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1. 发明申请

WO2012099881A2 MUTANT PROTEINS AS CANCER-SPECIFIC BIOMARKERS 审中-公开
标题翻译：突变蛋白作为癌症特异性生物标志物
公开(公告)号：WO2012099881A2
公开(公告)日：2012-07-26
申请号：PCT/US2012021553
申请日：2012-01-17
申请人： UNIV JOHNS HOPKINS , VOGELSTEIN BERT , WANG QING , PANDEY AKHILESH , KINZLER KENNETH W , PAPADOPOULOS NICKOLAS
发明人： VOGELSTEIN BERT , WANG QING , PANDEY AKHILESH , KINZLER KENNETH W , PAPADOPOULOS NICKOLAS
IPC分类号： G01N33/68 , G01N33/551 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/574 , G01N33/6848
摘要： Altered protein products resulting from somatic mutations are directly identified and quantified by mass spectrometry. The peptides expressed from normal and mutant alleles are detected by Selected Reaction Monitoring (SRM) of their product ions using a triple quadrupole mass spectrometer. As a prototypical example of this approach, we quantify the number and fraction of mutant Ras protein present in cancer cell lines. There were an average of 1.3 million molecules of Ras protein per cell and the ratio of mutant to normal Ras proteins ranged from 0.49 to 5.6. Similarly, we detected and quantified mutant Ras proteins in clinical specimens such as colorectal and pancreatic tumor tissues as well as in pre-malignant pancreatic cyst fluids. These methods are useful for diagnostic applications.
摘要翻译：通过质谱法直接鉴定和定量由体细胞突变产生的改变的蛋白质产物。使用三重四极质谱仪通过其产物离子的选择性反应监测（SRM）来检测从正常和突变等位基因表达的肽。作为这种方法的原型实例，我们量化了存在于癌细胞系中的突变型Ras蛋白的数量和分数。每个细胞平均有130万个Ras蛋白分子，突变体与正常Ras蛋白的比例范围为0.49至5.6。同样，我们在临床标本如结直肠癌和胰腺肿瘤组织以及恶变前胰腺囊液中检测并定量了突变型Ras蛋白。这些方法对诊断应用程序很有用。

2. 发明申请

WO2008032240A3 OVERCHARGE AND OVERDISCHARGE PROTECTION IN LITHIUM-ION BATTERIES 审中-公开
标题翻译：锂离子电池的过度和超标保护
公开(公告)号：WO2008032240A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007053578
申请日：2007-09-05
申请人： HIGH POWER LITHIUM S A , EXNAR IVAN , WANG QING
发明人： EXNAR IVAN , WANG QING
IPC分类号： H01M4/48 , H01M4/485 , H01M4/58 , H01M10/0525 , H01M10/0567 , H01M10/36
CPC分类号： H01M10/4235 , H01M4/485 , H01M4/5825 , H01M10/0525 , H01M10/0567
摘要： A lithium-ion battery comprising a first electrode made of cathodic material, a second electrode made of anodic material and an electrolyte, said lithium-ion battery containing an overcharge protection material consisting of redox molecules, characterized by the fact that said redox molecules have a reduction potential which is lower than said anodic material.
摘要翻译：一种锂离子电池，包括由阴极材料制成的第一电极，由阳极材料制成的第二电极和电解质，所述锂离子电池含有由氧化还原分子组成的过充电保护材料，其特征在于所述氧化还原分子具有还原电位低于所述阳极材料。

3. 发明申请

WO2007078916A3 HIGH ELECTRIC ENERGY DENSITY POLYMER CAPACITORS WITH FAST DISCHARGE SPEED AND HIGH EFFICIENCY BASED ON UNIQUE POLY(VINYLIDENE FLUORIDE) COPOLYMERS AND TERPOLYMERS AS DIELECTRIC MATERIALS 审中-公开
标题翻译：具有快速放电速度和高效率的高电能密度聚合物电容器，基于独特的聚（乙烯基氟化物）共聚物和作为介电材料的TERPOLYMERS
公开(公告)号：WO2007078916A3
公开(公告)日：2007-08-30
申请号：PCT/US2006048258
申请日：2006-12-18
申请人： PENN STATE RES FOUND , ZHANG QIMING , CHU BAOJIN , ZHOU XIN , LU YINGYING , WANG QING , NEESE BRET
发明人： ZHANG QIMING , CHU BAOJIN , ZHOU XIN , LU YINGYING , WANG QING , NEESE BRET
IPC分类号： H01G4/18
CPC分类号： H01G4/186 , Y02T10/7022
摘要： An improved charge or energy storage device having a dielectric charge or energy storage layer including: (i) a copolymer or terpolymer selected from P(VDF-CTFE), P(VDF-CFE), P(VDF-HFP)1 P(VDF-CDFE), P(VDF-TrFE-CTFE), P(VDF- TrFE-CFE), P(VDF-TrFE-HFP)1 P(VDF-TrFE-CDFE)1 P(VDF-TFE-CTFE), P(VDF-TFE-CFE), P(VDF-TFE-HFP), and P(VDF-TFE-CDFE); or (ii) a polymer blend of PVDF homopolymer with a copolymer selected from P(VDF-CTFE); P(VDF-CFE); P(VDF-HFP); and P(VDF- CDFE); or (iii) a polymer blend of a PVDF homopolymer with a terpolymer selected from P(VDF-TrFE-CTFE); P(VDF-TrFE-CFE); P(VDF-TrFE-HFP); P(VDF-TrFE-CDFE); P(VDF-TFE-CTFE); P(VDF-TFE-CFE); P(VDF-TFE- HFP); and P(VDF-TFE-CDFE); or (iv) a polymer blend of copolymer selected from P(VDF-CTFE); P(VDF-CFE); P(VDF-HFP); and P(VDF-CDFE); with a terpolymer selected from P(VDF-TrFE-CTFE); P(VDF-TrFE-CFE); P(VDF-TrFE-HFP); P(VDF- TrFE-CDFE); P(VDF-TFE-CTFE); P(VDF-TFE-CFE); P(VDF-TFE-HFP); and P(VDF-TFE-CDFE).
摘要翻译：一种具有介电电荷或能量存储层的改进的电荷或能量存储装置，包括：（i）选自P（VDF-CTFE），P（VDF-CFE），P（VDF-HFP）1 P（VDF）的共聚物或三元共聚物 -CDFE），P（VDF-TrFE-CTFE），P（VDF-TrFE-CFE），P（VDF-TrFE-HFE）（VDF-TFE-CFE），P（VDF-TFE-HFP）和P（VDF-TFE-CDFE）; 或（ii）PVDF均聚物与选自P（VDF-CTFE）的共聚物的聚合物共混物; P（VDF-CFE）; P（VDF-HFP）; 和P（VDF-CDFE）; 或（iii）PVDF均聚物与选自P（VDF-TrFE-CTFE）的三元共聚物的聚合物共混物; P（VDF-TrFE的-CFE）; P（VDF-TrFE的-HFP）; P（VDF-TrFE的-CDFE）; P（VDF-TFE-CTFE）; P（VDF-TFE-CFE）; P（VDF-TFE-HFP）; 和P（VDF-TFE-CDFE）; 或（iv）选自P（VDF-CTFE）的共聚物的共聚物; P（VDF-CFE）; P（VDF-HFP）; 和P（VDF-CDFE）; 具有选自P（VDF-TrFE-CTFE）的三元共聚物; P（VDF-TrFE的-CFE）; P（VDF-TrFE的-HFP）; P（VDF-TrFE-CDFE）; P（VDF-TFE-CTFE）; P（VDF-TFE-CFE）; P（VDF-TFE-HFP）; 和P（VDF-TFE-CDFE）。

4. 发明申请

WO03012062A9 ANIMAL MODEL WITH DISRUPTED FGF14 GENE 审中-公开
标题翻译：具有破坏性FGF14基因的动物模型
公开(公告)号：WO03012062A9
公开(公告)日：2004-04-15
申请号：PCT/US0224419
申请日：2002-07-31
申请人： UNIV WASHINGTON , ORNITZ DAVID M , WANG QING , BARDGETT MARK E , WONG MICHAEL , WOZNIAK DAVID F , LOU JUNYANG , YAMADA KELVIN
发明人： ORNITZ DAVID M , WANG QING , BARDGETT MARK E , WONG MICHAEL , WOZNIAK DAVID F , LOU JUNYANG , YAMADA KELVIN
IPC分类号： A01K67/027 , C07K14/50 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , A01K67/00 , A01K67/033 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C07K14/50 , C12N2800/30
摘要： The disclosure describes a unique animal model which is useful for studying the role of FGF14 in the central nervous system (CNS) and testing of potential drugs for treatment of CNS diseases. To provide this animal model, the Fgf14 gene is disrupted in mice by replacing the second and third exons with beta-galactosidase. Neuropharmacological studies are disclosed which show that the Fgf14 deficient mice have disrupted striatal-nigra and striatal-pallidal pathways resulting in increased excitatory input to the cortex. The paroxysmal hyperkinetic disorder in Fgf14 deficient mice phenocopies a form of dystonia, a disease often associated with dysfunction of the putamen.
摘要翻译：本公开描述了一种独特的动物模型，其可用于研究FGF14在中枢神经系统（CNS）中的作用以及用于治疗CNS疾病的潜在药物的测试。为了提供这种动物模型，通过用β-半乳糖苷酶代替第二和第三外显子，Fgf14基因在小鼠中被破坏。公开了神经药理学研究，其显示Fgf14缺陷小鼠已经破坏了纹状体黑质和纹状体 - 苍白球途径，导致对皮质的兴奋性输入增加。 Fgf14缺陷型小鼠阵发性超动力障碍是一种肌张力障碍，一种通常与壳核功能障碍有关的疾病。

5. 发明申请

WO03012062A2 ANIMAL MODEL WITH DISRUPTED DOLLAR I(FGF14) GENE 审中-公开
标题翻译：具有DOLLAR I（FGF14）基因的动物模型
公开(公告)号：WO03012062A2
公开(公告)日：2003-02-13
申请号：PCT/US0224419
申请日：2002-07-31
申请人： UNIV WASHINGTON , ORNITZ DAVID M , WANG QING , BARDGETT MARK E , WONG MICHAEL , WOZNIAK DAVID F , LOU JUNYANG , YAMADA KELVIN
发明人： ORNITZ DAVID M , WANG QING , BARDGETT MARK E , WONG MICHAEL , WOZNIAK DAVID F , LOU JUNYANG , YAMADA KELVIN
IPC分类号： A01K67/027 , C07K14/50 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , C12N
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C07K14/50 , C12N2800/30
摘要： The disclosure describes a unique animal model which is useful for studying the role of FGF14 in the central nervous system (CNS) and testing of potential drugs for treatment of CNS diseases. To provide this animal model, the Fgf14 gene is disrupted in mice by replacing the second and third exons with beta -galactosidase. Neuropharmacological studies are disclosed which show that the Fgf14 deficient mice have disrupted striatal-nigra and striatal-pallidal pathways resulting in increased excitatory input to the cortex. The paroxysmal hyperkinetic disorder in Fgf14 deficient mice phenocopies a form of dystonia, a disease often associated with dysfunction of the putamen.
摘要翻译：本公开描述了一种独特的动物模型，其可用于研究FGF14在中枢神经系统（CNS）中的作用以及用于治疗CNS疾病的潜在药物的测试。为了提供这种动物模型，通过用β-半乳糖苷酶代替第二和第三外显子，Fgf14基因在小鼠中被破坏。公开了神经药理学研究，其显示Fgf14缺陷小鼠已经破坏了纹状体黑质和纹状体 - 苍白球途径，导致对皮质的兴奋性输入增加。 Fgf14缺陷型小鼠阵发性超动力障碍是一种肌张力障碍，一种通常与壳核功能障碍有关的疾病。

6. 发明申请

WO2006131873A3 LITHIUM RECHARGEABLE ELECTROCHEMICAL CELL 审中-公开
标题翻译：锂可充电电化学细胞
公开(公告)号：WO2006131873A3
公开(公告)日：2007-07-19
申请号：PCT/IB2006051781
申请日：2006-06-02
申请人： HIGH POWER LITHIUM S A , GRAETZEL MICHAEL , EXNAR IVAN , WANG QING
发明人： GRAETZEL MICHAEL , EXNAR IVAN , WANG QING
IPC分类号： H01M4/62 , H01M4/04 , H01M4/131 , H01M4/1391 , H01M10/0525 , H01M10/058 , H01M10/36
CPC分类号： H01M4/131 , H01M4/0416 , H01M4/1391 , H01M4/624 , H01M10/0525 , H01M10/058
摘要： This invention concerns a lithium rechargeable electrochemical cell comprising an electrochemically addressable electrode system. The electrodes are composed of a cathodic lithium insertion material ( 2 ) incorporating a p-type conductive compound ( 4 ) , and an anodic lithium insertion material ( 3 ) incorporating an n-type conductive compound ( 5 ) . Such a rechargeable electrochemical cell is suitable for high energy density applications. The present invention also concerns the general use of conductive compounds and electrochemically addressable electrode systems comprising similar components which are suitable for use in the electrochemical cell .
摘要翻译：本发明涉及一种包含电化学可寻址电极系统的锂可再充电电化学电池。电极由掺有p型导电化合物（4）的阴极锂插入材料（2）和包含n型导电化合物（5）的阳极锂插入材料（3）组成。这种可充电电化学电池适用于高能量密度应用。本发明还涉及导电化合物和电化学可寻址电极系统的一般用途，其包括适合用于电化学电池的类似组分。

7. 发明申请

WO2006055927A3 PATHOGENIC GENE AND PROTEIN ASSOCIATED WITH PAROXYSMAL DYSKINESIA AND EPILEPSY 审中-公开
标题翻译：与病原菌和蛋白质相关的致病基因和蛋白质
公开(公告)号：WO2006055927A3
公开(公告)日：2007-04-12
申请号：PCT/US2005042215
申请日：2005-11-17
申请人： CLEVELAND CLINIC FOUNDATION , WANG QING
发明人： WANG QING
IPC分类号： C12N15/00
CPC分类号： C07K14/705
摘要： A method of identifying a patient that has, or is at risk of developing general epilepsy and/or paroxysmal dyskinesia includes detecting an alteration of the KCNMAI gene that disrupts the function of the BK channel so as to produce general epilepsy and/or paroxysmal dyskinesia.
摘要翻译：鉴定患有发生一般性癫痫和/或阵发性运动障碍的患者的方法包括检测破坏BK通道功能的KCNMAI基因的改变，以产生一般的癫痫和/或阵发性运动障碍。

8. 发明申请

WO2010124171A2 SYSTEM AND METHOD FOR INFORMATION DELIVERY INCLUDING DELIVERY VIA VIDEO-BASED KEYED OR TAGGED CONTENT 审中-公开
标题翻译：用于信息传递的系统和方法，包括基于视频键盘或标签内容的传送
公开(公告)号：WO2010124171A2
公开(公告)日：2010-10-28
申请号：PCT/US2010032180
申请日：2010-04-23
申请人： TELEGENT SYSTEMS INC , SHENG SAMUEL , BYDELEY DAVID , LEVY GARY , WANG QING
发明人： SHENG SAMUEL , BYDELEY DAVID , LEVY GARY , WANG QING
IPC分类号： H04N7/08 , H04N7/00
CPC分类号： H04N7/088 , H04H20/38 , H04H60/33 , H04H60/65 , H04H60/73 , H04N21/2353 , H04N21/4622 , H04N21/4667 , H04N21/472 , H04N21/858
摘要： An interactive device/system of and method for delivery, receipt and/or decoding of and/or response to keyed or tagged video content provided in connection with one or more video broadcasts (for example, television or streaming video). Responsive thereto, the system and method may deliver and/or receive video and/or audio information. Such delivery and/or receipt of video and/or audio information may be responsive to content embedded in the broadcast but not visually observed, responsive to broadcast content that is visually observed and then parsed and correlated with a predetermined response, and responsive to a user/operator instruction, input and/or request. The interactive video receiving device may determine a video-based broadcast is an interactive video-based broadcast, wherein, the device automatically provides interaction options and or based on a response by the user/viewer to the video-based broadcast, the video receiving device transmits "interest-level" data (i.e., data which is representative of the viewer's level of interest to the video-based broadcast) to obtain additional information regarding the video-based broadcast. Other inventions are also disclosed.
摘要翻译：用于与一个或多个视频广播（例如，电视或流式视频）相关联地提供的关键或标记的视频内容的交付，接收和/或解码和/或响应的交互设备/系统和方法。响应于此，系统和方法可以传送和/或接收视频和/或音频信息。视频和/或音频信息的这种传送和/或接收可以响应于在视频观察并随后被解析并与预定响应相关联并且响应于用户的广播内容而广播内容而不是视觉上观察到的内容 /操作员指令，输入和/或请求。交互式视频接收设备可以确定基于视频的广播是基于视频的交互式广播，其中，设备自动地提供交互选项，或者基于用户/观看者对基于视频的广播的响应，视频接收设备发送“利益级别”数据（即，代表观看者对基于视频的广播感兴趣的级别的数据），以获得关于基于视频的广播的附加信息。还公开了其它发明。

9. 发明申请

WO2007116363A3 LITHIUM RECHARGEABLE ELECTROCHEMICAL CELL 审中-公开
标题翻译：锂可充电电化学电池
公开(公告)号：WO2007116363A3
公开(公告)日：2007-12-21
申请号：PCT/IB2007051246
申请日：2007-04-06
申请人： HIGH POWER LITHIUM S A , EXNAR IVAN , WANG QING , GRAETZEL MICHAEL , ZAKEERUDDIN SHAIK MOHAMMED , KAVAN LADISLAV
发明人： EXNAR IVAN , WANG QING , GRAETZEL MICHAEL , ZAKEERUDDIN SHAIK MOHAMMED , KAVAN LADISLAV
IPC分类号： H01M4/13 , H01M4/58 , H01M10/0525 , H01M10/0562 , H01M10/0565 , H01M10/0567 , H01M10/058 , H01M10/36
CPC分类号： H01M10/0525 , H01B1/122 , H01M4/13 , H01M4/5825 , H01M10/0562 , H01M10/0565 , H01M10/0567 , H01M10/058 , H01M2300/0025
摘要： This invention concerns a lithium rechargeable electrochemical cell containing electrochemical redox active compounds in the electrolyte. The cell is composed of two compartments, where the cathodic compartment comprises a cathodic lithium insertion material and one or more of p-type redox active compound(s) in the electrolyte; the anodic compartment comprises an anodic lithium insertion material and one or more of n-type redox active compound(s) in the electrolyte. These two compartments are separated by a separator and the redox active compounds are confined only in each compartment. Such a rechargeable electrochemical cell is suitable for high energy density applications. The present invention also concerns the general use of redox active compounds and electrochemically addressable electrode systems containing similar components which are suitable for use in the electrochemical cell.
摘要翻译：本发明涉及在电解质中含有电化学氧化还原活性化合物的可充电锂电化学电池。电池由两个隔室组成，其中阴极隔室包含阴极锂插入材料和电解质中的一种或多种p型氧化还原活性化合物; 阳极室包含阳极锂插入材料和电解质中的一种或多种n型氧化还原活性化合物。这两个隔室被隔板隔开，氧化还原活性化合物仅限于每个隔室。这种可再充电的电化学电池适用于高能量密度应用。本发明还涉及氧化还原活性化合物和含有适用于电化学电池的类似组分的电化学可寻址电极体系的一般用途。

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