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1. 发明申请

WO2010106063A3 COMPOSITE MATERIALS LOADED WITH THERAPEUTIC AND DIAGNOSTIC AGENTS COMPRISING POLYMER NANOPARTICLES AND POLYMER FIBERS 审中-公开
标题翻译：药物和诊断负载的复合材料综合聚合物纳米微粒以及聚合物纤维
公开(公告)号：WO2010106063A3
公开(公告)日：2011-09-29
申请号：PCT/EP2010053381
申请日：2010-03-16
申请人： UNIV GIESSEN JUSTUS LIEBIG , UNIV MARBURG PHILIPPS , TRANSMIT GMBH , SCHMEHL THOMAS , NGUYEN JULIANE , BECK-BROICHSITTER MORITZ , GESSLER TOBIAS , KISSEL THOMAS , THIEME MARCEL
发明人： SCHMEHL THOMAS , NGUYEN JULIANE , BECK-BROICHSITTER MORITZ , GESSLER TOBIAS , KISSEL THOMAS , THIEME MARCEL
IPC分类号： A61K9/51 , A61K9/70
CPC分类号： A61K9/5153 , A61K9/70
摘要： The invention relates to composite materials comprising polymer nanofibers and polymer nanoparticles, wherein at least one of the two polymer materials is loaded with a substance selected from therapeutic and diagnostic agents. Fibers and nanoparticles can comprise identical or different polymers; the polymer materials are, however, biocompatible in every case. Therapeutic and diagnostic agents can be hydrophilic or lipophilic and the two polymer materials likewise. The at least one polymer material and the substance with which said material is loaded are either both hydrophilic or both lipophilic. The polymer nanoparticles of the composite materials have a diameter of 10 nm to 600 nm. The polymer fibers have diameters of 10 nm to 50 µm and lengths of 1 µm to several meters. The invention further relates to a method for producing said composite materials. Polymer nanoparticles can be produced in different ways, such as through controlled precipitation of a polymer solution that optionally comprises a loading substance. The nanoparticles are then mixed with another polymer and a loading substance as applicable, depending on whether particles, fibers or both are to be loaded with substance. The processing of this solution into composites comprising polymer fibers polymer nanoparticles can occur by means of electrospinning, melt spinning, extruding or template process. Composite materials according to the invention are suitable for the production of pharmaceuticals that release therapeutically or diagnostically effective substances slowly and in a controlled manner.
摘要翻译：本发明提供了包含制备的聚合物纳米纤维和纳米颗粒的聚合物复合材料，其特征在于，在治疗和诊断中加载的物质中选择的两种聚合物材料中的至少一种。纤维和纳米颗粒可以由相同或不同的聚合物; 然而，聚合材料是在每种情况下生物相容的。治疗和诊断由此可以是亲水性或亲脂性，以及两种聚合物材料为好。所述至少一种聚合物材料和与它加载的物质，无论是二者均为亲水或亲脂。复合材料的聚合物纳米颗粒的直径为10nm至600nm的。所述聚合物纤维具有从10纳米至50微米的直径和1微米长度可达几米。本发明提供了一种制备所述复合材料的进一步处理。聚合物纳米颗粒可以以各种方式通过聚合物溶液的控制的沉淀来制备，例如，任选地含有负载物质。随后，将纳米颗粒与另一种聚合物混合，并且如果必要的话，装载物质，根据不同的颗粒，纤维，或两者是否将被装载的物质。这种解决方案的处理，以复合材料，其包括聚合物纤维的聚合物纳米颗粒可以，例如，静电纺丝，熔融纺丝，挤出或通过装置发生模板。根据本发明的复合材料是适合于释放治疗或诊断活性物质缓慢和受控的药物中的用途。

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