOUBLE GATE 审中-公开
标题翻译：具有双门的半导体器件
公开(公告)号：WO1993021659A1
公开(公告)日：1993-10-28
申请号：PCT/GB1993000792
申请日：1993-04-15
申请人： BRITISH TECHNOLOGY GROUP LTD. , LEE, Michael, John
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： H01L29/784
CPC分类号： H01L29/78648 , H01L27/0883
摘要： An integrated circuit arrangement comprising a pair of insulated-gate transistor devices connectible in series, the first transistor of said pair being operable as a depletion-mode device whilst the second transistor of said pair serves as an enhancement-mode device. A separately-biasable gate electrode permits the threshold voltage of the depletion-mode transistor to be adjusted independently.
摘要翻译：一种集成电路装置，包括可串联连接的一对绝缘栅晶体管器件，所述对的第一晶体管可操作为耗尽型器件，而所述一对的第二晶体管用作增强型器件。单独偏置的栅极允许单独调节耗尽型晶体管的阈值电压。

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